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Nanorod-Shaped Basic Al2O3 Catalyzed N,N-Diformylation of Bisuracil Derivatives: A Greener "NOSE" Approach. 纳米棒状碱性氧化铝催化双尿嘧啶衍生物的N,N-二甲酰化:一种更环保的“鼻子”方法。
ISRN Organic Chemistry Pub Date : 2013-06-26 eCollection Date: 2013-01-01 DOI: 10.1155/2013/793159
Vijay K Das, Ashim J Thakur
{"title":"Nanorod-Shaped Basic Al2O3 Catalyzed N,N-Diformylation of Bisuracil Derivatives: A Greener \"NOSE\" Approach.","authors":"Vijay K Das,&nbsp;Ashim J Thakur","doi":"10.1155/2013/793159","DOIUrl":"https://doi.org/10.1155/2013/793159","url":null,"abstract":"<p><p>A feasible \"NOSE\" (nanoparticles-catalyzed organic synthesis enhancement) protocol has been developed for N,N-diformylation of bisuracil derivatives using nano-Al2O3 rods as an efficient, inexpensive, and recyclable catalyst under solvent-free reaction condition at 40°C. The catalyst was reused up to the 4th cycle without affecting the rate and yield of the N,N-diformylation products appreciably. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2013 ","pages":"793159"},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/793159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition. 13C同位素作为嗅觉识别振动理论测试的潜力。
ISRN Organic Chemistry Pub Date : 2013-05-26 eCollection Date: 2013-01-01 DOI: 10.1155/2013/515810
Karel D Klika
{"title":"The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition.","authors":"Karel D Klika","doi":"10.1155/2013/515810","DOIUrl":"https://doi.org/10.1155/2013/515810","url":null,"abstract":"<p><p>The continuing debate over the basis of odorant recognition with respect to the molecular shape (\"lock and key\") theory versus the vibrational theory could potentially be resolved by the testing of (13)C-labeled odorants. The application of (13)C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (ΔG) for acetophenone and octan-1-ol, two odorants for which the (2)D (deuterium) isotopomers have previously been shown to be discernible from their respective (1)H (normal) counterparts by Drosophila melanogaster. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2013 ","pages":"515810"},"PeriodicalIF":0.0,"publicationDate":"2013-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/515810","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and evaluation of anticancer activity. 二氧化硅负载周期酸催化剂合成2-芳基苯并咪唑及其抗癌活性评价。
ISRN Organic Chemistry Pub Date : 2013-04-24 eCollection Date: 2013-01-01 DOI: 10.1155/2013/453682
Vyankat A Sontakke, Sougata Ghosh, Pravin P Lawande, Balu A Chopade, Vaishali S Shinde
{"title":"A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and evaluation of anticancer activity.","authors":"Vyankat A Sontakke,&nbsp;Sougata Ghosh,&nbsp;Pravin P Lawande,&nbsp;Balu A Chopade,&nbsp;Vaishali S Shinde","doi":"10.1155/2013/453682","DOIUrl":"https://doi.org/10.1155/2013/453682","url":null,"abstract":"<p><p>A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2013 ","pages":"453682"},"PeriodicalIF":0.0,"publicationDate":"2013-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/453682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Synthesis, Characterization, and BSA Binding Studies of Some New Benzamides Related to Schiff Base. 席夫碱类苯并胺类化合物的合成、表征及与BSA的结合研究。
ISRN Organic Chemistry Pub Date : 2013-04-07 eCollection Date: 2013-01-01 DOI: 10.1155/2013/791591
M K Prashanth, M Madaiah, H D Revanasiddappa, K N Amruthesh
{"title":"Synthesis, Characterization, and BSA Binding Studies of Some New Benzamides Related to Schiff Base.","authors":"M K Prashanth,&nbsp;M Madaiah,&nbsp;H D Revanasiddappa,&nbsp;K N Amruthesh","doi":"10.1155/2013/791591","DOIUrl":"10.1155/2013/791591","url":null,"abstract":"<p><p>Condensation of amine 1 with aldehyde 2 gives Schiff base, N-(4-((benzofuran-2-ylmethylene) amino)phenyl)acetamide 3. Schiff base on N-acylation with different substituted acid chlorides in the presence of triethylamine gives the corresponding benzamides, N-acetyl-N-(4-((benzofuran-2-ylmethylene)amino)phenyl)substitutedbenzamide (NABP) 5a-j. The structures of newly synthesized compounds were characterized by elemental analysis, (1)H NMR, (13)C NMR FT-IR, and mass spectral studies. Compounds 3 and 5a-j have been screened for their antimicrobial activity using the disc diffusion and minimum inhibitory concentration (MIC) method against the selected bacterial and fungal strain. Compounds 5a, 5e, 5g, and 5h were found to be more active against all tested strains. The antioxidant properties were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radical scavenging methods. Compounds 5i and 5j showed predominant antioxidant activities among the synthesized analogues. The interaction between NABP and bovine serum albumin (BSA) was investigated using fluorescence and ultraviolet spectroscopic techniques at 298 K under imitated physiological conditions. The results revealed that NABP caused the fluorescence quenching of BSA through a static quenching procedure. The binding constants and the number of binding sites were calculated. The binding distance between the donor (BSA) and acceptor (NABP) was determined based on Forster's theory. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2013 ","pages":"791591"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/791591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Noncovalent functionalization of graphene in suspension. 悬浮液中石墨烯的非共价功能化。
