JAMA dermatology最新文献

{"title":"Neighborhood Socioeconomic Status and New Hidradenitis Suppurativa Diagnoses in a Single Health System.","authors":"Aileen Y Chang, Maria Elena Sanchez-Anguiano, Krittin Supapannachart, Erin H Amerson, Haley B Naik, Stephen Shiboski, Mindy C Derouen, Jinoos Yazdany","doi":"10.1001/jamadermatol.2025.1190","DOIUrl":"10.1001/jamadermatol.2025.1190","url":null,"abstract":"<p><strong>Importance: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition. Risk factors for developing HS (eg smoking and obesity) are influenced by social drivers of health at the neighborhood level. However, the association of neighborhood-level socioeconomic status (nSES) and HS has not been adequately assessed.</p><p><strong>Objective: </strong>To evaluate the association of nSES with new HS diagnoses among dermatology patients within a single health system.</p><p><strong>Design, setting, and participants: </strong>This was a cross-sectional study of patients of the dermatology clinics at the University of California San Francisco health system between August 1, 2019, and May 31, 2024, who were also residents of the San Francisco Bay Area at index visit. Data analyses were performed from June 1, 2024, to February 11, 2025.</p><p><strong>Exposure: </strong>Census tract-level index measure of nSES that incorporated income, poverty, housing cost, rental cost, education, occupation, and employment. Quintiles of nSES were assigned based on nSES distribution in the San Francisco Bay Area counties.</p><p><strong>Main outcomes and measures: </strong>A new HS diagnosis during the study period, identified by the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision code, and confirmed by medical record review. Logistic regression models were constructed and fit by generalized estimating equations accounting for clustering by census tract with nSES quintile as the primary exposure (reference used was quintile 5, the highest nSES quintile); new HS diagnosis as the binary outcome; and age, sex, and race and ethnicity as confounders. In secondary analyses, smoking status, obesity, and health insurance type were assessed as possible mediators.</p><p><strong>Results: </strong>The analyses included a total of 65 766 patients (mean [SD] age, 50.4 [18.3] years; 41.8% female), of whom 485 (0.7%) had a new HS diagnosis. Greater odds of a new HS diagnosis were observed in lower-SES neighborhoods (Q1-Q4)-after adjusting for age, sex, and race and ethnicity, odds ratio for Q1 was 3.32 (95% CI, 2.46-4.49); Q2, 2.25 (95% CI, 1.62-3.12); Q3, 1.97 (95% CI, 1.46-2.66); and Q4, 1.44 (95% CI, 1.06-1.96) (P <.001 [linear trend]). In race-stratified analyses, greater odds of a new HS diagnosis were observed among patients residing in lower-SES neighborhoods, although this pattern did not reach statistical significance at the 5% level in all racial and ethnic groups.</p><p><strong>Conclusions and relevance: </strong>This cross-sectional study found that nSES was independently associated with a new diagnosis of HS among dermatology patients. This finding supports the hypothesis that neighborhood-level factors may influence the development of HS.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hutchinson-Gilford Progeria Syndrome.","authors":"Yu-Ting Tsai, Yi-Chien Yang","doi":"10.1001/jamadermatol.2025.0793","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0793","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Histopathologic, and Molecular Features and Treatment of Multiple Xanthogranuloma in Adults.","authors":"Elissa Annabi, Thibault Mahévas, François Chasset, Julien Haroche, Didier Bessis, Nicolas Dupin, Camille Hua, Nicolas Kluger, Abdellatif Tazi, Marie Jachiet, Adèle de Masson, Jean-François Emile, Fanélie Jouenne, Baptiste Louveau, Pierre Sohier, Samia Mourah, Maxime Battistella, Jean-David Bouaziz","doi":"10.1001/jamadermatol.2025.0886","DOIUrl":"10.1001/jamadermatol.2025.0886","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidradenitis Suppurativa Unroofing Procedure Costs in the Context of Medical Inflation.","authors":"Zachary Ruffolo, Ashwath J Sampath, Allison Locy, Peter A Khoury, Austin Cohrs, Matthew Helm, Galen Foulke","doi":"10.1001/jamadermatol.2025.0819","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0819","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining Mucocutaneous Crohn Disease.","authors":"Julie Y Ramseier, Amar R Deshpande, Anna Haemel","doi":"10.1001/jamadermatol.2025.1114","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.1114","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roflumilast Foam, 0.3%, for Psoriasis of the Scalp and Body: The ARRECTOR Phase 3 Randomized Clinical Trial.","authors":"Melinda J Gooderham, Javier Alonso-Llamazares, Jerry Bagel, Neal Bhatia, Michael Bukhalo, Janet DuBois, Laura K Ferris, Lawrence Green, Leon H Kircik, Benjamin Lockshin, Wei Jing Loo, Kim A Papp, Jennifer Soung, Melissa S Seal, Scott Snyder, Saori Kato, David Krupa, Patrick Burnett, David R Berk, David H Chu","doi":"10.1001/jamadermatol.2025.1136","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.1136","url":null,"abstract":"<p><strong>Importance: </strong>Current topical treatments for scalp psoriasis are limited by formulation, efficacy, and/or safety.</p><p><strong>Objective: </strong>To assess safety and efficacy of roflumilast foam, 0.3%, in patients with psoriasis of the scalp and body.</p><p><strong>Design, setting, and participants: </strong>This was a phase 3 double-blinded, vehicle-controlled randomized clinical trial conducted between August 24, 2021, and June 3, 2022, at 49 sites in Canada and the US. Eligible participants were 12 years and older with plaque psoriasis affecting up to 25% of the scalp and body, at least 10% of the scalp, and up to 20% of nonscalp areas, with a minimum Scalp-Investigator Global Assessment (S-IGA) score of 3 (moderate), and minimum Body-IGA (B-IGA) score of 2 (mild). Data analyses were performed from September 9 to December 30, 2022.