K. Derkach, V. Bondareva, N. E. Basova, A. Shpakov
{"title":"胰岛素原c肽改善胰岛素水平正常但不升高的2型糖尿病大鼠的代谢和激素参数","authors":"K. Derkach, V. Bondareva, N. E. Basova, A. Shpakov","doi":"10.33647/2074-5982-18-3-90-94","DOIUrl":null,"url":null,"abstract":"In type 2 diabetes mellitus (DM2), the impaired functions of the brain insulin system are associated with the weakened insulin transport through the blood-brain barrier due to insulin resistance. Insulin deficiency in the brain can be corrected by intranasal administration of insulin (II), whose effect may be enhanced by intranasal administration of C-peptide (ICP). In this work, we study the effect of treating hyperinsulinemic and normoinsulinemic DM2 rats with ICP (36 µg/rat/day), II (20 µg/rat/day) and ICP+II on metabolic and hormonal parameters. In normoinsulinemic DM2, ICP attenuated thyroid hormone deficiency and enhanced the restorative effects of II on glucose, insulin, and leptin sensitivity. In hyperinsulinemic DM2, ICP was ineffective, and its combination with II weakened the restorative effects of II. Thus, ICP and its combination with II are effective in restoring metabolic and hormonal parameters in normoinsulinemic, but not hyperinsulinemic, DM2.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"31 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Proinsulin C-peptide Improves metabolic and Hormonal Parameters in Rats with Type 2 Diabetes Mellitus Having Normal but not Elevated Insulin Levels\",\"authors\":\"K. Derkach, V. Bondareva, N. E. Basova, A. Shpakov\",\"doi\":\"10.33647/2074-5982-18-3-90-94\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In type 2 diabetes mellitus (DM2), the impaired functions of the brain insulin system are associated with the weakened insulin transport through the blood-brain barrier due to insulin resistance. Insulin deficiency in the brain can be corrected by intranasal administration of insulin (II), whose effect may be enhanced by intranasal administration of C-peptide (ICP). In this work, we study the effect of treating hyperinsulinemic and normoinsulinemic DM2 rats with ICP (36 µg/rat/day), II (20 µg/rat/day) and ICP+II on metabolic and hormonal parameters. In normoinsulinemic DM2, ICP attenuated thyroid hormone deficiency and enhanced the restorative effects of II on glucose, insulin, and leptin sensitivity. In hyperinsulinemic DM2, ICP was ineffective, and its combination with II weakened the restorative effects of II. Thus, ICP and its combination with II are effective in restoring metabolic and hormonal parameters in normoinsulinemic, but not hyperinsulinemic, DM2.\",\"PeriodicalId\":14837,\"journal\":{\"name\":\"Journal Biomed\",\"volume\":\"31 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal Biomed\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33647/2074-5982-18-3-90-94\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal Biomed","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33647/2074-5982-18-3-90-94","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Proinsulin C-peptide Improves metabolic and Hormonal Parameters in Rats with Type 2 Diabetes Mellitus Having Normal but not Elevated Insulin Levels
In type 2 diabetes mellitus (DM2), the impaired functions of the brain insulin system are associated with the weakened insulin transport through the blood-brain barrier due to insulin resistance. Insulin deficiency in the brain can be corrected by intranasal administration of insulin (II), whose effect may be enhanced by intranasal administration of C-peptide (ICP). In this work, we study the effect of treating hyperinsulinemic and normoinsulinemic DM2 rats with ICP (36 µg/rat/day), II (20 µg/rat/day) and ICP+II on metabolic and hormonal parameters. In normoinsulinemic DM2, ICP attenuated thyroid hormone deficiency and enhanced the restorative effects of II on glucose, insulin, and leptin sensitivity. In hyperinsulinemic DM2, ICP was ineffective, and its combination with II weakened the restorative effects of II. Thus, ICP and its combination with II are effective in restoring metabolic and hormonal parameters in normoinsulinemic, but not hyperinsulinemic, DM2.