JACC. Cardiovascular imaging最新文献

{"title":"Prognostic Time Frame of Plaque and Hemodynamic Characteristics and Integrative Risk Prediction for Acute Coronary Syndrome.","authors":"Seokhun Yang,Jae Wook Jung,Sang-Hyeon Park,Jinlong Zhang,Keehwan Lee,Doyeon Hwang,Kyu-Sun Lee,Sang-Hoon Na,Joon-Hyung Doh,Chang-Wook Nam,Tae Hyun Kim,Eun-Seok Shin,Eun Ju Chun,Su-Yeon Choi,Hyun Kuk Kim,Young Joon Hong,Hun-Jun Park,Song-Yi Kim,Mirza Husic,Jess Lambrechtsen,Jesper M Jensen,Bjarne L Nørgaard,Daniele Andreini,Pal Maurovich-Horvat,Bela Merkely,Martin Penicka,Bernard de Bruyne,Abdul Ihdayhid,Brian Ko,Georgios Tzimas,Jonathon Leipsic,Javier Sanz,Mark G Rabbat,Farhan Katchi,Moneal Shah,Nobuhiro Tanaka,Ryo Nakazato,Taku Asano,Mitsuyasu Terashima,Hiroaki Takashima,Tetsuya Amano,Yoshihiro Sobue,Hitoshi Matsuo,Hiromasa Otake,Takashi Kubo,Masahiro Takahata,Takashi Akasaka,Teruhito Kido,Teruhito Mochizuki,Hiroyoshi Yokoi,Taichi Okonogi,Tomohiro Kawasaki,Koichi Nakao,Tomohiro Sakamoto,Taishi Yonetsu,Tsunekazu Kakuta,Yohei Yamauchi,Charles A Taylor,Jeroen J Bax,Leslee J Shaw,Peter H Stone,Jagat Narula,Bon-Kwon Koo","doi":"10.1016/j.jcmg.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.02.003","url":null,"abstract":"BACKGROUNDThe relevant time frame for predicting future acute coronary syndrome (ACS) based on coronary lesion characteristics remains uncertain.OBJECTIVESThe aim of this study was to investigate the association of lesion characteristics with test-to-event time and their prognostic impact on ACS.METHODSThe EMERALD II (Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II) study analyzed 351 patients who underwent coronary computed tomography angiography (CTA) and experienced ACS between 1 month and 3 years of follow-up. Lesions identified on coronary CTA were classified as culprit (n = 363) or nonculprit (n = 2,088) on the basis of invasive coronary angiography findings at the time of ACS. Core laboratory coronary CTA analyses assessed 4 domains: degree of stenosis, plaque burden, number of adverse plaque characteristics (APC) (low-attenuation plaque, positive remodeling, spotty calcification, and napkin-ring sign), and changes in coronary CTA-derived fractional flow reserve across the lesion (ΔFFRCT). Patients were categorized into short (<1 year), mid (1-2 years), and long (2-3 years) test-to-event time groups.RESULTSPatient characteristics, including cardiovascular risk factors, did not differ across short, mid, and long test-to-event groups (P > 0.05 for all), and the proportion of ACS culprit lesions was similar (P = 0.552). Among culprit lesions, shorter test-to-event time was associated with higher luminal stenosis, plaque burden, and ΔFFRCT (P for trend < 0.001 for all). The predictability for ACS culprit lesions based on the combined 4 characteristics tended to decrease over time and significantly reduced beyond 2 years (AUC: 0.851 vs 0.741; P = 0.006). In predicting ACS risk within test-to-event time <2 years using obstructive lesions (stenosis ≥ 50%), APC ≥2, plaque burden ≥70%, and ΔFFRCT ≥0.10, the risk was elevated compared to the average proportion of lesions becoming ACS culprit (12.1%) in the following subsets: lesions with 4 characteristics (proportion of lesions becoming ACS culprit: 49.3%; P < 0.001), lesions with 3 characteristics (obstructive lesions with plaque burden ≥70% and either ΔFFRCT ≥0.10 [proportion of lesions becoming ACS culprit: 33.0%; P < 0.001] or APC ≥2 [proportion of lesions becoming ACS culprit: 31.2%; P < 0.001]), and lesions with 2 characteristics (plaque burden ≥70% and ΔFFRCT ≥0.10; proportion of lesions becoming ACS culprit: 21.5%; P = 0.016).CONCLUSIONSIncreased luminal stenosis, plaque burden, and ΔFFRCT were associated with shorter test-to-ACS event time. The prognostic impact of lumen, plaque, and local hemodynamic characteristics was most relevant to ACS risk within a 2-year period, with higher risk observed when specific combinations of them were present. (Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II [EMERALD II] Study; NCT03591","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"26 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of PM2.5 With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study.","authors":"Andrew Y Chang,Joel D Kaufman,Annabel Xulin