JAMA dermatology最新文献

{"title":"Error in Author Byline.","authors":"","doi":"10.1001/jamadermatol.2025.3992","DOIUrl":"10.1001/jamadermatol.2025.3992","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annular Cutaneous Lesion of the Neck.","authors":"Yi-Xiao Wang, Min Gao, Li-Xiong Gu","doi":"10.1001/jamadermatol.2025.2592","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.2592","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Opportunities for AI in Dermatology Residency.","authors":"Lia E Gracey, Vinod E Nambudiri, Veronica Rotemberg, Andrea D Maderal","doi":"10.1001/jamadermatol.2025.3366","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3366","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sunburn and Cutaneous Squamous Cell Carcinoma: A Meta-Analysis.","authors":"Isaac Weber, Kaiping Liao, Tran Dang, Malay Shah, Mackenzie R Wehner","doi":"10.1001/jamadermatol.2025.3473","DOIUrl":"10.1001/jamadermatol.2025.3473","url":null,"abstract":"<p><strong>Importance: </strong>While UV radiation is a known carcinogen associated with cutaneous squamous cell carcinoma (cSCC), sunburn's specific role remains less clear.</p><p><strong>Objective: </strong>To quantitatively assess the association between sunburn history and the risk of developing cSCC.</p><p><strong>Data sources: </strong>A comprehensive search of Embase, PubMed, and Cochrane Library (CENTRAL) was conducted from inception up to May 6, 2025, with no language or date restrictions. Search terms included Non melanoma skin cancer or nonmelanoma skin cancer or NMSC or squamous cell carcinoma or SCC or cSCC or Bowen disease and Sunburn or sun exposure or sunlight or sun damage or ultraviolet radiation or ultraviolet light or ultraviolet rays.</p><p><strong>Study selection: </strong>The study included analytical investigations of the general population that assessed the association between cSCC and any type of sunburn history at any age. The initial screening of 9310 titles and abstracts by 3 masked independent reviewers resulted in 279 articles for full-text review, with 43 ultimately meeting eligibility criteria.</p><p><strong>Data extraction and synthesis: </strong>This study follows the Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guideline. Two reviewers worked independently to extract relevant data. The random effects DerSimonian-Laird method was used to pool data.</p><p><strong>Main outcome and measures: </strong>The main outcome was the risk of developing cSCC. Main measures included sunburn frequency (both undefined and painful, blistering, and/or severe) in any life period, categorized into ordinal variables: none, low, medium, and high. The primary analysis was the most adjusted measure of association, standardized to odds ratio (OR). This incorporated adjusted measures of association when available and unadjusted measures when adjusted measures were absent.</p><p><strong>Results: </strong>Seventeen studies with a combined 321 473 participants were included in the meta-analysis. Pooled analyses of the most adjusted results revealed significantly increased odds of developing cSCC with medium (OR, 1.51; 95% CI, 1.26-1.81) and high (OR, 1.69; 95% CI, 1.39-2.06) lifetime painful, blistering, and/or severe sunburn frequencies. Similarly, high frequencies of painful, blistering, and/or severe sunburns in childhood were significantly associated with increased cSCC odds (OR, 3.11; 95% CI, 1.26-7.66). A history of any painful, blistering, and/or severe sunburn was also significantly associated with increased odds of cSCC (OR, 1.38; 95% CI, 1.06-1.79).</p><p><strong>Conclusions and relevance: </strong>This meta-analysis supports an association between painful, blistering, and/or severe sunburns and cSCC.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prices and Spending for Phosphodiesterase 4 Inhibitors in Pulmonary and Dermatologic Disease.","authors":"Nikhita J Perry, John S Barbieri, Benjamin N Rome","doi":"10.1001/jamadermatol.2025.3289","DOIUrl":"10.1001/jamadermatol.2025.3289","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean Diet and Patients With Psoriasis: The MEDIPSO Randomized Clinical Trial.","authors":"Javier Perez-Bootello, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Leticia Goni, Zenaida Vazquez-Ruiz, Fernando Neria, Ruth Cova-Martin, Jorge Naharro-Rodriguez, Asuncion Ballester-Martinez, Cristina Pindado-Ortega, Diana Monge, Andrew Blauvelt, Pedro Jaen, Nehal Mehta, Joel M Gelfand, Miguel A Martinez-Gonzalez, Álvaro Gonzalez-Cantero","doi":"10.1001/jamadermatol.2025.3410","DOIUrl":"10.1001/jamadermatol.2025.3410","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Despite growing interest on the role of diet in the prevention and treatment of psoriasis, randomized clinical trials are lacking. The Mediterranean diet is known for its anti-inflammatory and cardiometabolic benefits, which may be relevant to psoriasis pathophysiology.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To assess whether a 16-week Mediterranean diet intervention would improve psoriasis severity in patients with mild to moderate disease.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;MEDIPSO (Impact of the Mediterranean Diet on Patients With Psoriasis), an open-label, single-center, single-blinded (evaluator) randomized clinical trial, was conducted from February 2024 to March 2025 at a dermatology referral clinic in Madrid, Spain. Participants were adults with mild to moderate psoriasis (Psoriasis Area and Severity Index [PASI] of 2-10, with higher scores indicating maximal disease) receiving stable topical therapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Interventions: &lt;/strong&gt;Participants were randomized 1:1 to the intervention or control group. The intervention group received a 16-week, dietitian-guided Mediterranean diet program, including nutritional counseling, educational materials, and weekly provision of extra virgin olive oil. The control group received standard low-fat dietary advice without dietitian supervision.