ISRN Pharmacology最新文献_第2页

Efficacy of Composite Extract from Leaves and Fruits of Medicinal Plants Used in Traditional Diabetic Therapy against Oxidative Stress in Alloxan-Induced Diabetic Rats. 传统糖尿病治疗药用植物叶果复合提取物对四氧嘧啶诱导的糖尿病大鼠氧化应激的影响。

ISRN Pharmacology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/608590

Brahm Kumar Tiwari, Dileep Kumar, A B Abidi, Syed Ibrahim Rizvi

{"title":"Efficacy of Composite Extract from Leaves and Fruits of Medicinal Plants Used in Traditional Diabetic Therapy against Oxidative Stress in Alloxan-Induced Diabetic Rats.","authors":"Brahm Kumar Tiwari, Dileep Kumar, A B Abidi, Syed Ibrahim Rizvi","doi":"10.1155/2014/608590","DOIUrl":"https://doi.org/10.1155/2014/608590","url":null,"abstract":"Oxidative stress plays a vital role in diabetic complications. To suppress the oxidative stress mediated damage in diabetic pathophysiology, a special focus has been given on composite extract (CE) and making small dose of naturally occurring antidiabetic plants leaf and fruits. The aim of the present study was to evaluate the beneficial role of CE against alloxan- (ALX-) induced diabetes of Wistar strain rats. A dose-dependent study for CE (25, 50, and 100 mg/kg body weight) was carried out to find the effective dose of the composite compound in ALX-induced diabetic rats. ALX exposure elevated the blood glucose, plasma advanced oxidation product (AOPP), sialic acid demonstrating disturbed antioxidant status.CE at a dose of 100 mg/kg body weight restored/minimised these alterations towards normal values. In conclusion, small dose of CE possesses the capability of ameliorating the oxidative stress in ALX-induced diabetes and thus could be a promising approach in lessening diabetic complications. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"608590"},"PeriodicalIF":0.0,"publicationDate":"2014-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/608590","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32259961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

Both castration and goserelin acetate ameliorate myocardial ischemia reperfusion injury and apoptosis in male rats. 去势和醋酸戈舍林均能改善雄性大鼠心肌缺血再灌注损伤和细胞凋亡。

ISRN Pharmacology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/206951

Najah R Hadi, Fadhil G Yusif, Maitham Yousif, Karrar K Jaen

{"title":"Both castration and goserelin acetate ameliorate myocardial ischemia reperfusion injury and apoptosis in male rats.","authors":"Najah R Hadi, Fadhil G Yusif, Maitham Yousif, Karrar K Jaen","doi":"10.1155/2014/206951","DOIUrl":"https://doi.org/10.1155/2014/206951","url":null,"abstract":"Although reperfusion of an ischemic organ is essential to prevent irreversible tissue damage, it may amplify tissue injury. This study investigates the role of endogenous testosterone in myocardial ischemia reperfusion and apoptosis in male rats. Material and method. Twenty four male rats were randomized into 4 equal groups: Group (1), sham group, rats underwent the same anesthetic and surgical procedure as the control group except for LAD ligation; Group (2), Active control group, rats underwent LAD ligation; Group (3), castrated, rats underwent surgical castration, left 3wks for recovery, and then underwent LAD ligation; and Group (4), Goserelin acetate treated, rats received 3.6 mg of Goserelin 3 wks before surgery and then underwent LAD ligation. At the end of experiment, plasma cTn I, cardiac TNF- α , IL1- β , ICAM-1, and Apoptosis level were measured and histological examination was made. Results. Compared to sham group, the levels of myocardial TNF- α , IL-1 β , ICAM-1, apoptosis, and plasma cTn I were significantly increased (P < 0.05) in control group and all rats showed significant myocardial injury (P < 0.05). Castration and Goserelin acetates significantly counteract the increase in myocardial levels of TNF- α , IL-1 β , ICAM-1, plasma cTn I, and apoptosis (P < 0.05) and significantly reduce (P < 0.05) the severity of myocardial injury. We conclude that castration and Goserelin acetates ameliorate myocardial I/R injury and apoptosis in rats via interfering with inflammatory reactions. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"206951"},"PeriodicalIF":0.0,"publicationDate":"2014-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/206951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32259960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Preventive Effects of a Kampo Medicine, Kakkonto, on Inflammatory Responses via the Suppression of Extracellular Signal-Regulated Kinase Phosphorylation in Lipopolysaccharide-Treated Human Gingival Fibroblasts. 汉布药Kakkonto通过抑制脂多糖处理的人牙龈成纤维细胞的细胞外信号调节激酶磷酸化来预防炎症反应。

