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Richard Lerner and the Birth of Antibody Libraries Richard Lerner和抗体文库的诞生
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-15 DOI: 10.1002/ijch.202300151
Dennis R. Burton
{"title":"Richard Lerner and the Birth of Antibody Libraries","authors":"Dennis R. Burton","doi":"10.1002/ijch.202300151","DOIUrl":"https://doi.org/10.1002/ijch.202300151","url":null,"abstract":"<p>Richard Lerner had many achievements in his outstanding career. He will perhaps be remembered most for taking the helm of Scripps Research, following the founding by and tenure of Frank Dixon, and building one of the most successful biomedical research institutes in the world. Two Nobel prizes at Scripps in the past two years and one of them a second Nobel speaks for itself. But I want to cover what many consider Richard's finest scientific achievement- the development of a whole new approach to making antibodies that has been revolutionary to many aspects of basic science and medicine. I was very fortunate to be a part of that development and I give an account here and my memories of Richard during that time.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"63 10-11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138454691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Richard A. Lerner – Little Known Facets of an Outstanding Man 理查德·勒纳:《一个杰出人物鲜为人知的一面》
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-15 DOI: 10.1002/ijch.202300140
Ehud Keinan
{"title":"Richard A. Lerner – Little Known Facets of an Outstanding Man","authors":"Ehud Keinan","doi":"10.1002/ijch.202300140","DOIUrl":"https://doi.org/10.1002/ijch.202300140","url":null,"abstract":"<p>Richard was mainly known as a gifted scientist, a charismatic leader, and an original and creative President. And he was my good friend and a role model for over three decades. The term impossible was not part of his vocabulary. I′ve learned from him that there is no limit to imagination and creativity, no limit to the number of assignments one can fulfill, and no limit to the magnitude of a dream one can turn into reality. Richard was blessed with the unique talent to quickly decipher the essence of people‘s thoughts and discover the hidden parts of their personalities, which allowed him to focus on what he defined as the most valuable issues and productive discussions. My experience with him included the joy of scientific discovery, the silent mode of human communication, the power of commitment and dedication, and the wildest sense of humor. Now, nearly two years after his departure, I feel free and obliged to share unknown stories and anecdotes that illuminate various facets of his personality.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"63 10-11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138454689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Richard Lerner (1938–2021) 理查德·勒纳(1938-2021)
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-15 DOI: 10.1002/ijch.202300150
Dr. Peter G. Schultz
{"title":"Richard Lerner (1938–2021)","authors":"Dr. Peter G. Schultz","doi":"10.1002/ijch.202300150","DOIUrl":"https://doi.org/10.1002/ijch.202300150","url":null,"abstract":"<p>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"63 10-11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138454690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STEM Structural Investigation of RE-Au-Si 1/1 Approximants 稀土-金-硅1/1近似物的STEM结构研究
IF 2.3 4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-14 DOI: 10.1002/ijch.202300117
Wilfried Bajoun Mbajoun, Vinko Sršan, Yu-Chin. Huang, Girma Hailu Gebresenbut, Cesar Pay Gómez, Sylvie Migot-Choux, Jaafar Ghanbaja, Sašo Šturm, Vincent Fournée, Julian Ledieu
{"title":"STEM Structural Investigation of RE-Au-Si 1/1 Approximants","authors":"Wilfried Bajoun Mbajoun,&nbsp;Vinko Sršan,&nbsp;Yu-Chin. Huang,&nbsp;Girma Hailu Gebresenbut,&nbsp;Cesar Pay Gómez,&nbsp;Sylvie Migot-Choux,&nbsp;Jaafar Ghanbaja,&nbsp;Sašo Šturm,&nbsp;Vincent Fournée,&nbsp;Julian Ledieu","doi":"10.1002/ijch.202300117","DOIUrl":"10.1002/ijch.202300117","url":null,"abstract":"<p>RE-Au-Si (RE=Ho, Tb) systems are 1/1 Tsai-type quasicrystalline approximants with a cluster center decoration that can vary from a disordered tetrahedron to a rare-earth atom. The local atomic structure of three different samples was observed by scanning transmission electron microscopy and interpreted in the light of high-angle annular dark field simulated scanning transmission electron microscopy images. It is found that the combination of these two methods allows to identify differences in the chemical decoration of the cluster centers through quantitative analysis of line profiles.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"64 10-11","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134901655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Electrochemical Reductive Transformation of C−C and C−O Multiple Bonds C-C 和 C-O 多键电化学还原转化的最新进展
