ISRN Pharmacology最新文献_第10页

Isoflavones-Enriched Soy Protein Prevents CCL(4)-Induced Hepatotoxicity in Rats. 富含异黄酮的大豆蛋白可预防CCL(4)诱导的大鼠肝毒性。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-03-01 DOI: 10.5402/2012/347930

Nesma A Z Sarhan, Ezzeldein S El-Denshary, Nabila S Hassan, Ferial M Abu-Salem, Mosaad A Abdel-Wahhab

{"title":"Isoflavones-Enriched Soy Protein Prevents CCL(4)-Induced Hepatotoxicity in Rats.","authors":"Nesma A Z Sarhan, Ezzeldein S El-Denshary, Nabila S Hassan, Ferial M Abu-Salem, Mosaad A Abdel-Wahhab","doi":"10.5402/2012/347930","DOIUrl":"https://doi.org/10.5402/2012/347930","url":null,"abstract":"The burden of liver disease in Egypt is exceptionally high due to the highest prevalence of hepatitis C virus (HCV) resulting in rising rates of hepatocellular carcinoma (HCC). The aim of the current study was to determine the isoflavones in soy and to evaluate the protective role of soy against CCl(4)-induced liver damage in rats. Four experimental groups were treated for 8 weeks and included the control group, soy-supplemented diet (20% w/w) group, the group treated orally with CCl(4) (100 mg/kg bw) twice a week, and the group fed soy-supplemented diet and treated with CCl(4). Blood and liver tissue samples were collected for biochemical analyses and histological examination. The results indicated that protein content was 45.8% and the total isoflavones recorded 167.3 mg/100 g soy. Treatment with CCl(4) resulted in a significant biochemical changes in serum liver tissue accompanied with severe oxidative stress and histological changes. Supplementation with soy succeeded to restore the elevation of liver enzymes activities and improved serum biochemical parameters. Moreover, soy supplementation improved the antioxidant enzymes, decreased lipid peroxidation, and improved the histological picture of the liver tissue. It could be concluded that soy-protein-enriched isoflavones may be a promising agent against liver diseases.","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":" ","pages":"347930"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/347930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40180009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn). Hippophae rhamnoides Linn.（沙棘）的补救前景。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-03-11 DOI: 10.5402/2012/436857

Chirag A Patel, Kalyani Divakar, Devdas Santani, Himanshu K Solanki, Jalaram H Thakkar

{"title":"Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn).","authors":"Chirag A Patel, Kalyani Divakar, Devdas Santani, Himanshu K Solanki, Jalaram H Thakkar","doi":"10.5402/2012/436857","DOIUrl":"10.5402/2012/436857","url":null,"abstract":"Sea buckthorn (Hippophae rhamnoides L.) constitutes thorny nitrogen fixing deciduous shrub. Sea buckthorn(SBT) is primarily valued for its very rich vitamins A, B(1), B(12), C, E, K, and P; flavonoids, lycopene, carotenoids, and phytosterols. and therapeutically important since it is rich with potent antioxidants. Scientifically evaluated pharmacological actions of SBT are like inflammation inhibited by reduced permeability, loss of follicular aggregation of lymphocytes from the inflamed synovium and suppress lymphocyte proliferation. SBT-reduced recurrence of angina, ischemic electrocardiogram which might be due to decreased myocardial oxygen consumption and inhibition of platelet aggregation induced by collagen. SBT can kill both cancer cells of S180, P388, SGC7901 and lymphatic leukemia (L1200). The antiulcer activity may be related to reduce gastric empty time, inhibiting proteolytic activity and promoting wound reparation processes of mucosa. SBT exerts antihypertensive effect in part by blocking angiotensin-2 receptor on cell surface. SBT decreased the level of stress hormones and enhanced hypoxic tolerance in animals indicating its anti-stress, adaptogenic activity. A lot of research work is still needed to find cellular and molecular mechanisms of these activities and also yet to be explored for its activity in osteoporosis, hemorrhage, cataract, urinary stone, acne, psoriasis, polyneuritis, cheilosis, glossities, baldness, anti-obesity, gout, and chronic prostitis.","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":" ","pages":"436857"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40180011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menadione : sodium orthovanadate combination eliminates and inhibits migration of detached cancer cells. 甲萘醌：正钒酸钠组合可消除和抑制脱落癌细胞的迁移。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-08-17 DOI: 10.5402/2012/307102

