{"title":"It’s More Than Just a Thick Ventricle","authors":"Mazen Hanna MD , Emmanuel Akintoye MD, MPH","doi":"10.1016/j.jcmg.2025.06.006","DOIUrl":"10.1016/j.jcmg.2025.06.006","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 8","pages":"Pages 882-883"},"PeriodicalIF":15.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Alwan MD, Ahmed Sayed MD, Nadeen N. Faza MD, Chiara Bucciarelli-Ducci MD, PhD, Panithaya Chareonthaitawee MD, Ahmad El Yaman MD, Asim Shaikh MD, Mahmoud Al Rifai MD, MPH, Mouaz H. Al-Mallah MD, MSc
{"title":"The Underrepresentation of Women Among Cardiac Imagers","authors":"Maria Alwan MD, Ahmed Sayed MD, Nadeen N. Faza MD, Chiara Bucciarelli-Ducci MD, PhD, Panithaya Chareonthaitawee MD, Ahmad El Yaman MD, Asim Shaikh MD, Mahmoud Al Rifai MD, MPH, Mouaz H. Al-Mallah MD, MSc","doi":"10.1016/j.jcmg.2025.03.008","DOIUrl":"10.1016/j.jcmg.2025.03.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 8","pages":"Pages 931-933"},"PeriodicalIF":15.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linda T. Aaserud MD , Christine Rootwelt-Norberg MD, PhD , Paul A.S. Olsen MD , Christian K. Five MD , Anna I. Castrini MD , Eivind W. Aabel MD, PhD , Kristina H. Haugaa MD, PhD , Øyvind H. Lie MD, PhD
{"title":"Disease Progression in Exercise-Induced Arrhythmogenic Cardiomyopathy Compared With Arrhythmogenic Right Ventricular Cardiomyopathy","authors":"Linda T. Aaserud MD , Christine Rootwelt-Norberg MD, PhD , Paul A.S. Olsen MD , Christian K. Five MD , Anna I. Castrini MD , Eivind W. Aabel MD, PhD , Kristina H. Haugaa MD, PhD , Øyvind H. Lie MD, PhD","doi":"10.1016/j.jcmg.2025.03.018","DOIUrl":"10.1016/j.jcmg.2025.03.018","url":null,"abstract":"<div><h3>Background</h3><div>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inheritable heart disease, whereas exercise-induced arrhythmogenic cardiomyopathy (EiAC) is a proposed acquired similar phenotype in athletes. The differences in disease progression between these entities are not well understood.</div></div><div><h3>Objectives</h3><div>This study aims to assess structural, functional, and arrhythmic disease progression in EiAC compared with ARVC.</div></div><div><h3>Methods</h3><div>This longitudinal cohort study included EiAC patients who were competitive endurance athletes (>24 MET-hours/week for >6 consecutive years) referred due to ventricular arrhythmias (VA), without inherited or genetic factors or other evident causes, and genotype-positive ARVC patients with a definite diagnosis and their genotype-positive family members for comparison. Disease progression was assessed by repeated echocardiographic examinations and incident VA during long-term follow-up.</div></div><div><h3>Results</h3><div>The authors included 125 ARVC patients (61 women, aged 38 ± 17 years) and 41 EiAC patients (6 women, aged 45 ± 13 years) and followed them for 96 months (Q1-Q3: 73-132 months) and 82 months (Q1-Q3: 50-118 months), respectively. The authors analyzed 730 echocardiographic examinations (538 ARVC, 192 EiAC). Right ventricular (RV) structure and function remained stable in EiAC patients, whereas those in ARVC patients deteriorated during follow-up. The 5-year and 10-year cumulative incidences of VA were similar between EiAC and ARVC patients.</div></div><div><h3>Conclusions</h3><div>RV structure and function deteriorated in ARVC patients but remained stable in EiAC patients during follow-up. The incidence of VA was high in both populations. These results indicate that EiAC patients should be followed closely over time regardless of structural and functional progression.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 8","pages":"Pages 853-863"},"PeriodicalIF":15.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benay Ozbay MD , Corey Rearick MD , Bharadwaj S. Satyavolu MD , Prem Soman MD, PhD , Timothy C. Wong MD , Matthew Starr MD , Bharat Pillai MD , Jianhui Zhu PhD , Abdullah Z. Azhar MD , William E. Katz MD , Leyla Elif Sade MD
