JACC. Heart failure最新文献

{"title":"Body Composition and Survival in Patients With Heart Failure","authors":"Dayana D. Mendonça MSc, PhD ,&nbsp;William V.R. da Silva MD ,&nbsp;Gabriela C. Souza MSc, PhD ,&nbsp;Dimitris V. Rados MD, MSc, PhD ,&nbsp;Andreia Biolo MD, MSc, PhD","doi":"10.1016/j.jchf.2025.01.016","DOIUrl":"10.1016/j.jchf.2025.01.016","url":null,"abstract":"<div><h3>Background</h3><div>Body composition is increasingly recognized as an important factor in the prognosis of patients with heart failure (HF). Variations in muscle mass, fat-free mass, and fat mass may influence survival outcomes, but the extent of these associations remains unclear.</div></div><div><h3>Objectives</h3><div>This study aims to evaluate the impact of body composition parameters on survival in patients with HF.</div></div><div><h3>Methods</h3><div>Five databases were searched through January 2024. Eligible papers reported associations between body composition parameters and survival in HF patients. All-cause mortality was the primary outcome. Risk of bias was evaluated using the Newcastle-Ottawa scale. A random-effects model was used to calculate the 95% CI and HR, with heterogeneity assessed using Cochran’s Q and <em>I</em>² tests.</div></div><div><h3>Results</h3><div>The analysis included 39 cohort studies involving 36,176 HF patients, with 21 studies included in the quantitative analysis. Low muscle mass (HR: 1.73 [95% CI: 1.32-2.26]; <em>I</em>² = 47%) (7 studies) was significantly associated with increased all-cause mortality risk. The prognostic significance of low muscle mass remained consistent across sensitivity and subgroup analysis. Elevated fat mass was not associated with a risk of death (pooled adjusted HR: 0.75 [95% CI: 0.26-2.12]; <em>I</em>² = 77%). Higher abdominal fat showed no significant mortality association.</div></div><div><h3>Conclusions</h3><div>The authors found a strong association between body composition parameters and all-cause mortality. Muscular wasting, measured by low muscle mass, was associated with increased mortality, strengthening the role of muscle mass in HF prognosis. In contrast, higher fat mass and abdominal adiposity showed no association. These findings underscore the importance of comprehensive body composition evaluation in HF prognosis. (Association of Body Composition with Overall Survival in Patients with Heart Failure: A Systematic Review and Meta-Analysis; <span><span>CRD42023488040</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 6","pages":"Pages 943-954"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-in-Human Implantable Inferior Vena Cava Sensor for Remote Care in Heart Failure","authors":"Paul R. Kalra MA, MB BChir, MD ,&nbsp;Irakli Gogorishvili MD ,&nbsp;George Khabeishvili MD ,&nbsp;Filip Málek MD, PhD, MBA ,&nbsp;Ondřej Toman PhD, MHA ,&nbsp;Chris Critoph BM, MD ,&nbsp;Andrew S. Flett MBBS, MD, CCDS ,&nbsp;Peter J. Cowburn MD ,&nbsp;Mandeep R. Mehra MD, MSc ,&nbsp;William S. Sheridan PhD ,&nbsp;John R. Britton PhD, MBA ,&nbsp;Teresa Buxo MSc ,&nbsp;Robyn M. Kealy MSc ,&nbsp;Annette Kent PhD ,&nbsp;Barry R. Greene PhD ,&nbsp;Kaushik Guha MD ,&nbsp;Roy S. Gardner MBChB, MD ,&nbsp;Ian Loke MBChB, MD ,&nbsp;Ali Vazir PhD, MBBS ,&nbsp;Jasper J. Brugts MD, PhD, MSc ,&nbsp;Kevin Damman MD, PhD","doi":"10.1016/j.jchf.2025.01.019","DOIUrl":"10.1016/j.jchf.2025.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Variations of inferior vena cava (IVC) area and collapsibility serve as early markers of congestion and predict risk for heart failure (HF) events.</div></div><div><h3>Objectives</h3><div>The aim of this first-in-human study (FUTURE-HF [First in Human Clinical Investigation of the FIRE1 System in Heart Failure Patients]) was to evaluate the safety and feasibility of a novel implantable IVC sensor for remote management in patients with HF. This paper is the final report on primary (3-month) and exploratory (6-month) endpoints.</div></div><div><h3>Methods</h3><div>Patients with HF hospitalizations within the previous year, with elevated natriuretic peptide levels, and on optimal HF treatment were included. The primary safety endpoints were procedural success without device- or procedure-related complications at 3 months. The primary technical endpoint was signal acquisition following implantation and at a clinic visit within 3 months. Sensor-derived IVC area was compared with computed tomography (CT)–based IVC dimensions. Patient adherence to daily readings and exploratory clinical findings at 6 months were assessed.