{"title":"The Complex Relationship Between Risk Factor Exposure and Coronary Epicardial as Well as Microvascular Disease","authors":"João A.C. Lima MD , Joanne D. Schuijf PhD","doi":"10.1016/j.jcmg.2024.09.011","DOIUrl":"10.1016/j.jcmg.2024.09.011","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 1","pages":"Pages 59-61"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teemu Maaniitty MD, PhD , Matias Mäenpää MD , Esa Harjulahti MD , Iida Kujala MD, PhD , Iida Stenström MD, PhD , Wail Nammas MD, PhD , Juhani Knuuti MD, PhD , Antti Saraste MD, PhD
{"title":"Lipid-Lowering Medication and Outcomes After Anatomical and Functional Imaging in Suspected Coronary Artery Disease","authors":"Teemu Maaniitty MD, PhD , Matias Mäenpää MD , Esa Harjulahti MD , Iida Kujala MD, PhD , Iida Stenström MD, PhD , Wail Nammas MD, PhD , Juhani Knuuti MD, PhD , Antti Saraste MD, PhD","doi":"10.1016/j.jcmg.2024.07.009","DOIUrl":"10.1016/j.jcmg.2024.07.009","url":null,"abstract":"<div><h3>Background</h3><div>Anatomical and functional imaging identify different phenotypes of coronary artery disease (CAD) that may have implications for lipid-lowering medication (LLM).</div></div><div><h3>Objectives</h3><div>The aim of this study was to assess the associations between LLM and long-term outcomes after combined anatomical and functional imaging in patients with suspected obstructive CAD.</div></div><div><h3>Methods</h3><div>Consecutive patients (n = 1,973; 41% men; median age: 63 years) underwent coronary computed tomography angiography (CTA) because of suspected CAD. Patients in whom obstructive CAD was not ruled out by CTA underwent ischemia testing by positron emission tomography. Data on LLM purchases were collected until 2 years, and the combined endpoints of death, myocardial infarction, and unstable angina pectoris were assessed at a median of 6.7 years.</div></div><div><h3>Results</h3><div>After imaging, LLM was used by 24% of patients with no CAD, 51% of patients with nonobstructive CAD, 72% of patients with obstructive CAD on CTA without myocardial ischemia, and 91% of patients with myocardial ischemia. The use of LLM decreased during follow-up, with 77% of patients with myocardial ischemia using LLM for 2 years. The use of LLM was associated with a lower annual rate of adverse events in patients with myocardial ischemia (6.1% vs 2.8%; <em>P =</em> 0.032) or obstructive CAD without myocardial ischemia (2.9% vs 1.4%; <em>P =</em> 0.004) but not in patients with nonobstructive CAD (1.5% vs 1.4%; <em>P =</em> 0.89) or no CAD (0.3% vs 0.3%; <em>P =</em> 0.68).</div></div><div><h3>Conclusions</h3><div>The CAD phenotype defined by anatomical and functional imaging guides the use of LLM. The presence of myocardial ischemia and anatomical obstructive coronary lesions were associated with a long-term outcome benefit from LLM.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 1","pages":"Pages 62-73"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Philipp von Stein MD , Jennifer von Stein MD , Christopher Hohmann MD , Hendrik Wienemann MD , Henning Guthoff MD , Maria I. Körber MD , Stephan Baldus MD , Roman Pfister MD , Rebecca T. Hahn MD , Christos Iliadis MD
{"title":"Atrial Functional Mitral Regurgitation Subtypes Undergoing Transcatheter Edge-to-Edge Repair","authors":"Philipp von Stein MD , Jennifer von Stein MD , Christopher Hohmann MD , Hendrik Wienemann MD , Henning Guthoff MD , Maria I. Körber MD , Stephan Baldus MD , Roman Pfister MD , Rebecca T. Hahn MD , Christos Iliadis MD","doi":"10.1016/j.jcmg.2024.06.019","DOIUrl":"10.1016/j.jcmg.2024.06.019","url":null,"abstract":"<div><h3>Background</h3><div>Two subtypes of atrial functional mitral regurgitation (AFMR) have been described, one is characterized by Carpentier type I and the other by Carpentier type IIIb leaflet motion.</div></div><div><h3>Objectives</h3><div>The authors sought to analyze echocardiographic characteristics and outcomes of AFMR subtypes undergoing mitral valve transcatheter edge-to-edge repair (M-TEER).