JACC. Cardiovascular imaging最新文献

{"title":"Valve Area Planimetry on 4D-CT for Significant Aortic Stenosis","authors":"Aro Daniela Arockiam MD, Akiva Rosenzveig MD, Tiffany Dong MD, Elio Haroun MD, Ankit Agrawal MD, Joseph El Dahdah MD, Rishabh Khurana MD, Aritra Paul MD, Odette Iskandar MD, Bianca Honnekeri MD, Jaideep Singh Bhalla MD, Agam Bansal MD, Serge Harb MD, Zoran Popovic MD, Leonardo Rodriguez MD, Brian Griffin MD, Samir Kapadia MD, Tom Kai Ming Wang MBChB, MD","doi":"10.1016/j.jcmg.2025.02.007","DOIUrl":"10.1016/j.jcmg.2025.02.007","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 838-840"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Promise to Practice","authors":"Márton Tokodi MD, PhD , Ádám Szijártó MSc","doi":"10.1016/j.jcmg.2025.05.003","DOIUrl":"10.1016/j.jcmg.2025.05.003","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 765-767"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turning the Tide in Bicuspid High-Gradient, AVA >1.0, Aortic Valve Stenosis","authors":"Kyriakos Dimitriadis MD, PhD, Panagiotis Iliakis MD, Konstantinos Aznaouridis MD, PhD, Konstantina Aggeli MD, PhD, Konstantinos Tsioufis MD, PhD","doi":"10.1016/j.jcmg.2025.05.008","DOIUrl":"10.1016/j.jcmg.2025.05.008","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 844-845"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Detection of Transthyretin Cardiac Amyloidosis Using 124I-Evuzamitide Positron Emission Tomography/Computed Tomography","authors":"Dia A. Smiley DO ,&nbsp;Andrew J. Einstein MD, PhD ,&nbsp;Kevin J. O’Gorman MD ,&nbsp;Denisse Santana MD ,&nbsp;Sergio Teruya MD, MSc ,&nbsp;Nicholas Chan MD ,&nbsp;Ani Nalbandian MD ,&nbsp;Timothy J. Poterucha MD ,&nbsp;Stephen T. Helmke MPH ,&nbsp;Akiva Mintz MD, PhD ,&nbsp;Kim Goldner CNMT, RT ,&nbsp;Miroslav Sekulic MD ,&nbsp;Alfonsina Mirabal MD ,&nbsp;Margaret O. Cuomo NP ,&nbsp;Samantha Guadalupe MHA ,&nbsp;Jeffeny De Los Santos MD, MHA ,&nbsp;Mary E. Paulino MD ,&nbsp;Kimberly A. Mateo MD ,&nbsp;Carlos M. Rodriguez MD ,&nbsp;Massiel Jimenez MD ,&nbsp;Mathew S. Maurer MD","doi":"10.1016/j.jcmg.2025.01.018","DOIUrl":"10.1016/j.jcmg.2025.01.018","url":null,"abstract":"<div><h3>Background</h3><div>Early detection of transthyretin cardiac amyloidosis (ATTR-CA) is vital, because currently available therapies are most effective early in the disease course. Although Perugini grade 2 or 3 uptake on scintigraphy using bone-avid tracers such as ^99mTc-pyrophosphate is highly specific for ATTR-CA, absent monoclonal proteins, sensitivity is about 70%. Positron emission tomographic (PET)/computed tomographic (CT) imaging using the novel radiolabeled heparan sulfate proteoglycan–binding peptide ¹²⁴I-evuzamitide has been shown to be useful for quantifying cardiac amyloid load in systemic amyloidosis.</div></div><div><h3>Objectives</h3><div>The aim of this study was to quantify myocardial ¹²⁴I-evuzamitide PET uptake and compare diagnostic performance with that of ^99mTc-pyrophosphate in patients with ATTR-CA and carriers.</div></div><div><h3>Methods</h3><div>Twenty-five subjects underwent imaging using ¹²⁴I-evuzamitide PET/CT imaging: 7 with wild-type ATTR-CA (all Columbia stage I) and 18 transthyretin amyloidosis (ATTR) variant-allele carriers with cardiomyopathy and/or neuropathy. Myocardial uptake was determined as left ventricular percentage of injected dose (mean activity concentration × volume/injected activity) and cardiac amyloid activity (mean specific uptake value × volume) within voxels with uptake above blood pool.</div></div><div><h3>Results</h3><div>Eleven subjects with ATTR and Perugini grade 0 or 1 ^99mTc-pyrophosphate cardiac scans had cardiac uptake of ¹²⁴I-evuzamitide, suggesting that ¹²⁴I-evuzamitide PET/CT imaging may detect ATTR amyloid deposits when ^99mTc-pyrophosphate cardiac scintigraphy does not. ¹²⁴I-evuzamitide showed myocardial uptake in all 5 subjects with variant ATTR with biopsy-proven disease and in 2 subjects with wild-type ATTR and negative (grade 0) results on ^99mTc-pyrophosphate scans but extracardiac biopsies showing ATTR. Myocardial amyloid load was moderately to strongly correlated with disease stage and with echocardiographic and quality-of-life measures.