Zahid M Delwar, Ake Siden, Mabel H Cruz, Juan S Yakisich

{"title":"Menadione : sodium orthovanadate combination eliminates and inhibits migration of detached cancer cells.","authors":"Zahid M Delwar, Ake Siden, Mabel H Cruz, Juan S Yakisich","doi":"10.5402/2012/307102","DOIUrl":"10.5402/2012/307102","url":null,"abstract":"Exposure of cancer cells to anticancer agents in cultures induces detachment of cells that are usually considered dead. These drug-induced detached cells (D-IDCs) may represent a clinical problem for chemotherapy since they may survive anoikis, enter the circulation, invade other tissues and resume proliferation, creating a metastasis, especially in tissues where the bioavailability of anticancer agents is not enough to eliminate all cancer cells. In this study we evaluated the antiproliferative effect of menadione : sodium orthovanadate (M : SO) combination on A549 lung cancer cells as well as the ability of M : SO to induce cell detachment. In addition, we followed the fate and chemosensitivity of M : SO-induced detached cells. Using transwell chambers, we found that a fraction of the M : SO-induced detached cells were viable and, furthermore, were able to migrate, re-attach, and resume proliferation when re-incubated in drug-free media. The total elimination of A549 detachment-resistant cells and M : SO-induced detached cells were successfully eliminated by equivalent M : SO concentration (17.5 μM : 17.5 μM). Thus, M : SO prevented cell migration. Similar results were obtained on DBTRG.05MG human glioma cells. Our data guarantee further studies to evaluate the in vivo occurrence of D-IDCs, their implications for invasiveness and metastasis and their sensitivity to anticancer drugs.","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2012 ","pages":"307102"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30889495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staphylococcus aureus Infection Induced Oxidative Imbalance in Neutrophils: Possible Protective Role of Nanoconjugated Vancomycin. 金黄色葡萄球菌感染诱发中性粒细胞氧化失衡：纳米共轭万古霉素的可能保护作用。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-03-15 DOI: 10.5402/2012/435214

Subhankari Prasad Chakraborty, Panchanan Pramanik, Somenath Roy

{"title":"Staphylococcus aureus Infection Induced Oxidative Imbalance in Neutrophils: Possible Protective Role of Nanoconjugated Vancomycin.","authors":"Subhankari Prasad Chakraborty, Panchanan Pramanik, Somenath Roy","doi":"10.5402/2012/435214","DOIUrl":"10.5402/2012/435214","url":null,"abstract":"Staphylococcus aureus infection causes oxidative stress in neutrophils. The immune cells use reactive oxygen species (ROS) for carrying out their normal functions while an excess amount of ROS can attack cellular components that lead to cell damage. The present study was aimed to test the protective role of nanoconjugated vancomycin against vancomycin-sensitive Staphylococcus aureus (VSSA) and vancomycin-resistant Staphylococcus aureus (VRSA) infection induced oxidative stress in neutrophils. VSSA- and VRSA-infection were developed in Swiss mice by intraperitoneal injection of 5 × 10(6) CFU/mL bacterial solutions. Nanoconjugated vancomycin was treated to VSSA- and VRSA-infected mice at its effective dose for 10 days. Vancomycin was treated to VSSA and VRSA infected mice at similar dose, respectively, for 10 days. The result reveals that in vivo VSSA and VRSA infection significantly increases the level of lipid peroxidation, protein oxidation, oxidized glutathione level, and nitrite generation and decreases the level of reduced glutathione, antioxidant enzyme status, and glutathione-dependent enzymes as compared to control group; which were increased or decreased significantly near to normal in nanoconjugated vancomycin-treated group. These finding suggests the potential use and beneficial protective role of nanoconjugated vancomycin against VSSA and VRSA infection induced oxidative imbalance in neutrophils.","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":" ","pages":"435214"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40180010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of prickly pear dried leaves, artichoke leaves, turmeric and garlic extracts, and their combinations on preventing dyslipidemia in rats. 刺梨干叶、洋蓟叶、姜黄和大蒜提取物及其组合对大鼠血脂异常的预防作用。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-07-02 DOI: 10.5402/2012/167979

Nidal A Qinna, Basma S Kamona, Tawfiq M Alhussainy, Hashem Taha, Adnan A Badwan, Khalid Z Matalka

{"title":"Effects of prickly pear dried leaves, artichoke leaves, turmeric and garlic extracts, and their combinations on preventing dyslipidemia in rats.","authors":"Nidal A Qinna, Basma S Kamona, Tawfiq M Alhussainy, Hashem Taha, Adnan A Badwan, Khalid Z Matalka","doi":"10.5402/2012/167979","DOIUrl":"https://doi.org/10.5402/2012/167979","url":null,"abstract":"The successful use of herbal combinations in managing diseases or conditions over a single herb has lead us to evaluate the anti-dyslipidemic properties of the combination of the artichoke leaves extract, turmeric extract, prickly pear dried leaves (PPL) and garlic extract versus each one alone in two different hyperlipidemic animal models. A two-week treatment of each of the natural extracts, combination 1 (artichoke, turmeric and PPL) or combination 2 (artichoke, turmeric, PPL and garlic) prior to a single intraperitoneal injection of Pluronic F-127 resulted in decreasing significantly serum LDL levels by garlic and PPL extracts and serum LDL/HDL ratios by turmeric, PPL, combination 1 and 2. In a 10-day high fat diet model, only the combination 1 and 2 lowered serum cholesterol, LDL by 8-12%, decreased significantly triglycerides, LDL/HDL ratio; and increased significantly HDL (P < 0.0001). However, a long term treatment of each natural product for 7 weeks resulted in decreasing significantly serum LDL levels and LDL/HDL ratio (P < 0.05-0.0001). Furthermore, only artichoke and PPL inhibited significantly HMG-CoA reductase activity (P < 0.05). In conclusion, short term, as well as long term, treatment using the combination of artichoke, turmeric, PPL and garlic extract prevents dyslipidemia; partially through inhibiting HMG-CoA reductase.","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2012 ","pages":"167979"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/167979","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30773960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Synthesis, urease inhibition, antioxidant, antibacterial, and molecular docking studies of 1,3,4-oxadiazole derivatives. 1,3,4-恶二唑衍生物的合成、脲酶抑制、抗氧化、抗菌及分子对接研究。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-08-13 DOI: 10.5402/2012/928901

