JACC. Cardiovascular imaging最新文献

{"title":"Intertwining Intravascular Imaging and Transcriptomics to Identify Responsiveness to PCSK9 Inhibitor Therapy","authors":"Farouc A. Jaffer MD, PhD","doi":"10.1016/j.jcmg.2026.02.002","DOIUrl":"10.1016/j.jcmg.2026.02.002","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 535-537"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147620783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Inflammatory Risk","authors":"Charalambos Antoniades MD, PhD, Kenneth Chan MBBS","doi":"10.1016/j.jcmg.2025.11.003","DOIUrl":"10.1016/j.jcmg.2025.11.003","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 490-493"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Scar in Hypertrophic Cardiomyopathy With Systolic Dysfunction","authors":"Raffaello Ditaranto MD, PhD, Hunain Shiwani MD, Maria Alessandra Schiavo MD, Rhodri H. Davies MD, PhD, James Malcolmson MD, Iain Pierce PhD, Chiara Baldovini MD, PhD, Reem Laymouna MD, Konstantinos Moschonas MD, Massimiliano Lorenzini MD, PhD, Luciano Potena MD, PhD, Igor Diemberger MD, PhD, Luigi Lovato MD, Luis R. Lopes MD, PhD, Elena Biagini MD, PhD, Saidi A. Mohiddin MD, James C. Moon MD, PhD","doi":"10.1016/j.jcmg.2025.09.018","DOIUrl":"10.1016/j.jcmg.2025.09.018","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 551-554"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Twin Model Predicts Prognosis in Pulmonary Arterial Hypertension","authors":"Shuang Leng PhD , Jiajun Guo MD , Samer Alabed MD, PhD, Ru-San Tan MBBS, Ping Chai MBBS, MMed, Lynette Teo MBChB, MMed, Xiaodan Zhao PhD, Alistair Young PhD, James M. Wild PhD, John C. Allen PhD, Dexiang Zong M.Eng, Ju Le Tan MBBS, James Wei-Luen Yip MD, Andrew J. Swift PhD, Yucheng Chen MD, PhD, David G. Kiely MD, Liang Zhong PhD","doi":"10.1016/j.jcmg.2025.11.006","DOIUrl":"10.1016/j.jcmg.2025.11.006","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 565-567"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Just When We Thought Viability Was in Jeopardy","authors":"Robert S. Zhang MD, Jonathan W. Weinsaft MD","doi":"10.1016/j.jcmg.2025.12.006","DOIUrl":"10.1016/j.jcmg.2025.12.006","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 475-477"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Future of CT-FFR","authors":"Marly van Assen PhD , Jin Young Kim MD","doi":"10.1016/j.jcmg.2026.01.009","DOIUrl":"10.1016/j.jcmg.2026.01.009","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 513-515"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Imaging Considerations for Masters-Aged Athletes","authors":"Dermot M. Phelan MD, PhD ,&nbsp;Guido Claessen MD, PhD ,&nbsp;Thijs M.H. Eijsvogels PhD ,&nbsp;Timothy W. Churchill MD ,&nbsp;Elizabeth H. Dineen DO ,&nbsp;Sabiha Gati BSc (Hons), MBBS, PhD ,&nbsp;J. Sawalla Guseh II MD ,&nbsp;Jeffrey J. Hsu MD, PhD ,&nbsp;Ankit B. Shah MD, MPH ,&nbsp;Brett W. Sperry MD ,&nbsp;Meagan M. Wasfy MD, MPH ,&nbsp;Andre La Gerche MBBS, PhD ,&nbsp;Matthew W. Martinez MD ,&nbsp;Michael Papadakis MBBS, MD ,&nbsp;Aaron L. Baggish MD ,&nbsp;Jonathan H. Kim MD, MSc ,&nbsp;American College of Cardiology Sports and Exercise Cardiology Council","doi":"10.1016/j.jcmg.2025.10.024","DOIUrl":"10.1016/j.jcmg.2025.10.024","url":null,"abstract":"<div><div>Masters athletes (MAs), defined as individuals ≥35 years of age who are engaged in competitive or high-volume recreational sports or exercise training, comprise a growing group regularly cared for in sports cardiology. The cardiovascular care of MAs can be challenging because many of the classical tenets in sports cardiology and exercise physiology were derived from young, competitive athletes and therefore do not fully generalize to the care of MAs. Appropriate implementation of multimodality cardiovascular imaging is essential to guide the risk stratification and clinical management of MAs. In this state-of-the-art review, physiological and pathologic considerations unique to MAs are highlighted. The strengths and limitations of specific cardiovascular imaging modalities are reviewed along with guidance on their appropriate use in the care of MAs. The purpose of this document is to represent the first primary reference on best practice considerations for the use of multimodality cardiovascular imaging in the care of MAs.