JAMA dermatology最新文献

{"title":"Epitope Spreading in Immune Checkpoint Inhibitor-Associated Bullous Pemphigoid.","authors":"Hiroshi Koga, Masahiro Tsutsumi, Kwesi Teye, Toshihiro Shirahama, Norito Ishii, Koichi Azuma, Takekuni Nakama","doi":"10.1001/jamadermatol.2024.6665","DOIUrl":"https://doi.org/10.1001/jamadermatol.2024.6665","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in the Figure.","authors":"","doi":"10.1001/jamadermatol.2025.0857","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0857","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reexamining Medication Impact in Hidradenitis Suppurativa and Pregnancy-Reply.","authors":"Nathalie Auger, Kaiyang Li, Émilie Brousseau","doi":"10.1001/jamadermatol.2025.0503","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0503","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatologic Care and Skin Health of Migrant Populations in the US: A Scoping Review.","authors":"Herbert B Castillo Valladares, Penelope Kim-Lim, Aileen Y Chang","doi":"10.1001/jamadermatol.2025.0404","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0404","url":null,"abstract":"<p><strong>Importance: </strong>Despite literature on migrant skin health globally, there remains a critical gap in understanding the dermatologic care and skin health of migrants in the US, where immigrants represent 13.9% of the population.</p><p><strong>Objective: </strong>To understand the spectrum of dermatologic conditions reported among US migrant populations, identify considerations for dermatologic care delivery, and synthesize the current literature on skin health.</p><p><strong>Evidence review: </strong>PubMed, Embase, and ClasePeriodica were searched for articles published from January 2000 to December 2022 using search terms related to dermatologic conditions and migrants. Original research articles, review articles, case reports, and case series that reported on dermatologic conditions affecting migrant populations within the US and US territories were included.</p><p><strong>Findings: </strong>Of 87 articles included, cross-sectional studies accounted for 37 (42.5%), followed by case reports and case series (36 [41.4%]), qualitative studies (3 [3.4%]), and a mixed-methods study (1 [1.1%]). Articles discussed a range of dermatologic conditions: infections (45 [51.7%]), inflammatory conditions (33 [37.9%]), traumatic wounds (16 [18.4%]), neoplasms (10 [11.5%]), pigmentary disorders (10 [11.5%]), signs of torture/violence (4 [4.6%]), cosmetic (3 [3.4%]), hair/nail disorders (1 [1.1%]), and genodermatoses (1 [1.1%]). Of 65 articles (74.6%) reporting migrants' country of origin, Mexico was most frequently reported (28 [43.0%]), followed by Guatemala (14 [21.5%]), Vietnam (8 [12.3%]), and 38 other countries. Four themes were developed: (1) exposures before and during migration were risk factors for dermatologic conditions that presented at destination; (2) occupational and environmental exposures were risk factors for dermatologic conditions that developed at destination; (3) structural factors limited migrants' access to quality health care; and (4) educational interventions targeting different learner groups were opportunities to improve skin health of migrants.</p><p><strong>Conclusions and relevance: </strong>This scoping review found that exposures before, during, and after migration and health care access are associated with the skin health of US migrant populations. Research opportunities include focusing on a broad spectrum of dermatologic diseases, countries of birth, occupations, and vulnerable populations, such as women and children, as well as implementing and evaluating policy that addresses structural barriers migrants face in accessing quality health care.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Applicability of a Risk Prediction Tool for Sentinel Node Positivity in Patients With Primary Cutaneous Melanoma.","authors":"Serigne N Lo, Caroline Gjorup, Annette Hougaard Chakera, Lisbet Rosenkrantz Hölmich, Marc Moncrieff, Alastair MacKenzie Ross, Oliver Cassell, Jiawen Ma, Marie Brinch-Møller Weitemeyer, Roger Olofsson Bagge, Siri Klausen, Vinicius F Calsavara, João P Duprat Neto, Eduardo Bertolli, Sydney Ch'ng, Robyn P M Saw, Kerwin F Shannon, Andrew J Spillane, Omgo E Nieweg, Jonathan R Stretch, Graham J Mann, Jenny L C Geh, Lauren E Haydu, Richard C W Martin, Cimarron Sharon, Giorgos C Karakousis, Mohammed Kashani-Sabet, George Adigbli, Mary-Ann El Sharouni, Jeffrey E Gershenwald, Richard A Scolyer, John F Thompson, Alexander H R Varey","doi":"10.1001/jamadermatol.2025.0318","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0318","url":null,"abstract":"<p><strong>Importance: </strong>The Melanoma Institute Australia (MIA) sentinel node (SN) metastasis risk calculator provides estimates of positivity for individual patients based on 6 standard clinicopathological parameters and the full 6-parameter model has been externally validated previously using US data. However, given its geographically widespread use, further validation is required to ensure its applicability to other populations.