JACC. Cardiovascular imaging最新文献

{"title":"How Big a Role for Invasive Hemodynamics in the Diagnosis of Heart Failure With Preserved Ejection Fraction?","authors":"Otto A Smiseth, James D Thomas, Thomas H Marwick, Frank A Flachskampf","doi":"10.1016/j.jcmg.2026.07.022","DOIUrl":"https://doi.org/10.1016/j.jcmg.2026.07.022","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) Is Continuously Associated With Progression of Aortic Valve Calcification Independent of Inflammatory, Mineral Metabolism, and Other Lipid Biomarkers.","authors":"Rafael Zubirán, Anna Wolska, Alan T Remaley","doi":"10.1016/j.jcmg.2026.07.023","DOIUrl":"https://doi.org/10.1016/j.jcmg.2026.07.023","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Exciting Future of Cardiovascular Imaging.","authors":"Christoph Gräni, Chiara Bucciarelli-Ducci, Marc R Dweck, William A Zoghbi","doi":"10.1016/j.jcmg.2026.07.015","DOIUrl":"https://doi.org/10.1016/j.jcmg.2026.07.015","url":null,"abstract":"<p><p>The field of cardiovascular imaging is entering an exciting era of accelerated innovation, fueled by advances in hardware, reconstruction algorithms, and artificial intelligence. Each imaging modality-echocardiography, computed tomography, cardiac magnetic resonance, and nuclear imaging-continues to evolve, with distinct strengths and constraints that complement one another. Collectively, these advances drive improved diagnostic accuracy, refine risk stratification, optimize therapy planning, and enable effective monitoring of treatment response. Artificial intelligence integration will increasingly support the entire imaging workflow, from acquisition planning and reconstruction to segmentation and quality control, facilitating faster, more reproducible, and quantitative imaging, and integrating imaging with multimodal clinical information to enable individualized management. Further, digital twins and physics-based simulation, powered by imaging-derived anatomy and tissue properties, provide mechanistic insight and a platform for scenario testing. This state-of-the-art review outlines key advances across all major modalities and explores how emerging technologies are driving the future of cardiovascular imaging toward data-driven predictive, personalized, and outcome-focused care.</p>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Blood Flow in Women From the CENTURY Trial: Potential Mechanisms for Sex Differences in Coronary Disease.","authors":"K Lance Gould, Nils P Johnson, Amanda E Roby, Richard L Kirkeeide, Linh P Bui, Monica B Patel, Danai Kitkungvan, Mary P Haynie, Susan M Hood, Patricia M Mendoza, Amy M Rickman, Tracy H Pipitone, Katelyn P Garner, Kelly Sander, Lindsey Harmon, Li-Wei Chen, Tung Nguyen, Dejian Lai, Ruosha Li, Stefano Sdringola, Navneet Narula, Jagat Narula, David D McPherson","doi":"10.1016/j.jcmg.2026.07.017","DOIUrl":"https://doi.org/10.1016/j.jcmg.2026.07.017","url":null,"abstract":"<p><strong>Background: </strong>Despite comparable cardiovascular risk factors, clinically manifest coronary artery disease (CAD) in women is delayed by up to 2 decades compared with men without a defined physiological basis.</p><p><strong>Objectives: </strong>This study aims to assess the mechanistic basis of sex differences in CAD using quantitative coronary blood flow (CBF) and coronary flow capacity measured by positron emission tomography in a post hoc analysis of the randomized CENTURY trial.</p><p><strong>Methods: </strong>CENTURY trial data were reanalyzed in 331 women vs 697 men for risk factors, age, quantitative CBF, coronary flow capacity, and clinical outcomes through 14 years of follow-up.</p><p><strong>Results: </strong>Women and men had similar age, body mass index, hypertension, diabetes, and cumulative summed risk scores. Still, women had less established CAD, lower coronary artery calcium, and fewer positron emission tomography perfusion defects. Women had approximately half the rates of all-cause death (log-rank P = 0.0223), death or myocardial infarction (log-rank P = 0.0138), revascularization (log-rank P = 0.0004), and major adverse cardiac events (log-rank P < 0.0001) compared with men by Kaplan-Meier plots. Rest and stress CBF were 33% higher in women than in men across all comparable strata of age, body mass index, risk factors, and treatment. When integrated with the published reports showing ∼10% smaller coronary arteries in women, these flow data suggest a potential global endothelial shear stress ∼82% higher in women than in men, suggesting a potential hypothetical chronic, diffuse, antiatherogenic differential mechanism.</p><p><strong>Conclusions: </strong>In the randomized CENTURY trial, women had higher CBF than men across all comparable strata. Combined with the smaller coronary arteries reported in the published reports, this higher CBF suggests a potential, hypothesized higher antiatherogenic ESS that may be a primary, sex-specific physiological mechanism underlying the delayed onset and modifying the course of CAD throughout women's lives. (Comprehensive LifEstyle ModificatioN, Optimal Pharmacological Treatment and Utilizing PET Imaging for Quantifying and Managing Stable CoronaRy ArterY Disease [CENTURY]; NCT00756379).</p>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommended Criteria to Define Right Ventricular Dysfunction in Severe Secondary Tricuspid Regurgitation: Association With Outcome.","authors":"Xavier Galloo, Marlieke F Dietz, Edgard A Prihadi, Federico Fortuni, Pieter van der Bijl, Erwan Donal, Rebecca T Hahn, Jeroen J Bax, Nina Ajmone Marsan","doi":"10.1016/j.jcmg.2026.07.018","DOIUrl":"https://doi.org/10.1016/j.jcmg.2026.07.018","url":null,"abstract":"<p><strong>Background: </strong>The TVARC (Tricuspid Valve Academic Research Consortium) and the ASE (American Society of Echocardiography) have proposed echocardiography cutoffs to define right ventricular (RV) dysfunction in secondary tricuspid regurgitation (STR), although these thresholds have not yet been validated.