ISRN Pharmacology Pub Date : 2014-02-18 eCollection Date: 2014-01-01 DOI: 10.1155/2014/784019

Hiroyuki Kitamura, Hiroko Urano, Toshiaki Ara

{"title":"Preventive Effects of a Kampo Medicine, Kakkonto, on Inflammatory Responses via the Suppression of Extracellular Signal-Regulated Kinase Phosphorylation in Lipopolysaccharide-Treated Human Gingival Fibroblasts.","authors":"Hiroyuki Kitamura, Hiroko Urano, Toshiaki Ara","doi":"10.1155/2014/784019","DOIUrl":"https://doi.org/10.1155/2014/784019","url":null,"abstract":"Periodontal disease is accompanied by inflammation of the gingiva and destruction of periodontal tissues, leading to alveolar bone loss in severe clinical cases. The chemical mediator prostaglandin E2 (PGE2) and cytokines such as interleukin- (IL-)6 and IL-8 have been known to play important roles in inflammatory responses and tissue degradation. In the present study, we investigated the effects of a kampo medicine, kakkonto (TJ-1), on the production of prostaglandin E2 (PGE2), IL-6, and IL-8 by human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS) from Porphyromonas gingivalis. Kakkonto concentration dependently suppressed LPS-induced PGE2 production but did not alter basal PGE2 levels. In contrast, kakkonto significantly increased LPS-induced IL-6 and IL-8 production. Kakkonto decreased cyclooxygenase- (COX-)1 activity to approximately 70% at 1 mg/mL but did not affect COX-2 activity. Kakkonto did not affect cytoplasmic phospholipase A2 (cPLA2), annexin1, or LPS-induced COX-2 expression. Kakkonto suppressed LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation, which is known to lead to ERK activation and cPLA2 phosphorylation. These results suggest that kakkonto decreased PGE2 production by inhibition of ERK phosphorylation which leads to inhibition of cPLA2 phosphorylation and its activation. Therefore, kakkonto may be useful to improve gingival inflammation in periodontal disease. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"784019"},"PeriodicalIF":0.0,"publicationDate":"2014-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/784019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32229879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase. Aloe succotrina 在大鼠体内的抗高血脂活性：可能由抑制 HMG-CoA 还原酶介导

ISRN Pharmacology Pub Date : 2014-02-17 eCollection Date: 2014-01-01 DOI: 10.1155/2014/243575

Dinesh Dhingra, Deepak Lamba, Ramesh Kumar, Pashupati Nath, Satyaprakash Gauttam

{"title":"Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase.","authors":"Dinesh Dhingra, Deepak Lamba, Ramesh Kumar, Pashupati Nath, Satyaprakash Gauttam","doi":"10.1155/2014/243575","DOIUrl":"10.1155/2014/243575","url":null,"abstract":"The present study was designed to investigate antihyperlipidemic activity of dried pulp of Aloe succotrina leaves in Wistar albino rats. Hyperlipidemia was induced in rats by feeding them high fat diet (HFD) or D-fructose (25% w/v) for 4 successive weeks. From 15th to 28th day, dried pulp (100 and 200 mg/kg, p.o) and atorvastatin (10 mg/kg, p.o.) per se were administered 2 h prior to feeding rats with HFD or fructose. Aloe succotrina did not significantly decrease the body weight of rats. The dried pulp and atorvastatin per se significantly decreased relative liver weight but did not significantly affect relative heart weight. HFD or fructose significantly increased serum total cholesterol, triglycerides, LDL-c, and VLDL, and decreased HDL-c; significantly increased liver MDA and decreased GSH levels. The dried pulp (200 mg/kg p.o.) significantly reversed high fat diet-induced and fructose-induced hyperlipidemia and atherogenic index. Aloe succotrina significantly decreased HMG Co-A reductase activity. Antihyperlipidemic effect of the dried pulp was comparable to atorvastatin. Thus, Aloe succotrina produced significant antihyperlipidemic activity in both HFD and fructose-induced hyperlipidemic rats, possibly through normalization of serum lipid profile, HMG-CoA reductase inhibitory activity, and amelioration of oxidative stress in liver. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"243575"},"PeriodicalIF":0.0,"publicationDate":"2014-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32229878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ixora coccinea Enhances Cutaneous Wound Healing by Upregulating the Expression of Collagen and Basic Fibroblast Growth Factor. Ixora coccinea 通过上调胶原蛋白和碱性成纤维细胞生长因子的表达促进皮肤伤口愈合。

