Israel Journal of Chemistry最新文献_第3页

Cover Picture: (Isr. J. Chem. 5/2024) 封面图片：（Isr.）

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-28 DOI: 10.1002/ijch.202480501

引用次数: 0

The 87th Annual Meeting of the Israel Chemical Society: April 3, 2024, Smolarz Auditorium, Tel Aviv University 以色列化学学会第 87 届年会：2024 年 4 月 3 日，特拉维夫大学斯莫拉兹礼堂

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-28 DOI: 10.1002/ijch.202400041

Ehud Keinan

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To what Extent could Solid-State Chemistry and Nanotechnology Impact Sustainable Lifestyle of Human Being on Earth in the Years to Come 固态化学和纳米技术会在多大程度上影响未来几年地球上人类的可持续生活方式？

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-27 DOI: 10.1002/ijch.202300069

Reshef Tenne

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Regulatory Role of RNA N6-Methyladenosine Modification in Plants 植物中 RNA N6-甲基腺苷修饰的调控作用

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-24 DOI: 10.1002/ijch.202400029

Subiding Tayier, Enlin Tian, Guifang Jia

{"title":"Regulatory Role of RNA N6-Methyladenosine Modification in Plants","authors":"Subiding Tayier, Enlin Tian, Guifang Jia","doi":"10.1002/ijch.202400029","DOIUrl":"https://doi.org/10.1002/ijch.202400029","url":null,"abstract":"N6-methyladenosine (m6A), as the most abundant and well-studied RNA modification, can be reversibly added or removed by m6A methyltransferase and demethylase. The further molecular and biological function of m6A is achieved by the recognition of its binding protein. m6A functions in the diverse progress of RNA processing, including transcription regulation, splicing, nuclear export, stability, and translation, to regulate the fate of cells. Although been extensively studied in various animal cell systems, research on m6A's regulatory functions in plant cells lags. In recent years, with a deepening understanding of the functions of m6A and the development of various sequencing technologies, researches on m6A in plant cells have gradually increased. In this review, we focused on discussing the molecular functions of m6A in the nucleus and cytoplasm, aiming to elucidate the specific molecular mechanisms by which m6A regulates the fate of RNAs in plants. Finally, we provide some perspectives on future investigations of the detailed molecular mechanism of m6A-mediated regulation in plants, which might provide insights into future strategies for achieving multiple growth regulatory processes in crops.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"64 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141488138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Discovery and Accurate Detection of Rare Nucleic Acid Modifications 发现并准确检测罕见的核酸修饰

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-24 DOI: 10.1002/ijch.202400024

Ru-Jia Luo, Hong-Xuan Chen, Jin-Wen Kong, Zhang Zhang, Nabieh Ayoub, Guan-Zheng Luo

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Expanding the Scope of Ribosome-Mediated Biosynthesis in vitro using tRNA-Aminoacylating Ribozyme 利用 tRNA 氨基酰化核糖体酶扩大核糖体介导的体外生物合成的范围

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-17 DOI: 10.1002/ijch.202300174

Namjin Cho, Haneul Jin, Hyewon Jeon, Kanghun Lee, Joongoo Lee

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Anionic Calixarenes in Biomembrane Transport of Peptides 多肽生物膜传输中的阴离子钙钛矿

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-17 DOI: 10.1002/ijch.202400023

Justin Neumann, Andreas Hennig

{"title":"Anionic Calixarenes in Biomembrane Transport of Peptides","authors":"Justin Neumann, Andreas Hennig","doi":"10.1002/ijch.202400023","DOIUrl":"https://doi.org/10.1002/ijch.202400023","url":null,"abstract":"Biomembranes function as hydrophobic barriers for hydrophilic substances enabling compartmentalization in biological systems. This poses, however, a problem for the targeted introduction of cargo into cells. The result is a high demand for delivery pathways into cells with the goal to investigate biological processes or to treat diseases by improved delivery. Polycationic cell-penetrating peptides (CPPs) are interesting as they can cross cell membranes and transport attached cargos directly into the cytosol. Their efficiency can be improved by anionic amphiphilic counterion activators, which bind to the CPPs to form charge-neutralized counterion-CPP complexes with sufficient hydrophobicity to cross the lipid bilayer membrane. This review summarizes recent results, which establish amphiphilic calixarenes as a new class of biocompatible and non-cytotoxic counterion activators with very high transport activities at nanomolar concentrations. We also include a brief summary of fluorescence-based assays with large unilamellar vesicles (LUVs) to investigate counterion-activated transport. Current methods use liposome-encapsulated, supramolecular host-dye reporter pairs including calixarenes, which provide new mechanistic insights and enable rapid in vitro identification of suitable activators. Taken together, amphiphilic calixarenes are currently emerging as prime candidates for counterion activation of membrane transport, which are highly modifiable and can be specifically tailored towards different cargoes and membrane types.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"64 6-7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202400023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141967954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical Applications of Supramolecular Macrocyclic Hosts in the Field of Herbal Medicines 超分子大环宿主在中草药领域的实际应用

