Jornal Vascular Brasileiro最新文献

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Lesões traumáticas de aorta em zona rural: série de casos com manifestações tardias e revisão dos aspectos terapêuticos 农村地区主动脉创伤性损伤:一系列晚期表现病例及治疗方面的回顾
Jornal Vascular Brasileiro Pub Date : 2023-05-12 DOI: 10.1590/1677-5449.202200141
J. M. Reis, Flávio Roberto Cavalleiro de Macêdo Ribeiro, Adib Koury Junior, G. Melo, Murilo Vasconcelos de Oliveira, V. Gomes, José Victor Freitas dos Santos, Sotero Gonçalves Sarquis Neto Segundo
{"title":"Lesões traumáticas de aorta em zona rural: série de casos com manifestações tardias e revisão dos aspectos terapêuticos","authors":"J. M. Reis, Flávio Roberto Cavalleiro de Macêdo Ribeiro, Adib Koury Junior, G. Melo, Murilo Vasconcelos de Oliveira, V. Gomes, José Victor Freitas dos Santos, Sotero Gonçalves Sarquis Neto Segundo","doi":"10.1590/1677-5449.202200141","DOIUrl":"https://doi.org/10.1590/1677-5449.202200141","url":null,"abstract":"Resumo As lesões traumáticas da aorta (LTA) torácica estão associadas a altas taxas de morbimortalidade. São classificadas de acordo com a extensão do dano, e a angiotomografia computadorizada tem as maiores sensibilidade e especificidade para identificar o grau de lesão e potenciais lesões associadas. As estratégias terapêuticas para LTA são baseadas no tipo de lesão, na extensão e nas lesões associadas. Pode auxiliar na definição de conduta também o grau de estabilidade do paciente, podendo ser manejo cirúrgico convencional, endovascular (TEVAR) ou conservador em casos selecionados. Entre os pacientes com anatomia vascular adequada, a cirurgia endovascular está associada a melhor sobrevida e a menos riscos. O objetivo deste artigo foi descrever uma série de quatro casos acompanhados em serviço terciário, em um estado com poucos serviços de alta complexidade. A terapêutica endovascular foi empregada como método preferencial. Os pacientes apresentaram evolução favorável sem complicações até a alta e encontram-se em acompanhamento ambulatorial.","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67418592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artéria subclávia direita aberrante: relato de caso e revisão de literatura 异常右锁骨下动脉:病例报告及文献综述
Jornal Vascular Brasileiro Pub Date : 2023-02-20 DOI: 10.1590/1677-5449.202101511
Michel Nasser, Bruna Beatriz Petrocheli, Thais Keltke Santos Felippe, Beatriz Isola, B. Pereira, Ana Luiza Carvalho Sartoreli, João Marques Batista Junior, G. Brandão
{"title":"Artéria subclávia direita aberrante: relato de caso e revisão de literatura","authors":"Michel Nasser, Bruna Beatriz Petrocheli, Thais Keltke Santos Felippe, Beatriz Isola, B. Pereira, Ana Luiza Carvalho Sartoreli, João Marques Batista Junior, G. Brandão","doi":"10.1590/1677-5449.202101511","DOIUrl":"https://doi.org/10.1590/1677-5449.202101511","url":null,"abstract":"Resumo A artéria subclávia direita aberrante, também conhecida como artéria lusória, é a anomalia do arco aórtico mais comum, ocorrendo entre 0,5 e 1% da população. Possui prevalência em mulheres e normalmente está associada a outras variações anatômicas, como o nervo laríngeo não recorrente, presente em 86,7% dos casos. Em sua maioria, a artéria subclávia direita aberrante não apresenta sintomas. Descrevemos essa alteração em uma paciente de 82 anos, hipertensa e assintomática, que havia sido submetida a uma angiotomografia toracoabdominal para a avaliação de uma dissecção crônica tipo III (DeBakey) associada à dilatação de aorta descendente. No achado, a artéria subclávia direita aberrante apresentava percurso retroesofágico associado a um divertículo de Kommerell. Devido à raridade, realizamos revisão bibliográfica integrativa das bases de dados MEDLINE, UpToDate, LILACS, SciELO e Portal CAPES dos últimos 6 anos e discutimos as alterações anatômicas mais frequentes, a sintomatologia e as condutas terapêuticas adotadas.","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67418191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grayscale median (GSM) post-processing, posterizing, and color mapping for carotid ultrasound. 用于颈动脉超声的灰度中值(GSM)后处理、海报化和色彩映射。
