JNCI Journal of the National Cancer Institute最新文献

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Response to Siegel, Kratzer, Smith et al. 对Siegel, Kratzer, Smith等人的回应。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-29 DOI: 10.1093/jnci/djaf096
Archie Bleyer, Lynn A G Ries, Danielle B Cameron, Sara A Mansfield, Stuart E Siegel, Ronald D Barr
{"title":"Response to Siegel, Kratzer, Smith et al.","authors":"Archie Bleyer, Lynn A G Ries, Danielle B Cameron, Sara A Mansfield, Stuart E Siegel, Ronald D Barr","doi":"10.1093/jnci/djaf096","DOIUrl":"https://doi.org/10.1093/jnci/djaf096","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RE: Colon, colorectal, and all cancer incidence increase in the young due to appendix reclassification. RE:由于阑尾重新分类,结肠、结直肠癌和所有癌症的发病率在年轻人中增加。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-29 DOI: 10.1093/jnci/djaf095
Rebecca L Siegel, Tyler B Kratzer, Robert A Smith, Ahmedin Jemal
{"title":"RE: Colon, colorectal, and all cancer incidence increase in the young due to appendix reclassification.","authors":"Rebecca L Siegel, Tyler B Kratzer, Robert A Smith, Ahmedin Jemal","doi":"10.1093/jnci/djaf095","DOIUrl":"https://doi.org/10.1093/jnci/djaf095","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rising incidence of early-onset colorectal cancer: impact of anatomy and histology. 早发性结直肠癌发病率上升:解剖学和组织学的影响。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-29 DOI: 10.1093/jnci/djaf094
Sara K Char, Jennifer A Chan, Kimmie Ng
{"title":"Rising incidence of early-onset colorectal cancer: impact of anatomy and histology.","authors":"Sara K Char, Jennifer A Chan, Kimmie Ng","doi":"10.1093/jnci/djaf094","DOIUrl":"https://doi.org/10.1093/jnci/djaf094","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ending nuclear weapons, before they end us†. 在核武器终结我们之前终结它们。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-19 DOI: 10.1093/jnci/djaf102
Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski
{"title":"Ending nuclear weapons, before they end us†.","authors":"Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski","doi":"10.1093/jnci/djaf102","DOIUrl":"https://doi.org/10.1093/jnci/djaf102","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Venkataraman and Mokbel. 对文卡塔拉曼和莫克贝尔的回应。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-08 DOI: 10.1093/jnci/djaf087
Luca Arecco, Eva Blondeaux, Elisa Agostinetto, Evandro de Azambuja, Matteo Lambertini, Lucia Del Mastro
{"title":"Response to Venkataraman and Mokbel.","authors":"Luca Arecco, Eva Blondeaux, Elisa Agostinetto, Evandro de Azambuja, Matteo Lambertini, Lucia Del Mastro","doi":"10.1093/jnci/djaf087","DOIUrl":"https://doi.org/10.1093/jnci/djaf087","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RE: Prognostic implications of risk definitions from the monarchE and NATALEE trials. RE: monarchE和NATALEE试验的风险定义对预后的影响。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-08 DOI: 10.1093/jnci/djaf086
Janhavi Venkataraman, Kefah Mokbel
{"title":"RE: Prognostic implications of risk definitions from the monarchE and NATALEE trials.","authors":"Janhavi Venkataraman, Kefah Mokbel","doi":"10.1093/jnci/djaf086","DOIUrl":"https://doi.org/10.1093/jnci/djaf086","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RE: Validation of a breast cancer assay for radiotherapy omission: an individual participant data meta-analysis. RE:乳腺癌放射治疗遗漏试验的验证:个体参与者数据荟萃分析。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-07 DOI: 10.1093/jnci/djaf115
Dan Li, Yun Liu, Qiongyu Duan, Xiaodong Chen
{"title":"RE: Validation of a breast cancer assay for radiotherapy omission: an individual participant data meta-analysis.","authors":"Dan Li, Yun Liu, Qiongyu Duan, Xiaodong Chen","doi":"10.1093/jnci/djaf115","DOIUrl":"https://doi.org/10.1093/jnci/djaf115","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Lehrer. 对莱勒的回应。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-01 DOI: 10.1093/jnci/djaf044
Andrea L Roberts, Laura D Kubzansky, Shelley S Tworoger