</div></div><div><h3>Methods</h3><div>Of 1,047 consecutive patients who underwent M-TEER, the authors identified those with isolated mitral annulus dilation (Carpentier I), termed AFMR-IAD, and those with atriogenic hamstringing characterized by restricted posterior mitral leaflet motion (Carpentier IIIb), termed AFMR-AH. Echocardiographic baseline characteristics and outcomes up to 1-year were analyzed.</div></div><div><h3>Results</h3><div>A total of 128 patients (12.2%) met AFMR criteria; 75 (58.6%) were identified as AFMR-IAD and 53 (41.4%) as AFMR-AH. AFMR-AH displayed greater left atrial and left ventricular volumes, greater mitral annulus, shorter and steeper posterior mitral leaflet, and more pronounced MR (all <em>P <</em> 0.05). Technical success was achieved in 98.7% (AFMR-IAD) and 86.8% (AFMR-AH) of patients (<em>P =</em> 0.009). At discharge, device detachments were exclusively observed in AFMR-AH (10.0%). MR ≤II was achieved in 95.6% and 78.6% at 30 days (<em>P</em> = 0.009) and in 93.0% and 74.1% at 1 year (<em>P =</em> 0.038) in patients with AFMR-IAD and AFMR-AH, respectively. AFMR-AH was associated with procedural failure (OR: 1.17 [95% CI: 1.00-1.38]; <em>P =</em> 0.045) at 30 days (43.4% vs 24.0%; <em>P =</em> 0.023) and all-cause mortality (HR: 2.54 [95% CI: 1.09-5.91]; <em>P =</em> 0.031) at 1 year (77% vs 92%, Kaplan-Meier estimated 1-year survival; <em>P =</em> 0.017).</div></div><div><h3>Conclusions</h3><div>AFMR-AH shows worse procedural and clinical outcomes following M-TEER than AFMR-IAD. Thus, vigilance regarding this pathology is warranted and alternative mitral valve therapies might need to be considered.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 1","pages":"Pages 16-29"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gilbert H.L. Tang MD, MSc, MBA , Syed Zaid MD , Rebecca T. Hahn MD , Vratika Aggarwal MD , Mohamad Alkhouli MD , Edris Aman MD , Sergio Berti MD , Y.S. Chandrashekhar MD, DM , Scott M. Chadderdon MD , Andreina D’Agostino MD , Neil P. Fam MD , Edwin C. Ho MD , Chad Kliger MD , Susheel K. Kodali MD , Parasuram Krishnamoorthy MD , Azeem Latib MD , Stamatios Lerakis MD, PhD , D. Scott Lim MD , Vaikom S. Mahadevan MD , Devi G. Nair MD , Ralph Stephan von Bardeleben MD
{"title":"Structural Heart Imaging Using 3-Dimensional Intracardiac Echocardiography","authors":"Gilbert H.L. Tang MD, MSc, MBA , Syed Zaid MD , Rebecca T. Hahn MD , Vratika Aggarwal MD , Mohamad Alkhouli MD , Edris Aman MD , Sergio Berti MD , Y.S. Chandrashekhar MD, DM , Scott M. Chadderdon MD , Andreina D’Agostino MD , Neil P. Fam MD , Edwin C. Ho MD , Chad Kliger MD , Susheel K. Kodali MD , Parasuram Krishnamoorthy MD , Azeem Latib MD , Stamatios Lerakis MD, PhD , D. Scott Lim MD , Vaikom S. Mahadevan MD , Devi G. Nair MD , Ralph Stephan von Bardeleben MD","doi":"10.1016/j.jcmg.2024.05.012","DOIUrl":"10.1016/j.jcmg.2024.05.012","url":null,"abstract":"<div><div><span>3-dimensional (3D) intracardiac echocardiography (ICE) is emerging as a promising complement and potential alternative to </span>transesophageal echocardiography<span> for imaging guidance in structural heart interventions. To establish standardized practices, our multidisciplinary expert position statement serves as a comprehensive guide for the appropriate indications and utilization of 3D-ICE in various structural heart procedures. The paper covers essential aspects such as the fundamentals of 3D-ICE imaging, basic views, and workflow recommendations specifically tailored for ICE-guided structural heart procedures, such as transeptal puncture, device closure of intracardiac structures, and transcatheter mitral and tricuspid valve interventions. Current challenges, future directions, and training requirements to ensure operator proficiency are also discussed, thereby promoting the safety and efficacy of this innovative imaging modality to support expanding its future clinical applications.</span></div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 1","pages":"Pages 93-115"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Time Interval Between Onset of Illness and Imaging in Patients With Takotsubo Syndrome","authors":"John E. Madias MD","doi":"10.1016/j.jcmg.2024.09.015","DOIUrl":"10.1016/j.jcmg.2024.09.015","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 1","pages":"Page 128"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}