JACC. Heart failure最新文献

{"title":"Cardiac Structure and Function in Women After Preeclampsia","authors":"Jessica V. Yao, Benjamen Wang, Camryn Wong, Andrew Browne, Stacey Peters, Andrew Taylor, Shaun Brennecke, Ingrid Winship, Dominica Zentner","doi":"10.1016/j.jchf.2026.103421","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103421","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"15 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment and Reversibility of Hepatic Abnormalities in Heart Failure","authors":"Jordan S. Sack, Muhammad Shahzeb Khan, Helen S. Te","doi":"10.1016/j.jchf.2026.103433","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103433","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"5 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149232876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A REBIRTH of Disease-Specific Therapy","authors":"Chinelo L. Onyilofor, Melinda B. Davis, Michael C. Honigberg","doi":"10.1016/j.jchf.2026.103418","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103418","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bromocriptine for Myocardial Recovery in Peripartum Cardiomyopathy","authors":"Tianxiu Wang, Andrea J. Ibarra, Donna Simpson, Jill Kirsch, Agnes Koczo, Joan E. Briller, Kaleab Z. Abebe, Dennis McNamara, Michael M. Givertz","doi":"10.1016/j.jchf.2026.103376","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103376","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"24 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Safety and Procedural Performance of an Interatrial Shunt for Heart Failure According to Ejection Fraction.","authors":"Josep Rodés-Cabau, Gregg W Stone, Saibal Kar, Stefan Verheye, Ariel Roguin, Jeroen Bax, Antoni Bayes-Genis, Julio Nunez, Jeremiah Depta, Michal Laufer-Perl, Gil Moravsky, Alicia Romero, Edgard Prihadi, Eugene S Chung, Matthew J Price, Michael Chenier, Dimitry Schewel, Sachin Kumar, Stephan Kische, Kunjan Bhatt, Kevin S Shah, Daniel J Donovan, Suzanne Hendrix, Patrick O'Keefe, William T Abraham, Michael R Zile, Stefan D Anker, Neal L Eigler, JoAnn Lindenfeld","doi":"10.1016/j.jchf.2026.103375","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103375","url":null,"abstract":"<p><strong>Background: </strong>Long-term device durability and phenotype-specific safety outcomes after interatrial shunting require further characterization.</p><p><strong>Objectives: </strong>This study aimed to evaluate the procedural success, device durability, and heart failure (HF) phenotype-specific safety outcomes of an interatrial shunt in the RELIEVE-HF trial.</p><p><strong>Methods: </strong>Randomized patients were assigned 1:1 to shunt or sham control with prespecified stratification by left ventricular ejection fraction (LVEF) into heart failure with reduced ejection fraction (HFrEF) (LVEF ≤40%) and heart failure with preserved ejection fraction (HFpEF) (LVEF >40%). Procedural performance, device durability, serious adverse events (SAEs), major adverse cardiovascular or neurological events (MACNE), major bleeding, and renal outcomes were assessed through 2 years.</p><p><strong>Results: </strong>Among 605 enrolled patients (508 randomized; 97 roll-in), shunt implantation was attempted in 370 and was successful in 369 (99.7%). Among implanted patients with follow-up (n = 348), no device- or procedure-related MACNE occurred through 2 years (0%; 95% CI: 0%-0.9%), and shunt patency was 99.4% (95% CI: 97.9%-99.9%). Prespecified LVEF-stratified analyses demonstrated divergent safety profiles. In HFrEF, shunt therapy was not associated with excess all-cause MACNE, major bleeding, or renal decline and was associated with lower SAE burden. In HFpEF, shunt therapy was associated with higher all-cause MACNE, greater SAE burden, increased major bleeding, and greater renal decline.</p><p><strong>Conclusions: </strong>Interatrial shunt implantation was mechanically reliable and durable through 2 years. Safety outcomes differed by HF phenotype, with no evidence of excess clinical safety events in HFrEF but increased adverse events in HFpEF. These findings support phenotype-specific evaluation of interatrial shunt therapy. (REducing Lung congestion symptoms using the v-wavE shunt in adVancEd Heart Failure [RELIEVE-HF]; NCT03499236).</p>","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"103375"},"PeriodicalIF":11.9,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of Serum Transthyretin to NT-proBNP Ratio in Transthyretin Amyloid Cardiomyopathy: Insights From ATTRibute-CM.","authors":"Peder L Myhre, Gillian Murtagh, Hanna K Gaggin, Prem Soman, Mazen Hanna, Daniel P Judge, Ahmad Masri, Michel G Khouri, Emer Joyce, Kevin M Alexander, Yuxi Liu, Onyedika J Ilonze, C Michael Gibson, James L Januzzi","doi":"10.1016/j.jchf.2026.103493","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103493","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"103493"},"PeriodicalIF":11.9,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transpulmonary Gradient vs Pulmonary Vascular Resistance for Post-Transplant Risk Stratification.","authors":"Ahmed A Zayed, Mathew Seplowe, Walid Sange, Bahy Abofrekha, Mohamad B Moumneh, Hadi Itani, Mohammad Ennab, Omar Khayat, Spencer Liu, Kenneth Dulnuan","doi":"10.1016/j.jchf.2026.103291","DOIUrl":"10.1016/j.jchf.2026.103291","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"103291"},"PeriodicalIF":11.