JAMA dermatology最新文献

{"title":"Best Practices for Managing Pseudofolliculitis Barbae: An Expert Consensus Delphi Study.","authors":"Simona A Alomary, Nicole J Baker, Grace Ugwueke, Haya Alkiswani, Prince Adotama, Olabola Awosika, Cheryl Burgess, Valerie Callender, Sunghun Cho, Jeanine Downie, Omar Ibrahimi, Joanna Ludzik, Tiffany Mayo, Hope Mitchell, Temitayo Ogunleye, Simon Ritchie, JiaDe Yu, Willis H Lyford, Nada Elbuluk, Susan C Taylor","doi":"10.1001/jamadermatol.2026.3579","DOIUrl":"https://doi.org/10.1001/jamadermatol.2026.3579","url":null,"abstract":"<p><strong>Importance: </strong>Pseudofolliculitis barbae (PFB) is a chronic inflammatory disease caused by penetration of a shaved, curved hair shaft into the skin. Standardized recommendations for diagnosing and managing PFB are needed.</p><p><strong>Objective: </strong>To establish expert consensus recommendations outlining best practices for diagnosing and managing PFB.</p><p><strong>Evidence review: </strong>A 3-round Delphi consensus study was conducted using a panel of board-certified US dermatologists with expertise in PFB. Consensus statements addressing diagnostic criteria, behavioral modification, topical and systemic therapies, procedural interventions, and occupational considerations were developed and evaluated using a 9-point Likert scale. Consensus was predefined as greater than or equal to 75% agreement.</p><p><strong>Findings: </strong>Forty statements associated with diagnostic criteria, medical and procedural management, and occupational considerations reached consensus. Behavioral modification of hair removal practices as first-line therapy, use of targeted topical and systemic treatments, and procedural interventions, such as laser hair removal, were supported. No agreement was reached regarding a standardized grading scale, the use of oral isotretinoin for refractory disease, superficial chemical peels, or the use of multiblade razors.</p><p><strong>Conclusions and relevance: </strong>Using a Delphi consensus study approach, expert consensus guidelines were established for diagnosing and managing PFB. These recommendations provide an evidence-informed framework to support clinical decision-making, guide future research efforts, and help inform policy considerations associated with PFB management.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lived Experience of Hirsutism in Transfeminine Individuals.","authors":"Sarah Gold, Marta Taye, Andrew Murdock, Francisco Delgado, Rebecca Goldberg, Meron Siira, Ketki Joshi, Vin Tangpricha, J Sonya Haw, Jason S Schneider, Michael Goodman, Cam Escoffery, Ashli Owen-Smith, Suephy C Chen, Howa Yeung","doi":"10.1001/jamadermatol.2026.3664","DOIUrl":"10.1001/jamadermatol.2026.3664","url":null,"abstract":"<p><strong>Importance: </strong>Hirsutism is commonly associated with gender dysphoria in transgender and gender-diverse individuals, with many seeking permanent hair removal. Little research has examined how hirsutism impacts life and stigma in gender minority groups.</p><p><strong>Objective: </strong>To examine lived experiences of hirsutism and hirsutism treatment in transgender and gender-diverse participants.</p><p><strong>Design, setting, and participants: </strong>This qualitative study included semistructured interviews with transgender women and nonbinary adults assigned male at birth across 3 clinical settings in Atlanta, Georgia, from February 7 to June 26, 2023.</p><p><strong>Exposure: </strong>Self-reported hirsutism.</p><p><strong>Main outcomes and measures: </strong>Interviews exploring experiences of hirsutism and hirsutism treatment were analyzed via thematic analysis.</p><p><strong>Results: </strong>Among 18 participants who completed the study, 17 were transgender women and 1 was a nonbinary individual assigned male at birth (mean [range] participant age, 38 [22-68] years). Fourteen participants self-rated clinically significant hirsutism levels, and only 1 reported having a diagnosis of hirsutism from a clinician. Participants described experiences of discrimination and rejection related to hirsutism and admitted avoiding social and romantic interactions in anticipation. Hirsutism was also reported to interfere with feminine gender expression and resulted in gender dysphoria. Many individuals went to great lengths to conceal visible hair in public, keeping razors or tweezers readily available for facial hair removal. Barriers to permanent hair removal included appointment burden, clinician attitude, lack of transgender-inclusive hair removal services, cost, and lack of insurance coverage.</p><p><strong>Conclusions and relevance: </strong>In this qualitative study, transgender women and nonbinary adults assigned male at birth described experiencing hirsutism-related stigma and facing barriers to permanent hair removal. Multilevel changes aimed to reduce stigma, educate clinicians on hair-removal options, expand transgender-inclusive hair-removal services, and advocate for insurance coverage for permanent hair removal are required to reduce barriers to access medically necessary permanent hair removal for gender dysphoria.