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The primary outcome was the change in the PASI from baseline to week 16. Secondary outcomes included changes in Mediterranean diet adherence, anthropometric and metabolic parameters, serum inflammatory cytokines, and patient-reported outcomes. Estimated marginal means (EMMs) at baseline and for the change from baseline to week 16 were reported, with the intervention effect presented as the between-group difference.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 45 individuals screened, 38 participants were enrolled and randomized (mean [SD] age, 46.4 [12.8] years; 25 males [65.8%]); 19 were randomized to the intervention group and 19 were randomized to the control group; 37 individuals (97.4%) completed the study. The EMM PASI change at week 16 was -3.4 (95% CI, -4.4 to -2.4) in the intervention group and 0.0 (95% CI, -1.0 to 1.0) in the control group; the between-group EMM difference was -3.4 (95% CI, -4.8 to -2.0; P &lt; .001). Nine of 19 participants in the Mediterranean diet group (47.4%) achieved PASI 75 (a 75% reduction in PASI) compared with none in the control group. A significant reduction in EMM hemoglobin A1c (glycated hemoglobin) was observed in the intervention group as compared with the control group (between-group EMM difference, -4.1 mmol/mol [95% CI, -6.9 to -1.3 mmol/mol]; P = .01).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;This randomized clinical trial found that a 16-week Mediterranean diet intervention significantly improved psoriasis severity in patients with mild to moderate disease receiving stable topical therapy. These findings suggest","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sunburns and Cutaneous Squamous Cell Carcinoma.","authors":"Adewole S Adamson, Howa Yeung","doi":"10.1001/jamadermatol.2025.3479","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3479","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous Tinea Manuum.","authors":"Vicente Peris-Espino, Eugeni Prat-Colilles, Isabel Bielsa Marsol","doi":"10.1001/jamadermatol.2025.3261","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3261","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective Assessment of Target Vitiligo Areas by Semiautomatic Analysis of Standardized UV Images.","authors":"Charles Jabour, Arnaud Bletterer, Thierry Passeron","doi":"10.1001/jamadermatol.2025.2740","DOIUrl":"10.1001/jamadermatol.2025.2740","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;The Target Vitiligo Area Scoring Index (Target-VASI) is the primary tool for evaluating localized vitiligo lesions; however, its uncalibrated estimation in clinical practice is limited by intrarater and interrater variability. While objective methods using tracing papers or imaging systems are available, these approaches are often tedious and rely on images that are not well contrasted.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To assess the reliability and the performance of a semiautomatic analysis of the lesions performed on standardized UV reflectance pictures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This validation study was part of a prospective, double-blind, randomized, placebo-controlled clinical trial conducted between September 2023 and February 2024 at a tertiary care center to evaluate a grafting-based therapy in difficult-to-treat vitiligo lesions. Participants included adult patients with a pair of stable vitiligo target lesions with surface areas between 2 cm2 and 20 cm2. Target-VASI was measured prior to treatment and 12 weeks after treatment by using 3 methods: the image-based system (UV image Target-VASI), tracing paper outlines (tracing paper Target-VASI), and assessments by an experienced clinician (clinician Target-VASI). The image-based system involved semiautomatic analysis of standardized UV reflectance images.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The Target-VASI estimation methods were compared for correlation, agreement, and repeatability, with relationships scored as weak, moderate, good/strong, and very good/very strong based on results.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 20 adult patients with a pair of stable vitiligo target lesions of surface area between 2 cm2 and 20 cm2 were enrolled. One was lost to follow-up, resulting in 19 evaluable participants included for the analysis. The mean (SD) age was 51.7 (10.7) years, and 12 (63.8%) were female. The mean (SD) vitiligo duration was 21.2 (14.4) years. A total of 61 tracing paper Target-VASIs and 76 UV image and clinician Target-VASIs were available for analysis. UV image Target-VASIs demonstrated strong correlations with tracing paper (r = 0.81 [95% CI, 0.71-0.89]; P &lt; .001) and clinician (r = 0.89 [95% CI, 0.83-0.93]; P &lt; .001) Target-VASIs. The agreement was also good, with mean (SD) biases of 0.81 (0.99) and 0.52 (0.76) for tracing paper and clinician Target-VASIs, respectively. Additionally, an intraclass correlation coefficient of 0.79 (95% CI, 0.60-0.88) indicated moderate to good reproducibility of Target-VASI measurements. Although errors, such as nonmatching lesion regions and oversegmented pigmentation, were identified, the overall UV image Target-VASI accuracy was largely maintained due to the precise detection of depigmented areas.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;In this investigation, the image-based system demonstrated reliable performance, suggesting its possible use in s","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide for Skin Cancer Chemoprevention.","authors":"Sarah T Arron","doi":"10.1001/jamadermatol.2025.3237","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.3237","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}