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Enabled Detection and Management of Physiological Instability in Heart Failure: Results of the Randomized LINK-HF2 Trial.","authors":"Konstantinos Sideris, Carsten Schmalfuss, Neil Lewis, Karim Sallam, Biykem Bozkurt, Thomas C Hanff, Michael T Young, Richard Schofield, Christos P Kyriakopoulos, Heather Hanson, Lina Brinker, Peter Wohlfahrt, Mandeep R Mehra, Tempa Curry, Cheri Knecht, Stephanie Tuckett, Richard E Nelson, Susan L Zickmund, Jorie M Butler, Jay M Edelberg, Gregory H Kurio, Stephan Wegerich, Stylianos Serghiou, Matt Pipke, Josef Stehlik","doi":"10.1016/j.jchf.2026.103422","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103422","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Artificial intelligence (AI)-enabled wearable monitoring can detect individualized physiological deviations preceding heart failure (HF) decompensation, but whether these signals can be translated into improved outcomes remains uncertain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This study aims to evaluate the feasibility of integrating AI-generated notifications with a structured clinician response algorithm into postdischarge HF care and to explore their association with HF events following hospitalization.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;LINK-HF2 (Detection of Physiological Anomaly Using Artificial Intelligence and Prevention of Heart Failure Hospitalization) was a prospective, randomized, open-label, blinded-endpoint study conducted at 5 Veterans Affairs medical centers. Adults hospitalized for acute HF were enrolled at discharge and assigned to AI-guided monitoring with clinician notification or to standard care. All participants wore a continuous multisensor patch for up to 90 days. A personalized similarity-based model detected deviations in cardiorespiratory and activity signals and generated notifications. Implementation outcomes included feasibility, acceptability, and usability. The main exploratory clinical endpoint was HF rehospitalization. Secondary exploratory clinical endpoints included the composite outcome of all-cause unplanned rehospitalizations, emergency department visits, and all-cause mortality. All clinical endpoints were compared through Cox proportional hazards models over the follow-up period.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 171 analyzed participants, 80 (46.8%) were assigned to intervention and 91 (53.2%) to control. Median monitoring adherence was 72.4% of follow-up days; clinicians responded to communicated notifications within a median of 1 day (range: 1-5 days), and qualitative analysis demonstrated high patient acceptance and clinician engagement, whereas identifying workflow integration and response uncertainty as the primary barriers to implementation. In exploratory analyses, HF rehospitalization occurred in 13 (16.3%) patients in the intervention group and 17 (18.7%) in the control group (HR: 0.90, 95% CI: 0.43-1.84; P = 0.76). The composite clinical endpoint also did not differ between groups (HR 1.03; 95% CI: 0.63-1.70; P = 0.89). The intervention group had a lower rate of AI-detected physiological instability than controls (HR: 0.76; 95% CI: 0.60-0.97; P = 0.025).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;AI-enabled continuous physiological monitoring was feasible and reduced AI-detected physiological instability. Although this feasibility study did not demonstrate a reduction in exploratory clinical events, these findings highlight that accurate physiological risk detection alone may be insufficient to modify clinical risk without mechanistically aligned and trusted therapeutic responses. (Detection of Physiological Anomaly Using Artificial Intelligence and Prevention of Heart Fa","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"103422"},"PeriodicalIF":11.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Failure With Improved Ejection Fraction: What Does \"Improved\" Mean in Women vs Men?","authors":"Carolyn S P Lam, Li Shen","doi":"10.1016/j.jchf.2026.103419","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103419","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"103419"},"PeriodicalIF":11.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Paced QRS to Assessing the Mechanical Substrate for Achieving Cardiac Resynchronization: A Leap of Faith or the Ground Truth?","authors":"Sana M Al-Khatib, Jagmeet P Singh","doi":"10.1016/j.jchf.2026.103427","DOIUrl":"https://doi.org/10.1016/j.jchf.2026.103427","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":" ","pages":"103427"},"PeriodicalIF":11.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}