ISRN Organic Chemistry Pub Date : 2013-03-28 eCollection Date: 2013-01-01 DOI: 10.1155/2013/656185
Wenzhi Yang, Sultan Akhtar, Klaus Leifer, Helena Grennberg
{"title":"Noncovalent functionalization of graphene in suspension.","authors":"Wenzhi Yang,&nbsp;Sultan Akhtar,&nbsp;Klaus Leifer,&nbsp;Helena Grennberg","doi":"10.1155/2013/656185","DOIUrl":"https://doi.org/10.1155/2013/656185","url":null,"abstract":"<p><p>Suspensions of graphene, prepared from graphite foil by sonochemical exfoliation, have been treated with new nonpolar pyrenebutyric amides. The assemblies, in suspension and after deposition on solid supports, were characterized by NMR, absorption, and fluorescence spectroscopy and by transmission electron microscopy, where the well-defined shape and size of an appended [60]fulleropyrrolidine unit facilitates TEM detection of the nonstationary molecules. The accumulated evidence, also including direct comparisons of carbon nanotubes treated with pyrene amides under the same conditions, proves the successful noncovalent functionalization of graphene suspended in non-polar solvent with non-polar pyrene derivatives. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2013 ","pages":"656185"},"PeriodicalIF":0.0,"publicationDate":"2013-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/656185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
DABCO Catalyzed Synthesis of Xanthene Derivatives in Aqueous Media. DABCO 在水介质中催化合成呫吨衍生物。
ISRN Organic Chemistry Pub Date : 2013-03-18 eCollection Date: 2013-01-01 DOI: 10.1155/2013/526173
Pradeep Paliwal, Srinivasa Rao Jetti, Anjna Bhatewara, Tanuja Kadre, Shubha Jain
{"title":"DABCO Catalyzed Synthesis of Xanthene Derivatives in Aqueous Media.","authors":"Pradeep Paliwal, Srinivasa Rao Jetti, Anjna Bhatewara, Tanuja Kadre, Shubha Jain","doi":"10.1155/2013/526173","DOIUrl":"10.1155/2013/526173","url":null,"abstract":"<p><p>The reaction of 5,5-dimethylcyclohexane-1,3-dione with various heteroarylaldehydes afforded the corresponding heteroaryl substituted xanthene derivatives 1(a-f). The reaction proceeds via the initial Knoevenagel, subsequent Michael, and final heterocyclization reactions using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a catalyst in aqueous media. The synthesized heteroaryl substituted xanthenes 1(a-f) reacted with malononitrile to obtain different alkylidenes 2(a-f). Short reaction time, environmentally friendly procedure, avoiding of cumbersome apparatus, and excellent yields are the main advantages of this procedure which makes it more economic than the other conventional methods. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2013 ","pages":"526173"},"PeriodicalIF":0.0,"publicationDate":"2013-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and in vitro evaluation of novel acyclic and cyclic nucleoside analogs with a thiadiazole ring. 新型含噻二唑环的无环和环核苷类似物的合成及体外评价。
ISRN Organic Chemistry Pub Date : 2013-03-05 eCollection Date: 2013-01-01 DOI: 10.1155/2013/159164
Yuxiang Zhao, Peter J McCarthy, Cyril Párkányi
{"title":"Synthesis and in vitro evaluation of novel acyclic and cyclic nucleoside analogs with a thiadiazole ring.","authors":"Yuxiang Zhao,&nbsp;Peter J McCarthy,&nbsp;Cyril Párkányi","doi":"10.1155/2013/159164","DOIUrl":"https://doi.org/10.1155/2013/159164","url":null,"abstract":"<p><strong>The synthesis of six thiadiazole nucleoside analogs is reported: </strong>5-diacetylamino-1,2,4-thiadiazol-3-one (1), 5-amino-2- (tetrahydrofuran-2-yl)-1,2,4-thiadiazol-3-one (2), 5-amino-3-[(2'-hydroxyethoxy)methyl]-1,3,4-thiadiazol-2-one (3), 5-amino-3-(4'-hydroxy-2'-hydroxymethyl-butyl)-1,3,4-thiadiazole-2-thione (4), (R)-5-amino-3-(2',3'-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (5), and (S)-5-amino-3-(2',3'-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (6). The synthesis, characterization, and properties of these new synthesized thiadiazole derivatives are discussed. A dimerization of 5-amino-3H-1,3,4-thiadiazole-2-thione (14) by sodium nitrite resulting in di-(5-amino-1,3,4-thiadiazol-2-yl) disulfide (19) is also reported. The preliminary in vitro evaluation of these newly synthesized compounds is discussed.</p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2013 ","pages":"159164"},"PeriodicalIF":0.0,"publicationDate":"2013-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/159164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis of Azidohydrin from Hura crepitans Seed Oil: A Renewable Resource for Oleochemical Industry and Sustainable Development. 胡拉籽油合成叠氮醚:油脂化工的可再生资源及可持续发展。