IF 0.8
Jornal Vascular Brasileiro Pub Date : 2023-02-10 eCollection Date: 2023-01-01 DOI: 10.1590/1677-5449.202200811
Pedro Luciano Mellucci, Matheus Bertanha, Rodrigo Gibin Jaldin, Winston Bonetti Yoshida, Marcone Lima Sobreira
{"title":"Grayscale median (GSM) post-processing, posterizing, and color mapping for carotid ultrasound.","authors":"Pedro Luciano Mellucci, Matheus Bertanha, Rodrigo Gibin Jaldin, Winston Bonetti Yoshida, Marcone Lima Sobreira","doi":"10.1590/1677-5449.202200811","DOIUrl":"10.1590/1677-5449.202200811","url":null,"abstract":"<p><p>Factors related to atherosclerotic plaques may indicate instability, such as ulcerations, intraplaque hemorrhages, lipid core, thin or irregular fibrous cap, and inflammation. The grayscale median (GSM) value is one of the most widespread methods of studying atherosclerotic plaques and it is therefore important to comprehensively standardize image post-processing. Post-processing was performed using Photoshop 23.1.1.202. Images were standardized by adjusting the grayscale histogram curves, setting the darkest point of the vascular lumen (blood) to zero and the distal adventitia to 190. Posterization and color mapping were performed. A methodology that presents the current state of the art in an accessible and illustrative way should contribute to the dissemination of GSM analysis. This article describes and illustrates the process step by step.</p>","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emotional impact on patients of venous thromboembolism 静脉血栓栓塞症患者的情绪影响
Jornal Vascular Brasileiro Pub Date : 2023-02-10 DOI: 10.1590/1677-5449.202201512
Alcides José Araújo Ribeiro, Marcos Arêas Marques
{"title":"The emotional impact on patients of venous thromboembolism","authors":"Alcides José Araújo Ribeiro, Marcos Arêas Marques","doi":"10.1590/1677-5449.202201512","DOIUrl":"https://doi.org/10.1590/1677-5449.202201512","url":null,"abstract":"","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48493213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of the pulmonary embolism rule-out criteria (PERC rule) and age-adjusted D-Dimer in patients undergoing computed tomography pulmonary angiography for diagnosis of pulmonary embolism. 肺栓塞排除标准(PERC规则)和年龄调整d -二聚体在肺血管造影患者肺栓塞诊断中的应用
Jornal Vascular Brasileiro Pub Date : 2023-01-01 DOI: 10.1590/1677-5449.202200222
John Jaime Sprockel Diaz, Luz Amaya Veronesi Zuluaga, Diana Carolina Coral Coral, Diana Marcela Fierro Rodriguez
{"title":"Application of the pulmonary embolism rule-out criteria (PERC rule) and age-adjusted D-Dimer in patients undergoing computed tomography pulmonary angiography for diagnosis of pulmonary embolism.","authors":"John Jaime Sprockel Diaz,&nbsp;Luz Amaya Veronesi Zuluaga,&nbsp;Diana Carolina Coral Coral,&nbsp;Diana Marcela Fierro Rodriguez","doi":"10.1590/1677-5449.202200222","DOIUrl":"https://doi.org/10.1590/1677-5449.202200222","url":null,"abstract":"<p><strong>Background: </strong>Diagnosis of pulmonary embolism (PE) constitutes a challenge for practitioners. Current practice involves use of pre-test probability prediction rules. Several strategies to optimize this process have been explored.</p><p><strong>Objectives: </strong>To explore whether application of the pulmonary embolism rule-out criteria (PERC rule) and age-adjusted D-dimer (DD) would have reduced the number of computed tomography pulmonary angiography (CTPA) examinations performed in patients with suspected PE.</p><p><strong>Methods: </strong>A retrospective cross-sectional study of adult patients taken for CTPA under suspicion of PE in 2018 and 2020. The PERC rule and age-adjusted DD were applied. The number of cases without indications for imaging studies was estimated and the operational characteristics for diagnosis of PE were calculated.