JAMA dermatology最新文献

{"title":"Successful Treatment of Alopecia Areata With One JAK Inhibitor After Failure of Other JAK Inhibitors.","authors":"Luiza Kalil, Brittany G Craiglow, Brett King","doi":"10.1001/jamadermatol.2025.3537","DOIUrl":"10.1001/jamadermatol.2025.3537","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Melanoma In Situ in the Age of Overdiagnosis.","authors":"Yaelle Shaked, Alyssa Swearingen, Jennifer A Stein, David Polsky","doi":"10.1001/jamadermatol.2025.3369","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3369","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Values and Preferences in Chronic Urticaria Treatment: A Systematic Review.","authors":"Xiajing Chu, Javeria Mubasher, Lina Chen, Alexandro W L Chu, Paul Oykhman, Romina Brignardello-Petersen, Gordon H Guyatt, Anja Fog Heen, David A Khan, David M Lang, Diane R Baker, Eric T Oliver, Javed Sheikh, Lisa A Beck, Moshe Ben-Shoshan, Sameer K Mathur, Susan Waserman, Emily F Cole, Jeffrey Chan, Kathryn E Wheeler, Kathryn P Trayes, Lauren Runyon, Paul Tran, Rachel N Asiniwasis, Donna D Gardner, Sanaz Eftekhari, Tonya Winders, Jamie Tattrie, Jonathan A Bernstein, Sarbjit S Saini, Derek K Chu","doi":"10.1001/jamadermatol.2025.3663","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3663","url":null,"abstract":"<p><strong>Importance: </strong>Patient and caregiver values and preferences should inform clinical management. An update to the American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology's Joint Task Force on Practice Parameters guidelines on chronic urticaria (CU) plans to incorporate them; however, a systematic review of evidence on the values and preferences of patients with CU and their caregivers has not been previously available.</p><p><strong>Objective: </strong>To synthesize patient and caregiver values and preferences regarding CU treatment options.</p><p><strong>Evidence review: </strong>A systematic search was conducted of MEDLINE, Embase, PsycINFO, and CINAHL databases, from inception to May 15, 2025, for studies addressing patient and/or caregiver values and preferences for CU management. Paired reviewers independently screened studies, extracted data, and assessed risk of bias. Thematic and inductive content analysis was used to qualitatively synthesize findings and certainty of evidence was rated per the Grading of Recommendations Assessment, Development and Evaluation-Confidence in the Evidence from Reviews of Qualitative Research approach.</p><p><strong>Findings: </strong>The search resulted in 18 studies addressing the values and preferences among 28 497 participants. Moderate certainty evidence showed that patients were likely to place a high value on rapid improvement (eg, 2 days to 2 weeks) of disease signs and symptoms, long-term effectiveness, and treatments that were easy to prepare, use, and self-manage-oral or topical treatments were favored over injections, with the least favored being infusions. Low certainty evidence suggested that patients accepted minor feasibility burdens for rapid and sustained symptom relief but prioritized safety and tolerability as the risk or severity of adverse effects (eg, kidney injury, vomiting) increased.</p><p><strong>Conclusions and relevance: </strong>This systematic review suggests that patients with CU place high value on immediate and sustained hive, itch, and swelling relief, particularly long-term symptom-free periods, but may shift to prioritizing avoiding harms and burdens as the risk and severity of adverse effects increases. These findings may serve as a resource to improve the trustworthiness of recommendations and inform future CU management and research.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Manifestation of Seronegative Granulomatosis With Polyangiitis.","authors":"Dylan J Parker, David G Grand, Angel M Moore, Jeffrey M Cloutier, Dorothea T Barton","doi":"10.1001/jamadermatol.2025.3528","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3528","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous Auricular Vagus Nerve Stimulation Treatment for Erythematotelangiectatic Rosacea: A Randomized Clinical Trial.","authors":"Jian Li, Jinyu Wei, Mingwang Zhang, Minmin Kong, Lijuan Xie, Mei Wan, Zhifei Pan, Jing Tian, Zuzhen Ou, Shuguang Chen, Aiai Xia, Li Tang, Zhiqiang Song, Jingming Hou, Fei Hao","doi":"10.1001/jamadermatol.2025.3796","DOIUrl":"10.1001/jamadermatol.2025.3796","url":null,"abstract":"<p><strong>Importance: </strong>Treatment of facial flushing and erythema for patients with erythematotelangiectatic rosacea (ETR) is challenging. Transcutaneous auricular vagus nerve stimulation (taVNS) therapy may be beneficial for treating ETR; however, it has not been rigorously evaluated in a randomized clinical trial.</p><p><strong>Objective: </strong>To evaluate the efficacy of taVNS for ETR compared with sham stimulation (SS).</p><p><strong>Design, setting, and participants: </strong>Enrollment for this single-center, randomized, double-blind, sham-controlled device clinical trial was initiated in February 2024 and ended in August 2024. The follow-up period ended in February 2025, and data were analyzed in March 2025. Patients with ETR that was accompanied by a Clinician's Erythema Assessment (CEA) score of at least 2 were selected from the Department of Dermatology of Southwest Hospital in China.