</p><p><strong>Objectives: </strong>This study aims to evaluate the prognostic value of the proposed thresholds for the main RV function parameters in a large real-world STR cohort.</p><p><strong>Methods: </strong>Consecutive patients with ≥ moderate-to-severe STR were included. RV function was assessed by tricuspid annular plane systolic excursion (TAPSE), fractional area change, right ventricular global longitudinal strain, and right ventricular free wall longitudinal strain (RVFWLS). The study outcome was the composite of all-cause mortality and heart failure hospitalization, censored for tricuspid valve intervention.</p><p><strong>Results: </strong>A total of 1,550 patients (mean age: 69 ± 13 years, 50% men) were included. During a median follow-up of 22 months (Q1-Q3: 3-63 months), 703 patients (45%) reached the composite endpoint. All proposed cutoffs were associated with outcomes in univariable Cox analyses, but after multivariable adjustment, mainly strain parameters remained significant. A multiparametric approach combining echocardiographic measures was evaluated, and a stepwise combined grading using TAPSE and RVFWLS showed the strongest association with the composite endpoint; the different grades of RV dysfunction (mild, moderate, and severe, respectively) also remained independently associated (overall value of P < 0.001 and P < 0.005 for TVARC and ASE cutoffs, respectively) with the endpoint.</p><p><strong>Conclusions: </strong>The TVARC and ASE cutoffs for RV dysfunction showed prognostic value in patients with significant STR. Combining TAPSE and RVFWLS may provide a pragmatic, exploratory framework for risk stratification of these patients.</p>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress CMR in Left Main and Multivessel Disease: Raising the Bar for Risk Stratification.","authors":"Christopher M Kramer, Jonathan A Pan","doi":"10.1016/j.jcmg.2026.08.001","DOIUrl":"10.1016/j.jcmg.2026.08.001","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":" ","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mitral Asterisk","authors":"Jonathan Sen MBBS, PhD","doi":"10.1016/j.jcmg.2026.05.006","DOIUrl":"10.1016/j.jcmg.2026.05.006","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 9","pages":"Pages 1074-1076"},"PeriodicalIF":19.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148393638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of Atherosclerotic Disease Risk and Adverse Metabolic Features Among Lower-Risk Adults","authors":"Leslee J. Shaw PhD (Deputy Editor, JACC: Cardiovascular Imaging),&nbsp;Y. Chandrashekhar MD, DM (Editor-in-Chief, JACC: Cardiovascular Imaging)","doi":"10.1016/j.jcmg.2026.07.005","DOIUrl":"10.1016/j.jcmg.2026.07.005","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 9","pages":"Pages 1167-1169"},"PeriodicalIF":19.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full issue PDF","authors":"","doi":"10.1016/S1936-878X(26)00405-5","DOIUrl":"10.1016/S1936-878X(26)00405-5","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 9","pages":"Pages I-CXLVII"},"PeriodicalIF":19.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148924466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Lipoprotein(a) With Coronary Atherosclerosis and Cardiovascular Events","authors":"Elias Björnson PhD,&nbsp;Göran Bergström MD, PhD,&nbsp;Jonas Brinck MD, PhD,&nbsp;David Erlinge MD, PhD,&nbsp;Carl Johan Östgren MD, PhD,&nbsp;Stefan Söderberg MD, PhD,&nbsp;Tomas Jernberg MD, PhD,&nbsp;Jan Borén MD, PhD,&nbsp;Emil Hagström MD, PhD","doi":"10.1016/j.jcmg.2026.05.020","DOIUrl":"10.1016/j.jcmg.2026.05.020","url":null,"abstract":"<div><h3>Background</h3><div>High lipoprotein(a) (Lp[a]) associates with elevated coronary heart disease event risk, but it remains uncertain whether this excess risk can be explained by increased coronary plaque burden.</div></div><div><h3>Objectives</h3><div>This study aims to determine whether Lp(a)-related excess cardiovascular risk in the general population is primarily explained by increased coronary atherosclerosis or by additional plaque vulnerability–related effects.</div></div><div><h3>Methods</h3><div>This study included 28,529 middle-aged individuals from the SCAPIS (Swedish CArdioPulmonary bioImage Study), a population-based cohort. Coronary atherosclerosis was assessed using coronary computed tomography angiography in 25,916 participants. Incident coronary events, defined as fatal or nonfatal myocardial infarction, were ascertained over a median follow-up of 7.8 years.</div></div><div><h3>Results</h3><div>High Lp(a) was present in 14% of participants and associated with severe/extensive coronary atherosclerosis (Segment Involvement Score &gt;4; OR: 1.38; 95% CI: 1.21-1.57) and coronary events (HR: 1.54; 95% CI: 1.18-2.0). Stratified, adjusted, and mediation analyses consistently suggested that the association between Lp(a) and coronary event risk is largely explained by greater atherosclerotic burden (<em>P</em> for mediation &lt;0.0001). Individuals with high Lp(a) developed atherosclerosis 2 to 3 years earlier and the population-attributable fraction of Lp(a) was 5% to 10% for severe atherosclerosis and around 7% for coronary events.</div></div><div><h3>Conclusion</h3><div>The findings suggest that Lp(a) increases coronary event risk primarily by driving a higher burden of atherosclerosis and that high Lp(a) accounts for 5% to 10% of total coronary disease burden in the population. These results support broad Lp(a) measurements and the use of coronary imaging for risk stratification in individuals with high Lp(a).</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 9","pages":"Pages 1110-1119"},"PeriodicalIF":19.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148476280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}