JAMA Psychiatry最新文献

{"title":"Childhood Maternal Warmth, Social Safety Schemas, and Adolescent Mental and Physical Health.","authors":"Jenna Alley, Dimitris I Tsomokos, Summer Mengelkoch, George M Slavich","doi":"10.1001/jamapsychiatry.2025.0815","DOIUrl":"10.1001/jamapsychiatry.2025.0815","url":null,"abstract":"<p><strong>Importance: </strong>Although early maternal warmth strongly predicts adolescent health, questions remain about the biopsychosocial mechanisms underlying this association.</p><p><strong>Objective: </strong>To understand how maternal warmth at 3 years of age shapes adolescent social safety schemas at 14 years of age and physical and mental health at 17 years of age.</p><p><strong>Design, setting, and participants: </strong>The Millennium Cohort Study tracks approximately 19 200 children born from late 2000 to early 2002 in the UK. Participants were assessed from ages 3 to 17 years.</p><p><strong>Exposure: </strong>Low maternal warmth (eg, lack of praise, negative tone of voice when speaking to the child) and maternal harshness (eg, using physical restraint, grabbing the child) were independently coded during a home visit (age 3 years).</p><p><strong>Main outcomes and measures: </strong>Social safety (age 14 years) was measured by children's responses to 3 items (eg, \"I have family and friends who help me feel safe, secure and happy\"). Physical health was self-reported on a scale ranging from 1 (excellent) to 5 (poor) (age 17 years). Psychological distress (age 17 years) was assessed using the 6-item Kessler Psychological Distress Scale. Psychiatric problems (age 17 years) was a latent variable composed of self-disclosed clinical diagnosis of depression/anxiety, self-harm, and suicidal behaviors.</p><p><strong>Results: </strong>The present sample included 8540 youths (52% female; 3.0% Black or Black British, 2.8% Indian, 6.7% Pakistani and Bangladeshi, 2.8% Mixed, 83% White, and 1.6% other). Data were analyzed from March 2024 to September 2024 using structural equation modeling. In models controlling for sex, ethnicity, income, neighborhood disadvantage, maternal mental health, and early cognitive ability, the paths from childhood maternal warmth (but not harshness) to social safety schemas at 14 years of age (b = 0.03; P < .001) and physical health at 17 years of age (b = 0.05; P = .02) were significant, suggesting that early maternal warmth enhances subsequent perceived social safety and physical health. Additionally, the paths from negative social safety schemas at 14 years of age to poorer physical health (b = 0.50; P < .001), psychological distress (b = 5.37; P < .001), and psychiatric problems (b = 0.21; P < .001) at 17 years of age were significant, suggesting that greater perceived social safety prospectively predicts better health. Social safety at 14 years of age mediated 20% to 100% of the effect of early maternal warmth on physical health, psychological distress, and psychiatric problems at 17 years of age (b = 0.01-0.15; P < .001 for all).</p><p><strong>Conclusions and relevance: </strong>These results show that early-life maternal warmth affected adolescent health by influencing perceptions of social safety. Improving parent-child relationships and enhancing youths' perceptions of social safety may thus improve adolescent h","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":" ","pages":"709-717"},"PeriodicalIF":22.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician Suicide and Associated Features-What Defines a Physician?-Reply.","authors":"Hirsh Makhija, Judy E Davidson, Sidney Zisook","doi":"10.1001/jamapsychiatry.2025.1113","DOIUrl":"10.1001/jamapsychiatry.2025.1113","url":null,"abstract":"","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":" ","pages":"746"},"PeriodicalIF":22.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and Amyloid Pathology-Methodological Aspects.","authors":"Nunzio Pomara, Chelsea Reichert Plaska, Bruno Pietro Imbimbo","doi":"10.1001/jamapsychiatry.2025.0956","DOIUrl":"10.1001/jamapsychiatry.2025.0956","url":null,"abstract":"","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":" ","pages":"744"},"PeriodicalIF":22.