</div></div><div><h3>Results</h3><div>Fifty patients underwent successful implantation (mean age 65 ± 9 years, 14% women, 72% in NYHA functional class III), with 49 contributing to the primary safety and technical endpoints at 3 months. Sensor-derived IVC area demonstrated excellent agreement with CT measurement (mean absolute error 13.53 mm² [3.55%] <em>R</em>² = 0.98). Median adherence was 96% at 6-month follow-up. Exploratory analyses of clinical outcomes suggested improvements in N-terminal pro–B-type natriuretic peptide, NYHA functional class, and quality of life and reduced HF events.</div></div><div><h3>Conclusions</h3><div>This first-in-human experience demonstrated that the implantation of an IVC sensor was safe and feasible. Sensor-derived IVC area demonstrated excellent correlation with CT-derived IVC area, and exploratory clinical outcomes suggest that this may serve as a novel tool for ambulatory management of congestion to facilitate remote care in HF. (First in Human Clinical Investigation of the FIRE1 System in Heart Failure Patients [FUTURE-HF]; <span><span>NCT04203576</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 6","pages":"Pages 1000-1010"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Heart Failure Etiology","authors":"Jane E. Wilcox MD, MSc ,&nbsp;G. Michael Felker MD","doi":"10.1016/j.jchf.2025.03.029","DOIUrl":"10.1016/j.jchf.2025.03.029","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 8","pages":"Article 102471"},"PeriodicalIF":10.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further Refining the In-Hospital Risk Assessment of Patients Presenting With Uncomplicated Acute Myocarditis","authors":"Enrico Ammirati MD, PhD ,&nbsp;Leslie T. Cooper Jr. MD","doi":"10.1016/j.jchf.2025.04.001","DOIUrl":"10.1016/j.jchf.2025.04.001","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 8","pages":"Article 102468"},"PeriodicalIF":10.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcoholic Cardiomyopathy–Attributed Mortality in the United States, 2010 to 2020","authors":"Marco Zuin MD, MS ,&nbsp;Karola Jering MD ,&nbsp;Bridget McGonagle BS ,&nbsp;Alyssa Sato BA ,&nbsp;Claudio Bilato MD, PhD ,&nbsp;Gregory Piazza MD, MS","doi":"10.1016/j.jchf.2025.04.006","DOIUrl":"10.1016/j.jchf.2025.04.006","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 7","pages":"Article 102486"},"PeriodicalIF":10.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 Receptor Agonists in Heart Failure With Reduced Ejection Fraction","authors":"João Sérgio Neves MD, PhD ,&nbsp;Catarina Vale MD ,&nbsp;Ana Rita Leite MD ,&nbsp;Adelino Leite-Moreira MD, PhD ,&nbsp;Faiez Zannad MD, PhD ,&nbsp;Javed Butler MD, MPH, MBA ,&nbsp;Milton Packer MD ,&nbsp;João Pedro Ferreira MD, PhD","doi":"10.1016/j.jchf.2025.03.035","DOIUrl":"10.1016/j.jchf.2025.03.035","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 7","pages":"Article 102489"},"PeriodicalIF":10.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Assessment of Spot Urinary Sodium as Predictor of Clinical Outcomes in Chronic Heart Failure.","authors":"Miguel Lorenzo, Eduardo Núñez, Rafael de la Espriella, Arturo Carratalá, Enrique Rodríguez, Jose Luis Górriz, Neus Valls, Antoni Bayés-Genís, Juan Sanchis, Julio Núñez","doi":"10.1016/j.jchf.2025.03.028","DOIUrl":"10.1016/j.jchf.2025.03.028","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102467"},"PeriodicalIF":10.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Heart Failure With Preserved Ejection Fraction in Patients Referred for Atrial Fibrillation Ablation.","authors":"Jan Riess, Julius Obergassel, Nils Pohlmann, Moritz Nies, Marc Lemoine, Ilaria My, Bruno Reißmann, Andreas Metzner, Paulus Kirchhof, Andreas Rillig","doi":"10.1016/j.jchf.2025.03.022","DOIUrl":"10.1016/j.jchf.2025.03.022","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102461"},"PeriodicalIF":10.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Gait Speed and Handgrip Strength in Patients With Advanced Systolic Heart Failure.","authors":"Tejus Satish, Nicholas S Hendren, Jennifer Thibodeau, Sarah Godfrey, Melanie Sulistio, Maryjane Farr, Mark H Drazner, W H Wilson Tang, Justin L Grodin","doi":"10.1016/j.jchf.2025.03.024","DOIUrl":"10.1016/j.jchf.2025.03.024","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102463"},"PeriodicalIF":10.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not All Pathogenic Variants Are Equal: How Founder Variants Lead Precision Medicine Journey in Hypertrophic Cardiomyopathy.","authors":"Babken Asatryan, Steven A Muller, Andreas S Barth","doi":"10.1016/j.jchf.2025.03.023","DOIUrl":"10.1016/j.jchf.2025.03.023","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"102462"},"PeriodicalIF":10.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}