胰岛素原c肽改善胰岛素水平正常但不升高的2型糖尿病大鼠的代谢和激素参数

K. Derkach, V. Bondareva, N. E. Basova, A. Shpakov
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引用次数: 0

摘要

在2型糖尿病(DM2)中,脑胰岛素系统的功能受损与胰岛素抵抗导致的胰岛素通过血脑屏障的转运减弱有关。脑内胰岛素缺乏症可以通过鼻内给药胰岛素(II)来纠正,其作用可以通过鼻内给药c肽(ICP)来增强。在这项工作中,我们研究了ICP(36µg/大鼠/天)、II(20µg/大鼠/天)和ICP+II治疗高胰岛素血症和正常胰岛素血症DM2大鼠对代谢和激素参数的影响。在正常胰岛素DM2水平下,ICP可减轻甲状腺激素缺乏,并增强II对葡萄糖、胰岛素和瘦素敏感性的恢复作用。在高胰岛素血症DM2中,ICP无效,与II合用削弱了II的恢复作用。因此,ICP及其联合II对恢复正常胰岛素水平的DM2的代谢和激素参数有效,但对高胰岛素水平的DM2无效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proinsulin C-peptide Improves metabolic and Hormonal Parameters in Rats with Type 2 Diabetes Mellitus Having Normal but not Elevated Insulin Levels
In type 2 diabetes mellitus (DM2), the impaired functions of the brain insulin system are associated with the weakened insulin transport through the blood-brain barrier due to insulin resistance. Insulin deficiency in the brain can be corrected by intranasal administration of insulin (II), whose effect may be enhanced by intranasal administration of C-peptide (ICP). In this work, we study the effect of treating hyperinsulinemic and normoinsulinemic DM2 rats with ICP (36 µg/rat/day), II (20 µg/rat/day) and ICP+II on metabolic and hormonal parameters. In normoinsulinemic DM2, ICP attenuated thyroid hormone deficiency and enhanced the restorative effects of II on glucose, insulin, and leptin sensitivity. In hyperinsulinemic DM2, ICP was ineffective, and its combination with II weakened the restorative effects of II. Thus, ICP and its combination with II are effective in restoring metabolic and hormonal parameters in normoinsulinemic, but not hyperinsulinemic, DM2.
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