Journal fur Hirnforschung最新文献_第9页

Remodeling of membrane-bound glycoproteins containing alpha-D-galactose in the cerebral endothelial cells of rats during blood-brain barrier maturation and alteration. 大鼠脑内皮细胞中含α - d-半乳糖的膜结合糖蛋白在血脑屏障成熟和改变过程中的重塑。

Journal fur Hirnforschung Pub Date : 1997-01-01

C H Wu, C Y Wen, J Y Shieh, E A Ling

{"title":"Remodeling of membrane-bound glycoproteins containing alpha-D-galactose in the cerebral endothelial cells of rats during blood-brain barrier maturation and alteration.","authors":"C H Wu, C Y Wen, J Y Shieh, E A Ling","doi":"","DOIUrl":"","url":null,"abstract":"In the course of the development of cerebral endothelia, the lectin labelling of alpha-D-galactosyl residues on the luminal front of the endothelial cells was gradually increased but that on the abluminal surface was concomitantly attenuated. In the latter, the isolectin (GSA I-B4) decoration was totally diminished with the maturation of the brain. Associated with this change, the end feet of astrocytes resting on the endothelia became lectin positive. Numerous cytoplasmic vacuoles, Golgi apparatus, vesicles and tubule-like structures were strongly labelled in the cerebral endothelia in the early stages of development but only sparse vacuoles and vesicles remained lectin-stained in the mature cerebral endothelia. Labelled pericytes closely associated with the wall of blood vessels, displayed a lectin binding pattern similar to that of the developing cerebral endothelia. Following the blood-brain barrier damage induced by a cold lesion, the altered cerebral endothelia that were surrounded by densely-stained macrophages/microglia or pericytes remained unstained with the isolectin. Present results suggest that during blood-brain barrier maturation, the brain endothelia develop a functional polarity whereby their membrane glycoprotein is down regulated. The membrane glycoprotein, however, underwent remodeling when the blood-brain barrier was disrupted.","PeriodicalId":14790,"journal":{"name":"Journal fur Hirnforschung","volume":"38 4","pages":"541-52"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20402912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitrergic, peptidergic and substance P innervation of the chick thymus. 鸡胸腺的氮能、肽能和P物质神经支配。

Journal fur Hirnforschung Pub Date : 1997-01-01

P Gulati, S S Tay, S K Leong

{"title":"Nitrergic, peptidergic and substance P innervation of the chick thymus.","authors":"P Gulati, S S Tay, S K Leong","doi":"","DOIUrl":"","url":null,"abstract":"Nitrergic and peptidergic innervation of the chick thymus was studied using histochemical and immunohistochemical methods. Nicotinamide adenine dinucleotide hydrogen phosphate-diaphorase (NADPH-d) histochemistry and anti-nitric oxide synthase (NOS) antibodies stained both nerve fibres and 'neuron-like' cells located in the septal connective tissue. NADPH-d and NOS were partially colocalised. Staining of NADPH-d positive neuron-like cells with the neuronal marker, neuron specific enolase, confirmed the neuronal nature of these cells. Antibodies against vasoactive intestinal peptide (VIP), neuropeptide tyrosine (NPY), substance P (SP) and calcitonin gene related peptide (CGRP) were used to map the peptidergic innervation of the chick thymus. The distribution of nerve fibres staining for the various neuroactive chemicals in specific thymic compartments was non-uniform. Out of all the peptides, VIP-containing nerves appeared to be the most abundant. In addition, double-labeling of the thymic sections revealed that VIP and NADPH-d were colocalised in the neuronal structures. Immunostaining of the chick embryos demonstrated that VIP, NPY, SP and CGRP were first expressed in the chick thymus during late ontogeny. The significance of these novel findings was discussed.","PeriodicalId":14790,"journal":{"name":"Journal fur Hirnforschung","volume":"38 4","pages":"553-64"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20402913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Species differences in the localisation of gamma-glutamyl transpeptidase immunopositive cells at the blood-brain interface. γ -谷氨酰转肽酶免疫阳性细胞在血脑界面定位的物种差异。

Journal fur Hirnforschung Pub Date : 1997-01-01

H F Zhang, W Y Ong, S K Leong, Y Laperche

引用次数: 0

Cardiac inhibitory neurons in gastropod snail Achatina fulica. 腹足纲蜗牛心脏抑制神经元的研究。

Journal fur Hirnforschung Pub Date : 1997-01-01

R Bychkov, V Zhuravlev, S Kadirov, T Safonova

引用次数: 0

Distribution of glutamine synthetase in the chick forebrain: implications for passive avoidance memory formation. 谷氨酰胺合成酶在鸡前脑中的分布:对被动回避记忆形成的影响。

Journal fur Hirnforschung Pub Date : 1997-01-01

B S O'Dowd, K T Ng, S R Robinson

引用次数: 0

Localization of nitric oxide synthase and NADPH-diaphorase in guinea pig and human cochleae. 一氧化氮合酶和nadph -脱氢酶在豚鼠和人耳蜗的定位。