</p><p><strong>Results: </strong>302 patients were included. PE was diagnosed in 29.8%. Only 27.2% of 'not probable' cases according to the Wells criteria had D-dimer assays. Age adjustment would have reduced tomography use by 11.1%, with an AUC of 0.5. The PERC rule would have reduced use by 7%, with an AUC of 0.72.</p><p><strong>Conclusions: </strong>Application of age-adjusted D-dimer and the PERC rule to patients taken for CTPA because of suspected PE seems to reduce the number of indications for the procedure.</p>","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complicações de acessos venosos centrais em um serviço de cirurgia vascular de um hospital de ensino: uma coorte prospectiva 某教学医院血管外科中心静脉通路并发症:一项前瞻性队列研究
Jornal Vascular Brasileiro Pub Date : 2023-01-01 DOI: 10.1590/1677-5449.202300701
Leonardo Jatczak, Renan Camargo Puton, Alencar Junior Lopes Proença, Leonardo Colussi Rubin, Luiza Brum Borges, Jaber Nashat Saleh, Mateus Picada Corrêa
{"title":"Complicações de acessos venosos centrais em um serviço de cirurgia vascular de um hospital de ensino: uma coorte prospectiva","authors":"Leonardo Jatczak, Renan Camargo Puton, Alencar Junior Lopes Proença, Leonardo Colussi Rubin, Luiza Brum Borges, Jaber Nashat Saleh, Mateus Picada Corrêa","doi":"10.1590/1677-5449.202300701","DOIUrl":"https://doi.org/10.1590/1677-5449.202300701","url":null,"abstract":"Resumo Contexto Os acessos venosos centrais são essenciais no manejo de pacientes hospitalizados; contudo, a sua inserção está sujeita a complicações que podem dificultar seu uso e causar morbidade aos pacientes. No Brasil, dados acerca da incidência dessas complicações e das variáveis associadas com esse desfecho são escassos. Objetivos Determinar a incidência de complicações mecânicas e de falhas de acessos venosos centrais de curta permanência realizados no serviço de Cirurgia Vascular de um hospital de ensino, além de identificar as variáveis associadas com a sua ocorrência. Métodos Tratou-se de uma coorte prospectiva com 73 tentativas de acesso venoso central realizadas em pacientes assistidos pelo serviço de Cirurgia Vascular de um hospital de ensino entre julho e outubro de 2022. Resultados Complicações mecânicas ocorreram em 12 tentativas de acessos (16,44%), e falhas, em 10 tentativas (13,70%). Os fatores associados às complicações mecânicas foram menor experiência do operador (p < 0,001), menor grau de especialização do operador (p = 0,014), falha na tentativa de acesso precedente à solicitação de auxílio ao serviço de Cirurgia Vascular (p = 0,008) e presença de pelo menos dois critérios de dificuldade (p = 0,007). Conclusões A incidência local de complicações mecânicas e de falhas dos acessos venosos centrais foi semelhante à descrita na literatura internacional, mas foi superior à descrita em trabalhos brasileiros. Os resultados sugerem que o grau de experiência do executor do acesso, a história de falha em tentativa precedente e a presença de pelo menos dois critérios de dificuldade verificados antes do procedimento estão associados com piores desfechos.","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135549298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel balloon-assisted technique to secure visceral catheterization during a chimney endovascular repair of a ruptured abdominal aortic aneurysm in a centenarian patient 一个新的气球辅助技术,以确保内脏导管在烟囱内修复腹主动脉瘤破裂的百岁病人
Jornal Vascular Brasileiro Pub Date : 2023-01-01 DOI: 10.1590/1677-5449.202300182
Francisco Leonardo Galastri, Leonardo Guedes Moreira Valle, Marcela Juliano Silva Cunha, Bruno Pagnin Schmid, Rodrigo Gobbo Garcia, David Salomão Lewi, Breno Boueri Affonso, Felipe Nasser