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-14 DOI: 10.1002/ijch.202300179

Huijuan Yu, Kejing Niu, Yuting Zhao, Yuefei Wang

{"title":"Practical Applications of Supramolecular Macrocyclic Hosts in the Field of Herbal Medicines","authors":"Huijuan Yu, Kejing Niu, Yuting Zhao, Yuefei Wang","doi":"10.1002/ijch.202300179","DOIUrl":"10.1002/ijch.202300179","url":null,"abstract":"Herbal medicines (HMs) are gaining increasing popularity and recognition worldwide due to their eco-friendliness and efficacy. With their multi-compounds, multi-targets, and multi-pathways characteristics, HMs have been used in treatment of various diseases. However, the clinical applications of preparations containing HMs have been limited due to their inherent physicochemical properties, including low water solubility, poor stability, and unsatisfactory bioavailability of bioactive compounds. Supramolecular macrocyclic hosts, like cyclodextrins, calixarenes, cucurbiturils, and pillararenes, are important objects of researches in supramolecular chemistry. These hosts have been utilized to encapsulate the ingredients, improve the solubility of poorly water-soluble components, enhance the stability of the tested compounds, increase the bioavailability of bioactive compounds, and ensure the safety of HMs. Herein, we provide a brief introduction to the theories of supramolecular chemistry and summarize the extensive applications of supramolecular macrocyclic hosts in the field of HMs. These applications encompass the screening of bioactive compounds in HMs and the enhancement of druggability for HMs. We hope this review can provide a strategy for dealing with the challenges of HMs, thereby enabling their better applications and development.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"64 6-7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Great Codon Escape: Vacating Codons for Genetic Code Expansion and Ribosome Stalling 密码子大逃亡空缺密码子促进遗传密码扩展和核糖体停滞

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-12 DOI: 10.1002/ijch.202400012

Antonius J. P. Hopstaken, Enno Große Wichtrup, Dr. Seino A. K. Jongkees

{"title":"The Great Codon Escape: Vacating Codons for Genetic Code Expansion and Ribosome Stalling","authors":"Antonius J. P. Hopstaken, Enno Große Wichtrup, Dr. Seino A. K. Jongkees","doi":"10.1002/ijch.202400012","DOIUrl":"10.1002/ijch.202400012","url":null,"abstract":"In ribosomal synthesis of peptides and proteins, genetic information is translated into an amino acid polymer according to the genetic code, which describes the translational command encoded by each codon. However, parts of the genetic code can be adjusted to customize translations. One option is to remove decoding for a specific codon, resulting in a vacant codon. Such vacant codons can be used to stall the ribosome for mechanistic studies and display techniques. Alternatively, the liberated codon can be assigned to encode for incorporation of a noncanonical building block for expansion of the genetic code. In this review we provide an overview of the methods currently available for vacating codons in prokaryotic translation (agnostic of how these are later applied), targeting factors such as amino-acyl tRNA synthetases, tRNA, release factors, and the initiation machinery. Moreover, we assess applicability and compatibility of the currently available techniques and discuss which have the potential to develop into even more powerful approaches in the future.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"64 8-9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202400012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular Approaches to the Detoxification of Nerve Agents 神经毒剂的超分子解毒方法

IF 2.3 4区化学

Israel Journal of Chemistry Pub Date : 2024-06-11 DOI: 10.1002/ijch.202400019

Prof. Dr. Stefan Kubik

引用次数: 0