ISRN Pharmacology最新文献

Gastroprotective Effect of Freeze Dried Stripped Snakehead Fish (Channa striata Bloch.) Aqueous Extract against Aspirin Induced Ulcerogenesis in Pylorus Ligated Rats. 冻干条形黑鱼对胃的保护作用水提物抗阿司匹林致幽门结扎大鼠溃疡的作用。

ISRN Pharmacology Pub Date : 2014-05-29 eCollection Date: 2014-01-01 DOI: 10.1155/2014/327606

Mohammed Safwan Ali Khan, Abdul Manan Mat Jais, Javeed Hussain, Faiza Siddiqua, A Gopala Reddy, P Shivakumar, D Madhuri

{"title":"Gastroprotective Effect of Freeze Dried Stripped Snakehead Fish (Channa striata Bloch.) Aqueous Extract against Aspirin Induced Ulcerogenesis in Pylorus Ligated Rats.","authors":"Mohammed Safwan Ali Khan, Abdul Manan Mat Jais, Javeed Hussain, Faiza Siddiqua, A Gopala Reddy, P Shivakumar, D Madhuri","doi":"10.1155/2014/327606","DOIUrl":"https://doi.org/10.1155/2014/327606","url":null,"abstract":"Channa striata (Bloch.) is a fresh water fish belonging to the family Channidae. The stripped snakehead fish possesses wide range of medicinal properties. In view of traditional use of C. striata for wound healing, the present study was undertaken to investigate the beneficial effects of orally administered freeze dried aqueous extract of Channa striata (AECS) in experimentally induced gastric ulcers in Wistar rats. Aspirin induced ulcerogenesis in pyloric ligation model was used for the assessment of antiulcer activity and Ranitidine (50 mg/kg) was employed as the standard drug. The various gastric parameters like volume of gastric juice, pH, free and total acidities, ulcer index, and levels of antioxidant enzymes like catalase, superoxide dismutase, and lipid peroxidation marker malondialdehyde were determined. AECS at concentrations of 40% and 50% w/v significantly decreased the volume of gastric juice and increased the levels of catalase while considerable decrease in free and total acidities and increase in superoxide dismutase were observed with the treatment of standard drug and AECS (50% w/v). All the test doses of AECS markedly decreased ulcer index and malondialdehyde compared to the standard drug whereas AECS 30% w/v did not alter volume of gastric juice, pH, free and total acidities, catalase, and superoxide dismutase. From these findings, it can be concluded that AECS is devoid of acid neutralizing effects at lower doses and possesses antisecretory and antiulcer activities and this could be related to its antioxidant mechanism. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"327606"},"PeriodicalIF":0.0,"publicationDate":"2014-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/327606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32465710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Clot Lysis and Antimitotic Study of Ficus glomerata Roxb Fruit Extracts. 无花果果实提取物的凝块溶解和抗有丝分裂研究。

ISRN Pharmacology Pub Date : 2014-03-31 eCollection Date: 2014-01-01 DOI: 10.1155/2014/975303

Kirankumar Shivasharanappa, Ramesh Londonkar

{"title":"Clot Lysis and Antimitotic Study of Ficus glomerata Roxb Fruit Extracts.","authors":"Kirankumar Shivasharanappa, Ramesh Londonkar","doi":"10.1155/2014/975303","DOIUrl":"https://doi.org/10.1155/2014/975303","url":null,"abstract":"The present study was carried out to investigate the thrombolytic and antimitotic potentiality of various extracts of fruits of Ficus glomerata, a traditional medicinal plant, using an in vitro assay method. Three crude extracts such as petroleum ether (FGPE), chloroform (FGCE), and methanol (FGME) were used for the study, with a standard (streptokinase) and negative control (sterile distilled water) to validate the method. The thrombolytic nature of the plant was found significant with methanol extract and chloroform and petroleum ether extracts have recorded mild activity, when compared with the negative control (sterile distilled water). The extracts have shown mild clot lysis, that is, 2.16%, 23.06%, 27.60%, and 47.74% of sterile distilled water, FGPE, FGCE, and FGME, respectively, while the standard (streptokinase) has shown 74.22% clot lysis. FGME inhibited the root growth in number as well as length effectively, followed by FGPE, while FGCE exhibited moderate antimitotic activity and it was supported by mitotic index. Therefore, the obtained results suggest that among all the extracts of plant the methanolic extract has shown highest thrombolytic and antimitotic activity. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"975303"},"PeriodicalIF":0.0,"publicationDate":"2014-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/975303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32488429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