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dry EEG-From Laboratory to Living Room.","authors":"Mohammad S E Sendi","doi":"10.1001/jamapsychiatry.2025.1073","DOIUrl":"10.1001/jamapsychiatry.2025.1073","url":null,"abstract":"","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":" ","pages":"742-743"},"PeriodicalIF":22.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and Amyloid Pathology-Methodological Aspects-Reply.","authors":"Wietse A Wiels, Julie E Oomens, Willemijn J Jansen","doi":"10.1001/jamapsychiatry.2025.0959","DOIUrl":"10.1001/jamapsychiatry.2025.0959","url":null,"abstract":"","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":" ","pages":"744-745"},"PeriodicalIF":22.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician Suicide and Associated Features-What Defines a Physician?","authors":"Flora Lum","doi":"10.1001/jamapsychiatry.2025.1110","DOIUrl":"10.1001/jamapsychiatry.2025.1110","url":null,"abstract":"","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":" ","pages":"745-746"},"PeriodicalIF":22.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Prescribing of Attention-Deficit/Hyperactivity Disorder Medication and Real-World Outcomes Over Time.","authors":"Lin Li,David Coghill,Arvid Sjölander,Honghui Yao,Le Zhang,Ralf Kuja-Halkola,Isabell Brikell,Paul Lichtenstein,Brian M D'Onofrio,Henrik Larsson,Zheng Chang","doi":"10.1001/jamapsychiatry.2025.1281","DOIUrl":"https://doi.org/10.1001/jamapsychiatry.2025.1281","url":null,"abstract":"ImportanceThe prescription of attention-deficit/hyperactivity disorder (ADHD) medications has risen substantially in many countries over the last 20 years. However, whether the real-world benefits of ADHD medications change with increased prescription rates within a society remains unknown.ObjectiveTo examine whether the associations between ADHD medications and real-world outcomes (self-harm, unintentional injury, traffic crashes, and crime) change as prescription rates rise.Design, Setting, and ParticipantsThis study used a self-controlled case series design. It was a population-based study using Swedish National Registers that included individuals who used ADHD medications in Sweden between 2006 and 2020. Data were analyzed from October 2023 to November 2024.ExposureADHD medication use.Main Outcomes and MeasuresRates of self-harm, unintentional injury, traffic crashes, and crime during medicated vs nonmedicated periods. The associations between ADHD medication and these real-world outcomes were examined across 3 time periods, 2006 to 2010, 2011 to 2015, and 2016 to 2020, during which ADHD medication prevalence increased from 0.6% to 2.8%.ResultsThere were 247 420 individuals identified (99 361 females [40.2%] and 148 059 males [59.8%]) aged 4 to 64 years in Sweden who used ADHD medications between 2006 and 2020. ADHD medication was consistently associated with lower risks for self-harm (incidence rate ratio [IRR] ranged from 0.77; 95% CI, 0.73-0.81 to 0.85; 95% CI, 0.82-0.88), unintentional injury (IRR ranged from 0.87; 95% CI, 0.84-0.89 to 0.93, 95% CI, 0.91-0.95), traffic crashes (IRR ranged from 0.71; 95% CI, 0.67-0.77 to 0.87; 95% CI, 0.83-0.91), and crime (IRR ranged from 0.73; 95% CI, 0.71-0.75 to 0.84; 95% CI, 0.82-0.85) across different age groups, sexes, and over time. However, the associations between ADHD medication use and lower risks of unintentional injury (P value for trend < .01), traffic crashes (P value for trend < .01), and crime (P value for trend < .01) appear to weaken over time as prescription rates increased. Changes in age and sex distribution of individuals receiving ADHD medication did not fully explain the weakening trend for unintentional injury and traffic crashes.Conclusions and RelevanceIn this study, ADHD medication remained associated with reduced risks of several serious real-world outcomes. However, the magnitude of these associations appears to have decreased alongside rising prescription rates over time. Thus, it is important to regularly evaluate medication use in different patient populations.","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":"8 1","pages":""},"PeriodicalIF":25.