Journal Biomedical and Biopharmaceutical Research最新文献_第2页

Ionic liquids as tools to improve gel formulations containing sparingly soluble phenolic acids 离子液体作为工具，以改善凝胶配方含有少量可溶性酚酸

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-06-01 DOI: 10.19277/bbr.19.1.280

Ana Júlio, Nádia Remtula, M. Nicolai, Tânia Santos de Almeida

{"title":"Ionic liquids as tools to improve gel formulations containing sparingly soluble phenolic acids","authors":"Ana Júlio, Nádia Remtula, M. Nicolai, Tânia Santos de Almeida","doi":"10.19277/bbr.19.1.280","DOIUrl":"https://doi.org/10.19277/bbr.19.1.280","url":null,"abstract":"Hydroxycinnamic acids, namely caffeic and p-coumaric acids, have several pharmaceutical and cosmetic applications, but due to their low aqueous solubility, their applicability can be limited. Ionic liquids (ILs) have been shown to be a valuable tool to improve the solubility and assist in the incorporation of various phenolic compounds into delivery systems. Thus, this work aims to evaluate the impact of incorporating three choline-based ILs, namely (2-hydroxyethyl)-trimethylammonium-L-phenylalanine [Cho][Phe], (2-hydroxyethyl)-trimethylammonium-L-glutamate [Cho][Glu] and (2-hydroxyethyl)-trimethylammonium-glycinate [Cho][Gly], into an aqueous gel formulation containing the poorly soluble caffeic and p-coumaric acids. The results obtained confirm that the ILs not only increase the drug solubility, but also allow higher amounts of both studied drugs to be incorporated into the gels, without interfering with the stability of the aqueous gels. Moreover, the ILs altered the fluidity of the gels, both in the absence and presence of both phenolic acids, as they increase the viscosity of the formulations, contributing to higher flow resistance of the gel, which may be better accepted by the consumer. Keywords: Ionic liquids; Hydroxycinnamic acids; Poorly soluble drugs; Gels; Increased Viscosity","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76435316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthropometric evaluation of pre-school and school-age children from the European Macaronesian regions 欧洲马卡罗尼西亚地区学龄前和学龄儿童的人体测量学评价

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-05-01 DOI: 10.19277/bbr.19.1.278

Nelson Tavares, Tatiana Silva, C. Ferreira-Pêgo

{"title":"Anthropometric evaluation of pre-school and school-age children from the European Macaronesian regions","authors":"Nelson Tavares, Tatiana Silva, C. Ferreira-Pêgo","doi":"10.19277/bbr.19.1.278","DOIUrl":"https://doi.org/10.19277/bbr.19.1.278","url":null,"abstract":"The growing prevalence of childhood obesity has triggered an interest in the effects of excessive weight gain in childhood. The identification of overweight and obese children at an early stage and their referral to start a treatment designed to achieve and/or maintain a healthy weight comprise fundamental foundations in sustaining a healthy state. A cross-sectional analysis was conducted to assess the prevalence of normal weight, overweight, and obesity in preschool and school children in the archipelago of Madeira and Azores, and the Canary Islands. The sample included 3481 individuals (1,768 boys and 1,713 girls) aged 3 to 9 years. The prevalence of pre-obesity (20.90% vs. 16.50%) and obesity (14.10% vs. 13.00%) was higher in girls and the Odds Ratio of overweight and obesity was higher in girls and between 4 and 9 years. The boys from Madeira and the Azores and the girls from Madeira had a higher probability [1.30 (1.02-1.67)] of having a high Body Mass Index. The results expose the need for educational strategies and interventional measures that contribute to the control of childhood obesity. Keywords: Anthropometric evaluation; Children; European Macaronesia; Obesity; Overweight","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"48 17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81389908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting suspected adverse reactions to COVID-19 vaccines in Portugal: side effects per vaccine type, gender, and age up to July 2021 报告葡萄牙对COVID-19疫苗的疑似不良反应:截至2021年7月每种疫苗类型、性别和年龄的副作用

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-04-27 DOI: 10.19277/bbr.19.1.277