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robustness of Network Meta-Analysis in Chronic Plaque Psoriasis.","authors":"Emilie Sbidian, Sivem Afach, Laurence Le Cleach","doi":"10.1001/jamadermatol.2026.3659","DOIUrl":"https://doi.org/10.1001/jamadermatol.2026.3659","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elephantiasic Pretibial Myxedema.","authors":"Anqi Xie, Tao Wang","doi":"10.1001/jamadermatol.2026.2978","DOIUrl":"https://doi.org/10.1001/jamadermatol.2026.2978","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perifollicular Repigmentation After Hair Transplant in Stable Discoid Lupus Erythematosus.","authors":"Jorge Larrondo, Marianne Gosch, Raúl Cabrera, Iván Guaya, Alex Castro, Amy J McMichael","doi":"10.1001/jamadermatol.2026.2872","DOIUrl":"https://doi.org/10.1001/jamadermatol.2026.2872","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Effectiveness, Safety, and Survival of Dupilumab in Pediatric Atopic Dermatitis.","authors":"Florence Vroman, Octavian I Bacos-Cosma, Laura Loman, Nicolaas P A Zuithoff, Marijke Kamsteeg, Anne-Moon van Tuyll van Serooskerken, Paula P M van Lümig, Albert J Oosting, Tom Hendriks, Marjolein S de Bruin-Weller, Marie-Louise A Schuttelaar, Marlies de Graaf","doi":"10.1001/jamadermatol.2026.3548","DOIUrl":"10.1001/jamadermatol.2026.3548","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Limited data are available on the long-term effectiveness and safety of dupilumab in pediatric patients with atopic dermatitis (AD) in a clinical setting.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To assess the clinical effectiveness, safety, drug survival, and reasons and associated factors for discontinuation of dupilumab across pediatric age groups with up to 3 years of follow-up.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This multicenter, prospective cohort study (BioDay Registry) was conducted across 4 academic and 3 nonacademic hospitals in the Netherlands from November 2019 to October 2025 and included pediatric patients (≤16 years) with moderate to severe AD who initiated treatment with dupilumab. Data were analyzed from September 2025 to January 2026.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposure(s): &lt;/strong&gt;Dupilumab was administered at the label-recommended dose. Dose reduction was initiated if clinically indicated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;Clinical effectiveness was evaluated by the Eczema Area and Severity Index (EASI) and Investigator Global Assessment (IGA). Additional outcomes included the Numeric Rating Scale (NRS) for pruritus, NRS for pain, and quality of life (QoL) scores. Safety was assessed by adverse events (AEs). Drug survival, reasons, and factors associated with discontinuation were evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Overall, 309 pediatric patients with AD (mean [SD] age, 10.2 [4.2] years; 150 female individuals [48.5%] and 159 male individuals [51.5%]) were treated with dupilumab; 51 (16.5%) were aged 6 months to 5 years (median follow-up, 45.0 [IQR, 26.0-101.0] weeks), 120 (38.8%) were aged 6 to 11 years (median follow-up, 80.0 [IQR, 32.0-135.0] weeks), and 138 (44.7%) were aged 12 to 16 years (median follow-up, 89.5 [IQR, 48.0-143.0] weeks) at baseline. Most patients maintained controlled AD, with mean EASI and NRS scores for pruritus remaining low after 3 years (3.4 [95% CI, 2.4-4.5] and 3.6 [95% CI, 3.1-4.1], respectively). Age groups differed significantly in NRS for pruritus and QoL scores over time, with children aged 6 months to 5 years consistently reporting higher scores than older children. The most frequently reported AE was dupilumab-associated ocular surface disease (113 [36.6%]). Fifty patients (50 [16.2%]) discontinued dupilumab, mainly due to ineffectiveness (19 [38.0%]) and/or AEs (15 [30.0%]), or administration problems (11 [22.0%]); most discontinuations occurred within 1.5 years. Three-year drug survival was 80.1%; allergic asthma, allergic rhinitis, and being age 6 to 11 years were associated with a lower risk of discontinuation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;The results of this cohort study suggest that dupilumab demonstrates long-term effectiveness and safety in pediatric AD in a clinical setting. Younger children show higher NRS scores for pruritus and greater QoL impairment and discontinue treatment more often due to admini","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperpigmented Plaques at Insulin Injection Sites.","authors":"Jhen-Yu Jwo, Wei-Hwa Lee, Hao-Jui Weng","doi":"10.1001/jamadermatol.2026.2786","DOIUrl":"https://doi.org/10.1001/jamadermatol.2026.2786","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple HRAS Hot-Spot Somatic Variations in a Patient With Eruptive Disseminated Spitz Nevi.","authors":"Amanda Z Jiang, Kenji V Aoki, Carly A Becker, Abigail Florell, Eric A Smith, Lewis J Kirkegaard, Caroline Laggis, Jamie Zussman, Patricia A Vitale, Anneli R Bowen, Douglas Grossman, Robert L Judson-Torres, Dekker C Deacon","doi":"10.1001/jamadermatol.2026.3428","DOIUrl":"10.1001/jamadermatol.2026.3428","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in Byline.","authors":"","doi":"10.1001/jamadermatol.2026.4303","DOIUrl":"10.1001/jamadermatol.2026.4303","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"US Food and Drug Administration's Adverse Event Reporting System-Highly Limited for Causal Inference in Dermatology.","authors":"Charles Lu, David J Margolis, Kaylin J Beiter","doi":"10.1001/jamadermatol.2026.3075","DOIUrl":"https://doi.org/10.1001/jamadermatol.2026.3075","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}