Journal Biomedical and Biopharmaceutical Research最新文献_第3页

Assessment of nutritional risk in elderly adults of a senior residence – a case study 老年住宅中老年人营养风险评估-个案研究

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.18.2.270

Diana Pereira, C. Ferreira-Pêgo, Bruno Sousa

{"title":"Assessment of nutritional risk in elderly adults of a senior residence – a case study","authors":"Diana Pereira, C. Ferreira-Pêgo, Bruno Sousa","doi":"10.19277/bbr.18.2.270","DOIUrl":"https://doi.org/10.19277/bbr.18.2.270","url":null,"abstract":"Elderly adults have reduced appetite and energy expenditure, and possible malnutrition is related to the decline in biological and physiological functions, as well as its consequences. The aim of this study was to assess the nutritional status and malnutrition risk in elderly adults living in a senior residence. A cross-sectional observational analysis was carried out between February and March 2019 in a private senior residence in which the complete Mini Nutritional Assessment (MNA) was applied. It was observed that of the total of 45 participants, 5 individuals had a normal nutritional status, 18 had malnutrition and 22 were at risk. Malnutrition was related to a decrease in intake in the last 3 months (p=0.015) or to the fact that they experienced some type of psychological stress or acute illness in the same period (p=0.023). A higher incidence of malnutrition was also found in bedridden individuals or those in wheelchairs (p<0.001), as well as in patients with severe dementia (p=0.010), with the presence of skin lesions or bedsores (p=0.006), weight loss in the previous 3 months (p=0.003), and decreased fluid consumption (p=0.017). In conclusion, in this residence we verified that the malnutrition and malnutrition risk values are high, highlighting the need for nutritional intervention. Keywords: Elderly adults, Malnutrition, Nutrition assessment, Nutritional status","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87975730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the influence of the application of a cosmetic formulation on the skin morphological characteristics by Reflectance Confocal Microscopy 用反射共聚焦显微镜评价化妆品配方对皮肤形态特征的影响

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.299

P. M. Maia Campos, Gabriela Maria D’Angelo Costa

{"title":"Evaluation of the influence of the application of a cosmetic formulation on the skin morphological characteristics by Reflectance Confocal Microscopy","authors":"P. M. Maia Campos, Gabriela Maria D’Angelo Costa","doi":"10.19277/bbr.19.2.299","DOIUrl":"https://doi.org/10.19277/bbr.19.2.299","url":null,"abstract":"Reflectance Confocal Microscopy (RCM) is a non-invasive imaging technique with near-histological resolution that allows evaluation of the morphological and structural characteristics of the skin. In this context, the aim of the study was to evaluate the influence of the application of a cosmetic formulation on the skin morphological characteristics by RCM. The study included six female subjects, aged 40 to 50 years. Measurements in terms of epidermis thickness, dermal papillae depth (DPD), interkeratinocytes brightness (IB), furrows morphology, skin surface homogeneity (SSH), honeycomb pattern, skin hyperpigmentation, dermal papillae and dermis morphology were performed using RCM before and after a 90-day period of formulation application on the face. The studied formulation showed a significance increase of DPD after the 90 day period, showing an improvement on the dermal-epidermal junction (DEJ). In addition, an increase of IB in the granular layer and an improvement of dermis morphology were observed after the treatment. In conclusion, the obtained results by RCM showed an improvement of morphological characteristics of the skin after application of the studied cosmetic formulation for 90 day period when compared to the initial baseline, as it improved epidermis and dermoepidermal junction morphology. Keywords: Clinical efficacy, Reflectance Confocal Microscopy, cosmetic formulation","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74538574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of a cosmetic formulation with vitamin B3 for the treatment of oily skin 含维生素B3的化妆品配方治疗油性皮肤的临床疗效