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in Byline.","authors":"","doi":"10.1001/jamapsychiatry.2025.1797","DOIUrl":"10.1001/jamapsychiatry.2025.1797","url":null,"abstract":"","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":" ","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence","authors":"Kevin Y. Sun, J. Eric Schmitt, Tyler M. Moore, Ran Barzilay, Laura Almasy, Laura M. Schultz, Allyson P. Mackey, Eren Kafadar, Zhiqiang Sha, Jakob Seidlitz, Travis T. Mallard, Zaixu Cui, Hongming Li, Yong Fan, Damien A. Fair, Theodore D. Satterthwaite, Arielle S. Keller, Aaron Alexander-Bloch","doi":"10.1001/jamapsychiatry.2025.1258","DOIUrl":"https://doi.org/10.1001/jamapsychiatry.2025.1258","url":null,"abstract":"ImportanceFunctional brain networks are associated with both behavior and genetic factors. To uncover biological mechanisms of psychopathology, it is critical to define how the spatial organization of these networks relates to genetic risk during development.ObjectiveTo determine the associations among transdiagnostic polygenic risk scores (PRSs), personalized functional brain networks (PFNs), and overall psychopathology (p-factor) during early adolescence.Design, Setting, and ParticipantsThe Adolescent Brain Cognitive Development (ABCD) Study is an ongoing longitudinal cohort study of 21 collection sites across the US. This cross-sectional analysis includes ABCD baseline data collected between September 2016 and October 2018. The ABCD Study is a multisite community-based study. The sample is largely recruited through school systems. ABCD exclusion criteria included severe sensory, intellectual, medical, or neurological issues that interfere with protocol and scanner contraindications. Split-half subsets were used for cross-validation, matched on age, ethnicity, family structure, handedness, parental education, site, sex, and anesthesia exposure. Data were analyzed from January 2023 to July 2024.ExposuresPolygenic risk scores of transdiagnostic genetic factors F1 (PRS-F1) and F2 (PRS-F2) derived from adults in Psychiatric Genomic Consortium and UK Biobanks datasets. PRS-F1 indexes liability for common psychiatric symptoms and disorders related to mood disturbance; PRS-F2 indexes liability for rarer forms of mental illness characterized by mania and psychosis.Main Outcomes and MeasuresP-factor derived from bifactor models of youth- and parent-reported mental health assessments and person-specific functional brain network topography derived from functional magnetic resonance imaging scans.ResultsTotal participants included 11 873 children aged 9 to 10 years; 5678 (47.8%) were female, and the mean (SD) age was 9.92 (0.62) years. PFN topography was found to be heritable (imaging subsample, n = 7459; 57.1% of vertices: mean &lt;jats:italic&gt;h&lt;/jats:italic&gt;&lt;jats:sup&gt;2&lt;/jats:sup&gt;, 0.35; false discovery rate–corrected &lt;jats:italic&gt;P&lt;/jats:italic&gt; &amp;amp;lt; .05). PRS-F1 was associated with p-factor (European ancestry subsample, n = 5815; &lt;jats:italic&gt;r&lt;/jats:italic&gt;, 0.12; 95% CI, 0.09-0.15; &lt;jats:italic&gt;P&lt;/jats:italic&gt; &amp;amp;lt; .001). Interindividual differences in functional network topography were associated with p-factor (imaging subsample, n = 7459; mean &lt;jats:italic&gt;r&lt;/jats:italic&gt;, 0.12), PRS-F1 (imaging and European ancestry subsample, n = 3982; mean &lt;jats:italic&gt;r&lt;/jats:italic&gt;, 0.05), and PRS-F2 (n = 3982; mean &lt;jats:italic&gt;r&lt;/jats:italic&gt;, 0.08). Cortical maps of p-factor and PRS-F1 regression coefficients were correlated (&lt;jats:italic&gt;r&lt;/jats:italic&gt;, 0.70; &lt;jats:italic&gt;P&lt;/jats:italic&gt; = .003, permutation test, N = 1000).Conclusions and RelevancePolygenic risk for transdiagnostic adulthood psychopathology was associated with both p-factor a","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":"70 1","pages":""},"PeriodicalIF":25.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Offering Psychedelic Treatments Before Assisted Dying for Psychiatric Conditions.","authors":"Christopher Poppe,Jan Christoph Bublitz,Dimitris Repantis","doi":"10.1001/jamapsychiatry.2025.1457","DOIUrl":"https://doi.org/10.1001/jamapsychiatry.2025.1457","url":null,"abstract":"","PeriodicalId":14800,"journal":{"name":"JAMA Psychiatry","volume":"8 1","pages":""},"PeriodicalIF":25.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}