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-08 DOI: 10.1002/ijch.202300102
Atreyee Halder, Kingshuk Mahanty, Debabrata Maiti, Dr. Suman De Sarkar
{"title":"Recent Advances in Electrochemical Reductive Transformation of C−C and C−O Multiple Bonds","authors":"Atreyee Halder,&nbsp;Kingshuk Mahanty,&nbsp;Debabrata Maiti,&nbsp;Dr. Suman De Sarkar","doi":"10.1002/ijch.202300102","DOIUrl":"10.1002/ijch.202300102","url":null,"abstract":"<p>In recent decades, electro-organic synthesis is indubitably emerging as a cornerstone of modern organic chemistry. Electrochemical organic transformations especially reduction reactions have made massive advancements in the last few years because of their sustainable and environ-friendly nature. Electro-reductive protocols can be used as a promising substitute for conventional reductants by expelling the requirement of the stoichiometric amount of metal reductants. The major challenges for these electro-reductive reactions are primarily the use of a sacrificial electrode and divided cells. These limitations can be resolved through smart reaction planning by employing cheap sacrificial reagents or paired electrolysis without compromising the sustainable viewpoint. Considering the rapid enhancement in this field, imparting an intangible understanding of this evolving area is essential and substantial. In this review, we portrayed the electrochemical reductive transformations of C−C and C−O bonds after 2015 along with detailed mechanistic insights.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"64 1-2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation PDIA1抑制NLRP3炎性小体组装和激活的药理学靶点
4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-08 DOI: 10.1002/ijch.202300125
Jessica D. Rosarda, Caroline R. Stanton, Emily B. Chen, Michael J. Bollong, R. Luke Wiseman
{"title":"Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation","authors":"Jessica D. Rosarda, Caroline R. Stanton, Emily B. Chen, Michael J. Bollong, R. Luke Wiseman","doi":"10.1002/ijch.202300125","DOIUrl":"https://doi.org/10.1002/ijch.202300125","url":null,"abstract":"Abstract The NLRP3 inflammasome is a cytosolic protein complex that regulates innate immune signaling in response to diverse pathogenic insults through the proteolytic processing and secretion of pro‐inflammatory cytokines such as IL‐1β. Hyperactivation of NLRP3 inflammasome signaling is implicated in the onset and pathogenesis of numerous diseases, motivating the discovery of new strategies to suppress NLRP3 inflammasome activity. We sought to define the potential for the proteostasis regulator AA147 to inhibit the assembly and activation of the NLRP3 inflammasome. AA147 is a pro‐drug that is metabolically converted to a reactive metabolite at the endoplasmic reticulum (ER) membrane to covalently modify ER‐localized proteins such as protein disulfide isomerases (PDIs). We show that AA147 inhibits NLRP3 inflammasome activity in monocytes and monocyte‐derived macrophages through a mechanism involving impaired assembly of the active inflammasome complex. This inhibition is mediated through AA147‐dependent covalent modification of PDIA1. Genetic depletion or treatment with other highly selective PDIA1 inhibitors similarly blocks NLRP3 inflammasome assembly and activation. Our results identify PDIA1 as a potential therapeutic target to mitigate NLRP3 inflammasome‐mediated pro‐inflammatory signaling implicated in etiologically diverse diseases.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"14 S1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of the Proteasome in Limiting Cellular Stress Associated with Protein Accumulation 蛋白酶体在限制与蛋白质积累相关的细胞应激中的作用
4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-07 DOI: 10.1002/ijch.202300120
Kate A. Kragness, Darci J. Trader
{"title":"The Role of the Proteasome in Limiting Cellular Stress Associated with Protein Accumulation","authors":"Kate A. Kragness, Darci J. Trader","doi":"10.1002/ijch.202300120","DOIUrl":"https://doi.org/10.1002/ijch.202300120","url":null,"abstract":"Abstract The proteasome is comprised of multiple subunits that catalyze the degradation of proteins to maintain cellular homeostasis. The proteasome targets protein substrates by two different pathways. The ubiquitin‐dependent pathway requires proteins to be labeled with a ubiquitin tag to signal for degradation by the 26S isoform of the proteasome. Protein degradation through this pathway declines during age progression. The ubiquitin‐independent pathway utilizes the 20S proteasome isoform. It can degrade misfolded and intrinsically disordered proteins to decrease cellular stress. Age‐related protein accumulation and aggregation can occur due to the decreased activity and expression of the proteasome. Protein accumulation causes increased cellular stress which can contribute to disease progression. Increasing proteasome activity could serve as a solution to eliminating and preventing protein accumulation. Studies have shown the value of the proteasome as a therapeutic entity to mitigate cellular stress. This perspective explores the link between proteasome activity and cellular stress caused by age‐related misfolded protein accumulation.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"48 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135480424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding and Overcoming Biochemical Diversity in AL Amyloidosis 了解和克服AL淀粉样变性的生化多样性
