JACC. Heart failure最新文献

{"title":"Further Refining the In-Hospital Risk Assessment of Patients Presenting With Uncomplicated Acute Myocarditis","authors":"Enrico Ammirati MD, PhD , Leslie T. Cooper Jr. MD","doi":"10.1016/j.jchf.2025.04.001","DOIUrl":"10.1016/j.jchf.2025.04.001","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 8","pages":"Article 102468"},"PeriodicalIF":10.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcoholic Cardiomyopathy–Attributed Mortality in the United States, 2010 to 2020","authors":"Marco Zuin MD, MS , Karola Jering MD , Bridget McGonagle BS , Alyssa Sato BA , Claudio Bilato MD, PhD , Gregory Piazza MD, MS","doi":"10.1016/j.jchf.2025.04.006","DOIUrl":"10.1016/j.jchf.2025.04.006","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 7","pages":"Article 102486"},"PeriodicalIF":10.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 Receptor Agonists in Heart Failure With Reduced Ejection Fraction","authors":"João Sérgio Neves MD, PhD , Catarina Vale MD , Ana Rita Leite MD , Adelino Leite-Moreira MD, PhD , Faiez Zannad MD, PhD , Javed Butler MD, MPH, MBA , Milton Packer MD , João Pedro Ferreira MD, PhD","doi":"10.1016/j.jchf.2025.03.035","DOIUrl":"10.1016/j.jchf.2025.03.035","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 7","pages":"Article 102489"},"PeriodicalIF":10.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Assessment of Spot Urinary Sodium as Predictor of Clinical Outcomes in Chronic Heart Failure.","authors":"Miguel Lorenzo, Eduardo Núñez, Rafael de la Espriella, Arturo Carratalá, Enrique Rodríguez, Jose Luis Górriz, Neus Valls, Antoni Bayés-Genís, Juan Sanchis, Julio Núñez","doi":"10.1016/j.jchf.2025.03.028","DOIUrl":"10.1016/j.jchf.2025.03.028","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102467"},"PeriodicalIF":10.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Heart Failure With Preserved Ejection Fraction in Patients Referred for Atrial Fibrillation Ablation.","authors":"Jan Riess, Julius Obergassel, Nils Pohlmann, Moritz Nies, Marc Lemoine, Ilaria My, Bruno Reißmann, Andreas Metzner, Paulus Kirchhof, Andreas Rillig","doi":"10.1016/j.jchf.2025.03.022","DOIUrl":"10.1016/j.jchf.2025.03.022","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102461"},"PeriodicalIF":10.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Gait Speed and Handgrip Strength in Patients With Advanced Systolic Heart Failure.","authors":"Tejus Satish, Nicholas S Hendren, Jennifer Thibodeau, Sarah Godfrey, Melanie Sulistio, Maryjane Farr, Mark H Drazner, W H Wilson Tang, Justin L Grodin","doi":"10.1016/j.jchf.2025.03.024","DOIUrl":"10.1016/j.jchf.2025.03.024","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102463"},"PeriodicalIF":10.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not All Pathogenic Variants Are Equal: How Founder Variants Lead Precision Medicine Journey in Hypertrophic Cardiomyopathy.","authors":"Babken Asatryan, Steven A Muller, Andreas S Barth","doi":"10.1016/j.jchf.2025.03.023","DOIUrl":"10.1016/j.jchf.2025.03.023","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102462"},"PeriodicalIF":10.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-Cause and Cardiovascular Mortality Among U.S. Adults With Preclinical Heart Failure: NHANES 1999-2018.","authors":"Gretell Henriquez-Santos, Ji-Eun Kim, Fang Zhu, Joseph J Shearer, Jungnam Joo, Maryam Hashemian, Véronique L Roger","doi":"10.1016/j.jchf.2025.03.018","DOIUrl":"10.1016/j.jchf.2025.03.018","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102457"},"PeriodicalIF":10.