JACC. Cardiovascular imaging最新文献

{"title":"Racial Differences in Cardiovascular Mortality Among Patients in the Coronary Artery Calcium Consortium","authors":"Quinn Capers IV MD","doi":"10.1016/j.jcmg.2025.04.005","DOIUrl":"10.1016/j.jcmg.2025.04.005","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages 676-678"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulnerable or High-Risk Plaque","authors":"Rocco Vergallo MD, PhD ,&nbsp;Seung-Jung Park MD, PhD ,&nbsp;Gregg W. Stone MD ,&nbsp;David Erlinge MD, PhD ,&nbsp;Italo Porto MD, PhD ,&nbsp;Ron Waksman MD ,&nbsp;Gary S. Mintz MD ,&nbsp;Fabrizio D’Ascenzo MD, PhD ,&nbsp;Sara Seitun MD ,&nbsp;Luca Saba MD ,&nbsp;Rozemarijn Vliegenthart MD, PhD ,&nbsp;Fernando Alfonso MD ,&nbsp;Armin Arbab-Zadeh MD, PhD, MPH ,&nbsp;Peter Libby MD ,&nbsp;Marcelo F. Di Carli MD ,&nbsp;James E. Muller MD ,&nbsp;Gerald Maurer MD ,&nbsp;Robert J. Gropler MD ,&nbsp;Y.S. Chandrashekhar MD ,&nbsp;Eugene Braunwald MD ,&nbsp;Ik-Kyung Jang MD, PhD","doi":"10.1016/j.jcmg.2024.12.004","DOIUrl":"10.1016/j.jcmg.2024.12.004","url":null,"abstract":"<div><div>The concept of high-risk plaque emerged from pathologic and epidemiologic studies 3 decades ago that demonstrated plaque rupture with thrombosis as the predominant mechanism of acute coronary syndrome and sudden cardiac death. Thin-cap fibroatheroma, a plaque with a large lipidic core covered by a thin fibrous cap, is the prototype of the rupture-prone plaque and has been traditionally defined as “vulnerable plaque.” Although knowledge on the pathophysiology of plaque instability continues to grow, the risk profile of our patients has shifted and the character of atherosclerotic disease has evolved, partly because of widespread use of lipid-lowering therapies and other preventive measures. In vivo intracoronary imaging studies indicate that superficial erosion causes up to 40% of acute coronary syndromes. This changing landscape calls for broader perspective, expanding the concept of high-risk plaque to the precursors of all major substrates of coronary thrombosis beyond plaque rupture. Other factors to take into consideration include dynamic changes in plaque composition, the importance of plaque burden, inflammatory activation (both local and systemic), healing mechanisms, regional hemodynamic pattern, properties of the fluid phase of blood, and the amount of myocardium at risk subtended by a lesion. Rather than the traditional focus limited to the thin-cap fibroatheroma, the authors advocate a more comprehensive approach that considers both morphologic features and biological activity of plaques and blood. This position paper highlights the challenges to the usual concept of high-risk plaque, proposes a broader definition, and analyzes its key morphologic features, the technological progress of plaque imaging (particularly using intracoronary imaging techniques), advances in pharmacologic therapies for plaque regression and stabilization, and the feasibility and efficacy of focal interventional treatments including preemptive plaque sealing.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages 709-740"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5-Year Echocardiographic Results of Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients","authors":"Rebecca T. Hahn MD ,&nbsp;Julien Ternacle MD, PhD ,&nbsp;Iria Silva MD ,&nbsp;Carlos Giuliani MD ,&nbsp;Antonela Zanuttini MD ,&nbsp;Alexis Théron MD ,&nbsp;Nicole Cristell MD ,&nbsp;Mathieu Bernier MD ,&nbsp;Sabah Skaf MD ,&nbsp;Jonathan Beaudoin MD ,&nbsp;Susheel K. Kodali MD ,&nbsp;Mark Russo MD ,&nbsp;Samir R. Kapadia MD ,&nbsp;Chris S. Malaisrie MD ,&nbsp;David J. Cohen MD, MSc ,&nbsp;Jonathon Leipsic MD ,&nbsp;Philipp Blanke MD ,&nbsp;Mathew R. Williams MD ,&nbsp;James M. McCabe MD ,&nbsp;David L. Brown MD ,&nbsp;Philippe Pibarot DVM, PhD","doi":"10.1016/j.jcmg.2025.01.015","DOIUrl":"10.1016/j.jcmg.2025.01.015","url":null,"abstract":"<div><h3>Background</h3><div>The PARTNER 3 (Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients with Aortic Stenosis) trial compared SAPIEN 3 transcatheter aortic valve replacement (TAVR) to surgery in low-risk patients with symptomatic, severe aortic stenosis. Echocardiographic outcomes at 5 years are unknown.