JACC. Cardiovascular imaging最新文献

{"title":"Association of Pericoronary Adipose Attenuation With Major Adverse Cardiovascular Events and High-Risk Plaque.","authors":"Neville Tan,Thomas H Marwick,Damini Dey,William Chan,Nitesh Nerlekar","doi":"10.1016/j.jcmg.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.04.008","url":null,"abstract":"BACKGROUNDThe characterization of pericoronary adipose tissue (PCAT) attenuation may provide adjunctive prognostic information to coronary evaluation at coronary computed tomography angiography. However, heterogeneity in measurement methodologies has led to uncertainties regarding its clinical applicability.OBJECTIVESThis systematic review and meta-analysis explores the impact of measurement methodology on the association between PCAT and major adverse cardiac events (MACE) and high-risk plaque (HRP).METHODSStudies linking PCAT to MACE and HRP were searched in online databases. Quantitative meta-analysis was only performed where univariable HR estimates were reported, and random effects modelling with 95% CIs are reported. Qualitative synthesis was performed where multivariable estimates were reported.RESULTSThere were 17 studies (10,482 patients) included. Quantitative analysis was performed in 8,396 patients, all with stable coronary artery disease; elevated right coronary artery (RCA)-PCAT attenuation was associated with MACE (HR: 1.22 [95% CI: 1.08-1.38]; P = 0.001), with weak significance in left circumflex-PCAT (HR: 1.03 [95% CI: 1.01-1.05]; P = 0.014), and left anterior descending artery-PCAT did not meet significance (HR: 1.01 [95% CI: 0.98-1.05]; P = 0.47). No quantitative synthesis was possible for association with HRP. Qualitatively, studies have shown a positive and significant association with RCA-PCAT and HRP (HR range: 1.03-5.62). Although studies adjusted for different risk modifiers in multivariable models, a positive association was found despite different measurement methodology (mean PCAT, fat attenuation index) and minor differences in study-defined cutoffs for elevated RCA-PCAT attenuation.CONCLUSIONSAlthough the strength of associations varied by measurement technique, PCAT is associated with MACE and high-risk plaque.","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"55 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valve Area Planimetry on 4D-CT for Significant Aortic Stenosis","authors":"Aro Daniela Arockiam MD, Akiva Rosenzveig MD, Tiffany Dong MD, Elio Haroun MD, Ankit Agrawal MD, Joseph El Dahdah MD, Rishabh Khurana MD, Aritra Paul MD, Odette Iskandar MD, Bianca Honnekeri MD, Jaideep Singh Bhalla MD, Agam Bansal MD, Serge Harb MD, Zoran Popovic MD, Leonardo Rodriguez MD, Brian Griffin MD, Samir Kapadia MD, Tom Kai Ming Wang MBChB, MD","doi":"10.1016/j.jcmg.2025.02.007","DOIUrl":"10.1016/j.jcmg.2025.02.007","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 838-840"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is New and Novel in Nuclear Cardiology","authors":"Vasken Dilsizian MD (Deputy Editor, JACC: Cardiovascular Imaging), Y. Chandrashekhar MD (Editor-in-Chief, JACC: Cardiovascular Imaging)","doi":"10.1016/j.jcmg.2025.06.003","DOIUrl":"10.1016/j.jcmg.2025.06.003","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 848-851"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Promise to Practice","authors":"Márton Tokodi MD, PhD , Ádám Szijártó MSc","doi":"10.1016/j.jcmg.2025.05.003","DOIUrl":"10.1016/j.jcmg.2025.05.003","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 765-767"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turning the Tide in Bicuspid High-Gradient, AVA >1.0, Aortic Valve Stenosis","authors":"Kyriakos Dimitriadis MD, PhD, Panagiotis Iliakis MD, Konstantinos Aznaouridis MD, PhD, Konstantina Aggeli MD, PhD, Konstantinos Tsioufis MD, PhD","doi":"10.1016/j.jcmg.2025.05.008","DOIUrl":"10.1016/j.jcmg.2025.05.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 844-845"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Detection of Transthyretin Cardiac Amyloidosis Using 124I-Evuzamitide Positron Emission Tomography/Computed Tomography","authors":"Dia A. Smiley DO ,&nbsp;Andrew J. Einstein MD, PhD ,&nbsp;Kevin J. O’Gorman MD ,&nbsp;Denisse Santana MD ,&nbsp;Sergio Teruya MD, MSc ,&nbsp;Nicholas Chan MD ,&nbsp;Ani Nalbandian MD ,&nbsp;Timothy J. Poterucha MD ,&nbsp;Stephen T. Helmke MPH ,&nbsp;Akiva Mintz MD, PhD ,&nbsp;Kim Goldner CNMT, RT ,&nbsp;Miroslav Sekulic MD ,&nbsp;Alfonsina Mirabal MD ,&nbsp;Margaret O. Cuomo NP ,&nbsp;Samantha Guadalupe MHA ,&nbsp;Jeffeny De Los Santos MD, MHA ,&nbsp;Mary E. Paulino MD ,&nbsp;Kimberly A. Mateo MD ,&nbsp;Carlos M. Rodriguez MD ,&nbsp;Massiel Jimenez MD ,&nbsp;Mathew S. Maurer MD","doi":"10.1016/j.jcmg.2025.01.018","DOIUrl":"10.1016/j.jcmg.2025.01.018","url":null,"abstract":"<div><h3>Background</h3><div>Early detection of transthyretin cardiac amyloidosis (ATTR-CA) is vital, because currently available therapies are most effective early in the disease course. Although Perugini grade 2 or 3 uptake on scintigraphy using bone-avid tracers such as ^99mTc-pyrophosphate is highly specific for ATTR-CA, absent monoclonal proteins, sensitivity is about 70%. Positron emission tomographic (PET)/computed tomographic (CT) imaging using the novel radiolabeled heparan sulfate proteoglycan–binding peptide ¹²⁴I-evuzamitide has been shown to be useful for quantifying cardiac amyloid load in systemic amyloidosis.