光声断层扫描-微循环研究的好消息

Tiago Granja, Sérgio Faloni de Andrade, L. Monteiro Rodrigues
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引用次数: 2

摘要

层析成像在预防医学和生物医学研究中是一项成熟的技术,尽管并非没有限制和担忧。光声层析成像(OAT)是近年来发展起来的一种结合光学和超声技术来解决深层组织成像空间分辨率的技术。除了安全优势外,OAT还允许对天然热弹性发色团进行多波长读数。在这项研究中,我们探索了多光谱光声成像(MSOT)同时从健康人类志愿者身上获取三种独立的发色团——脱氧血红蛋白(Hb)、氧合血红蛋白(HbO2)和黑色素的能力,其中HbO2在950 nm、Hb在750 nm和黑色素在680 nm处的最大摩尔消光。稍后,我们将演示采集过程中的图像稳定性如何对整个MSOT数据采集的最佳分辨率,精度和一致性至关重要。从记录的扫描,工作流分层进行数据评估。使用MSOT专用软件从深度(15 mm3)血管的3D图像分析中提取结果。这个新系统提供的可能性,特别是在血管病理生理学方面,是巨大的,可以扩展到现有知识之外。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optoaccoustic Tomography – good news for microcirculatory research
Tomographic imaging is a well established technology in preventive medicine and biomedical research, although not without limitations and concerns. Optoacoustic tomography (OAT) is a recent development that bridges optical and sonographic techniques to solve spatial resolution in deep-tissue imaging. In addition to safety advantages, OAT allows multiple wavelength readings for natural thermoelastic chromophores. In this study, we explore Multi Spectral Optoacoustic Tomography (MSOT) capacities to simultaneously acquire three independent chromophores – deoxygenated haemoglobin (Hb), oxygenated haemoglobin (HbO2), and melanin, from healthy human volunteers, with maximal molar extinction of HbO2 at 950 nm, Hb at 750 nm and melanin at 680 nm. Later we demonstrate how image stability during acquisition is fundamental for optimal resolution, precision and consistency of high throughout MSOT data collection. From recorded scans, a workflow is layered for data evaluation. With the MSOT dedicated software results were extracted from 3D image analysis of deep (15 mm3) vessels. The possibilities offered by this new system, specially in vascular pathophysiology, are immense and can be extended beyond current knowledge.
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