</p><p><strong>Objective: </strong>To further externally validate the MIA SN metastasis risk calculator and increase its precision by refinement of the 95% CIs.</p><p><strong>Design, setting, and participants: </strong>A retrospective multicenter cohort study was carried out using data from 4 continents, including the national Danish Melanoma Database and cancer centers in the UK (n = 3), US (n = 2), New Zealand (n = 1), Sweden (n = 1), and Brazil (n = 1). All patients aged 18 years or older who had an SN biopsy performed for an invasive primary cutaneous melanoma and data available on the following parameters: SN status, patient age at diagnosis, Breslow thickness, and melanoma subtype were included (n = 15 731). Available data were also collected on ulceration status, lymphovascular invasion, and the tumor mitotic rate. Data were collected between July 2021 and December 2023, and the analysis was conducted between January 2024 and June 2024.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was the area under the curve (AUC) of the receiver operating characteristics for the full (6-parameter) risk prediction model. Secondary outcomes were the AUCs for each country and for the limited models (3-5 parameters), the model calibration, and the recalculated 95% CIs for the models. Decision curve analysis was performed to assess the tool's clinical utility.</p><p><strong>Results: </strong>The whole pooled cohort consisted of 15 731 patients; 4989 had all 6 parameters available. The AUC was 73.0% (95% CI, 70.6%-75.3%) in the subset with all 6 parameters available, and 70.8%, 71.5%, and 70.1% when 1, 2, or 3 optional parameters were missing, respectively. Calibration was excellent, with an intercept and calibration slope of 0.01 (95% CI, -0.02 to 0.03) and 1.03 (95% CI, 0.90-1.16), respectively. The updated 95% CI ranges were substantially tighter, with a median reduction of more than 75%.</p><p><strong>Conclusions and relevance: </strong>This study found that the MIA SN-positivity calculator performed best with all 6 parameters and has been significantly improved (version 2), with the same risk point estimates but much tighter 95% CIs. These results demonstrated that the calculator was robust, precise, and applicable to geographically widespread melanoma populations.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reexamining Medication Impact in Hidradenitis Suppurativa and Pregnancy.","authors":"Yan-Han Li, Shu-Han Chuang, Hui-Ju Yang","doi":"10.1001/jamadermatol.2025.0507","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0507","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Checkpoint Inhibitor-Induced Lipodystrophy.","authors":"Julia Riganti, Ana C Torre, Pietro Sollena, Dimitra Koumaki, Azael Freites-Martinez, Julie Delyon, Antoine Communie, Michela Starace, Luca Rapparini, Aimilios Lallas, Dimitrios Mavroudis, Devaux Suzanne, Luis D Mazzuoccolo, Mattheos Bobos, Vincent Sibaud, Zoe Apalla","doi":"10.1001/jamadermatol.2025.0359","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0359","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standard Dermatoscope Images vs an Autonomous Total Body Photography and Dermoscopic Imaging Device.","authors":"Pau Rosés-Gibert, Cristina Heras, Narcis Ricart, Enric Campmol, Núria Ferrera, Susana Puig, J Malvehy","doi":"10.1001/jamadermatol.2025.0565","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0565","url":null,"abstract":"<p><strong>Importance: </strong>Recent advancements in autonomous medical devices for skin imaging offer the potential to improve the efficiency and quality of total body photography (TBP) and dermatoscopic documentation, which are essential in treating patients with skin cancer, especially those with high-risk melanoma with atypical mole syndrome.</p><p><strong>Objective: </strong>To compare the image quality and time efficiency of an autonomous TBP and dermoscopic device for TBP and dermoscopic imaging with traditional manual digital dermoscopic techniques.</p><p><strong>Design, setting, and participants: </strong>A prospective cohort study was conducted from March 1, 2023, to October 30, 2023, comparing image quality and time efficiency between an autonomous TBP and dermoscopic device and manual dermoscopic documentation across 316 patients with atypical mole syndrome at 2 dermatology clinics in Spain. All analyses took place in June 2024.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was the acceptability of the images, assessed by 2 independent dermatologists. Secondary outcomes included diagnostic agreement between the 2 methods and time efficiency for image acquisition.