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.18.2.273

Marcella Gabarra Almeida Leite, Patrícia Maria Berardo Gonçalves Maia Campos

{"title":"Clinical efficacy of a cosmetic formulation with vitamin B3 for the treatment of oily skin","authors":"Marcella Gabarra Almeida Leite, Patrícia Maria Berardo Gonçalves Maia Campos","doi":"10.19277/bbr.18.2.273","DOIUrl":"https://doi.org/10.19277/bbr.18.2.273","url":null,"abstract":"Oily skin has special needs, as the treatment and prevention of non-inflammatory acne and sebum control, maintaining skin barrier function and hydration. In this context, the importance of the development of specific and innovative cosmetics formulations to to fulfill the needs of this type of skin is evident. In this view, the aim of this study was the evaluation of the clinical efficacy of a cosmetic formulation containing Vitamin B3 in the treatment of oily skin using biophysical and skin imaging techniques. Female volunteers (n=40) between 18 to 30 years old with oily skin and/or mild inflammatory acne were recruited and received a formulation containing, or not (vehicle), 3% of Vitamin B3. Stratum corneum water content, transepidermal water loss (TEWL), sebum content and quantity of porphyrins were analyzed before (baseline) and after 28 days of application. Finally, an efficacy perception questionnaire was applied at the study end. The formulation with vitamin B3, showed a significant reduction of sebum and porphyrin content. The study participants in the assessment of perceived efficacy also reported these results. The studied formulation with Vitamin B3 was effective for oily skin care, acting on important parameters, such as controlling oiliness and improving skin appearance. Keywords: cosmetics, Niacinamide, skin physiology, oily skin, biophysical and skin imaging","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78277502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiphospholipid Syndrome (Clinical case) 抗磷脂综合征(临床一例)

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.292

Bruno Sousa

引用次数: 0

Pretest questionnaire for anti-ageing cosmetic claims substantiation: a description of validation of efficacy and sensory perception questionnaires 抗衰老化妆品声称证实的前测问卷:功效和感官知觉问卷验证的描述

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.298

Mariane Massufero Vergilio, Gislaine Ricci Leonardi, Laura Moretti Aiello, Tamiris Anselmo

{"title":"Pretest questionnaire for anti-ageing cosmetic claims substantiation: a description of validation of efficacy and sensory perception questionnaires","authors":"Mariane Massufero Vergilio, Gislaine Ricci Leonardi, Laura Moretti Aiello, Tamiris Anselmo","doi":"10.19277/bbr.19.2.298","DOIUrl":"https://doi.org/10.19277/bbr.19.2.298","url":null,"abstract":"The application of questionnaires for the assessment and collection of data on target audiences and new products is a very common practice in the field of cosmetics. However, to obtain reliable results, it is essential to pretest the instrument to detect possible problems and inconsistencies. The aim of this study was to demonstrate the entire pre-testing process of two questionnaires used in the cosmetic claims substantiation area; a skin self-assessment questionnaire and a sensory analysis questionnaire for cosmetic formulations. According to the pretest protocol analysis, 15 women were interviewed for each questionnaire. All difficulties were recorded, categorized, and analyzed. Subsequently, the inconsistencies found were corrected in the final version of the instrument. During the validation of the questionnaires, the biggest problem faced was related to the application of scales and technical concepts within the questions. This difficulty means that respondents are unable to represent their real perception of the evaluated product. This problem can be solved by adding detailed explanations in the footer or within the wording of each question. In conclusion, learning and applying the pre-test in questionnaires can ensure greater reliability and clarity in research results in the cosmetic area. Keywords: Questionnaires, cosmetics, substantiation of claims, self-efficacy, sensory attributes","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85868648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral intake of Bioactive Collagen Peptides in the improvement of skin and hair: clinical studies by instrumental measurements 口服生物活性胶原肽改善皮肤和头发:仪器测量的临床研究

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.297

P. M. Maia Campos, Maísa Oliveira de Melo, Marina Mendes Fossa Shirata, Marcella Gabarra Leite

{"title":"Oral intake of Bioactive Collagen Peptides in the improvement of skin and hair: clinical studies by instrumental measurements","authors":"P. M. Maia Campos, Maísa Oliveira de Melo, Marina Mendes Fossa Shirata, Marcella Gabarra Leite","doi":"10.19277/bbr.19.2.297","DOIUrl":"https://doi.org/10.19277/bbr.19.2.297","url":null,"abstract":"The effect of collagen peptides on various aspects of skin and hair physiology is known but needs further studies. Thus, the objective of this study was to evaluate the clinical changes in skin and hair after 90 days of treatment with oral supplementation of 5 g/day of collagen peptides. For this, 60 healthy female participants were enrolled, aged 45 to 60 years old, with the primary objective of evaluating the effect of the ingestion of a bioactive collagen peptides-based supplementation in the cutaneous microrelief, reduction of wrinkles, thickness, and echogenicity of the dermis, as well as in the mechanical properties of the hair using biophysical and skin imaging techniques. The present study showed important benefits in relevant skin visual parameters, dermis density, and hair strength with the obtained data. In addition, considering that the aging process affects the hair's mechanical resistance due to hair fiber thinner, the proposed treatment was effective for aged hair. In conclusion, the collagen peptides oral supplementation is essential not only for improving skin conditions but also for hair care once it significantly increases the mechanical hair resistance evaluated by objective measurements. Keywords: Collagen peptides, skin aging, skin imaging techniques, hair mechanical properties, clinical study","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88213676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplementation with Moringa oleifera leaves flour prevents fructose-based metabolic disorders in young rats 补充辣木叶面粉可以防止幼鼠体内果糖代谢紊乱