A review on protocatechuic Acid and its pharmacological potential. 原儿茶酸及其药理潜力的研究进展。

ISRN Pharmacology Pub Date : 2014-03-26 eCollection Date: 2014-01-01 DOI: 10.1155/2014/952943

Sahil Kakkar, Souravh Bais

{"title":"A review on protocatechuic Acid and its pharmacological potential.","authors":"Sahil Kakkar, Souravh Bais","doi":"10.1155/2014/952943","DOIUrl":"https://doi.org/10.1155/2014/952943","url":null,"abstract":"Flavonoids and polyphenols are heterocyclic molecules that have been associated with beneficial effects on human health, such as reducing the risk of various diseases like cancer, diabetes, and cardiovascular and brain diseases. Protocatechuic acid (PCA) is a type of widely distributed naturally occurring phenolic acid. PCA has structural similarity with gallic acid, caffeic acid, vanillic acid, and syringic acid which are well-known antioxidant compounds. More than 500 plants contain PCA as active constituents imparting various pharmacological activity and these effects are due to their antioxidant activities, along with other possible mechanisms, such as anti-inflammatory properties and interaction with several enzymes. Over the past two decades, there have been an increasing number of publications on polyphenols and flavonoids, which demonstrate the importance of understanding the chemistry behind the antioxidant activities of both natural and synthesized compounds, considering the benefits from their dietary ingestion as well as pharmacological use. This work aims to review the pharmacological effects of PCA molecules in humans and the structural aspects that contribute to these effects. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"952943"},"PeriodicalIF":0.0,"publicationDate":"2014-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/952943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32488428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 499

Effect of educational intervention on adverse drug reporting by physicians: a cross-sectional study. 教育干预对医生不良反应报告的影响:一项横断面研究。

ISRN Pharmacology Pub Date : 2014-03-18 eCollection Date: 2014-01-01 DOI: 10.1155/2014/259476

Manisha Bisht, Shruti Singh, D C Dhasmana

引用次数: 32

Antidepressant Effects of Mallotus oppositifolius in Acute Murine Models. 荷花对急性小鼠模型的抗抑郁作用。

ISRN Pharmacology Pub Date : 2014-03-12 eCollection Date: 2014-01-01 DOI: 10.1155/2014/324063

Kennedy K E Kukuia, Priscilla K Mante, Eric Woode, Elvis O Ameyaw, Donatus W Adongo

{"title":"Antidepressant Effects of Mallotus oppositifolius in Acute Murine Models.","authors":"Kennedy K E Kukuia, Priscilla K Mante, Eric Woode, Elvis O Ameyaw, Donatus W Adongo","doi":"10.1155/2014/324063","DOIUrl":"https://doi.org/10.1155/2014/324063","url":null,"abstract":"Objective. Hydroalcoholic extract of leaves of Mallotus oppositifolius (MOE), a plant used for CNS conditions in Ghana, was investigated for acute antidepressant effects in the forced swimming (FST) and tail suspension tests (TST). Results. In both FST and TST, MOE (10, 30, and 100 mg kg(-1)) significantly decreased immobility periods and frequencies. A 3-day pretreatment with 200 mg kg(-1), i.p., para-chlorophenylalanine (PCPA), a tryptophan hydroxylase inhibitor, reversed the decline in immobility and the increase of swimming score induced by MOE in the modified FST. Pretreatment with reserpine alone (1 mg kg(-1)), α -methyldopa alone (400 mg kg(-1), i.p.), or a combination of both drugs failed to reverse the decline in immobility or the increase in swimming score caused by the extract in the modified FST. The extract potentiated the frequency of head twitch responses induced by 5-hydroxytryptamine. Pretreatment with d-serine (600 mg kg(-1), i.p.), glycine/NMDA agonist, abolished the behavioural effects of MOE while d-cycloserine (2.5 mg kg(-1), i.p.), a glycine/NMDA partial agonist, potentiated it in both TST and modified FST. Conclusion. The extract exhibited antidepressant effects in mice which is mediated by enhancement of serotoninergic neurotransmission and inhibition of glycine/NMDA receptor activation. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"324063"},"PeriodicalIF":0.0,"publicationDate":"2014-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/324063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32521254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

An improved experimental model of hemorrhoids in rats: evaluation of antihemorrhoidal activity of an herbal formulation. 改进的大鼠痔疮实验模型:中药制剂抗痔疮活性的评价。

ISRN Pharmacology Pub Date : 2014-03-11 eCollection Date: 2014-01-01 DOI: 10.1155/2014/530931