4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-06 DOI: 10.1002/ijch.202300128
Gareth J. Morgan
{"title":"Understanding and Overcoming Biochemical Diversity in AL Amyloidosis","authors":"Gareth J. Morgan","doi":"10.1002/ijch.202300128","DOIUrl":"https://doi.org/10.1002/ijch.202300128","url":null,"abstract":"Abstract Amyloid fibril deposition causes progressive tissue damage and organ failure in the systemic amyloid diseases, and therapies that suppress aggregation lead to clinical benefit. Small molecules that prevent aggregation by binding to precursor proteins are effective for amyloid transthyretin (ATTR) amyloidosis. However, in amyloid light chain (AL) amyloidosis, fibrils are formed by antibody light chains and every patient has a unique protein sequence that aggregates. The highly diverse sequences of these light chains appear to determine whether an individual is at risk of amyloidosis, the distribution of amyloid deposits and the progression of disease. Light chains are therefore challenging drug targets. This review explores the parallels between AL amyloidosis and ATTR amyloidosis to describe the discovery of small molecules that can stabilize light chains. These molecules have potential as therapies for AL amyloidosis, highlighting potential opportunities for drug discovery in other diseases of protein misfolding.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"15 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135679326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scanning Tunnelling Microscopy Studies of Tsai-Type Quasicrystal Approximants 蔡型准晶近似物的扫描隧道显微镜研究
IF 2.3 4区 化学
Israel Journal of Chemistry Pub Date : 2023-11-02 DOI: 10.1002/ijch.202300116
Dr. Sam Coates, Dominic Burnie, Dr. Hem Raj Sharma, Ronan McGrath
{"title":"Scanning Tunnelling Microscopy Studies of Tsai-Type Quasicrystal Approximants","authors":"Dr. Sam Coates,&nbsp;Dominic Burnie,&nbsp;Dr. Hem Raj Sharma,&nbsp;Ronan McGrath","doi":"10.1002/ijch.202300116","DOIUrl":"10.1002/ijch.202300116","url":null,"abstract":"<p>We review scanning tunnelling microscopy (STM) studies of the surfaces of periodic Tsai-type approximants. Although they are useful analogues to the Tsai-type quasicrystals, the surfaces of these periodic approximants behave in subtly different and often more complex ways when compared to their quasiperiodic cousins. We present a summary of STM studies conducted upon Tsai-type approximants; we discuss the various differences and similarities between phases and surface directions, and compare these to the surfaces of the related quasicrystalline phases. We also present open questions which have been raised by these studies, and offer potential routes to answer them.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"64 10-11","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135973475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quasicrystal Structure Prediction: A Review 准晶体结构预测研究进展
IF 2.3 4区 化学
Israel Journal of Chemistry Pub Date : 2023-10-16 DOI: 10.1002/ijch.202300122
Michael Widom, Marek Mihalkovič
{"title":"Quasicrystal Structure Prediction: A Review","authors":"Michael Widom,&nbsp;Marek Mihalkovič","doi":"10.1002/ijch.202300122","DOIUrl":"10.1002/ijch.202300122","url":null,"abstract":"<p>Predicting quasicrystal structures is a multifaceted problem that can involve predicting a previously unknown phase, predicting the structure of an experimentally observed phase, or predicting the thermodynamic stability of a given structure. We survey the history and current state of these prediction efforts with a focus on methods that have improved our understanding of the structure and stability of known metallic quasicrystal phases. Advances in the structural modeling of quasicrystals, along with first principles total energy calculation and statistical mechanical methods that enable the calculation of quasicrystal thermodynamic stability, are illustrated by means of cited examples of recent work.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"64 10-11","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136079036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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