{"title":"Primary Left Atrial Cardiopathy in Transthyretin Amyloidosis Cardiomyopathy by Multimodality Imaging","authors":"Benay Ozbay MD , Corey Rearick MD , Bharadwaj S. Satyavolu MD , Prem Soman MD, PhD , Timothy C. Wong MD , Matthew Starr MD , Bharat Pillai MD , Jianhui Zhu PhD , Abdullah Z. Azhar MD , William E. Katz MD , Leyla Elif Sade MD","doi":"10.1016/j.jcmg.2025.04.007","DOIUrl":"10.1016/j.jcmg.2025.04.007","url":null,"abstract":"<div><h3>Background</h3><div>Thrombotic event (TE) risk is high in transthyretin amyloid cardiomyopathy (ATTR-CM).</div></div><div><h3>Objectives</h3><div>The authors sought to explore left atrial (LA) remodeling in ATTR-CM and its association with TE risk in comparison to other phenotypes of left ventricular hypertrophy (LVH).</div></div><div><h3>Methods</h3><div>Subjects who underwent speckle tracking echocardiography, Tc-99m pyrophosphate scintigraphy, serum and urine immune electrophoresis, per registry protocol, were retrospectively identified (n = 405). Cardiac magnetic resonance and endomyocardial biopsy were used per clinical indication. Subjects with cardiac amyloidosis other than ATTR-CM were excluded, those with nonamyloid LVH served as controls. Propensity score matching was performed for age, sex, coronary artery disease, and diabetes. Longitudinal follow-up was performed over 5 years for TEs.</div></div><div><h3>Results</h3><div>In all ATTR-CM (n =149) and LVH (n =165) in a propensity matched cohort (104:104), ATTR-CM subjects had decreased left atrial reservoir strain (LASr), smaller left atrial volume index, more intense late gadolinium hyperenhancement, and increased LA stiffness as compared to LVH. In ATTR-CM, LASr correlated poorly with E/e′, was severely depressed regardless of the diastolic dysfunction grade (in those with sinus rhythm), and did not correlate with left atrial volume index, in contrast to the LVH group. LASr and LA stiffness were associated with ATTR-CM independently of diastolic dysfunction and atrial fibrillation (AF) (OR: 1.2 and OR: 1.9, respectively; <em>P <</em> 0.001 and <em>P =</em> 0.002). Furthermore, LASr and LA stiffness were independently associated with TEs (n = 20) during follow-up, regardless of CHA<sub>2</sub>DS<sub>2</sub>-VASc or prevalent AF at baseline, in ATTR-CM.</div></div><div><h3>Conclusions</h3><div>Primary LA cardiopathy seems to be associated with TEs in ATTR-CM, independently of AF, CHA<sub>2</sub>DS<sub>2</sub>-VASc, and LA dilatation, unlike other LVH phenotypes.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 8","pages":"Pages 867-881"},"PeriodicalIF":15.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Davide Margonato MD, Hideki Koike MD, Miho Fukui MD, PhD, Takahiro Nishihara MD, Felipe Kazmirczak MD, Victor Cheng MD, John Lesser MD, Marc R. Dweck MD, PhD, Maurice Enriquez-Sarano MD, João L. Cavalcante MD
{"title":"Severe Aortic Stenosis With High Noncalcific Aortic Valve Volume","authors":"Davide Margonato MD, Hideki Koike MD, Miho Fukui MD, PhD, Takahiro Nishihara MD, Felipe Kazmirczak MD, Victor Cheng MD, John Lesser MD, Marc R. Dweck MD, PhD, Maurice Enriquez-Sarano MD, João L. Cavalcante MD","doi":"10.1016/j.jcmg.2025.03.012","DOIUrl":"10.1016/j.jcmg.2025.03.012","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 8","pages":"Pages 928-930"},"PeriodicalIF":15.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}