</div></div><div><h3>Objectives</h3><div>This study sought to compare 5-year echocardiographic results of TAVR and surgery in the PARTNER 3 trial.</div></div><div><h3>Methods</h3><div>Echocardiograms for 1,000 randomized patients were obtained at baseline, 30 days, 1 year, and annually through 5 years and were analyzed by a core lab consortium. The composite primary endpoint of death, stroke, or rehospitalization was adjudicated by a clinical events committee.</div></div><div><h3>Results</h3><div>At 5 years, ≥ mild aortic regurgitation was higher following TAVR vs surgery (24.5% vs 6.3%; <em>P &lt;</em> 0.001), with low ≥ moderate aortic regurgitation in both groups. TAVR patients had higher mean transaortic gradient (12.8 ± 6.5 vs 11.7 ± 5.6 mm Hg; <em>P &lt;</em> 0.001), stroke volume index (44.6 ± 9.7 vs 41.1 ± 9.2; <em>P &lt;</em> 0.0001), and aortic valve area (1.87 ± 0.46 vs 1.82 ± 0.46; <em>P =</em> 0.895). Fewer TAVR patients had low-flow stroke volume index (<em>P &lt;</em> 0.001) and left ventricular hemodynamic burden (valvulo-arterial impedance; <em>P &lt;</em> 0.01). Tricuspid annular plane systolic excursion was also higher with TAVR (<em>P &lt;</em> 0.001), as was right ventricular–to–pulmonary artery coupling (<em>P &lt;</em> 0.0001). In the combined cohorts, 30-day moderate to severe prosthesis-patient mismatch, mild to severe aortic regurgitation, or low stroke volume index were not predictive of clinical outcomes; only low right ventricular–to–pulmonary artery coupling and high valvulo-arterial impedance at 30 days were associated with increased risk of the 5-year composite primary endpoint.</div></div><div><h3>Conclusions</h3><div>In low-risk patients with severe aortic stenosis, TAVR, compared to surgery, was associated with similar, stable valve hemodynamics at 5 years with less frequent low-flow state, lower valvulo-arterial impedance, and better right ventricular function. (PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients with Aortic Stenosis [P3]; <span><span>NCT02675114</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages 625-640"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in the Setting of Mitral Annular Disjunction","authors":"Alon Shechter MD, MHA,&nbsp;Robert J. Siegel MD","doi":"10.1016/j.jcmg.2025.03.009","DOIUrl":"10.1016/j.jcmg.2025.03.009","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Page 744"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board/Officers","authors":"","doi":"10.1016/S1936-878X(25)00205-0","DOIUrl":"10.1016/S1936-878X(25)00205-0","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages i-iv"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building Consensus on Advanced Imaging in Cardiac Sarcoidosis","authors":"Sanjay Divakaran MD, MPH,&nbsp;Garrick C. Stewart MD, MPH","doi":"10.1016/j.jcmg.2025.03.005","DOIUrl":"10.1016/j.jcmg.2025.03.005","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages 693-695"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cardiovascular Magnetic Resonance Phenotype of Lamin Heart Disease","authors":"Constantin-Cristian Topriceanu MD ,&nbsp;Mashael Al-Farih PhD ,&nbsp;George Joy MBBS, PhD ,&nbsp;Fiona