JNCI Journal of the National Cancer Institute最新文献

{"title":"RE:Comparing waist circumference with body mass index on obesity-related cancer risk: a pooled Swedish study.","authors":"Shuting Yin, Jie Dong","doi":"10.1093/jnci/djaf110","DOIUrl":"https://doi.org/10.1093/jnci/djaf110","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention.","authors":"James Yarmolinsky, Matthew A Lee, Evelyn Lau, Ferran Moratalla-Navarro, Emma E Vincent, Ruifang Li-Gao, Patrick C N Rensen, Ko Willems van Dijk, Kostas K Tsilidis, Apiwat Sangphukieo, Elmira Ebrahimi, Jochen Hampe, Loïc Le Marchand, Franzel J B van Duijnhoven, Kala Visvanathan, Michael O Woods, Marcela Guevara, Sabina Sieri, Giovanna Masala, Keren Papier, Shama Virani, Tom Dudding, Abbas Dehghan, Alexander G Smith, Dennis Wang, Victor Moreno, Marc J Gunter, Ioanna Tzoulaki","doi":"10.1093/jnci/djaf137","DOIUrl":"10.1093/jnci/djaf137","url":null,"abstract":"<p><strong>Background: </strong>The role of lipid-perturbing medications in cancer risk is unclear.</p><p><strong>Methods: </strong>We employed cis-Mendelian randomization and colocalisation to evaluate the role of 5 lipid-perturbing drug targets (ANGPTL3, ANGPTL4, APOC3, CETP, PCSK9) in risk of 5 cancers (breast, colorectal, head and neck, ovarian, prostate). We triangulated findings using pre-diagnostic protein measures in prospective analyses in EPIC (977 colorectal cancer cases, 4,080 sub-cohort members) and the UK Biobank (860 colorectal cancer cases, 50,177 controls). To gain mechanistic insight into the role of ANGPTL4 in carcinogenesis, we examined the impact of the ANGPTL4 p.E40K loss-of-function variant on differential gene expression in normal colon tissue in BarcUVa-Seq. Finally, we evaluated the association of colon tumour ANGPTL4 expression with cancer-specific mortality in TCGA.</p><p><strong>Results: </strong>In analysis of 78,473 cases and 107,143 controls, genetically-proxied circulating ANGPTL4 inhibition was associated with reduced colorectal cancer risk (ORSD decrease: 0.76,95%CI:0.66-0.89,P=5.52x10-4,PPcolocalisation=0.83). This association was replicated using pre-diagnostic circulating ANGPTL4 concentrations in EPIC (HRlog10 decrease:0.91,95%CI:0.84-0.98,P=0.01) and the UK Biobank (HRSD decrease:0.93,95%CI:0.86-0.99,P=0.03). In gene-set enrichment analysis of differential gene expression in 445 colon tissue samples, ANGPTL4 loss-of-function down-regulated several cancer-related biological pathways (P  FDR<0.05), including those involved in cellular proliferation, epithelial-to-mesenchymal transition, and bile acid metabolism. In analysis of 465 colon cancer patients, lower ANGPTL4 tumour expression was associated with reduced colorectal cancer-specific mortality risk (HRlog2 decrease:0.66,95%CI:0.50-0.87,P=2.92x10-3).</p><p><strong>Conclusions: </strong>Our integrative proteogenomic and observational analyses suggest a potential protective role of lower circulating ANGPTL4 concentrations in colorectal cancer risk. These findings support further evaluation of ANGPTL4 as a therapeutic target for colorectal cancer prevention.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: The association of where patients with prostate cancer live and receive care on racial treatment inequities.","authors":"","doi":"10.1093/jnci/djaf142","DOIUrl":"https://doi.org/10.1093/jnci/djaf142","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppression of LKB1-mutant lung adenocarcinoma by natural killer cells from females.","authors":"Yijian Fan, Rui Jin, Lenore Monterroza, Xiuju Liu, Chunzi Huang, Angelo Marra, Xiulei Mo, Haian Fu, Melissa Gilbert-Ross, Adam I Marcus, Rabindra Tirouvanziam, Yuan Liu, Frank Schneider, Wei Zhou","doi":"10.1093/jnci/djaf138","DOIUrl":"https://doi.org/10.1093/jnci/djaf138","url":null,"abstract":"<p><strong>Background: </strong>This study addressed the enigma of sex differences in smoking-related lung cancer, particularly focusing on the low LKB1 mutation frequency in female patients with lung adenocarcinoma (LUAD).</p><p><strong>Methods: </strong>Sex-bias was studied with a genetically engineered mouse model and various tail-vein injection models. Immune cells were analyzed by antibody-depletion study, flow cytometry, and immunofluorescence. The relevance of our findings to human disease was validated by evaluating various LUAD datasets. All statistical tests are 2-sided.