ISRN Organic Chemistry最新文献

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Synthesis, physiochemical properties, photochemical probe, and antimicrobial effects of novel norfloxacin analogues. 新型诺氟沙星类似物的合成、理化性质、光化学探针及抗菌作用。
ISRN Organic Chemistry Pub Date : 2011-03-06 eCollection Date: 2011-01-01 DOI: 10.5402/2011/184754
Dina A Bakhotmah, Reda M Abdul-Rahman, Mohammad S Makki, Mohamed A El-Zahabi, Mansor Suliman
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引用次数: 3
A Study of Solvent Effects in the Solvolysis of Propargyl Chloroformate. 氯甲酸丙炔溶剂分解的溶剂效应研究。
ISRN Organic Chemistry Pub Date : 2011-01-01 DOI: 10.5402/2011/767141
Malcolm J D'Souza, Anthony M Darrington, Dennis N Kevill
{"title":"A Study of Solvent Effects in the Solvolysis of Propargyl Chloroformate.","authors":"Malcolm J D'Souza,&nbsp;Anthony M Darrington,&nbsp;Dennis N Kevill","doi":"10.5402/2011/767141","DOIUrl":"https://doi.org/10.5402/2011/767141","url":null,"abstract":"<p><p>The specific rates of solvolysis of propargyl chloroformate (1) are analyzed in 22 solvents of widely varying nucleophilicity and ionizing power values at 25.0 °C using the extended Grunwald-Winstein equation. Sensitivities to solvent nucleophilicity (l) of 1.37 and to solvent ionizing power (m) of 0.47 suggest a bimolecular process with the formation of a tetrahedral intermediate. A plot of the rates of solvolysis of 1 against those previously reported for phenyl chloroformate (2) results in a correlation coefficient (R) of 0.996, a slope of 0.86, and an F-test value of 2161. The unequivocal correlation between these two substrates attest that the stepwise association-dissociation (A(N) + D(N)) mechanism previously proposed for 2 is also operative in 1.</p>","PeriodicalId":14730,"journal":{"name":"ISRN Organic Chemistry","volume":"2011 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/767141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30232711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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