ISRN Pharmacology Pub Date : 2014-01-29 eCollection Date: 2014-01-01 DOI: 10.1155/2014/751824

Aadesh Upadhyay, Pronobesh Chattopadhyay, Danswrang Goyary, Papiya Mitra Mazumder, Vijay Veer

{"title":"Ixora coccinea Enhances Cutaneous Wound Healing by Upregulating the Expression of Collagen and Basic Fibroblast Growth Factor.","authors":"Aadesh Upadhyay, Pronobesh Chattopadhyay, Danswrang Goyary, Papiya Mitra Mazumder, Vijay Veer","doi":"10.1155/2014/751824","DOIUrl":"10.1155/2014/751824","url":null,"abstract":"Background. Ixora coccinea L. (Rubiaceae) has been documented for traditional use in hypertension, menstrual irregularities, sprain, chronic ulcer, and skin diseases. In the present study, I. coccinea was subjected to in vitro and in vivo wound healing investigation. Methods. Petroleum ether, chloroform, methanol, and water sequential I. coccinea leaves extracts were evaluated for in vitro antioxidant, antimicrobial, and fibroblast proliferation activities. The promising I. coccinea methanol extract (IxME) was screened for in vivo wound healing activity in Wistar rat using circular excision model. Wound contraction measurement, hydroxyproline quantification, and western blot for collagen type III (COL3A1), basic fibroblast growth factor (bFGF), and Smad-2, -3, -4, and -7 was performed with 7-day postoperative wound granulation tissue. Gentamicin sulfate (0.01% w/w) hydrogel was used as reference standard. Results. IxME showed the potent antimicrobial, antioxidant activities, with significant fibroblast proliferation inducing activity, as compared to all other extracts. In vivo study confirmed the wound healing accelerating potential of IxME, as evidenced by faster wound contraction, higher hydroxyproline content, and improved histopathology of granulation tissue. Western blot analysis revealed that the topical application of I. coccinea methanol extract stimulates the fibroblast growth factor and Smad mediated collagen production in wound tissue. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":" ","pages":"751824"},"PeriodicalIF":0.0,"publicationDate":"2014-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40305311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Useful Medicinal Properties of the Root-Bark Extract of Alstonia boonei (Apocynaceae) May Be Connected to Antioxidant Activity. 杜鹃花(夹竹桃科)根皮提取物的药用价值可能与其抗氧化活性有关。

ISRN Pharmacology Pub Date : 2014-01-27 eCollection Date: 2014-01-01 DOI: 10.1155/2014/741478

Miracle Oluebubechukwu Obiagwu, Chibueze Peter Ihekwereme, Daniel Lotanna Ajaghaku, Festus Basden Chinedu Okoye

引用次数: 17

Efficacy and clinical determinants of antipsychotic polypharmacy in psychotic patients experiencing an acute relapse and admitted to hospital stay: results from a cross-sectional and a subsequent longitudinal pilot study. 对急性复发并住院的精神病患者使用抗精神病药物的疗效和临床决定因素：一项横断面和后续纵向试点研究的结果。

ISRN Pharmacology Pub Date : 2014-01-27 eCollection Date: 2014-01-01 DOI: 10.1155/2014/762127