{"title":"Response to Lehrer.","authors":"Andrea L Roberts, Laura D Kubzansky, Shelley S Tworoger","doi":"10.1093/jnci/djaf044","DOIUrl":"10.1093/jnci/djaf044","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"1088-1089"},"PeriodicalIF":9.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis. 辐射诱导的正常组织毒性与类风湿关节炎高遗传风险的关联。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-01 DOI: 10.1093/jnci/djae349
Alan McWilliam, Deborah Marshall, Sarah L Kerns, Gillian C Barnett, Ana Vega, Thodori Kapouranis, Miguel E Aguado Barrera, Barbara Avuzzi, David Azria, Jenny Chang-Claude, Ananya Choudhury, Carla Coedo Costa, Alison Dunning, Marie-Pierre Farcy-Jacquet, Corinne Faivre-Finn, Sara Gutiérrez-Enríquez, Olivia Fuentes-Ríos, Antonio Gómez Caamaño, Maarten Lambrecht, Carlos López Pleguezuelos, Tiziana Rancati, Tim Rattay, Dirk de Ruysscher, Petra Seibold, Elena Sperk, Christopher Talbot, Adam Webb, Liv Veldeman, Barry S Rosenstein, Catharine M L West
{"title":"Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis.","authors":"Alan McWilliam, Deborah Marshall, Sarah L Kerns, Gillian C Barnett, Ana Vega, Thodori Kapouranis, Miguel E Aguado Barrera, Barbara Avuzzi, David Azria, Jenny Chang-Claude, Ananya Choudhury, Carla Coedo Costa, Alison Dunning, Marie-Pierre Farcy-Jacquet, Corinne Faivre-Finn, Sara Gutiérrez-Enríquez, Olivia Fuentes-Ríos, Antonio Gómez Caamaño, Maarten Lambrecht, Carlos López Pleguezuelos, Tiziana Rancati, Tim Rattay, Dirk de Ruysscher, Petra Seibold, Elena Sperk, Christopher Talbot, Adam Webb, Liv Veldeman, Barry S Rosenstein, Catharine M L West","doi":"10.1093/jnci/djae349","DOIUrl":"10.1093/jnci/djae349","url":null,"abstract":"<p><strong>Background: </strong>Overlapping genes are involved with rheumatoid arthritis (RA) and DNA repair pathways. Therefore, we hypothesized that patients with a high polygenic risk score for RA will have an increased risk of radiotherapy toxicity given the involvement of DNA repair.</p><p><strong>Methods: </strong>Primary analysis was performed on 1494 prostate cancer, 483 lung cancer, and 1820 breast cancer patients assessed for development of radiotherapy toxicity in the REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) study. Validation cohorts were available from the Radiogenomics Consortium. All patients had undergone curative-intent radiotherapy and were assessed prospectively for toxicity. Germline genomic data was available for all patients, allowing a polygenic risk score to be calculated using 101 RA risk variants. Polygenic risk score was analyzed as a continuous variable and with a more than 90th percentile cutoff. Associations with acute and late standardized total average toxicity (STAT) scores and individual toxicity endpoints were analyzed in multivariable models with preselected adjustment variables.</p><p><strong>Results: </strong>Increasing polygenic risk score for RA did not increase the risk of STAT-acute or STAT-late in any cohort. There was an increased risk of late esophagitis in the lung cancer cohort (coefficient = 0.018, P = .01), however this was not validated (P = .79). No individual acute or late toxicity endpoints were statistically significantly associated with polygenic risk score for the prostate or breast cohorts. No statistically significant results were found in the validation cohorts in multivariable models.</p><p><strong>Conclusions: </strong>Patients with a high genetic risk for RA do not show increased levels of toxicity after radiotherapy suggesting treatment planning does not need to be modified for such patients.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"1018-1026"},"PeriodicalIF":9.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RE: Timing of depression in relation to risk of ovarian cancer. 回复:抑郁时间与卵巢癌风险的关系。
IF 9.9 1区 医学
JNCI Journal of the National Cancer Institute Pub Date : 2025-05-01 DOI: 10.1093/jnci/djaf043
Steven Lehrer
{"title":"RE: Timing of depression in relation to risk of ovarian cancer.","authors":"Steven Lehrer","doi":"10.1093/jnci/djaf043","DOIUrl":"10.1093/jnci/djaf043","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"1086-1087"},"PeriodicalIF":9.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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