</p><p><strong>Interventions: </strong>Once-daily roflumilast foam, 0.3%, or vehicle for 8 weeks.</p><p><strong>Main outcomes and measures: </strong>Coprimary end points were S-IGA and B-IGA success (clear [0] or almost clear [1] plus ≥2-grade improvement) at week 8. Secondary end points included S-IGA success at weeks 2 and 4, change in Scalp Itch-Numeric Rating Scale (SI-NRS), and SI-NRS and Worst Itch-NRS (WI-NRS) success (≥4-point improvement in patients with baseline score of ≥4). Safety and tolerability were also assessed.</p><p><strong>Results: </strong>A total of 432 patients (mean [SD] age, 47.3 [14.8] years; 243 women [56.3%]) were randomized to roflumilast foam (n = 281) or vehicle (n = 151). At week 8, 66.4% of the roflumilast group achieved S-IGA success vs 27.8% of the vehicle group (P < .001); and 45.5% of the roflumilast group achieved B-IGA success compared with 20.1% of the vehicle group (P < .001). Rates for S-IGA success at week 2 and SI-NRS and WI-NRS success at weeks 2, 4, and 8 were significantly higher for roflumilast vs vehicle. Improvements in SI-NRS were greater for the roflumilast vs the vehicle group as early as the first assessment (24 hours after the first application). Both study groups had low rates of adverse events and favorable tolerability profiles.</p><p><strong>Conclusions and relevance: </strong>This randomized clinical trial found that roflumilast foam, 0.3%, improved signs and symptoms of psoriasis on the scalp and body, including pruritus, with low rates of adverse events in patients 12 years and older. These results demonstrate the potential of roflumilast foam, 0.3%, as monotherapy for patients with psoriasis of the scalp and body.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05028582.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi Panel for the Development of Diagnostic Criteria for Metastatic Cutaneous Crohn Disease: A Consensus Statement.","authors":"Joseph Ebriani, Karla Santiago-Soltero, Ellen E Anshelevich, Rahul S Dalal, Bridget Shields, Alexandra Charrow, Manasi Agrawal, Afsaneh Alavi, Susan Burgin, Ahuva Cices, Alexandra J Coromilas, Edward W Cowen, Noah Goldfarb, Jennifer L Hsiao, Jean S McGee, Alex G Ortega-Loayza, Martina Porter, Misha Rosenbach, Katharina S Shaw, Karolyn A Wanat, Alice J Watson, Serre-Yu Wong","doi":"10.1001/jamadermatol.2025.1115","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.1115","url":null,"abstract":"<p><strong>Importance: </strong>Metastatic cutaneous Crohn disease (MCD) is a rare condition for which there are currently no published diagnostic criteria. Formal MCD diagnostic criteria will expand clinical care and research by enabling future diagnostic code validation, crystallizing a more uniform disease entity for the purposes of translational research, and allowing the development of more formalized outcome measures aimed at treatment response.</p><p><strong>Objective: </strong>To define a set of criteria for the diagnosis of MCD.</p><p><strong>Evidence review: </strong>In this consensus statement, a panel of experts on MCD and related conditions was assembled. Their opinions were gathered regarding the clinical and histologic findings that are sufficient, necessary, and highly suggestive of MCD through serial survey. Subsequent surveys were continued until consensus was achieved. Sufficient was defined as a feature that, if noted, would enable diagnosis of MCD without any other signs, symptoms, or testing. Necessary was defined as a feature that must be present to establish a diagnosis of MCD. Highly suggestive referred to any other features that were indicative of MCD but did not qualify as sufficient or necessary to diagnose MCD.</p><p><strong>Findings: </strong>Of 24 experts invited, 19 agreed to participate, with a 79% to 100% response rate across 5 rounds conducted. Five patients were also invited to participate, but none opted to participate, citing lack of clinical expertise and time concerns. The experts were all from the US; 5 (26%) have practiced medicine for 0 to 5 years, 5 (26%) practiced for 6 to 10 years, 6 (32%) practiced for 11 to 15 years, and 3 (16%) practiced for more than 20 years. A total of 18 experts (95%) worked in an academic practice setting. There was consensus agreement that MCD could present as oral disease, genital disease, or, rarely, in another location. Consensus was achieved on 2 major and 5 minor criteria for genital/other subtypes of MCD and 5 minor criteria for oral MCD. There was consensus that, while there are some pathological findings that are highly suggestive of MCD, histologic criteria are not necessary for diagnosis.</p><p><strong>Conclusions and relevance: </strong>A panel of experts reached consensus on the diagnostic criteria for MCD described in this study. These criteria include major and minor clinical criteria, along with histopathological criteria for the diagnosis of genital and oral MCD. This consensus is a crucial step in the diagnosis of and future treatment development for MCD, a rare and clinically understudied condition.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indurated Red Nodules and Plaques on the Thigh of a Female Patient.","authors":"Sara Saldarriaga Santamaría, Lauren Yi, Sarah Gradecki","doi":"10.1001/jamadermatol.2025.1084","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.1084","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Synovitis, Acne, Pustulosis, Hyperstosis, and Osteitis Syndrome With Abrocitinib.","authors":"Dawei Huang, Yujing Zhao, Yuling Shi, Xuemei Yi","doi":"10.1001/jamadermatol.2025.1010","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.1010","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Isolated Red Plaque on the Anterior Chest.","authors":"Bin Peng, Xiaojuan Nan, Songmei Geng","doi":"10.1001/jamadermatol.2025.0745","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.0745","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}