Chan MBBS ,&nbsp;Matt Webber MBChB, PhD ,&nbsp;Denis C. Ilie-Ablachim PhD ,&nbsp;Hunain Shiwani BMBS ,&nbsp;Mansoon Tamang BSc ,&nbsp;Catherine Banks BSc ,&nbsp;Stephen Pettit MD, PhD ,&nbsp;Steffen E. Petersen MBChB, MD(Res), DPhil (Oxon), MPH ,&nbsp;Ben O’Brien MD ,&nbsp;Alun D. Hughes PhD ,&nbsp;Iain Pierce PhD ,&nbsp;William E. Moody MBChB, PhD ,&nbsp;Richard P. Steeds MBBS, MD ,&nbsp;Paolo E. Puddu MD, PhD ,&nbsp;Peter Kellman PhD ,&nbsp;Konstantinos Savvatis MD, PhD ,&nbsp;Saidi Mohiddin MBChB, MD ,&nbsp;Gabriella Captur MD, MSc, PhD","doi":"10.1016/j.jcmg.2025.01.004","DOIUrl":"10.1016/j.jcmg.2025.01.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Lamin (&lt;em&gt;LMNA&lt;/em&gt;) heart disease is a lethal form of dilated cardiomyopathy (DCM).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The authors explored its cardiovascular magnetic resonance (CMR) phenotype to discover prognostically useful and subclinical biomarkers.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This prospective multicenter study recruited 4 groups: &lt;em&gt;LMNA&lt;/em&gt; carriers with left ventricular ejection fraction ≥55% (Lamin+EF), &lt;em&gt;LMNA&lt;/em&gt; carriers with left ventricular ejection fraction &lt;50% (Lamin–EF), individuals with DCM with wild-type &lt;em&gt;LMNA&lt;/em&gt; (DCMwt), and healthy volunteers. Phantom-calibrated CMR comprising cines, late gadolinium enhancement, and multiparametric mapping was undertaken. Left ventricular shapes were reconstructed using generalized Procrustes analysis. Serum biomarkers were collected at the time of CMR. Using a major adverse cardiovascular events (MACE) outcome of cardiovascular death, life-threatening ventricular tachyarrhythmia, heart transplantation, or atrioventricular block requiring pacing, we explored the prognostic value of CMR metrics using Cox regression.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 187 individuals were recruited (50% male): 29 with Lamin+EF (38 ± 14 years), 38 with Lamin–EF (45 ± 17 years), 73 with DCMwt (45 ± 15 years), and 47 healthy volunteers (44 ± 20 years). Compared to HVs, Lamin+EF had longer phantom-normalized T&lt;sub&gt;2&lt;/sub&gt; by 10 (95% CI: 2-20), higher ECV by 3% (95% CI: 1%-6%), and worse myocardial dynamics. Compared with DCMwt participants, Lamin+EF participants had better myocardial dynamics, higher phantom-normalized T&lt;sub&gt;2&lt;/sub&gt; (20 vs 12; &lt;em&gt;P =&lt;/em&gt; 0.010), higher serum troponin (27 ng/L vs 5 ng/L; &lt;em&gt;P &lt;&lt;/em&gt; 0.001), and higher C-reactive protein (8 mg/L vs 3 mg/L; &lt;em&gt;P =&lt;/em&gt; 0.021). Lamin–EF participants had similar myocardial dynamics but higher serum troponin (13 ng/L vs 5 ng/L; &lt;em&gt;P &lt;&lt;/em&gt; 0.001), higher N-terminal pro–B-type natriuretic peptide (668 pg/mL vs 228 pg/mL; &lt;em&gt;P =&lt;/em&gt; 0.025), longer phantom-normalized T&lt;sub&gt;2&lt;/sub&gt; by 16 (95% CI: 1-31), and higher extracellular volume by 5% (95% CI: 1%-9%) than DCMwt participants. Over 4 years, 21% of lamin and 6% of DCMwt participants experienced MACE (&lt;em&gt;P &lt;&lt;/em&gt; 0.001). In lamin participants, each 1% increase in global late gadolinium enhancement and each 1% decrease in Procrustes trajectory sizes associated with HRs for MACE of 1.15 (95% CI: 1.02-1.30) and 1.01 (95% CI: 1.01-1.02), respectively (both &lt;em&gt;P ≤&lt;/em&gt; 0.025).