Journal fur Hirnforschung Pub Date : 1997-01-01

R S Ruan, S K Leong, K H Yeoh

{"title":"Localization of nitric oxide synthase and NADPH-diaphorase in guinea pig and human cochleae.","authors":"R S Ruan, S K Leong, K H Yeoh","doi":"","DOIUrl":"","url":null,"abstract":"The distributions of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) and nitric oxide synthase (NOS) in mammalian cochlea were studied at light and electron microscope levels by NADPH-d histochemistry and brain NOS (bNOS) immunohistochemistry. The cochleae from 15 albino guinea pigs were perilymphatically fixed with 2% periodate-lysine-paraformaldehyde, decalcified in 10% EDTA and processed for light and electron microscopy after NADPH-d or NOS staining in frozen and vibratome sections respectively. One human cochlea was available for light microscope examination of NADPH-d or bNOS stained sections. Light microscope results revealed that type I neurons and nerve fibers of the spiral ganglion cells were labeled by bNOS immunohistochemistry as well as NADPH-d histochemistry in both guinea pig and human cochleae. At subcellular level, NADPH-d reaction product was localized in the mitochondria of the neuronal cytoplasm and axoplasm and in the cytoplasm of the vascular endothelium. The immunoreaction products of bNOS were evenly distributed in the neuronal cytoplasm and axoplasm. Myelinated and unmyelinated fibers in the intraganglionic spiral bundle and the inner spiral and inner radial fibers below the inner hair cells were labeled for bNOS. The nerve endings below the outer hair cells were not stained. NOS immunoreaction product was also found in the outer hair cells, Schwann cells of myelinated nerve fibers, Deiter's cells, pillar cells and the tympanic lamina cells. No difference was found in the staining pattern of both NADPH-d and NOS reaction products between human and guinea pig cochleae at the light microscope level. The results suggest that NO plays an important role in the maintenance of auditory function in the mammal.","PeriodicalId":14790,"journal":{"name":"Journal fur Hirnforschung","volume":"38 4","pages":"433-41"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20401831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neural cell recognition molecule F11 is expressed on Müller cells and Schwann cells in vitro. 神经细胞识别分子F11在体外<s:1>勒细胞和雪旺细胞上表达。

Journal fur Hirnforschung Pub Date : 1997-01-01

E Willbold, T Brümmendorf, F G Rathjen, H Schwarz, B Weiss

引用次数: 0

Cognitive impairments after lesions of the neostriatum caudolaterale and its thalamic afferent in pigeons: functional similarities to the mammalian prefrontal system? 鸽子尾侧新纹状体及其丘脑传入损伤后的认知障碍:与哺乳动物前额叶系统的功能相似性?

Journal fur Hirnforschung Pub Date : 1997-01-01

O Güntürkün

{"title":"Cognitive impairments after lesions of the neostriatum caudolaterale and its thalamic afferent in pigeons: functional similarities to the mammalian prefrontal system?","authors":"O Güntürkün","doi":"","DOIUrl":"","url":null,"abstract":"Several studies suggest that the neostriatum caudolaterale (NCL) of birds is equivalent to the mammalian prefrontal cortex (PFC). The aim of the present study was to analyze the functional importance of the NCL and the n. dorsolateralis posterior thalami (DLP), the main thalamic afferent structure of the NCL, in tasks which are generally used to assess mammalian prefrontal functions. The DLP is, due to its subtelencephalic connectivities, different from the mammalian n. mediodorsalis (MD), the thalamic afferent nucleus of the PFC. However, it is possible that in its interactions with the forebrain the DLP subserves similar functions as the mammalian MD. Pigeons with lesions of the NCL, the DLP or, as a thalamic control, the n. geniculatus lateralis, pars dorsalis (GLd) were tested in a delayed alternation and in a go/no-go task. The results demonstrate that NCL-lesioned birds are impaired in both tasks, while DLP-lesioned animals display deficits only in the delayed alternation experiment. The performance of the GLd-lesioned pigeons was not attenuated in either task. It is concluded that the functional similarities of the prefrontal cortex and the NCL extent at least partly to their thalamic afferent structures, although these diencephalic nuclei differ considerably in their anatomy.","PeriodicalId":14790,"journal":{"name":"Journal fur Hirnforschung","volume":"38 1","pages":"133-43"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20015604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anisocoria--a pupillary sign of hippocampal lesions: an experimental study in the cat by using neurotoxins. 异色——海马病变的瞳孔征象:一项用神经毒素在猫身上进行的实验研究。

Journal fur Hirnforschung Pub Date : 1997-01-01

N Hashida, K Shoumura, N Ichinohe, J Hirama, H Amayasu

{"title":"Anisocoria--a pupillary sign of hippocampal lesions: an experimental study in the cat by using neurotoxins.","authors":"N Hashida, K Shoumura, N Ichinohe, J Hirama, H Amayasu","doi":"","DOIUrl":"","url":null,"abstract":"Pupillary inequality developed after unilateral lesions of the hippocampal formation (HF) of the cat. Lesions were made by an injection of a small amount of colchicine, ibotenic acid or kainic acid. In all anisoric cats, the pupil on the side of the lesions was invariably smaller than its partner. Evident pupillary inequality developed in the cats with dorsal HF lesions. Although there was a considerable variation in the extent and the location of lesions among these cats, the involvement of the giganto-pyramidal CA 3-2 appeared very responsible for the development of the pupillary sign. However, an evidently anisoric cat hat a lesion affecting only the prosubiculum and the subiculum in the posterior part of the dorsal HF. Despite a large involvement of CA 3-2 with or without coincident injuries to CA1, the prosubiculum and the subiculum, only slight pupillary inequality developed following ventral HF lesions. Evident anisocoria in the cats with large dorsal HF lesions disappeared after bilateral cervical sympathectomy, implying that the asymmetry of sympathetic nervous activity might be critically involved in the development of the pupillary sign. The hippocampo-spinal pathway relayed by the lateral septal nucleus and, then, by the lateral hypothalamic area to terminate in the intermedio-lateral cell column of the spinal cord was considered to be most concerned with anisocoria caused by HF lesions.","PeriodicalId":14790,"journal":{"name":"Journal fur Hirnforschung","volume":"38 1","pages":"9-26"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20016330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical scaling in mammals: a repeating units model. 哺乳动物的皮层缩放:重复单元模型。

Journal fur Hirnforschung Pub Date : 1997-01-01

J Prothero

引用次数: 0