Tan,Sanjiv J Shah,Ravi B Patel,Helene Margolis,Bruce M Psaty,Julius M Gardin,Sadeer Al-Kindi,Thomas R Austin,Michelle C Odden","doi":"10.1016/j.jcmg.2025.01.016","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.01.016","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"65 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and Ethnic Differences Among Patients Referred for Noninvasive Coronary Artery Disease Evaluation.","authors":"Catherine X Wright, Erica S Spatz, Edward J Miller, Attila Feher","doi":"10.1016/j.jcmg.2025.01.017","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.01.017","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Artery Calcium Scoring Improves Allocation of the GLP-1 Receptor Agonist Semaglutide","authors":"Robert A. Kloner MD, PhD , Matthew J. Budoff MD","doi":"10.1016/j.jcmg.2024.10.007","DOIUrl":"10.1016/j.jcmg.2024.10.007","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 4","pages":"Pages 462-464"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Imaging Trends","authors":"Ahmed Sayed MD, Mahmoud Al Rifai MD, MPH, Maria Alwan MD, Ahmad El Yaman MD, Asim Shaikh MD, William Zoghbi MD, Mouaz H. Al-Mallah MD, MSc","doi":"10.1016/j.jcmg.2024.12.011","DOIUrl":"10.1016/j.jcmg.2024.12.011","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 4","pages":"Pages 511-513"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes in Patients Undergoing TAVR Planning with Contrast-Enhanced CT vs Noncontrast CT and CMR","authors":"Besir Besir MD, Judah Rajendran MD, Shivabalan Kathavarayan Ramu MD, Maryam Muhammad Ali Majeed-Saidan MD, Aditya Mantha MD, Rishi Puri MD, PhD, Grant W. Reed MD, James Yun MD, Amar Krishnaswamy MD, Serge C. Harb MD, Samir R. Kapadia MD","doi":"10.1016/j.jcmg.2025.01.009","DOIUrl":"10.1016/j.jcmg.2025.01.009","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 4","pages":"Pages 514-516"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Standardized Threshold of Global Longitudinal Strain in Asymptomatic Aortic Regurgitation","authors":"Simon Leboube MD, PhD, Denise Auberson MD, Georgios Tzimas MD, Pierre Monney MD, Panagiotis Antiochos MD","doi":"10.1016/j.jcmg.2025.01.008","DOIUrl":"10.1016/j.jcmg.2025.01.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 4","pages":"Page 517"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thresholds for Intervention in Valve Disease","authors":"Thomas H. Marwick MBBS, PhD, MPH (Executive Editor, JACC: Cardiovascular Imaging), Y. Chandrashekhar MD, DM (Editor-in-Chief, JACC: Cardiovascular Imaging)","doi":"10.1016/j.jcmg.2025.03.001","DOIUrl":"10.1016/j.jcmg.2025.03.001","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 4","pages":"Pages 519-521"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting Hemorrhagic Myocardial Infarction With 3.0-T CMR","authors":"Yinyin Chen MD, PhD ,&nbsp;Hang Jin MD, PhD ,&nbsp;Xingming Guan PhD ,&nbsp;Hsin-Jung Yang PhD ,&nbsp;Xinheng Zhang MS ,&nbsp;Zhenhui Chen PhD ,&nbsp;Shing Fai Chan PhD ,&nbsp;Dhirendra Singh PhD ,&nbsp;Nithya Jambunathan PhD ,&nbsp;Khalid Youssef PhD ,&nbsp;Keyur P. Vora MD, MS ,&nbsp;Gabriel Gruionu PhD ,&nbsp;Sanjana K. Dharmakumar ,&nbsp;Glen Schmeisser MS ,&nbsp;Richard Tang MD ,&nbsp;Mengsu Zeng MD ,&nbsp;Rohan Dharmakumar PhD","doi":"10.1016/j.jcmg.2024.10.006","DOIUrl":"10.1016/j.jcmg.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Hemorrhagic myocardial infarction (hMI) can rapidly diminish the benefits of reperfusion therapy and direct the heart toward chronic heart failure. T2∗ cardiac magnetic resonance (CMR) is the reference standard for detecting hMI. However, the lack of clarity around the earliest time point for detection, time-dependent changes in hemorrhage volume, and the optimal methods for detection can limit the development of strategies to manage hMI.</div></div><div><h3>Objectives</h3><div>The authors investigated CMR signal characteristics of hMI through time-lapse multiparametric mapping using a clinically relevant animal model and evaluated the translatability in ST-segment elevation MI patients when possible.</div></div><div><h3>Methods</h3><div>Canines (N = 20) underwent 3.0-T CMR at baseline and various time points over the first week of reperfused MI. Time-dependent relationships between T1, T2, and T2∗ mapping of hMI, non-hMI, and remote territories were determined. Reperfused ST-segment elevation MI patients (N = 50) were studied to establish clinically feasibility.