Bridget O’Connell PharmD , Anju Sahay PhD , Aradhana Verma MD , Hayden B. Bosworth PhD , Tomasz Jurga PharmD , Orly Vardeny PharmD, MS , Paul L. Hess MD, MHS , Dave L. Dixon PharmD , Benjamin W. Van Tassell PharmD , Paul A. Heidenreich MD, MS , Alexander T. Sandhu MD, MS
{"title":"Call to Action","authors":"Bridget O’Connell PharmD , Anju Sahay PhD , Aradhana Verma MD , Hayden B. Bosworth PhD , Tomasz Jurga PharmD , Orly Vardeny PharmD, MS , Paul L. Hess MD, MHS , Dave L. Dixon PharmD , Benjamin W. Van Tassell PharmD , Paul A. Heidenreich MD, MS , Alexander T. Sandhu MD, MS","doi":"10.1016/j.jchf.2025.102552","DOIUrl":"10.1016/j.jchf.2025.102552","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 9","pages":"Article 102552"},"PeriodicalIF":10.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neela D. Thangada MD, Sadiya S. Khan MD, Matthew J. Feinstein MD, MSc
{"title":"Disentangling Convergent and Divergent Pathways to HFpEF and HFrEF","authors":"Neela D. Thangada MD, Sadiya S. Khan MD, Matthew J. Feinstein MD, MSc","doi":"10.1016/j.jchf.2025.102557","DOIUrl":"10.1016/j.jchf.2025.102557","url":null,"abstract":"","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 9","pages":"Article 102557"},"PeriodicalIF":10.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mineralocorticoid Receptor Antagonists in Myocardial Infarction Patients","authors":"Marc-André d’Entremont MD, MPH , Zain Cheema MD , Bertram Pitt MD , Sasko Kedev MD, PhD , Jan Hein Cornel MD, PhD , Goran Stankovic MD, PhD , Raul Moreno MD, PhD , Robert Storey MD, PhD , Matthias Bossard MD , Ashwin Chauhan BSc , Gilles Montalescot MD, PhD , Farzin Beygui MD, PhD , Faiez Zannad MD, PhD , Sanjit Jolly MD, MSc , Mineralocorticoid Antagonist Post Myocardial Infarction Trialist Collaboration","doi":"10.1016/j.jchf.2025.102531","DOIUrl":"10.1016/j.jchf.2025.102531","url":null,"abstract":"<div><h3>Background</h3><div>It is unclear whether routine mineralocorticoid antagonist (MRA) use benefits all post–myocardial infarction (MI) patients.</div></div><div><h3>Objectives</h3><div>This study aims to perform a systematic review and study-level meta-analysis of randomized controlled trials comparing MRA vs no MRA in post-MI participants.</div></div><div><h3>Methods</h3><div>Using the intention-to-treat population, we used a fixed effect model with Peto odds ratios (ORs). Key outcomes were death and new or worsening heart failure (HF). Results were presented comparing the post-MI HF trial vs post-MI non-HF trials.</div></div><div><h3>Results</h3><div>Eleven trials, including 18,111 post-MI participants (9,064 MRA, 9,047 no MRA), were included; one trial (n = 6,642) recruited HF patients. Participants randomized to MRA compared to no MRA had a lower risk of death (OR: 0.85 [95% CI: 0.76-0.95]; I<sup>2</sup> = 0%) and new or worsening HF (OR: 0.83 [95% CI: 0.73-0.94]; I<sup>2</sup> = 26.8%). In the post-MI HF trial, MRA participants experienced a mortality benefit with a numerically larger risk difference (RD) (478/3,319 vs 554/3,313; OR: 0.84 [95% CI: 0.73-0.96]; RD: –2.3% [95% CI: –3.9% to –0.6%]) than in post-MI non-HF trials (219/5,745 vs 249/5,734; OR: 0.87 [95% CI: 0.72-1.05]; RD –0.5% [95% CI: –1.2% to 0.2%]; interaction <em>P =</em> 0.73). In the post-MI HF trial, MRA allocation decreased new or worsening HF (345/3,319 vs 391/3,313; OR: 0.87 [95% CI: 0.74-1.01]; RD: –1.4% [95% CI: –2.8% to 0.1%]) like in the post-MI non-HF trials (126/5,251 vs 167/5,241; OR: 0.75 [95% CI: 0.58-0.94]; RD: –0.8% [95% CI: –1.3% to –0.2%]; interaction <em>P =</em> 0.29).</div></div><div><h3>Conclusions</h3><div>In post-MI patients, MRAs decrease the risk of all-cause mortality and new or worsening HF regardless of HF status. Numerically smaller absolute risk reductions were observed in the post-MI non-HF trials compared to the post-MI HF trial.</div></div>","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 9","pages":"Article 102531"},"PeriodicalIF":10.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nisha Hosadurg MBBS, MS , Patricia Rodriguez Lozano MD, MS , Amit R. Patel MD , Christopher M. Kramer MD
{"title":"Cardiac Magnetic Resonance in the Evaluation and Management of Nonischemic Cardiomyopathies","authors":"Nisha Hosadurg MBBS, MS , Patricia Rodriguez Lozano MD, MS , Amit R. Patel MD , Christopher M. Kramer MD","doi":"10.1016/j.jchf.2025.102525","DOIUrl":"10.1016/j.jchf.2025.102525","url":null,"abstract":"<div><div>Cardiac magnetic resonance is an essential tool in the evaluation and management of patients with suspected or diagnosed nonischemic cardiomyopathies (NICMs). It is considered the gold standard for accurately quantifying cardiac chamber dimensions, function, and mass, aiding in the initial diagnosis of myocardial dysfunction and/or dilation. Its unique value lies in its ability to characterize the myocardium using techniques such as late gadolinium enhancement, T1, T2, and T2∗ mapping, and extracellular volume fraction estimation, all of which have been histologically validated in specific clinical scenarios. These features enable specific diagnoses of the etiology of NICM, assess prognosis, guide management decisions, and potentially evaluate treatment response. This has allowed the widespread and increasing use of cardiac magnetic resonance in NICMs.</div></div>","PeriodicalId":14687,"journal":{"name":"JACC. Heart failure","volume":"13 9","pages":"Article 102525"},"PeriodicalIF":10.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}