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.294

Izabel Carolina Bousfield Terranova, Izabelle Coelho Souza, Isadora Simas Ribeiro, Milena Fronza Broering, Aline De Faveri, Marina Jagielski Goss, Ana Mara de Oliveira Silva, R. Niero, Eduardo Augusto Steffens, Larissa Benvenutti, Luciano Vitali, S. Gonçalves, Isabel Daufenback Machado, Nara Lins Meira Quintão, J. R. Santin

{"title":"Supplementation with Moringa oleifera leaves flour prevents fructose-based metabolic disorders in young rats","authors":"Izabel Carolina Bousfield Terranova, Izabelle Coelho Souza, Isadora Simas Ribeiro, Milena Fronza Broering, Aline De Faveri, Marina Jagielski Goss, Ana Mara de Oliveira Silva, R. Niero, Eduardo Augusto Steffens, Larissa Benvenutti, Luciano Vitali, S. Gonçalves, Isabel Daufenback Machado, Nara Lins Meira Quintão, J. R. Santin","doi":"10.19277/bbr.19.2.294","DOIUrl":"https://doi.org/10.19277/bbr.19.2.294","url":null,"abstract":"Moringa oleifera leaves flour is amply used to treat metabolic conditions. The aim was to assess the M. oleifera flour (MOF) on metabolic changes induced by fructose. Phenolic compounds were determined by LC-ESI-MS/MS. Wistar rats were distributed in groups: 1) Control (normal-chow + water); 2) Fructose (normal-chow + fructose (20%) in water) and 3) Feed with MOF20% + fructose (20%) in water. At the end of the 4th week of treatment, the animals were submitted to insulin resistance (IR) test, blood collection and histological evaluation. MOF contains phenolic compounds such as quercetin and chlorogenic acid. MOF supplementation promotes reduction in glycemia, insulin, triglycerides. The supplementation improved the insulin sensitivity. In the histological analysis, MOF supplementation reduced the adipocyte hypertrophy and the lipid deposition in the liver. The data obtained showed that MOF supplementation presented a protective effect against the harmful consequences of excessive fructose consumption. Keywords: Moringa oleifera, metabolic syndrome, diabetes, fructose, mice","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87796671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilot study of unconventional food plant (UFP): adherence to nasturtium (Tropaeolum majus L.) in the diet and monitoring of biometric and clinical indicators 非常规食用植物(UFP)的试点研究:饮食中旱金莲(Tropaeolum majus L.)的粘附性以及生物特征和临床指标的监测

Journal Biomedical and Biopharmaceutical Research Pub Date : 2022-01-01 DOI: 10.19277/bbr.19.2.295

Sérgio Faloni de Andrade, Maria da Graça Lopes Serrador, A. Pereira da Silva, Rejane Giacomelli Tavares, L. Monteiro Rodrigues, M. C. Costa

{"title":"Pilot study of unconventional food plant (UFP): adherence to nasturtium (Tropaeolum majus L.) in the diet and monitoring of biometric and clinical indicators","authors":"Sérgio Faloni de Andrade, Maria da Graça Lopes Serrador, A. Pereira da Silva, Rejane Giacomelli Tavares, L. Monteiro Rodrigues, M. C. Costa","doi":"10.19277/bbr.19.2.295","DOIUrl":"https://doi.org/10.19277/bbr.19.2.295","url":null,"abstract":"The flowers of Tropaeolum majus, popularly known as \"capuchinha,\" garden nasturtium, nasturtium, Indian cress, or monks cress, are currently used worldwide as a food supplement and in plant-based diets, being added to smoothies, soups, mayonnaise and salads by consumers in search of sources of substances considered beneficial to human health. Most studies have shown nutritional qualities and beneficial effects of the plant, especially its flowers and respective aqueous extracts in vitro and in animals. Thus, this pilot study was designed to evaluate the acceptance and possible benefits of daily consumption of 20 g T. majus flowers per day for 30 days in healthy participants. Before and after ingestion, body composition, heart rate, blood pressure, and hematological and biochemical parameters were analysed. Results have shown good acceptance and safe use of T. majus flowers in a balanced and varied diet. However, it is important to highlight that this is the first exploratory study regarding these issues in healthy humans, and therefore, despite the widespread consumption described, additional studies are needed to deepen the results in biometric and clinical indicators in a larger number of volunteers. Keywords: Tropaeolum majus, unconventional food plant (UFP), nasturtium, edible flowers","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84311144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid UV-Vis spectroscopy methods for quantification of ranitidine tablets 快速紫外可见光谱法测定雷尼替丁片的含量