Muhammad Hanif, Khurram Shoaib, Muhammad Saleem, Nasim Hasan Rama, Sumera Zaib, Jamshed Iqbal

引用次数: 48

The new method developed for evaluation of anthelmintic activity by housefly worms and compared with conventional earthworm method. 建立了家蝇驱虫活性评价的新方法，并与传统的蚯蚓法进行了比较。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-03-18 DOI: 10.5402/2012/709860

V Murugamani, L Raju, V Baskar Anand Raj, Manjir Sarma Kataki, G Girija Sankar

{"title":"The new method developed for evaluation of anthelmintic activity by housefly worms and compared with conventional earthworm method.","authors":"V Murugamani, L Raju, V Baskar Anand Raj, Manjir Sarma Kataki, G Girija Sankar","doi":"10.5402/2012/709860","DOIUrl":"https://doi.org/10.5402/2012/709860","url":null,"abstract":"Evaluation of anthelmintic activity of any drug when carried out in laboratory conditions by using the isolated worms from nature cannot be adaptable with artificial laboratory conditions. Therefore, the present study aims at developing a new adaptable method for evaluation of anthelmintic activity. The present anthelmintic activity study reveals a new methodology with housefly worms cultured in laboratory conditions that resemble parasitic pinworms found in human being. We studied the anthelmintic activities of various drugs on housefly worms and earthworms. The results showed that the housefly worms had taken more time for paralysis and death. Even after paralysis the time taken for death is more in housefly worms in spite of smaller size and lesser weight of the worms compared to earthworms. The study concluded that the earthworms have not adapted to the artificial laboratory conditions leading to erratic results. Therefore, culturing of housefly worms was carried out to evaluate the anthelmintic activity and found an easy, prominent, eco-friendly, and reproducible method in all aspects such as equal age, size, and weight of worms used for the experiment.","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":" ","pages":"709860"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/709860","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40180014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Behcet's Disease: New Concepts in Cardiovascular Involvements and Future Direction for Treatment. 白塞氏病：心血管受累的新概念和未来治疗方向。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-03-08 DOI: 10.5402/2012/760484

M B Owlia, G Mehrpoor

引用次数: 0

Characteristics and Prevalence of Latent Autoimmune Diabetes in Adults (LADA). 成人潜伏性自身免疫性糖尿病(LADA)的特点和患病率。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-04-08 DOI: 10.5402/2012/580202

Priyanka P Brahmkshatriya, Anita A Mehta, Banshi D Saboo, Ramesh K Goyal

{"title":"Characteristics and Prevalence of Latent Autoimmune Diabetes in Adults (LADA).","authors":"Priyanka P Brahmkshatriya, Anita A Mehta, Banshi D Saboo, Ramesh K Goyal","doi":"10.5402/2012/580202","DOIUrl":"https://doi.org/10.5402/2012/580202","url":null,"abstract":"Diabetes, one of the most commonly seen metabolic disorders, is affecting a major area of population in many developing as well as most of the developed countries and is becoming an alarming concern for the rising cost of the healthcare system. Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is less recognized and underdiagnosed type of diabetes which appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age at onset and initial response to oral hypoglycemic agents). An epidemiological study was carried out on 500 patients in the western region of India. Various parameters such as age at onset, duration of diabetes, gender, basal metabolic index (BMI), type of diabetes, family history, HbA1c levels, cholesterol levels, and current treatment regimen were evaluated and correlated with type 1 and type 2 diabetes. Moreover, diagnostic markers for LADA, namely, GAD autoantibodies and C-peptide levels, were determined for 80 patients selected from the epidemiological study. Some of the results obtained were found to be consistent with the literature whereas some results were found to be contradictory to the existing data.","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2012 ","pages":"580202"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/580202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30610828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre. 红枣水提物的急性和慢性毒性评价。

ISRN Pharmacology Pub Date : 2012-01-01 Epub Date: 2012-03-20 DOI: 10.5402/2012/789651

Seewaboon Sireeratawong, Supaporn Vannasiri, Urarat Nanna, Tipaya Singhalak, Kanjana Jaijoy

引用次数: 8