JACC. Cardiovascular imaging最新文献

{"title":"Early Detection of Transthyretin Cardiac Amyloidosis Using ¹²⁴I-Evuzamitide Positron Emission Tomography/Computed Tomography.","authors":"Dia A Smiley, Andrew J Einstein, Kevin J O'Gorman, Denisse Santana, Sergio Teruya, Nicholas Chan, Ani Nalbandian, Timothy J Poterucha, Stephen T Helmke, Akiva Mintz, Kim Goldner, Miroslav Sekulic, Alfonsina Mirabal, Margaret O Cuomo, Samantha Guadalupe, Jeffeny De Los Santos, Mary E Paulino, Kimberly A Mateo, Carlos M Rodriguez, Massiel Jimenez, Abdirahman Wardhere, Dimitrios Bampatsias, Michelle Castillo, Boyu Peng, Mathew S Maurer","doi":"10.1016/j.jcmg.2025.01.018","DOIUrl":"10.1016/j.jcmg.2025.01.018","url":null,"abstract":"<p><strong>Background: </strong>Early detection of transthyretin cardiac amyloidosis (ATTR-CA) is vital, because currently available therapies are most effective early in the disease course. Although Perugini grade 2 or 3 uptake on scintigraphy using bone-avid tracers such as ^99mTc-pyrophosphate is highly specific for ATTR-CA, absent monoclonal proteins, sensitivity is about 70%. Positron emission tomographic (PET)/computed tomographic (CT) imaging using the novel radiolabeled heparan sulfate proteoglycan-binding peptide ¹²⁴I-evuzamitide has been shown to be useful for quantifying cardiac amyloid load in systemic amyloidosis.</p><p><strong>Objectives: </strong>The aim of this study was to quantify myocardial ¹²⁴I-evuzamitide PET uptake and compare diagnostic performance with that of ^99mTc-pyrophosphate in patients with ATTR-CA and carriers.</p><p><strong>Methods: </strong>Twenty-five subjects underwent imaging using ¹²⁴I-evuzamitide PET/CT imaging: 7 with wild-type ATTR-CA (all Columbia stage I) and 18 transthyretin amyloidosis (ATTR) variant-allele carriers with cardiomyopathy and/or neuropathy. Myocardial uptake was determined as left ventricular percentage of injected dose (mean activity concentration × volume/injected activity) and cardiac amyloid activity (mean specific uptake value × volume) within voxels with uptake above blood pool.</p><p><strong>Results: </strong>Eleven subjects with ATTR and Perugini grade 0 or 1 ^99mTc-pyrophosphate cardiac scans had cardiac uptake of ¹²⁴I-evuzamitide, suggesting that ¹²⁴I-evuzamitide PET/CT imaging may detect ATTR amyloid deposits when ^99mTc-pyrophosphate cardiac scintigraphy does not. ¹²⁴I-evuzamitide showed myocardial uptake in all 5 subjects with variant ATTR with biopsy-proven disease and in 2 subjects with wild-type ATTR and negative (grade 0) results on ^99mTc-pyrophosphate scans but extracardiac biopsies showing ATTR. Myocardial amyloid load was moderately to strongly correlated with disease stage and with echocardiographic and quality-of-life measures.</p><p><strong>Conclusions: </strong>¹²⁴I-evuzamitide PET/CT imaging can identify myocardial amyloid in variant transthyretin allele carriers and wild-type subjects when ^99mTc-pyrophosphate does not. (Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR; NCT05635045).</p>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Established and Emerging Fluorine-18-Labeled Cardiac PET Radiotracers.","authors":"René R Sevag Packard, Matthieu Pelletier-Galarneau, Saurabh Malhotra, Sharmila Dorbala, Wengen Chen, Vasken Dilsizian","doi":"10.1016/j.jcmg.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.03.011","url":null,"abstract":"<p><p>Positron emission tomography (PET)/computed tomography is a major imaging strategy for cardiovascular disease characterization. Whereas multiple radioisotopes can be used for PET imaging of cardiac disease processes, fluorine-18 (¹⁸F) presents key advantages. These include availability as a unit dose given a favorable half-life of 109.7 minutes and a short positron range leading to a high spatial resolution. In this context, there is growing interest in the development of novel ¹⁸F-labeled probes applied to cardiac PET imaging, which in turn provide clinicians with new methods to evaluate disease pathways of interest. Beyond ¹⁸F-fluorodeoxyglucose, used in routine clinical practice to scrutinize myocardial viability, cardiac sarcoidosis, as well as prosthetic valve and cardiac device infection, new ¹⁸F-labeled radiopharmaceuticals have undergone clinical evaluation. These include ¹⁸F-flurpiridaz, which was recently approved by the U.S. Food and Drug Administration for myocardial perfusion imaging and that is also amenable to accurate myocardial blood flow quantitation, ¹⁸F-sodium fluoride to detect metabolically active epicardial coronary atherosclerotic lesions, and the ¹⁸F-labeled amyloid radiotracers florbetapir, flutemetamol, and florbetaben. This review will further explore emerging ¹⁸F-labeled probes applied to cardiac sarcoidosis, myocardial innervation, and ongoing fibrosis/fibroblast activation.