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Diabetic Cardiomyopathy and Treatment Response to AT-001: Insights From the ARISE-HF Study.","authors":"Vanessa Blumer, James L Januzzi, Yuxi Liu, Javed Butler, Justin A Ezekowitz, Riccardo Perfetti, Julio Rosenstock, Stefano Del Prato, W H Wilson Tang, Alessia Urbinati, Faiez Zannad, Gregory D Lewis, Scott D Solomon, Sheila Hedge, Nasrien E Ibrahim, Carolyn S P Lam","doi":"10.1016/j.jchf.2025.02.015","DOIUrl":"10.1016/j.jchf.2025.02.015","url":null,"abstract":"<p><strong>Background: </strong>Diabetic cardiomyopathy (DbCM) is a significant cause of heart failure (HF) in individuals with type 2 diabetes mellitus. Although sex differences are noted in HF patients, it is unclear if such differences exist in those with DbCM and whether sex-based differences affect treatment responses.</p><p><strong>Objectives: </strong>This analysis focuses on sex differences in baseline characteristics of study participants with DbCM at high risk for progression to overt HF and sex-based treatment responses to high-dose AT-001, a novel aldose reductase inhibitor.</p><p><strong>Methods: </strong>The ARISE-HF trial was a Phase 3, randomized, international, placebo-controlled study designed to evaluate the efficacy and safety of AT-001 in study participants with DbCM.</p><p><strong>Results: </strong>Of 691 participants, 348 (50.4%) were women. At baseline, women had higher N-terminal pro-B-type natriuretic peptide concentrations (92 vs 60 ng/L; P < 0.001), lower peak oxygen uptake (13.87 vs 17.59 mL/kg/min; P < 0.001), shorter cardiopulmonary exercise testing durations (8.47 vs 11.05 minutes; P < 0.001), and worse quality of life and health status (Kansas City Cardiomyopathy Questionnaire overall summary score 87.79 vs 92.55; P < 0.001; Physical Activity Scale for the Elderly score 137.87 vs 171.09; P < 0.001) compared with men. Despite these differences, there were no significant sex differences in the efficacy or tolerability of high-dose AT-001 compared with placebo. The placebo-corrected oxygen uptake change was 0.26 for women and 0.27 for men (P = 0.58), and changes from baseline to month 15 in Kansas City Cardiomyopathy Questionnaire and Physical Activity Scale for the Elderly scores showed no significant sex differences (all P > 0.05).</p><p><strong>Conclusions: </strong>Despite baseline differences between women and men with DbCM, the efficacy and safety of high-dose AT-001 are comparable across sexes. These findings highlight the presence of sex-specific characteristics in DbCM and underscore the importance of further research to understand potential sex-specific mechanisms. (Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure Trial [ARISE-HF]; NCT04083339).</p>","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102433"},"PeriodicalIF":10.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralocorticoid Receptor Antagonist Use in Hypertension to Prevent Heart Failure.","authors":"Bertram Pitt, Anand Vaidya","doi":"10.1016/j.jchf.2025.02.021","DOIUrl":"10.1016/j.jchf.2025.02.021","url":null,"abstract":"<p><p>Mineralocorticoid receptor antagonists (MRAs) reduce cardiovascular mortality and heart failure (HF) hospitalizations across the spectrum of HF. Beyond their recognized benefits in patients with established HF, the value of MRA therapy may be undervalued for the prevention of HF in patients with hypertension. Emerging evidence indicates that a substantial proportion of patients considered to have \"idiopathic\" or \"essential\" hypertension have mineralocorticoid receptor overactivation by under-recognized mechanisms (such as, primary aldosteronism pathophysiology, cortisol dysregulation, and ligand-independent activation). The recognition that MRAs may address an operative mechanism of HF pathogenesis, and that implementation of therapy early in the course of hypertension may prevent the incidence of HF, suggests a new strategy to prevent HF that warrants further investigation. This review summarizes new evidence and theories which suggest that increased use of MRAs in hypertension may decrease incident HF by addressing common and under-recognized mechanisms of mineralocorticoid receptor overactivation.</p>","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102452"},"PeriodicalIF":10.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}