{"title":"Thresholds for Intervention in Primary Mitral Regurgitation and Sex-Based Outcome Disparities","authors":"Makoto Mori MD, PhD, Danial Ahmad MD, MPH","doi":"10.1016/j.jcmg.2026.06.008","DOIUrl":"10.1016/j.jcmg.2026.06.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 10","pages":"Pages 1219-1221"},"PeriodicalIF":19.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Giulia Pavon MD, Luca Bergamaschi MD, PhD, Marco Guglielmo MD, Francesco Angeli MD, Matteo Armillotta MD, Damiano Fedele MD, Lucio Barile PhD, Antonino Cassotta PhD, Paolo di Taranto MD, Pietro Costantini MD, Giovanni Pedrazzini MD, Pim van der Harst MD, Juerg Schwitter MD, PhD, Marco Valgimigli MD, PhD, Carmine Pizzi MD, Robin Nijveldt MD
{"title":"Multiparametric Cardiac Magnetic Resonance Characterization of the Noninfarcted Myocardium","authors":"Anna Giulia Pavon MD, Luca Bergamaschi MD, PhD, Marco Guglielmo MD, Francesco Angeli MD, Matteo Armillotta MD, Damiano Fedele MD, Lucio Barile PhD, Antonino Cassotta PhD, Paolo di Taranto MD, Pietro Costantini MD, Giovanni Pedrazzini MD, Pim van der Harst MD, Juerg Schwitter MD, PhD, Marco Valgimigli MD, PhD, Carmine Pizzi MD, Robin Nijveldt MD","doi":"10.1016/j.jcmg.2026.03.015","DOIUrl":"10.1016/j.jcmg.2026.03.015","url":null,"abstract":"<div><div>Acute myocardial infarction (AMI) remains a major cause of cardiovascular illness and death. Advanced imaging techniques, particularly cardiac magnetic resonance (CMR), have become essential in assessing tissue alterations within the infarcted zone. The CMR published reports focus primarily on evaluating infarct size and the peri-infarct region in the context of AMI. Recent evidence highlights that the noninfarcted myocardium (NIM) surrounding the infarct sustains functional, structural, and inflammatory changes due to ischemic injury. CMR can detect significant changes in the NIM, such as inflammation, interstitial expansion, and altered myocardial deformation. These findings indicate that the NIM is not merely passive but is actively involved in the progression of heart disease after AMI. Targeting the NIM with novel therapeutic strategies, such as anti-inflammatory and antifibrotic treatments, shows promise for improving patient outcomes. This review aims to define the role and imaging criteria for exploring the NIM after AMI and to highlight its emerging significance as a tool for risk stratification and a potential therapeutic target.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 10","pages":"Pages 1256-1270"},"PeriodicalIF":19.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenqing Xu MD, Fen Sa PhD, Yanyan Song MD, Shujuan Yang PhD, Zhixiang Dong MD, Xingrui Chen PhD, Yun Tang PhD, Kaisaierjiang Aisikaier PhD, Xuan Ma MD, Xi Jia MD, Pengyu Zhou MD, Bo Li MD, Yujie Liu PhD, Kankan Zhao PhD, Kai Yang MD, Xiuyu Chen PhD, Lei Xu MD, Yun Peng MD, Sanjay K. Prasad MD, Hui Liu MD, Shihua Zhao MD, PhD
{"title":"Cardiac MRI-Derived Right Ventricular Strain for Risk Stratification in Pediatric and Adolescent Arrhythmogenic Cardiomyopathy","authors":"Wenqing Xu MD, Fen Sa PhD, Yanyan Song MD, Shujuan Yang PhD, Zhixiang Dong MD, Xingrui Chen PhD, Yun Tang PhD, Kaisaierjiang Aisikaier PhD, Xuan Ma MD, Xi Jia MD, Pengyu Zhou MD, Bo Li MD, Yujie Liu PhD, Kankan Zhao PhD, Kai Yang MD, Xiuyu Chen PhD, Lei Xu MD, Yun Peng MD, Sanjay K. Prasad MD, Hui Liu MD, Shihua Zhao MD, PhD","doi":"10.1016/j.jcmg.2026.05.018","DOIUrl":"10.1016/j.jcmg.2026.05.018","url":null,"abstract":"<div><h3>Background</h3><div>Pediatric and adolescent arrhythmogenic cardiomyopathy (ACM) is a clinically severe phenotype that remains underrepresented in cardiac magnetic resonance (CMR) research. The prognostic value of CMR-derived right ventricular deformation analysis in this population is unclear.</div></div><div><h3>Objectives</h3><div>This study sought to describe the burden of severe cardiac outcomes in pediatric and adolescent ACM, and to assess the prognostic and incremental value of CMR-derived right ventricular global longitudinal strain (RVGLS) for risk stratification when incorporated into conventional clinical and CMR markers.