</p>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Left Atrial Function After Device Closure of Patent Foramen Ovale in Cryptogenic Stroke Patients.","authors":"Teresa Gil-Jiménez, Rocío García-Orta, Inmaculada Villegas-Rodríguez, Juan Caballero-Borrego, Eduardo Moreno-Escobar","doi":"10.1016/j.jcmg.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.04.003","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Aortic Stenosis With High Noncalcific Aortic Valve Volume: A Novel Marker of Myocardial Fibrosis.","authors":"Davide Margonato,Hideki Koike,Miho Fukui,Takahiro Nishihara,Felipe Kazmirczak,Victor Cheng,John Lesser,Marc R Dweck,Maurice Enriquez-Sarano,João L Cavalcante","doi":"10.1016/j.jcmg.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.03.012","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"15 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good FFR_CT Test-Retest Reproducibility: The Importance of High Coronary CT Angiography Image Quality.","authors":"Nadia Iraqi, Martin Bødtker Mortensen, Niels Peter Rønnow Sand, Martin Busk, Kristian Tækker Madsen, Erik Lerkevang Grove, Kamilla Bech Pedersen, Helle Kanstrup, Timothy A Fairbairn, Erik Parner, Jesper Møller Jensen, Bjarne Linde Nørgaard","doi":"10.1016/j.jcmg.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.02.009","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Transesophageal Echocardiography: First-in-Human Experience.","authors":"Jury Schewel, Rebecca T Hahn, Martin B Leon, Dimitry Schewel","doi":"10.1016/j.jcmg.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.04.001","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Underrepresentation of Women Among Cardiac Imagers: An Analysis of Cardiologists Based on Medicare Part B Data, 2013-2022.","authors":"Maria Alwan,Ahmed Sayed,Nadeen N Faza,Chiara Bucciarelli-Ducci,Panithaya Chareonthaitawee,Ahmad El Yaman,Asim Shaikh,Mahmoud Al Rifai,Mouaz H Al-Mallah","doi":"10.1016/j.jcmg.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.03.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"129 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Searching for Insights Into the Timing of Intervention in Aortic Regurgitation Using Machine Learning","authors":"Rhodri H. Davies PhD,&nbsp;Thomas A. Treibel PhD","doi":"10.1016/j.jcmg.2025.02.004","DOIUrl":"10.1016/j.jcmg.2025.02.004","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 5","pages":"Pages 569-571"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis","authors":"Rafail A. Kotronias MBChB, MSc,&nbsp;Giovanni L. de Maria MD, PhD,&nbsp;Cheng Xie MBChB,&nbsp;Sheena Thomas BSc,&nbsp;Kenneth Chan MBBS,&nbsp;Leonardo Portolan MD,&nbsp;Jeremy P. Langrish MBBChir, PhD,&nbsp;Jason Walsh MBChB,&nbsp;Thomas J. Cahill MBBS, DPhil,&nbsp;Andrew J. Lucking MBChB, PhD,&nbsp;Jonathan Denton DCR,&nbsp;Robyn Farrall BSc,&nbsp;Caroline Taylor BSc,&nbsp;Nikant Sabharwal MBChB,&nbsp;David A. Holdsworth BMBCh, DPhil,&nbsp;Thomas Halborg MSc,&nbsp;Stefan Neubauer MD,&nbsp;Adrian P. Banning MBChB, MD,&nbsp;Keith M. Channon MBChB, MD,&nbsp;Charalambos Antoniades MD, PhD,&nbsp;Timothy A. Fairbairn","doi":"10.1016/j.jcmg.2024.11.005","DOIUrl":"10.1016/j.jcmg.2024.11.005","url":null,"abstract":"<div><h3>Background</h3><div>Clinical guidelines do not recommend coronary computed tomographic angiography (CTA) in elderly patients or in the presence of heavy coronary calcification. Photon-counting coronary computed tomographic angiography (PCCTA) introduces ultrahigh in-plane resolution and multienergy imaging, but the ability of this technology to overcome these limitations is unclear.</div></div><div><h3>Objectives</h3><div>The authors evaluate the ability of PCCTA to quantitatively assess coronary luminal stenosis in the presence and absence of calcification, comparing both the ultrahigh-resolution (UHR)-PCCTA and the multienergy standard-resolution (SR)-PCCTA with the criterion-standard 3-dimensional invasive quantitative coronary angiography (3D QCA).</div></div><div><h3>Methods</h3><div>The authors included 100 patients who had both PCCTA and invasive coronary angiography (ICA). They comparatively evaluated luminal diameter stenosis with PCCTA and 3D QCA, anatomic disease severity (according to CAD-RADS [Coronary Artery Disease–Reporting and Data System]) and the diagnostic performance of PCCTA in identifying coronary arteries with ≥50% diameter stenosis on 3D QCA requiring invasive hemodynamic severity evaluation and/or revascularization.