Mohammed Azeemuddin, Gollapalle Lakshminarayanashastry Viswanatha, Mohamed Rafiq, Agadi HireMath Thippeswamy, Mirza Rizwan Baig, Kethaganahalli Jayaramaiah Kavya, Pralhad Sadashiv Patki, Ramakrishnan Shyam

{"title":"An improved experimental model of hemorrhoids in rats: evaluation of antihemorrhoidal activity of an herbal formulation.","authors":"Mohammed Azeemuddin, Gollapalle Lakshminarayanashastry Viswanatha, Mohamed Rafiq, Agadi HireMath Thippeswamy, Mirza Rizwan Baig, Kethaganahalli Jayaramaiah Kavya, Pralhad Sadashiv Patki, Ramakrishnan Shyam","doi":"10.1155/2014/530931","DOIUrl":"10.1155/2014/530931","url":null,"abstract":"Objective. To improve the existing experimental model of croton oil-induced hemorrhoids in rats by using Evans Blue (EB) dye extravasation technique. Further, an herbal formulation (Pilex) was evaluated for its antihemorrhoidal activity in this model. Methods. Two sets of experiments were carried out: first to improve the experimental model and to validate the same using Pilex and second to evaluate the effect of Pilex on cytoarchitecture of rectoanal tissue in croton oil-induced hemorrhoids. In both sets, hemorrhoids were induced to all the animals, except normal controls, by applying croton oil via rectoanal region and the effect of Pilex ointment (PO), Pilex granules (PG), and combination of PG and PO was evaluated. In the first set, extravasation of EB dye, TNF- α , IL-6, and rectoanal coefficient (RAC) was determined. In the second set, severity of score, RAC, and histopathology were evaluated. Results. The elevated levels of TNF- α , IL-6, and extravasations of EB dye were decreased with the Pilex treatment. The cytoarchitecture of rectoanal portion of the animals treated with Pilex was near to normal. Conclusion. The improved experimental model of hemorrhoid is useful in quantifying the inflammatory exudates and extent of inflammation. In this improved experimental model Pilex showed antihemorrhoidal activity, which further validates its clinical usage. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"530931"},"PeriodicalIF":0.0,"publicationDate":"2014-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/530931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32488427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Antihyperlipidemic and Antioxidant Potential of Paeonia emodi Royle against High-Fat Diet Induced Oxidative Stress. 芍药抗高脂饮食诱导氧化应激的抗高脂血症和抗氧化潜力。

ISRN Pharmacology Pub Date : 2014-03-10 eCollection Date: 2014-01-01 DOI: 10.1155/2014/182362

Bilal A Zargar, Mubashir H Masoodi, Bahar Ahmed, Showkat A Ganie

引用次数: 22

Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine. 小檗（小檗科）各种提取物及其活性成分小檗碱的抗真菌、抗利什曼病和细胞毒性活性。

ISRN Pharmacology Pub Date : 2014-03-10 eCollection Date: 2014-01-01 DOI: 10.1155/2014/602436

Hossein Mahmoudvand, Seyyed Amin Ayatollahi Mousavi, Asghar Sepahvand, Fariba Sharififar, Behrouz Ezatpour, Fatemeh Gorohi, Ebrahim Saedi Dezaki, Sareh Jahanbakhsh

{"title":"Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine.","authors":"Hossein Mahmoudvand, Seyyed Amin Ayatollahi Mousavi, Asghar Sepahvand, Fariba Sharififar, Behrouz Ezatpour, Fatemeh Gorohi, Ebrahim Saedi Dezaki, Sareh Jahanbakhsh","doi":"10.1155/2014/602436","DOIUrl":"10.1155/2014/602436","url":null,"abstract":"In this study, in vitro antidermatophytic activity against Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, and Microsporum gypseum was studied by disk diffusion test and assessment of minimum inhibitory concentration (MIC) using CLSI broth macrodilution method (M38-A2). Moreover, antileishmanial and cytotoxicity activity of B. vulgaris and berberine against promastigotes of Leishmania major and Leishmania tropica were evaluated by colorimetric MTT assay. The findings indicated that the various extracts of B. vulgaris particularly berberine showed high potential antidermatophytic against pathogenic dermatophytes tested with MIC values varying from 0.125 to >4 mg/mL. The results revealed that B. vulgaris extracts as well as berberine were effective in inhibiting L. major and L. tropica promastigotes growth in a dose-dependent manner with IC50 (50% inhibitory concentration) values varying from 2.1 to 26.6 μ g/mL. Moreover, it could be observed that berberine as compared with B. vulgaris exhibited more cytotoxicity against murine macrophages with CC50 (cytotoxicity concentration for 50% of cells) values varying from 27.3 to 362.6 μ g/mL. Results of this investigation were the first step in the search for new antidermatophytic and antileishmanial drugs. However, further works are required to evaluate exact effect of these extracts in animal models as well as volunteer human subjects. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"602436"},"PeriodicalIF":0.0,"publicationDate":"2014-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32465711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promotive effect of topical ketoconazole, minoxidil, and minoxidil with tretinoin on hair growth in male mice. 外用酮康唑、米诺地尔和米诺地尔与曲妥珠单抗对雄性小鼠毛发生长的促进作用