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 538-550"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Prognostic Value of LGE in LV Dilatation With Preserved LVEF and Dilated Cardiomyopathy","authors":"Trecy Gonçalves MD,&nbsp;Théo Pezel MD, PhD,&nbsp;Suzanne Duhamel MD,&nbsp;Francesca Sanguineti MD,&nbsp;Philippe Garot MD,&nbsp;Alexandre Unger MD,&nbsp;Jean Guillaume Dillinger MD, PhD,&nbsp;Valérie Bousson MD, PhD,&nbsp;Solenn Toupin PhD,&nbsp;Jérôme Garot MD, PhD","doi":"10.1016/j.jcmg.2025.10.008","DOIUrl":"10.1016/j.jcmg.2025.10.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 558-560"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Proximity","authors":"Jennifer H. Mieres MD,&nbsp;Amgad N. Makaryus MD","doi":"10.1016/j.jcmg.2025.12.002","DOIUrl":"10.1016/j.jcmg.2025.12.002","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 460-462"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracoronary Imaging and Transcriptomic Characteristics Before and After Maximum Lipid-Lowering Therapy","authors":"Annapoorna S. Kini MD ,&nbsp;Yuliya Vengrenyuk PhD ,&nbsp;JiaJia Liu PhD ,&nbsp;Keisuke Yasumura MD ,&nbsp;Pruthvi C. Revaiah MD, PhD ,&nbsp;Aishwaria Mandava PhD ,&nbsp;Hardik Shah BS ,&nbsp;Joseph M. Sweeny MD ,&nbsp;Sahil Khera MD ,&nbsp;Vishal Kapur MD ,&nbsp;Parasuram Melarcode-Krishnamoorthy MD ,&nbsp;Amit Hooda MD ,&nbsp;Shingo Minatoguchi MD ,&nbsp;Nimisha Baruah MD ,&nbsp;Derek A. Pineda NP ,&nbsp;Vivian Chen MS ,&nbsp;Ethan Ellis BS ,&nbsp;Aana Hahn MS ,&nbsp;Prakash Krishnan MD ,&nbsp;Usman Baber MD ,&nbsp;Samin K. Sharma MD","doi":"10.1016/j.jcmg.2025.12.013","DOIUrl":"10.1016/j.jcmg.2025.12.013","url":null,"abstract":"<div><h3>Background</h3><div>Despite extensive evidence of the beneficial effects of proprotein convertase subtilisin/kexin type 9 inhibition on clinical outcomes, the mechanisms for favorable outcomes remain poorly understood.</div></div><div><h3>Objectives</h3><div>The authors evaluated alterations in plaque morphology using intracoronary imaging and gene expression in peripheral blood mononuclear cells after adding evolocumab to maximum statin therapy.</div></div><div><h3>Methods</h3><div>A total of 110 stable coronary artery disease patients receiving maximally tolerated statin therapy were treated with evolocumab 140 mg every 2 weeks for 26 weeks. Serial optical coherence tomography, intravascular ultrasound, and near-infrared spectroscopy of nonobstructive lesions were performed in all patients at baseline and 26-week follow-up; peripheral blood mononuclear cells were isolated for bulk RNA transcriptomic sequencing. Machine learning models were used to predict baseline transcriptomic signatures of beneficial imaging response of plaque stabilization.</div></div><div><h3>Results</h3><div>After evolocumab treatment, optical coherence tomography–verified fibrous cap thickness (FCT) increased from 70.9 ± 21.7 to 97.7 ± 31.1 μm (mean 26.8 ± 22.3 μm; <em>P &lt;</em> 0.001), and maximal lipid core burden index within 4 mm (LCBI) decreased from 306.8 ± 177.6 to 213.1 ± 168.0 (mean −93.7 ± 140.5; <em>P &lt;</em> 0.001). In addition, there was a significant reduction in the percentage atheroma volume (−1.38% ± 1.48%; <em>P &lt;</em> 0.001) defined by intravascular ultrasound. In total, 922 up-regulated and 571 down-regulated differentially expressed genes were identified at follow-up. Among 110 patients, 88 (80%) demonstrated FCT increase &gt;0 (FCT responders), and 86 (78%) demonstrated LCBI reduction &gt;0 (LCBI responders). Whereas multiple canonical pathways modulating immune cell adhesion, recruitment and communication were down-regulated, those associated with mitochondrial function, cell survival, and protein synthesis were significantly up-regulated in response to evolocumab. Elastic net models with 38 genes for FCT increase (AUC = 0.97) and 71 genes for LCBI reduction (AUC = 0.86) were able to predict patient response using baseline genes with high accuracy. The transcriptomic signature of beneficial response included pathways modulating inflammation, matrix metalloproteinases, neutrophil degranulation, and oxygen exchange.</div></div><div><h3>Conclusions</h3><div>In stable coronary artery disease, intravascular imaging–verified beneficial changes in plaque morphology after evolocumab treatment were associated with restored mitochondrial function, suppressed inflammation, and alleviated oxidative stress. Similar studies of plaque morphology with noninvasive modalities would allow the confirmation of novel pathways of plaque stabilization in response to maximized lipid-lowering therapy in larger number of subjects.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 4","pages":"Pages 516-534"},"PeriodicalIF":15.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}