</div></div><div><h3>Conclusions</h3><div>¹²⁴I-evuzamitide PET/CT imaging can identify myocardial amyloid in variant transthyretin allele carriers and wild-type subjects when ^99mTc-pyrophosphate does not. (Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR; <span><span>NCT05635045</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 799-811"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unknowing the Unknown","authors":"Gary R. Small BSc, MB, ChB, PhD,&nbsp;Rob S.B. Beanlands MD","doi":"10.1016/j.jcmg.2025.06.001","DOIUrl":"10.1016/j.jcmg.2025.06.001","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 812-814"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S1936-878X(25)00302-X","DOIUrl":"10.1016/S1936-878X(25)00302-X","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages I-CV"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Established and Emerging Fluorine-18–Labeled Cardiac PET Radiotracers","authors":"René R. Sevag Packard MD, PhD ,&nbsp;Matthieu Pelletier-Galarneau MD ,&nbsp;Saurabh Malhotra MD ,&nbsp;Sharmila Dorbala MD, MPH ,&nbsp;Wengen Chen MD ,&nbsp;Vasken Dilsizian MD","doi":"10.1016/j.jcmg.2025.03.011","DOIUrl":"10.1016/j.jcmg.2025.03.011","url":null,"abstract":"<div><div>Positron emission tomography (PET)/computed tomography is a major imaging strategy for cardiovascular disease characterization. Whereas multiple radioisotopes can be used for PET imaging of cardiac disease processes, fluorine-18 (¹⁸F) presents key advantages. These include availability as a unit dose given a favorable half-life of 109.7 minutes and a short positron range leading to a high spatial resolution. In this context, there is growing interest in the development of novel ¹⁸F-labeled probes applied to cardiac PET imaging, which in turn provide clinicians with new methods to evaluate disease pathways of interest. Beyond ¹⁸F-fluorodeoxyglucose, used in routine clinical practice to scrutinize myocardial viability, cardiac sarcoidosis, as well as prosthetic valve and cardiac device infection, new ¹⁸F-labeled radiopharmaceuticals have undergone clinical evaluation. These include ¹⁸F-flurpiridaz, which was recently approved by the U.S. Food and Drug Administration for myocardial perfusion imaging and that is also amenable to accurate myocardial blood flow quantitation, ¹⁸F-sodium fluoride to detect metabolically active epicardial coronary atherosclerotic lesions, and the ¹⁸F-labeled amyloid radiotracers florbetapir, flutemetamol, and florbetaben. This review will further explore emerging ¹⁸F-labeled probes applied to cardiac sarcoidosis, myocardial innervation, and ongoing fibrosis/fibroblast activation.</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 815-833"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good FFRCT Test-Retest Reproducibility","authors":"Nadia Iraqi MD,&nbsp;Martin Bødtker Mortensen MD, PhD,&nbsp;Niels Peter Rønnow Sand MD, PhD,&nbsp;Martin Busk MD, PhD,&nbsp;Kristian Tækker Madsen MD, PhD,&nbsp;Erik Lerkevang Grove MD, PhD,&nbsp;Kamilla Bech Pedersen RT,&nbsp;Helle Kanstrup MD, PhD,&nbsp;Timothy A. Fairbairn MD, PhD,&nbsp;Erik Parner MSc, PhD,&nbsp;Jesper Møller Jensen MD, PhD,&nbsp;Bjarne Linde Nørgaard MD, PhD","doi":"10.1016/j.jcmg.2025.02.009","DOIUrl":"10.1016/j.jcmg.2025.02.009","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 834-837"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Time Frame of Plaque and Hemodynamic Characteristics and Integrative Risk Prediction for Acute Coronary Syndrome","authors":"Seokhun Yang MD ,&nbsp;Jae Wook Jung MD ,&nbsp;Sang-Hyeon Park MD ,&nbsp;Jinlong Zhang MD ,&nbsp;Keehwan Lee MD ,&nbsp;Doyeon Hwang MD ,&nbsp;Kyu-Sun Lee MD ,&nbsp;Sang-Hoon Na MD ,&nbsp;Joon-Hyung Doh MD ,&nbsp;Chang-Wook Nam MD ,&nbsp;Tae Hyun Kim MD ,&nbsp;Eun-Seok Shin MD ,&nbsp;Eun Ju Chun MD ,&nbsp;Su-Yeon Choi MD ,&nbsp;Hyun Kuk Kim MD ,&nbsp;Young Joon Hong MD ,&nbsp;Hun-Jun Park MD ,&nbsp;Song-Yi Kim MD ,&nbsp;Mirza Husic MD ,&nbsp;Jess Lambrechtsen MD ,&nbsp;Bon-Kwon Koo MD","doi":"10.1016/j.jcmg.2025.02.003","DOIUrl":"10.1016/j.jcmg.2025.02.003","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The relevant time frame for predicting future acute coronary syndrome (ACS) based on coronary lesion characteristics remains uncertain.