C. Pires

{"title":"Reporting suspected adverse reactions to COVID-19 vaccines in Portugal: side effects per vaccine type, gender, and age up to July 2021","authors":"C. Pires","doi":"10.19277/bbr.19.1.277","DOIUrl":"https://doi.org/10.19277/bbr.19.1.277","url":null,"abstract":"dverse drug reactions (ADRs) of COVID-2019 vaccines require close monitoring. This study aimed to describe and discuss the most frequent ADRs of COVID-2019 vaccines and their prevalence per age group, gender, and vaccine type in Portugal up to 22 July 2021. ADR reports of COVID-19 vaccines were collected from a public report of INFARMED, I.P. (the Portuguese Medicines Agency). There were 11,314 ADRs notified per 11,002,983 COVID-19 vaccines administered in Portugal - 1 ADR per 1,000 vaccines administered and 0.4 serious ADR per 1,000 vaccines administered. The most commonly reported ADRs were myalgia, headache, pyrexia, pain at the injection site, and fatigue. More ADRs occurred in women and younger individuals. A slightly higher percentage of reported ADRs occurred with Vaxzervria. In conclusion, ADRs were mainly related to non-serious reactions. COVID-19 vaccines maintain a favourable safety profile in Portugal, although the types and prevalence of ADRs are likely to differ between different types of COVID-19 vaccines. Men may need to be motivated to more frequently report ADRs. Keywords: COVID-19; adverse drug reactions; vaccination; COVID-19 vaccines; pharmacovigilance","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81595847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors influencing breastfeeding duration among Portuguese mothers 影响葡萄牙母亲母乳喂养时间的因素

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-04-06 DOI: 10.19277/bbr.19.1.276

Mariana Z. de Oliveira

引用次数: 0

Exploratory Study on Municipalization of Health in Angola – Characterization of Human Resources for Health staffing and Health Units’ managers’ profile in Healthcare services and Training institutions of Cabinda Province 安哥拉卫生市民化的探索性研究——卡宾达省卫生服务和培训机构卫生人员人力资源特征和卫生单位管理人员概况

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-03-28 DOI: 10.19277/bbr.19.1.274

Teresa Macosso, Maria do Céu Costa, João Gregório, Alberto Macosso

{"title":"Exploratory Study on Municipalization of Health in Angola – Characterization of Human Resources for Health staffing and Health Units’ managers’ profile in Healthcare services and Training institutions of Cabinda Province","authors":"Teresa Macosso, Maria do Céu Costa, João Gregório, Alberto Macosso","doi":"10.19277/bbr.19.1.274","DOIUrl":"https://doi.org/10.19277/bbr.19.1.274","url":null,"abstract":"In Angola, the scarcity of human resources for health (HRH) is well known. Lately, there has been a focus on education and professional training structures, as well as the necessary profile of health units’ managers. The general objective of this study was to describe the perceptions of HRH Managers of Primary Health units of Cabinda Province about HRH training and retention. A cross-sectional observational study was performed, with semi-structured interviews supported by a survey, followed by a focus group, addressed at a convenience sample of HRH and Health Units managers in the province of Cabinda. 10 health units participated, where 13 managers were interviewed. As for the HRH profile, there is a majority of nurses, with a ratio of nurses to physicians of 8.6:1. As for the profile of managers, only three are postgraduate technicians in management. Training schools’ output in the previous year was 746 senior and middle technicians. Managers cited two main areas of improvement as essential to address the HRH imbalances in Cabinda: \"Leadership empowerment\" and \"Improving information system efficiency\". Opportunities were identified to improve the training of Health students, retention of HRH and managers of Health and training units in Cabinda. The definition of policies for HRH in Cabinda should focus on improving health teaching and management conditions with a special focus on empowerment of leaderships, and reinforcing the use of management tools and information systems. Desirably, implementing Management, Control and Quality Assurance Systems. Keywords: Health Workforce; Quality of Health Care; Health Management; Angola","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87513202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ablation of Kex2 activity enhances proIAPP proteotoxicity in yeast 消蚀Kex2活性可增强酵母中proIAPP的蛋白毒性

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.301

Sofia Ferreira, Ana F. Raimundo, Inês Farrim, Regina Menezes

{"title":"Ablation of Kex2 activity enhances proIAPP proteotoxicity in yeast","authors":"Sofia Ferreira, Ana F. Raimundo, Inês Farrim, Regina Menezes","doi":"10.19277/bbr.19.2.301","DOIUrl":"https://doi.org/10.19277/bbr.19.2.301","url":null,"abstract":"Pancreatic deposition of Islet Amyloid PolyPeptide (IAPP) is a histopathological hallmark of type 2 diabetes. Inadequate processing of immature IAPP by proprotein convertases (PCs) leads to the accumulation of unprocessed forms, which in turn favors increased aggregate formation in pancreatic β-cells. Kexin 2 (Kex2) of Saccharomyces cerevisiae is the prototype of eukaryotic PCs family, but to date no direct correlations between Kex2 activity and preproIAPP processing in yeast have been reported. In this study we aimed to address the possible role of Kex2 on IAPP maturation as a tool to investigate the contribution of impaired processing towards IAPP proteototoxicity. Genetically modified S. cerevisiae models lacking the KEX2 gene and carrying different chimeric fusions of human IAPP linked to GFP were used. The cytotoxic effects of Kex2 ablation were assessed by means of growth curve analysis and cell viability assays using flow cytometry. IAPP protein profile was evaluated by immunoblotting assays using an anti-IAPP antibody. Intracellular IAPP aggregates were monitored by confocal fluorescence microscopy. Data showed that kex2 mutants exhibit growth defects, potentiated by preproIAPP-GFP, proIAPP-GFP and mature IAPP-GFP expression with an increased cytotoxicity for proIAPP-GFP. Notwithstanding, Kex2 absence does not seem to affect IAPP protein pattern nor the frequency/distribution of intracellular IAPP aggregates in yeast. Our findings suggest that Kex2 is not essential for IAPP processing in yeast, at least under the conditions tested. Keywords: Amylin, Islet Amyloid Polypeptide (IAPP), Kexin 2, Prohormone processing, Saccharomyces cerevisiae","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90771761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optoaccoustic Tomography – good news for microcirculatory research 光声断层扫描-微循环研究的好消息