</div></div><div><h3>Results</h3><div>The authors analyzed 257 vessels and 343 plaques. UHR-PCCTA luminal evaluation relative to 3D QCA was more precise than SR-PCCTA (median difference: 3% [Q1-Q3: 1%-6%] vs 6% [Q1-Q3: 2%-11%]; <em>P &lt;</em> 0.001), particularly in severely calcified arteries (median difference 3% [Q1-Q3: 1%-6%] vs 6% [Q1-Q3: 3%-13%]; <em>P =</em> 0.002). Per-vessel agreement for CAD-RADS between UHR-PCCTA and 3D QCA was near-perfect (κ = 0.90 [Q1-Q3: 0.84-0.95]; <em>P &lt;</em> 0.001), and it was substantial for SR-PCCTA (κ = 0.63 [Q1-Q3: 0.54-0.71]; <em>P &lt;</em> 0.001), especially in severely calcified arteries: κ = 0.90 (Q1-Q3: 0.83-0.97; <em>P &lt;</em> 0.001) and κ = 0.67 (Q1-Q3: 0.56-0.77; <em>P &lt;</em> 0.001), respectively. Per-vessel diagnostic performance of SR- and UHR-PCCTA was excellent: AUC: 0.94 (95% CI: 0.91-0.98; <em>P &lt;</em> 0.001) and 0.99 (95% CI: 0.98-1.00; <em>P &lt;</em> 0.001), respectively. UHR-PCCTA diagnostically outperformed SR-PCCTA: ΔAUC: 0.05 (95% CI: 0.01-0.08; <em>P =</em> 0.01).</div></div><div><h3>Conclusions</h3><div>PCCTA compares favorably with ICA for lumen assessment and anatomic disease severity classification in patients presenting with acute coronary syndrome or patients referred for ICA. UHR-PCCTA luminal evaluation is superior to SR-PCCTA, especially in patients with heavy coronary calcification. UHR-PCCTA has excellent diagnostic performance in identifying coronary arteries with ≥50% luminal stenosis on 3D QCA, outperforming standard-resolution imaging.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 5","pages":"Pages 572-585"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Relevance and Lower Limit of the Reference Range of Left Ventricular Global Longitudinal Strain","authors":"Daniel A. Morris MD ,&nbsp;Chung-Lieh Hung MD ,&nbsp;Tor Biering-Sørensen MD ,&nbsp;Tatiana Kuznetsova MD ,&nbsp;Erwan Donal MD ,&nbsp;Wojciech Kosmala MD ,&nbsp;Masaaki Takeuchi MD ,&nbsp;Roberto Lang MD ,&nbsp;Marijana Tadic MD ,&nbsp;Chun-Yan Ma MD ,&nbsp;Evgeny Belyavskiy MD ,&nbsp;Henryk Dreger MD ,&nbsp;Matthias Schneider-Reigbert MD ,&nbsp;Athanasios Frydas MD","doi":"10.1016/j.jcmg.2024.11.004","DOIUrl":"10.1016/j.jcmg.2024.11.004","url":null,"abstract":"<div><h3>Background</h3><div>The lower limit of the reference normal range (LLN) of left ventricular global longitudinal strain (GLS) for each ultrasound software vendor and its prognostic relevance in the elderly and in asymptomatic patients at risk for heart failure (HF) remain uncertain.</div></div><div><h3>Objectives</h3><div>In this study, the authors sought to validate the LLN of GLS for each ultrasound software vendor and its prognostic relevance in the elderly and in asymptomatic patients at risk for HF.</div></div><div><h3>Methods</h3><div>To identify the LLN of GLS with the use of 2-dimensional speckle-tracking transthoracic echocardiography, a meta-analysis of studies including healthy subjects was conducted, followed by a validation study in a large cohort of healthy subjects. To validate the prognostic relevance of the LLN of GLS, 2 validation cohort studies were carried out, including elderly subjects aged ≥80 years and asymptomatic ambulatory patients with preserved left ventricular ejection fraction at risk for HF.</div></div><div><h3>Results</h3><div>The meta-analysis, which included 47 studies with a total of 23,208 healthy adult subjects, identified the LLN for GLS at 16% (absolute value) across various ultrasound software vendors, including EchoPac, TomTec, and QLab. In the validation cohort study, which included 2,217 healthy adult subjects, a GLS cutoff of 16% was also identified as the LLN. Concerning the prognostic relevance of the LLN of GLS, a value of GLS &lt;16% was significantly associated with HF hospitalization in asymptomatic ambulatory patients at risk for HF (n = 667; OR within 6 years: 5.1 [95% CI: 1.5-17.0]) and in elderly subjects (n = 159; OR within 2 years: 3.1 [95% CI: 1.1-8.8]).</div></div><div><h3>Conclusions</h3><div>This clinical validation study provides important clinical data concerning the LLN of GLS (identified and validated at 16%) and its prognostic relevance in the elderly and in asymptomatic ambulatory patients at risk for HF.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 5","pages":"Pages 525-536"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}