</p><p><strong>Interventions: </strong>Patients were allocated to the taVNS group (stimulation pulses at a frequency of 30 Hz and a pulse width of 200 μs for 30 minutes per day) or the SS group at a 1:1 ratio. Both groups received 3 weeks of treatment and 24 weeks of follow-up.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was CEA score after 3 weeks of treatment. The secondary outcomes included improvements in erythema and facial flushing, sleep disorders, migraine, anxiety, fatigue, and depression, as measured via clinical tools.</p><p><strong>Results: </strong>Seventy-two participants (67 female individuals [93.1%]; median [IQR] age: 29.5 [24.0-36.0] years) with ETR were randomized into either the taVNS (36 [50.0%]) or SS groups (36 [50.0%]). At 3 weeks, the mean (SD) CEA score was lower in the taVNS group than the SS group (1.56 [0.84] vs 2.47 [0.81]; mean difference, -0.92; 95% CI, -1.3 to -0.53; P < .001). Moreover, taVNS also reduced the severity of anxiety (mean difference, -5.42; 95% CI, -8.11 to -2.73; P < .001) and depression (mean difference, -6.22; 95% CI, -9.69 to -2.75; P < .001). This relief persisted until the follow-up period. The effects on sleep disorders, migraine, and fatigue were consistent with the previously described indicators. Adverse events were not common for taVNS (2 of 36 [5.6%]) and SS (3 of 36 [8.3%]).</p><p><strong>Conclusions and relevance: </strong>This randomized clinical trial demonstrated that treating ETR with taVNS concurrently ameliorated cutaneous symptoms and systemic comorbidities, and the results suggest that taVNS is a novel therapeutic option for ETR management.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Register Identifier: ChiCTR2400080637.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head Lice.","authors":"Allison E Miller","doi":"10.1001/jamadermatol.2025.2658","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.2658","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validating the Use of ICD-10 Codes for Identifying Vitiligo.","authors":"Debby Cheng, Katherine Sanchez, Ursula Biba, Nora Bensellam, Sherry Ershadi, Samantha Gregoire, Yevgeniy R Semenov, Arash Mostaghimi, John S Barbieri, Nicholas Theodosakis","doi":"10.1001/jamadermatol.2025.3512","DOIUrl":"10.1001/jamadermatol.2025.3512","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to Scarring Alopecia.","authors":"Jiana Wyche, Maryanne Senna, Crystal Aguh","doi":"10.1001/jamadermatol.2025.3540","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3540","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Porokeratosis Ptychotropica With Upadacitinib.","authors":"Shuai Zhang, Lu Bian, Meng-Yao Zhang, Jin-Fa Dou, Hong-Wei Liu, Jian-Guo Li, Jian-Bo Wang","doi":"10.1001/jamadermatol.2025.3519","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3519","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitators and Barriers to the Timely Diagnosis and Treatment of Melanoma in Latino Persons.","authors":"Kimberly A Miller, Priscilla Marìn, Rosario Aguero, Guillermo Muñoz, Marlene Caldera, Jennifer B Unger, Ashley B Crew, Fumito Ito, Lourdes Baezconde-Garbanati, Myles G Cockburn","doi":"10.1001/jamadermatol.2025.3620","DOIUrl":"10.1001/jamadermatol.2025.3620","url":null,"abstract":"<p><strong>Importance: </strong>While mortality from melanoma has decreased in non-Hispanic White individuals over the last decade due to new and effective therapies, disparities in survival remain for Latino populations. Latino patients have lower overall incidence of melanoma than non-Hispanic White patients but are more likely to be diagnosed with thicker, more advanced tumors, leading to higher mortality.</p><p><strong>Objective: </strong>To identify the facilitators and barriers Latino patients face prior to melanoma diagnosis and treatment and to inform strategies that expedite care and improve survival rates in this population.</p><p><strong>Design, setting, and participants: </strong>This qualitative study used reflexive thematic analysis of interviews with Latino patients with melanoma of any stage at diagnosis conducted in Los Angeles County, California, between May and November 2023. Patients were identified from the California Cancer Registry, part of the Surveillance, Epidemiology, and End Results Program.</p><p><strong>Main outcomes and measures: </strong>A semistructured interview guide designed to explore multiple themes related to potential barriers and facilitators to timely diagnosis of melanoma among Latino patients.</p><p><strong>Results: </strong>Of 20 included Latino patients with melanoma, 13 (65%) were female, and the median (range) age was 56.5 (41-79) years. Half of the interviews were conducted in Spanish, and 15 participants (75%) were diagnosed at an early stage (in situ or regional). A total of 6 themes were identified: 2 facilitators, including patients as advocates for their health care and linguistically appropriate care, and 4 barriers, including barriers to timely care due to health insurance procedures, delays in accessing specialty referral, low awareness of melanoma prior to diagnosis, and a lack of linguistically appropriate care.</p><p><strong>Conclusions and relevance: </strong>This qualitative study identified multifaceted challenges faced by Latino patients as they seek both diagnosis and treatment of melanoma. Findings suggest several recommendations to accelerate time to diagnosis and prompt initiation of treatment to reduce disparities experienced by this patient population.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}