</p><p><strong>Results: </strong>A significant percentage of females are resistant to LKB1-mutant tumor formation in our models, reflecting this sex difference in humans. NK cells were identified as a critical factor in this sex-biased response. This sex difference was observed primarily in LKB1-mutant LUADs, probably due to their low MHC-I level, making them the ideal target for NK cells through the \"missing-self\" recognition. While females resistant to LKB1-mutant LUAD formation did not have enhancement of any specific NK subpopulation, our immunofluorescence analysis revealed high numbers of NKs in female lungs even with the presence of LKB1-mutant LUAD. Our GSEA analysis of TCGA-LUAD dataset also showed that female LKB1-mutant LUAD patients have a stronger NK-mediated response after adjusting for other male-female differences using LKB1-wild type LUAD dataset.</p><p><strong>Conclusion: </strong>Females have a stronger NK-mediated response against LKB1-mutant LUAD, which was present both in our mouse model and the human LUAD dataset. This study revealed a novel role of NK cells in suppressing LKB1-mutant LUAD in females, which should be assessed in the clinical setting in the future.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental disorders and socioeconomic outcomes in women with cervical cancer, their children and co-parents.","authors":"Jiangrong Wang, Stina Salomonsson, Demet Sönmez, Sara Nordqvist Kleppe, Adina L Feldman, Marcus Sven Andersson, Goran Bencina, Fang Fang, Karin Sundström","doi":"10.1093/jnci/djaf129","DOIUrl":"https://doi.org/10.1093/jnci/djaf129","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer often affects women who are in the middle of life and may carry substantial mental and socioeconomic impact also on families. We performed a generation-spanning study to elucidate this burden.</p><p><strong>Methods: </strong>We utilized nationwide registers during 1991-2018 in Sweden to perform two matched cohort studies based on a source population of more than 5 million women. The individual sub-study included 6060 cases of cervical cancer diagnosed during 2006-2018 and 5 population comparators individually matched to each case by age, birth year and region (n = 30300). The family sub-study included 9332 cases of cervical cancer diagnosed during 1991-2016 and 45,674 matched population comparators and all their children and co-parents.</p><p><strong>Results: </strong>We found an increased risk for mental disorders in cases compared to comparators, particularly during the first two years post-diagnosis (HR = 3.74, 95% CI = 3.45-4.06). Socioeconomic status changed negatively in cases after their diagnosis a decreased income and increased need for financial aid appeared within 2 years whereas unemployment escalated from two years after cancer diagnosis. We further found an increased risk of mental disorders in both children and co-parents of the cases, compared to the children and co-parents of the comparators.Furthermore, we observed negative socioeconomic trajectories in the co-parents and lower educational attainment in the children of the cases, especially if the case had died of her cancer.</p><p><strong>Conclusions: </strong>Women with cervical cancer, and their close family members, display increased risk of negative mental health and socioeconomic outcomes after diagnosis. The lower educational attainment in children appears particularly worrying.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Saidi and Jones.","authors":"Tim Palmer, Kimberley Kavanagh, Kate Cuschieri, Ross Cameron, Catriona Graham, Allan Wilson, Kirsty Roy","doi":"10.1093/jnci/djaf131","DOIUrl":"https://doi.org/10.1093/jnci/djaf131","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Efficacy and safety of personalized optimal programmed cell death 1 ligand combinations in advanced non-small cell lung cancer: a network meta-analysis.","authors":"Junmei Zhang, Shuai Wang, Tingting Li, Xuefei Liu","doi":"10.1093/jnci/djaf132","DOIUrl":"https://doi.org/10.1093/jnci/djaf132","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Invasive cervical cancer incidence following bivalent human papillomavirus vaccination: a population-based observational study of age at immunization, dose, and deprivation.","authors":"Samir A Saidi, Mark A Jones","doi":"10.1093/jnci/djaf130","DOIUrl":"https://doi.org/10.1093/jnci/djaf130","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Zhang, Wang, Li et al.","authors":"Xianjing Chu, Wentao Tian, Rongrong Zhou","doi":"10.1093/jnci/djaf133","DOIUrl":"https://doi.org/10.1093/jnci/djaf133","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not all trials are created equal: the unique role of the NCI National Clinical Trials Network.","authors":"Thomas J George, Theodore S Hong","doi":"10.1093/jnci/djaf114","DOIUrl":"https://doi.org/10.1093/jnci/djaf114","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}