ISRN Pharmacology Pub Date : 2014-03-09 eCollection Date: 2014-01-01 DOI: 10.1155/2014/575423

Muhsin A Aldhalimi, Najah R Hadi, Fadaa A Ghafil

{"title":"Promotive effect of topical ketoconazole, minoxidil, and minoxidil with tretinoin on hair growth in male mice.","authors":"Muhsin A Aldhalimi, Najah R Hadi, Fadaa A Ghafil","doi":"10.1155/2014/575423","DOIUrl":"10.1155/2014/575423","url":null,"abstract":"Recently topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia. Minoxidil is a vasodilatory medication used primarily as antihypertensive drug. It was discovered to have the side effect of hair growth and reversing baldness. Tretinoin is commonly used topically for acne treatment and in the treatment of photoaging. It is used by some as hair loss treatment. Objective. To compare the stimulatory effect of Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on hair growth in a mouse model. Materials and Methods. Coat hairs on the dorsal skin of seven weeks old male mice were gently clipped and then stained by using commercial dye. These mice were divided into four groups each of five treated with topical application of ethanol 95%, Ketoconazole solution 2%, Minoxidil solution 5%, and Minoxidil with Tretinoin solution 0.1%, respectively. The drugs were applied once daily for three weeks, the clipped area was photographed, and the ratio of regrown coat area was calculated. Results. The results demonstrated that Ketoconazole, Minoxidil, and Minoxidil with Tretinoin had a significant stimulatory effect on hair growth compared with the control group and Minoxidil was the most effective drug among them. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"575423"},"PeriodicalIF":0.0,"publicationDate":"2014-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32263760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of arachidonic Acid metabolism in the rat kidney by sulforaphane: implications for regulation of blood pressure. 萝卜硫素对大鼠肾脏花生四烯酸代谢的调节:对血压调节的影响。

ISRN Pharmacology Pub Date : 2014-03-09 eCollection Date: 2014-01-01 DOI: 10.1155/2014/683508

Fawzy Elbarbry, Anke Vermehren-Schmaedick, Agnieszka Balkowiec

{"title":"Modulation of arachidonic Acid metabolism in the rat kidney by sulforaphane: implications for regulation of blood pressure.","authors":"Fawzy Elbarbry, Anke Vermehren-Schmaedick, Agnieszka Balkowiec","doi":"10.1155/2014/683508","DOIUrl":"https://doi.org/10.1155/2014/683508","url":null,"abstract":"Background. We investigated the effects of sulforaphane (SF), the main active isothiocyanate in cruciferous vegetables, on arachidonic acid (AA) metabolism in the kidney and its effect on arterial blood pressure, using spontaneously hypertensive rats (SHR) as models. Methods. Rats were treated for 8 weeks with either drinking water alone (control) or SF (20 or 40 mg/kg) added to drinking water. Mean arterial pressure (MAP) was measured at 7-day intervals throughout the study. At the end of treatment rats were euthanized, and kidneys were harvested to prepare microsomes and measure enzymes involved in regulation of vasoactive metabolites: CYP4A, the key enzyme in the formation of 20-hydroxyeicosatetraenoic acid, and the soluble epoxide hydrolase, which is responsible for the degradation of the vasodilator metabolites such as epoxyeicosatetraenoic acids. Effect of SF on kidney expression of CYP4A was investigated by immunoblotting. Results. We found that treatment with SF leads to significant reductions in both, the expression and activity of renal CYP4A isozymes, as well as the activity of soluble epoxide hydrolase (sEH). Consistent with these data, we have found that treatment with SF resisted the progressive rise in MAP in the developing SHR in a dose-dependent manner. Conclusion. This is the first demonstration that SF modulates the metabolism of AA by both P450 enzymes and sEH in SHR rats. This may represent a novel mechanism by which SF protects SHR rats against the progressive rise in blood pressure. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"683508"},"PeriodicalIF":0.0,"publicationDate":"2014-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/683508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32263761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15