</p><p><strong>Results: </strong>Overall, mean (SD) age of patients was 47.13 (3.31) years. The number of male patients was 105 (33%), while the number of female patients was 211 (66%). The autonomous TBP and dermoscopic device produced dermoscopic images with a mean (SD) quality score of 9.84 (0.72), compared with 9.44 (0.85) for manual digital dermoscopy, with no significant differences by body site or lesion type. Diagnostic classification agreement between the 2 methods was 91.60%, with most discrepancies related to small benign lesions. The mean (SD) imaging time for the autonomous device was 570 (169) seconds, compared with 606 (286) seconds for the manual method.</p><p><strong>Conclusions and relevance: </strong>This cohort study found that the autonomous TBP and dermoscopic device produced images of comparable quality to standard dermoscopic techniques while operating with greater time efficiency. These findings suggest that the device may contribute to clinical workflow optimization in dermatology by supporting TBP and dermoscopic imaging.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Cutaneous and Mucosal Direct Immunofluorescence Testing Practices in the US.","authors":"Julia S Lehman, Anthony P Fernandez, Kristin M Leiferman, Nooshin K Brinster, Donna A Culton, Randie H Kim, Jeffrey P North, Benjamin K Stoff, Michael J Camilleri, Margaret M Cocks, Rosalie Elenitsas, Maxwell A Fung, Raminder K Grover, Jaroslaw J Jedrych, Melanie K Kuechle, Jennifer M McNiff, Ata S Moshiri, Kiran Motaparthi, Michael J Murphy, Carlos H Nousari, Sara C Shalin, John J Zone, Alina G Bridges","doi":"10.1001/jamadermatol.2025.0339","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0339","url":null,"abstract":"<p><strong>Importance: </strong>Direct immunofluorescence (DIF) testing has been an important ancillary tool for the diagnosis of various inflammatory mucocutaneous conditions for more than 50 years. Current DIF test panels are based on historical clinical descriptions; few studies have rigorously addressed preanalytical, analytical, and/or postanalytical aspects, and even fewer have been replicated or validated. Recent unresolved key issues include whether DIF testing and test panels should be triaged or truncated based on clinical indication or histopathologic findings.</p><p><strong>Objective: </strong>To assess levels of consensus regarding practical aspects of DIF testing among immunodermatology testing specialists in the US.</p><p><strong>Design, setting, and participants: </strong>Using modified Delphi methods with a priori characterized criteria, a survey containing 54 statements pertaining to DIF testing was created and distributed to assess consensus. Statements not initially reaching consensus were discussed in 2 live virtual sessions, which were supplemented by relevant literature review and free-text survey comments. These statements were then reassessed in a second survey. Immunodermatology testing specialists in US academic institution-based and independent laboratories were invited based on serving as immunodermatology laboratory medical directors, authoring pertinent literature, or delivering relevant talks at major conferences or by referral. The first survey was conducted from January to February 2024, and the second survey was conducted from March to April 2024.</p><p><strong>Main outcomes and measures: </strong>The primary measured outcome was degree of consensus for various DIF testing practice, including DIF testing triage by histopathology/dermatopathology findings and DIF testing panel tailored truncations by clinical indication.</p><p><strong>Results: </strong>A total of 23 respondents to the survey invitation had a mean (SD) of 18.5 (11.1) years and median (range) of 20.0 (1.5-46.0) years in immunodermatology laboratory practice. Consensus was achieved for 46 of 54 statements (85.2%) in the initial survey and for an additional 4 statements in the second survey (50 of 54 [92.6%]). Strong consensus was found against tailored truncation of DIF panel based on the clinical indication in the first survey round. The general acceptability of triaging specimens for DIF testing based on histopathology findings remained without consensus after both surveys.</p><p><strong>Conclusions and relevance: </strong>Overall, participating US specialists in immunodermatology laboratory testing agreed on many practical aspects of DIF testing, including matters not queried previously. The findings also revealed areas of continued controversy and identified issues for prioritized future study.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tripe Palms.","authors":"Pedro Simões Farinha, Margarida Brito Caldeira, João Oliveira Torres","doi":"10.1001/jamadermatol.2025.0195","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0195","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}