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.18.269

Tiago Granja, Sérgio Faloni de Andrade, L. Monteiro Rodrigues

{"title":"Optoaccoustic Tomography – good news for microcirculatory research","authors":"Tiago Granja, Sérgio Faloni de Andrade, L. Monteiro Rodrigues","doi":"10.19277/bbr.18.269","DOIUrl":"https://doi.org/10.19277/bbr.18.269","url":null,"abstract":"Tomographic imaging is a well established technology in preventive medicine and biomedical research, although not without limitations and concerns. Optoacoustic tomography (OAT) is a recent development that bridges optical and sonographic techniques to solve spatial resolution in deep-tissue imaging. In addition to safety advantages, OAT allows multiple wavelength readings for natural thermoelastic chromophores. In this study, we explore Multi Spectral Optoacoustic Tomography (MSOT) capacities to simultaneously acquire three independent chromophores – deoxygenated haemoglobin (Hb), oxygenated haemoglobin (HbO2), and melanin, from healthy human volunteers, with maximal molar extinction of HbO2 at 950 nm, Hb at 750 nm and melanin at 680 nm. Later we demonstrate how image stability during acquisition is fundamental for optimal resolution, precision and consistency of high throughout MSOT data collection. From recorded scans, a workflow is layered for data evaluation. With the MSOT dedicated software results were extracted from 3D image analysis of deep (15 mm3) vessels. The possibilities offered by this new system, specially in vascular pathophysiology, are immense and can be extended beyond current knowledge.","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75408348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of the protective and moisturizing effects of cosmetic formulations for the skin containing extracts with film-forming properties 含有具有成膜特性的提取物的护肤配方的保护和保湿效果的评价

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.293

Bruna Penachin, L. Kakuda, P. M. Maia Campos

{"title":"Evaluation of the protective and moisturizing effects of cosmetic formulations for the skin containing extracts with film-forming properties","authors":"Bruna Penachin, L. Kakuda, P. M. Maia Campos","doi":"10.19277/bbr.19.2.293","DOIUrl":"https://doi.org/10.19277/bbr.19.2.293","url":null,"abstract":"The development of formulations that provide efficient film-forming properties is important since film formation can protect the skin and hair from the action of external aggressors, such as pollution. Thus, the aim of this study was to evaluate the film-forming effect of cosmetic formulations for the skin containing extracts of Kappaphycus alvarezii and Caesalpinia spinosa, as well as the use of hemisqualane as an alternative to synthetic silicones. The evaluation of efficacy was performed by biophysical techniques and skin imaging techniques, as well as by a sensorial analysis. Sixteen women, aged 18 to 30 years, participated in the study. The results obtained demonstrated that the presence of the extracts in the formulation enabled the formation of a film that helped maintain skin barrier integrity, reduced desquamation, and improved parameters related to hydration. Finally, the study also showed that there were no significant differences between the formulations containing silicones and hemisqualane, which supports the use of hemisqualane as a more sustainable alternative in cosmetic formulations. Keywords: biopolymer, film-forming effect, hemisqualane, clinical efficacy, cosmetics","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84288460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XXXVI Annual Meeting of Federation of Societies of Experimental Biology (FeSBE) Abstracts 第三十六届实验生物学学会联合会(FeSBE)年会摘要

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.291

E. Colombari

引用次数: 0

Abstract Book - InnovDelivery '22 - I Lusophone Meeting on Innovative Delivery Systems 摘要书籍- InnovDelivery '22 - I创新交付系统葡语会议

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.289

Catarina Pereira Leite, Andreia A Rosatella, S. Reis, André Rolim Baby, J. Marto, Gislaine Ricci Leonardi, Ana Júlio, C. Almeida, João Vieira

引用次数: 0