{"title":"A novel balloon-assisted technique to secure visceral catheterization during a chimney endovascular repair of a ruptured abdominal aortic aneurysm in a centenarian patient","authors":"Francisco Leonardo Galastri, Leonardo Guedes Moreira Valle, Marcela Juliano Silva Cunha, Bruno Pagnin Schmid, Rodrigo Gobbo Garcia, David Salomão Lewi, Breno Boueri Affonso, Felipe Nasser","doi":"10.1590/1677-5449.202300182","DOIUrl":"https://doi.org/10.1590/1677-5449.202300182","url":null,"abstract":"Abstract A 100-year-old male patient was admitted with a ruptured abdominal aortic aneurysm due to type IA endoleak. Given the proximity of the ruptured site to the superior mesenteric artery (SMA) and renal arteries, a ChEVAR was indicated. Catheterization of the target visceral vessels was a challenging procedural step because of an intensely tortuous thoracic aorta. This hostile aortic anatomy also inhibited exchange for a super stiff guide-wire and selective cannulation with the diagnostic catheter was repeatedly lost when guidewire exchange was attempted. To overcome this issue, a 5 x 40 mm balloon catheter was placed 3cm into the target arteries. The balloon was then inflated below the nominal pressure limit enabling safe exchange for a super stiff guidewire and placement of three 90-cm long 7Fr guiding sheaths. The procedure was thus safely performed with deployment of an aortic extension and the bridging stents.","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135659849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of seasonal and monthly variation and location of deep vein thrombosis 深静脉血栓形成的季节、月变化及部位评价
Jornal Vascular Brasileiro Pub Date : 2023-01-01 DOI: 10.1590/1677-5449.202300802
Serkan Burç Deşer, Berk Arapi
{"title":"Evaluation of seasonal and monthly variation and location of deep vein thrombosis","authors":"Serkan Burç Deşer, Berk Arapi","doi":"10.1590/1677-5449.202300802","DOIUrl":"https://doi.org/10.1590/1677-5449.202300802","url":null,"abstract":"Abstract Background Deep vein thrombosis of the lower extremities is associated with a significant burden of comorbidities. Objectives In this study, our objective was to investigate the presence of seasonal variation in deep vein thrombosis (DVT) and assess the location of the thrombus. Methods Out of 8177 patients admitted to two university hospitals and referred to outpatient clinics, we included a total of 611 consecutive patients (316 females, 295 males) diagnosed with acute deep vein thrombosis in this retrospective study. The mean age of the patients was 59.35±18.49 years, ranging from 1 to 96 years. Patients were categorized into four groups by age. Results DVT was found to be more frequent in the summer (n = 190 or 31%, p = 0.003) and specifically in August (n = 65 or 10.6%, p = 0.014), while it was least frequent in the spring (n = 128 or 20.9%) and in May (n = 40 or 6.5%). However, when comparing seasons, no significant differences were observed in terms of seasonal variation (p = 0.062) or monthly variation (p = 0.143). Conclusions Contrary to previous studies, this study demonstrated a higher occurrence of DVT during the summer, particularly in August. However, it did not reveal a clear seasonal pattern. One plausible explanation for these findings could be the adverse winter conditions and transportation challenges within the province, which may result in fewer DVT patients being able to reach hospitals for timely treatment.","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136304844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined superior mesenteric artery syndrome and nutcraker syndrome presenting as acute pancreatitis: a case report. 肠系膜上动脉综合征合并胡桃钳综合征表现为急性胰腺炎1例。
Jornal Vascular Brasileiro Pub Date : 2023-01-01 DOI: 10.1590/1677-5449.202201612
Bárbara Neto Castro, Ana Rita Ferreira, Susana Graça, Manuel Oliveira