ISRN Organic Chemistry Pub Date : 2012-11-06 eCollection Date: 2012-01-01 DOI: 10.5402/2012/873046
Adewale Adewuyi, Andrea Göpfert, Thomas Wolff, B V S K Rao, R B N Prasad
{"title":"Synthesis of Azidohydrin from Hura crepitans Seed Oil: A Renewable Resource for Oleochemical Industry and Sustainable Development.","authors":"Adewale Adewuyi,&nbsp;Andrea Göpfert,&nbsp;Thomas Wolff,&nbsp;B V S K Rao,&nbsp;R B N Prasad","doi":"10.5402/2012/873046","DOIUrl":"https://doi.org/10.5402/2012/873046","url":null,"abstract":"<p><p>The replacement of petrochemicals by oleochemical feedstocks in many industrial and domestic applications has resulted in an increase in demand for biobased products and as such recognizing and increasing the benefits of using renewable materials. In line with this, the oil extracted from the seed of Hura crepitans was characterized by an iodine value of 120.10 ± 0.70 g Iodine/100 g and a saponification number of 210.10 ± 0.40 mg KOH/g with the dominant fatty acid being C18:2 (52.8 ± 0.10%). The epoxidised fatty acid methyl esters prepared from the oil were used to synthesise the azidohydrin with a yield of 91.20%. The progress of the reaction was monitored and confirmed using FTIR and NMR. This showed the seed oil of Hura crepitans as a renewable resource that can be used to make valuable industrial and domestic products. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2012 ","pages":"873046"},"PeriodicalIF":0.0,"publicationDate":"2012-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/873046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Facile Iodine-Catalyzed Michael Addition of Indoles to α,α'-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones. 易碘催化吲哚与α，α′-双(芳基亚甲基)环戊酮的Michael加成:E-2-(3-吲哚苯基甲基)-5-苯基亚甲基环戊酮的高效合成
ISRN Organic Chemistry Pub Date : 2012-11-05 eCollection Date: 2012-01-01 DOI: 10.5402/2012/674629
Rammohan Pal, Arpita Das Gupta, Asok K Mallik
{"title":"Facile Iodine-Catalyzed Michael Addition of Indoles to α,α'-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones.","authors":"Rammohan Pal,&nbsp;Arpita Das Gupta,&nbsp;Asok K Mallik","doi":"10.5402/2012/674629","DOIUrl":"https://doi.org/10.5402/2012/674629","url":null,"abstract":"<p><p>Iodine-catalyzed reaction of indoles with α,α'-bis(arylmethylene)cyclopentanones afforded one diastereomer of the corresponding Michael adducts, namely, E-2-(3-indolylphenylmethyl)-5-phenylmethylenecyclopentanones, in a good yield. The products form a new group of indole derivatives. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2012 ","pages":"674629"},"PeriodicalIF":0.0,"publicationDate":"2012-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/674629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Langmuir-blodgett films of supported polyester dendrimers. 支撑聚酯树枝状聚合物的 Langmuir-blodgett 薄膜。
ISRN Organic Chemistry Pub Date : 2012-10-16 eCollection Date: 2012-01-01 DOI: 10.5402/2012/906839
Rocío Redón, M Pilar Carreón-Castro, F J Mendoza-Martínez
{"title":"Langmuir-blodgett films of supported polyester dendrimers.","authors":"Rocío Redón, M Pilar Carreón-Castro, F J Mendoza-Martínez","doi":"10.5402/2012/906839","DOIUrl":"10.5402/2012/906839","url":null,"abstract":"<p><p>Amphiphiles with a dendritic structure are attractive materials as they combine the features of dendrimers with the self-assembling properties and interfacial behavior of water-air affinities. We have synthesized three generations of polyester dendrimers and studied their interfacial properties on the Langmuir films. The behavior obtained was, as a rule, the lowest generation dendrimers behaving like traditional amphiphiles and the larger molecules presenting complicated isotherms. The Langmuir films of these compounds have been characterized by their surface pressure versus molecular area (π/A) and Brewster angle microscopy (BAM) observations. </p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2012 ","pages":"906839"},"PeriodicalIF":0.0,"publicationDate":"2012-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31747199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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