</div></div><div><h3>Results</h3><div>Although hMI was evident &lt;1 hour after reperfusion on histopathology, it was not reliably detected with T1, T2, or T2∗ CMR. However, 24 hours to 7 days postreperfusion, hMI was detectable on T2∗ (27.0 ± 2.4 ms [baseline] vs 11.7 ± 2.8 ms [hMI]; <em>P &lt;</em> 0.001), with stable volume and transmurality. In T2 maps, hMI was most visible 5 to 7 days postreperfusion with an area under the curve of 0.98 (sensitivity and specificity ≥0.95) relative to T2∗. However, this was not the case with T1 (sensitivity &lt;0.8, across all time points).</div></div><div><h3>Conclusions</h3><div>HMI cannot be reliably detected with T1, T2, or T2∗ on 3.0-T CMR immediately after reperfusion. However, T2∗ CMR can be used to diagnose hMI between 24 hours and 7 days postreperfusion. T2 maps at 3.0-T are a strong alternative to T2∗ maps for diagnosing hMI, provided CMR is performed 5 to 7 days postreperfusion. However, diagnosing hMI with T1 is significantly more challenging at 3.0-T compared with both T2∗ and T2.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 4","pages":"Pages 436-447"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism and Impact of Left Atrial Dyssynchrony on Long-Term Clinical Outcome During Cardiac Resynchronization Therapy","authors":"Lars-Egil R. Hammersboen MD ,&nbsp;Marie Stugaard MD, PhD ,&nbsp;Alexis Puvrez MD ,&nbsp;Camilla K. Larsen MD, PhD ,&nbsp;Espen W. Remme MSc, PhD ,&nbsp;Erik Kongsgård MD, PhD ,&nbsp;Jürgen Duchenne MSc, PhD ,&nbsp;Elena Galli MD, PhD ,&nbsp;Faraz H. Khan MD ,&nbsp;Ole Jakob Sletten MD ,&nbsp;Martin Penicka MD, PhD ,&nbsp;Erwan Donal MD, PhD ,&nbsp;Jens-Uwe Voigt MD, PhD ,&nbsp;Otto A. Smiseth MD, PhD ,&nbsp;John M. Aalen MD, PhD","doi":"10.1016/j.jcmg.2024.09.008","DOIUrl":"10.1016/j.jcmg.2024.09.008","url":null,"abstract":"<div><h3>Background</h3><div>Left bundle branch block (LBBB) causes left atrial (LA) dyssynchrony. It is unknown if LA dyssynchrony impacts long-term prognosis.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to determine mechanisms of LA dyssynchrony in LBBB and if LA dyssynchrony impacts long-term prognosis.</div></div><div><h3>Methods</h3><div>In a prospective multicenter study of 168 heart failure patients with LBBB, echocardiographic strain imaging was done before and after 6 months with cardiac resynchronization therapy (CRT). Outcome was assessed after 6 years. Dyssynchrony was measured relative to septum as delay in left ventricular (LV) lateral wall shortening and LA lateral wall stretch. Response to CRT was defined as at least 15% reduction in LV end-systolic volume.</div></div><div><h3>Results</h3><div>Before CRT, there was marked LA dyssynchrony of 105 ± 76 ms, which decreased to 37 ± 68 ms in CRT-responders (<em>P</em> &lt; 0.001), whereas nonresponders showed only a modest reduction in LA dyssynchrony (<em>P</em> &lt; 0.05). There was strong association between LA and LV dyssynchrony (<em>r</em> = 0.70), consistent with direct LV-LA mechanical interaction. CRT caused modest increase in LA reservoir strain (<em>P</em> &lt; 0.01) and marked increase of LV filling time (<em>P</em> &lt; 0.001) in responders. Mortality after 6 years was 21% (35 deaths). LA dyssynchrony did not independently predict mortality. However, the combination of preserved LA reservoir strain (≥18%) and resolved LA dyssynchrony (≤53 ms) after 6 months with CRT was associated with excellent long term-prognosis: HR: 0.11 (95% CI: 0.03-0.42) vs preserved reservoir strain and persistent LA dyssynchrony.</div></div><div><h3>Conclusions</h3><div>LA dyssynchrony in LBBB was attributed to direct LV-LA mechanical interactions. CRT improved diastolic function by increasing LV filling time. Patients with preserved LA reservoir strain and resolution of LA dyssynchrony by CRT had excellent long-term prognosis. (Contractile Reserve in Dyssynchrony: A Novel Principle to Identify Candidates for Cardiac Resynchronization Therapy [CRID-CRT]; <span><span>NCT02525185</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 4","pages":"Pages 421-432"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}