Journal Biomedical and Biopharmaceutical Research Pub Date : 2021-12-31 DOI: 10.19277/bbr.18.2.271

P. Rijo, L. Ribeiro, M. Nicolai, P. Pereira, C. Faustino

{"title":"Rapid UV-Vis spectroscopy methods for quantification of ranitidine tablets","authors":"P. Rijo, L. Ribeiro, M. Nicolai, P. Pereira, C. Faustino","doi":"10.19277/bbr.18.2.271","DOIUrl":"https://doi.org/10.19277/bbr.18.2.271","url":null,"abstract":"Ranitidine is a histamine H2-receptor antagonist that inhibits gastric acid secretion, commonly used in the treatment and prophylaxis of peptic ulcer and gastroesophageal reflux disease. Over-the-counter ranitidine hydrochloride tablets are available in several European countries as well as the US for the relief of indigestion and heartburn. Commercial tablets containing the equivalent of 150 mg of ranitidine were analysed following extraction. Ranitidine is water-soluble, thus avoiding the use of organic solvents. Standard aqueous solutions of ranitidine hydrochloride were used to construct a calibration curve. This graduate laboratory experiment describes a simple, inexpensive, safe, and “green” procedure for the quantification of ranitidine tablets by UV spectrophotometry. The entire procedure provides an pedagogical opportunity to approach a realistic analytical scenario, typical of a quality control laboratory, by designing an attractive and engaging hands-on session. An average content of 148 ± 1 mg of ranitidine was determined using both standard addition and external calibration methods and results are in agreement with Pharmacopoeia. Keywords: Analytical chemistry, ranitidine, drugs/pharmaceuticals, quantitative analysis, UV-Vis spectroscopy","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90081827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single versus mixed edge activators in caffeine-loaded transfersomes: physicochemical and cytotoxicity assessment 负载咖啡因的转移体中的单一边缘激活剂与混合边缘激活剂:物理化学和细胞毒性评估

Journal Biomedical and Biopharmaceutical Research Pub Date : 2021-12-31 DOI: 10.19277/bbr.18.2.267

Í. Guerreiro, A. Fernandes, C. Rosado, C. Pereira-Leite, Marta Rodrigues

{"title":"Single versus mixed edge activators in caffeine-loaded transfersomes: physicochemical and cytotoxicity assessment","authors":"Í. Guerreiro, A. Fernandes, C. Rosado, C. Pereira-Leite, Marta Rodrigues","doi":"10.19277/bbr.18.2.267","DOIUrl":"https://doi.org/10.19277/bbr.18.2.267","url":null,"abstract":"The performance of transfersomes as nanovesicular systems to enhance the skin permeation of bioactive compounds may be modulated according to their composition of edge activators (EAs). Vesicle size, deformability, and encapsulation efficiency can be altered when using nonionic surfactants as EAs with opposing hydrophilic-lipophilic balance (HLB). Thus, this work aimed to assess the impact on the physicochemical properties and the in vitro cytotoxicity profile of transfersomal formulations composed of single or mixed EAs, with opposing HLB values. Transfersomes made of single or mixed nonionic surfactants (Tween® 80 and/or Span® 80) were prepared in the presence and absence of caffeine, used as a model hydrophilic compound. Single or mixed EAs-containing transfersomes displayed promising physicochemical properties for cutaneous applications and were found to be stable for one month of refrigerated storage. Moreover, all transfersomal formulations were compatible with a keratinocyte cell line upon 24 h treatment. Altogether, these preliminary data suggest that the use of mixed nonionic surfactants as EAs may be further explored to modulate the performance of transfersomes as skin permeation enhancers. Keywords: Vesicular systems, nanotechnology, nonionic surfactants, caffeine","PeriodicalId":14771,"journal":{"name":"Journal Biomedical and Biopharmaceutical Research","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74465320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1