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The aim of this study was to investigate the association of lesion characteristics with test-to-event time and their prognostic impact on ACS.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The EMERALD II (Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II) study analyzed 351 patients who underwent coronary computed tomography angiography (CTA) and experienced ACS between 1 month and 3 years of follow-up. Lesions identified on coronary CTA were classified as culprit (n = 363) or nonculprit (n = 2,088) on the basis of invasive coronary angiography findings at the time of ACS. Core laboratory coronary CTA analyses assessed 4 domains: degree of stenosis, plaque burden, number of adverse plaque characteristics (APC) (low-attenuation plaque, positive remodeling, spotty calcification, and napkin-ring sign), and changes in coronary CTA–derived fractional flow reserve across the lesion (ΔFFR&lt;sub&gt;CT&lt;/sub&gt;). Patients were categorized into short (&lt;1 year), mid (1-2 years), and long (2-3 years) test-to-event time groups.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Patient characteristics, including cardiovascular risk factors, did not differ across short, mid, and long test-to-event groups (&lt;em&gt;P &gt;&lt;/em&gt; 0.05 for all), and the proportion of ACS culprit lesions was similar (&lt;em&gt;P =&lt;/em&gt; 0.552). Among culprit lesions, shorter test-to-event time was associated with higher luminal stenosis, plaque burden, and ΔFFR&lt;sub&gt;CT&lt;/sub&gt; (&lt;em&gt;P&lt;/em&gt; for trend &lt; 0.001 for all). The predictability for ACS culprit lesions based on the combined 4 characteristics tended to decrease over time and significantly reduced beyond 2 years (AUC: 0.851 vs 0.741; &lt;em&gt;P =&lt;/em&gt; 0.006). In predicting ACS risk within test-to-event time &lt;2 years using obstructive lesions (stenosis ≥ 50%), APC ≥2, plaque burden ≥70%, and ΔFFR&lt;sub&gt;CT&lt;/sub&gt; ≥0.10, the risk was elevated compared to the average proportion of lesions becoming ACS culprit (12.1%) in the following subsets: lesions with 4 characteristics (proportion of lesions becoming ACS culprit: 49.3%; &lt;em&gt;P &lt;&lt;/em&gt; 0.001), lesions with 3 characteristics (obstructive lesions with plaque burden ≥70% and either ΔFFR&lt;sub&gt;CT&lt;/sub&gt; ≥0.10 [proportion of lesions becoming ACS culprit: 33.0%; &lt;em&gt;P &lt;&lt;/em&gt; 0.001] or APC ≥2 [proportion of lesions becoming ACS culprit: 31.2%; &lt;em&gt;P &lt;&lt;/em&gt; 0.001]), and lesions with 2 characteristics (plaque burden ≥70% and ΔFFR&lt;sub&gt;CT&lt;/sub&gt; ≥0.10; proportion of lesions becoming ACS culprit: 21.5%; &lt;em&gt;P =&lt;/em&gt; 0.016).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Increased luminal stenosis, plaque burden, and ΔFFR&lt;sub&gt;CT&lt;/sub&gt; were associated with shorter test-to-ACS event time. The prognostic impact of lumen, plaque, and local hemodynamic charact","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 784-795"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin Therapy Persistence Following Opportunistic Screening for Coronary Artery Calcium on Nongated Chest CTs","authors":"Sarkis G. Bouladian BS,&nbsp;Summer Ngo BS,&nbsp;Domenico Mastrodicasa MD,&nbsp;David Eng MS,&nbsp;Nishith Khandwala MS,&nbsp;Doug Sousa BS,&nbsp;Akshay S. Chaudhari PhD,&nbsp;David J. Maron MD,&nbsp;Fatima Rodriguez MD, MPH,&nbsp;Alexander T. Sandhu MD, MS","doi":"10.1016/j.jcmg.2025.03.007","DOIUrl":"10.1016/j.jcmg.2025.03.007","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"18 7","pages":"Pages 841-843"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}