{"title":"Combined superior mesenteric artery syndrome and nutcraker syndrome presenting as acute pancreatitis: a case report.","authors":"Bárbara Neto Castro,&nbsp;Ana Rita Ferreira,&nbsp;Susana Graça,&nbsp;Manuel Oliveira","doi":"10.1590/1677-5449.202201612","DOIUrl":"https://doi.org/10.1590/1677-5449.202201612","url":null,"abstract":"<p><p>Superior mesenteric artery syndrome designates compression of the third part of the duodenum between the superior mesenteric artery and the aorta. This condition has a low incidence, being more common in thin young women. Nutcracker syndrome is compression of the left renal vein between the superior mesenteric artery and the aorta. Both entities are rare, and their coexistence has been reported in a few cases. Conservative treatment targeting weight gain is sufficient in most cases. An association between the superior mesenteric artery syndrome and acute pancreatitis has rarely been reported. We intend to describe the case of an 18-year-old girl who was admitted to the emergency room with epigastric pain and emesis. Our investigation revealed acute acalculous pancreatitis. During work-up, we discovered superior mesenteric artery syndrome and a compressed left renal vein. The patient is on conservative treatment, and her symptoms have improved.</p>","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9805806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive assessment of markers of apoptosis and cell proliferation during progression of atherosclerosis after surgery in patients with peripheral arterial disease. 外周动脉疾病患者手术后动脉粥样硬化进展过程中细胞凋亡和细胞增殖标志物的综合评估
Jornal Vascular Brasileiro Pub Date : 2023-01-01 DOI: 10.1590/1677-5449.202200292
Roman Evgenyevich Kalinin, Igor Aleksandrovich Suchkov, Emma Anatolievna Klimentova
{"title":"Comprehensive assessment of markers of apoptosis and cell proliferation during progression of atherosclerosis after surgery in patients with peripheral arterial disease.","authors":"Roman Evgenyevich Kalinin,&nbsp;Igor Aleksandrovich Suchkov,&nbsp;Emma Anatolievna Klimentova","doi":"10.1590/1677-5449.202200292","DOIUrl":"https://doi.org/10.1590/1677-5449.202200292","url":null,"abstract":"<p><strong>Background: </strong>Determination of predictors that can affect development of atherosclerosis progression in the postoperative period is an urgent problem in vascular surgery.</p><p><strong>Objectives: </strong>Integrated assessment of markers of apoptosis and cell proliferation in atherosclerotic lesions and their progression after surgery in patients with peripheral arterial diseases.</p><p><strong>Methods: </strong>The investigation included 30 patients with stage IIB-III peripheral arterial disease. All patients have undergone open surgical interventions on the arteries of the aorto-iliac and femoral-popliteal segments. During these interventions, intraoperative specimens were obtained from the vascular wall with atherosclerotic lesions. The following values were evaluated: VEGF А165, PDGF BB, and sFas. Samples of normal vascular wall were obtained from post-mortem donors and used as a control group.</p><p><strong>Results: </strong>The levels of Bax and p53 were increased (p<0.001) in samples from arterial wall with atherosclerotic plaque, while sFas values were reduced (p<0.001), compared to their levels in control samples. Values of PDGF BB and VEGF A165 were 1.9 and 1.7 times higher in atherosclerotic lesion samples (p=0.001), in comparison with the control group. The levels of p53 and Bax were increased against a background of reduced sFas levels in samples with progression of atherosclerosis compared to their baseline values in samples with atherosclerotic plaque (p<0.05).</p><p><strong>Conclusions: </strong>Initially increased values of the Bax marker against a background of reduced sFas values in vascular wall samples from patients with peripheral arterial disease is associated with risk of atherosclerosis progression in the postoperative period.</p>","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10736053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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