</div></div><div><h3>Methods</h3><div>This multicenter study included consecutive pediatric and adolescent patients (≤21 years of age) with ACM who underwent baseline CMR evaluation. We assessed clinical, electrocardiographic, and CMR parameters according to the 2010 Task Force Criteria, along with biventricular strain parameters. Severe cardiac outcomes were defined as a composite of malignant ventricular arrhythmias (MVAs), heart transplantation, and heart failure–related death.</div></div><div><h3>Results</h3><div>The cohort included 102 patients (16.3 ± 3.4 years; 72% male) and 95 controls (mean age: 15.6 ± 3.3 years; 70% male). During a median of 58-month follow-up, 51 (50%) patients experienced severe cardiac outcomes and 28 (27.5%) MVA outcomes. Reduced RVGLS was independently associated with severe cardiac outcomes (HR: 1.14; <em>P</em> = 0.004) and MVA outcomes (subdistribution HR: 1.15; <em>P</em> < 0.001) after adjustment for clinical and conventional CMR parameters. Incorporation of RVGLS significantly improved prediction of severe cardiac outcomes beyond both right ventricular–based and left ventricular–based multivariable models, with significant improvement in discrimination and reclassification. Kaplan-Meier analysis further showed that RVGLS ≥−12.2% identified patients at higher risk of severe cardiac outcomes and MVA outcomes (both log-rank <em>P</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>Pediatric and adolescent ACM manifests a malignant phenotype with high burden of heart failure and arrhythmia. RVGLS provides independent and incremental prognostic value beyond conventional CMR markers and could improve risk stratification in this high-risk population.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 10","pages":"Pages 1222-1235"},"PeriodicalIF":19.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148476281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can Artificial Intelligence Read the Echocardiogram Like or Better Than an Expert?","authors":"Jae K. Oh MD, Chieh-Ju Chao MD","doi":"10.1016/j.jcmg.2026.08.002","DOIUrl":"10.1016/j.jcmg.2026.08.002","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 10","pages":"Pages 1201-1203"},"PeriodicalIF":19.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond the Adult Paradigm","authors":"Robert M. Hamilton MD, Shaylyn Joseph MSc","doi":"10.1016/j.jcmg.2026.07.019","DOIUrl":"10.1016/j.jcmg.2026.07.019","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 10","pages":"Pages 1236-1238"},"PeriodicalIF":19.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camila V. Blair MD, Sarah K. Gustus MS, ATC, Kevin S. Boyd BS, Daniel M. Huck MD, MPH, Kenneth Chan MBBS, Charalambos Antoniades MD, PhD, Ron Blankstein MD, Meagan M. Wasfy MD, MPH
{"title":"Dynamic Changes in Coronary Artery Inflammation Detected by Coronary Computed Tomography Angiography in Marathoners","authors":"Camila V. Blair MD, Sarah K. Gustus MS, ATC, Kevin S. Boyd BS, Daniel M. Huck MD, MPH, Kenneth Chan MBBS, Charalambos Antoniades MD, PhD, Ron Blankstein MD, Meagan M. Wasfy MD, MPH","doi":"10.1016/j.jcmg.2026.06.004","DOIUrl":"10.1016/j.jcmg.2026.06.004","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 10","pages":"Pages 1289-1291"},"PeriodicalIF":19.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148416612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jedrzej Sarnecki MD, Ramun Schmid MSc, Patrick Badertscher MD, Ivo Strebel PhD, Martin Segeroth MD, Maurice Pradella MD, Felix Mahfoud MD, Michael J. Zellweger MD, Christian Mueller MD, Philip Haaf MD
{"title":"Expert Human Readers vs ECG Criteria for Detecting Left Ventricular Hypertrophy","authors":"Jedrzej Sarnecki MD, Ramun Schmid MSc, Patrick Badertscher MD, Ivo Strebel PhD, Martin Segeroth MD, Maurice Pradella MD, Felix Mahfoud MD, Michael J. Zellweger MD, Christian Mueller MD, Philip Haaf MD","doi":"10.1016/j.jcmg.2026.05.008","DOIUrl":"10.1016/j.jcmg.2026.05.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 10","pages":"Pages 1283-1285"},"PeriodicalIF":19.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148335988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}