</div></div><div><h3>Objectives</h3><div>The aim of this study was to quantify myocardial ¹²⁴I-evuzamitide PET uptake and compare diagnostic performance with that of ^99mTc-pyrophosphate in patients with ATTR-CA and carriers.</div></div><div><h3>Methods</h3><div>Twenty-five subjects underwent imaging using ¹²⁴I-evuzamitide PET/CT imaging: 7 with wild-type ATTR-CA (all Columbia stage I) and 18 transthyretin amyloidosis (ATTR) variant-allele carriers with cardiomyopathy and/or neuropathy. Myocardial uptake was determined as left ventricular percentage of injected dose (mean activity concentration × volume/injected activity) and cardiac amyloid activity (mean specific uptake value × volume) within voxels with uptake above blood pool.</div></div><div><h3>Results</h3><div>Eleven subjects with ATTR and Perugini grade 0 or 1 ^99mTc-pyrophosphate cardiac scans had cardiac uptake of ¹²⁴I-evuzamitide, suggesting that ¹²⁴I-evuzamitide PET/CT imaging may detect ATTR amyloid deposits when ^99mTc-pyrophosphate cardiac scintigraphy does not. ¹²⁴I-evuzamitide showed myocardial uptake in all 5 subjects with variant ATTR with biopsy-proven disease and in 2 subjects with wild-type ATTR and negative (grade 0) results on ^99mTc-pyrophosphate scans but extracardiac biopsies showing ATTR. Myocardial amyloid load was moderately to strongly correlated with disease stage and with echocardiographic and quality-of-life measures.</div></div><div><h3>Conclusions</h3><div>¹²⁴I-evuzamitide PET/CT imaging can identify myocardial amyloid in variant transthyretin allele carriers and wild-type subjects when ^99mTc-pyrophosphate does not. (Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR; <span><span>NCT05635045</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 799-811"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unknowing the Unknown","authors":"Gary R. Small BSc, MB, ChB, PhD,&nbsp;Rob S.B. Beanlands MD","doi":"10.1016/j.jcmg.2025.06.001","DOIUrl":"10.1016/j.jcmg.2025.06.001","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 812-814"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S1936-878X(25)00302-X","DOIUrl":"10.1016/S1936-878X(25)00302-X","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages I-CV"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Established and Emerging Fluorine-18–Labeled Cardiac PET Radiotracers","authors":"René R. Sevag Packard MD, PhD ,&nbsp;Matthieu Pelletier-Galarneau MD ,&nbsp;Saurabh Malhotra MD ,&nbsp;Sharmila Dorbala MD, MPH ,&nbsp;Wengen Chen MD ,&nbsp;Vasken Dilsizian MD","doi":"10.1016/j.jcmg.2025.03.011","DOIUrl":"10.1016/j.jcmg.2025.03.011","url":null,"abstract":"<div><div>Positron emission tomography (PET)/computed tomography is a major imaging strategy for cardiovascular disease characterization. Whereas multiple radioisotopes can be used for PET imaging of cardiac disease processes, fluorine-18 (¹⁸F) presents key advantages. These include availability as a unit dose given a favorable half-life of 109.7 minutes and a short positron range leading to a high spatial resolution. In this context, there is growing interest in the development of novel ¹⁸F-labeled probes applied to cardiac PET imaging, which in turn provide clinicians with new methods to evaluate disease pathways of interest. Beyond ¹⁸F-fluorodeoxyglucose, used in routine clinical practice to scrutinize myocardial viability, cardiac sarcoidosis, as well as prosthetic valve and cardiac device infection, new ¹⁸F-labeled radiopharmaceuticals have undergone clinical evaluation. These include ¹⁸F-flurpiridaz, which was recently approved by the U.S. Food and Drug Administration for myocardial perfusion imaging and that is also amenable to accurate myocardial blood flow quantitation, ¹⁸F-sodium fluoride to detect metabolically active epicardial coronary atherosclerotic lesions, and the ¹⁸F-labeled amyloid radiotracers florbetapir, flutemetamol, and florbetaben. This review will further explore emerging ¹⁸F-labeled probes applied to cardiac sarcoidosis, myocardial innervation, and ongoing fibrosis/fibroblast activation.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 815-833"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good FFRCT Test-Retest Reproducibility","authors":"Nadia Iraqi MD,&nbsp;Martin Bødtker Mortensen MD, PhD,&nbsp;Niels Peter Rønnow Sand MD, PhD,&nbsp;Martin Busk MD, PhD,&nbsp;Kristian Tækker Madsen MD, PhD,&nbsp;Erik Lerkevang Grove MD, PhD,&nbsp;Kamilla Bech Pedersen RT,&nbsp;Helle Kanstrup MD, PhD,&nbsp;Timothy A. Fairbairn MD, PhD,&nbsp;Erik Parner MSc, PhD,&nbsp;Jesper Møller Jensen MD, PhD,&nbsp;Bjarne Linde Nørgaard MD, PhD","doi":"10.1016/j.jcmg.2025.02.009","DOIUrl":"10.1016/j.jcmg.2025.02.009","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 834-837"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}