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;The CMR phenotype of &lt;em&gt;LMNA&lt;/em&gt; carriers with preserved left ventricular systolic function consists of longer T&lt;sub&gt;2&lt;/sub&gt;, higher serum troponin levels, higher extracellular volume, and impaired strain. CMR-derived focal fibrosis and strain biomarkers are prognostic, and future studies should explore their added clinical utility beyond the currently available MACE risk prediction tools. (The Deep Phenotyp","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages 644-660"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and Ethnic Differences in Long-Term Cardiovascular Mortality Among Women and Men From the CAC Consortium","authors":"Shmuel Rosenblatt BS ,&nbsp;Michael J. Blaha MD, MPH ,&nbsp;Ron Blankstein MD ,&nbsp;Khurram Nasir MD, MPH ,&nbsp;Fay Lin MD ,&nbsp;Yvette Yeboah-Kordieh MBChB, MPH ,&nbsp;Daniel S. Berman MD ,&nbsp;Michael D. Miedema MD, MPH ,&nbsp;Seamus P. Whelton MD, MPH ,&nbsp;John Rumberger MD ,&nbsp;Matthew J. Budoff MD ,&nbsp;Jonathon Leipsic MD ,&nbsp;Leslee J. Shaw PhD","doi":"10.1016/j.jcmg.2025.01.013","DOIUrl":"10.1016/j.jcmg.2025.01.013","url":null,"abstract":"<div><h3>Background</h3><div>Despite an increasingly diverse population, knowledge regarding racial and ethnic disparities is limited among women and men undergoing atherosclerotic cardiovascular (ASCVD) risk assessment.</div></div><div><h3>Objectives</h3><div>The aim of this study was to compare cardiovascular (CV) mortality by ASCVD risk and coronary artery calcium (CAC) scores among Black and Hispanic women and men compared with other participants.</div></div><div><h3>Methods</h3><div>From the CAC Consortium, 42,964 participants with self-reported race and ethnicity were followed for a median of 11.7 years. Multivariable Cox proportional hazards regression models were used to estimate CV mortality, with separate analyses by sex.</div></div><div><h3>Results</h3><div>One-third of enrollees were women; 977 self-reported as Black, 1,349 as Hispanic, 1,621 as Asian, and 740 as American Indian/Native Alaskan/Hawaiian or unspecified; the remainder were White. Black women and men had higher ASCVD risk and CAC scores yielding the highest CV mortality compared with other participants. Among Black women and men with a 0 CAC or ASCVD risk score &lt;5%, HRs were 6- to 9-fold higher than that of other women and men. In men with CAC scores ≥100, Black men (HR: 4.2; <em>P &lt;</em> 0.001) had the highest CV mortality compared to all other men. A similar high-risk pattern was noted for Black women with CAC scores ≥100 (<em>P &lt;</em> 0.001), even with adjustment for the ASCVD risk score. Overall, Hispanics had an intermediate CV mortality, less than that of Black participants. This was notable for Hispanic men with a CAC score of 0 (HR: 3.6; <em>P =</em> 0.006) and CAC ≥100 (HR: 2.3; <em>P =</em> 0.03).</div></div><div><h3>Conclusions</h3><div>The disproportionately high and excess CV mortality among Black women and men represents significant barriers to reducing the burden of ASCVD through effective risk assessment using ASCVD risk and CAC scores.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages 664-675"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Phenotype Identification","authors":"Karolina M. Zareba MD ,&nbsp;Ray E. Hershberger MD","doi":"10.1016/j.jcmg.2025.02.008","DOIUrl":"10.1016/j.jcmg.2025.02.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages 661-663"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selection for Publication in JACC: Cardiovascular Imaging","authors":"Thomas H. Marwick MBBS, PhD, MPH (Executive Editor, JACC: Cardiovascular Imaging),&nbsp;Leslee J. Shaw PhD (Deputy Editor, JACC: Cardiovascular Imaging),&nbsp;Y. Chandrashekhar MD, DM (Editor-in-Chief, JACC: Cardiovascular Imaging)","doi":"10.1016/j.jcmg.2025.05.001","DOIUrl":"10.1016/j.jcmg.2025.05.001","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 6","pages":"Pages 747-749"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}