Felice Iasevoli, Elisabetta F Buonaguro, Massimo Marconi, Emanuela Di Giovambattista, Maria Paola Rapagnani, Domenico De Berardis, Giovanni Martinotti, Monica Mazza, Raffaele Balletta, Nicola Serroni, Massimo Di Giannantonio, Andrea de Bartolomeis, Alessandro Valchera

{"title":"Efficacy and clinical determinants of antipsychotic polypharmacy in psychotic patients experiencing an acute relapse and admitted to hospital stay: results from a cross-sectional and a subsequent longitudinal pilot study.","authors":"Felice Iasevoli, Elisabetta F Buonaguro, Massimo Marconi, Emanuela Di Giovambattista, Maria Paola Rapagnani, Domenico De Berardis, Giovanni Martinotti, Monica Mazza, Raffaele Balletta, Nicola Serroni, Massimo Di Giannantonio, Andrea de Bartolomeis, Alessandro Valchera","doi":"10.1155/2014/762127","DOIUrl":"10.1155/2014/762127","url":null,"abstract":"Background. Antipsychotic polypharmacy is used in several psychiatric disorders, despite poor evidence existing to support this practice. Aim. We evaluated whether psychotic patients in acute relapse exposed to antipsychotic polypharmacy (AP + AP) showed different demographic, clinical, or psychopathological features compared to those exposed to one antipsychotic (AP) and whether AP + AP patients showed significantly higher improvement compared to AP patients after a 4-week treatment. Methods. Inpatients were subdivided into AP + AP and AP ones. In the cross-sectional step, patients were compared according to demographics, clinical variables, and scores on rating scales. In the longitudinal step, patients remained for 4 weeks under admission medications and were compared for clinical improvement. Results. AP + AP patients were more frequently diagnosed with schizophrenia and mental retardation as a comorbid illness. AP + AP patients were more frequently under first-generation antipsychotics and had worse clinical presentation. After 4 weeks of treatment, both AP + AP and AP patients improved compared to the baseline. However, AP patients scored significantly less than AP + AP patients at the Clinical Global Impression Scale at the 4-week time point but not at the baseline, indicating a treatment-specific improvement. Conclusions. Antipsychotic polypharmacy may be offered to specific types of psychotic patients. However, efficacy of this strategy is limited at best. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"762127"},"PeriodicalIF":0.0,"publicationDate":"2014-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32174774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant effects of bovine lactoferrin on dexamethasone-induced hypertension in rat. 牛乳铁蛋白对地塞米松致高血压大鼠的抗氧化作用。

ISRN Pharmacology Pub Date : 2014-01-22 eCollection Date: 2014-01-01 DOI: 10.1155/2014/943523

Leila Safaeian, Hadi Zabolian

{"title":"Antioxidant effects of bovine lactoferrin on dexamethasone-induced hypertension in rat.","authors":"Leila Safaeian, Hadi Zabolian","doi":"10.1155/2014/943523","DOIUrl":"https://doi.org/10.1155/2014/943523","url":null,"abstract":"Dexamethasone- (Dex-) induced hypertension is associated with enhanced oxidative stress. Lactoferrin (LF) is an iron-binding glycoprotein with antihypertensive properties. In this study, we investigated the effect of chronic administration of LF on oxidative stress and hypertension upon Dex administration. Male Wistar rats were treated by Dex (30 μ g/kg/day subcutaneously) or saline for 14 days. Oral bovine LF (30, 100, 300 mg/kg) was given from day 8 to 14 in a reversal study. In a prevention study, rats received 4 days of LF treatment followed by Dex and continued during the test period. Systolic blood pressure (SBP) was measured using tail-cuff method. Thymus weight was used as a marker of glucocorticoid activity. Plasma hydrogen peroxide (H2O2) concentration and ferric reducing antioxidant power (FRAP) value were determined. Dexamethasone significantly increased SBP and plasma H2O2 level and decreased thymus and body weights. LF lowered (P < 0.01) and dose dependently prevented (P < 0.001) Dex-induced hypertension. LF prevented body weight loss and significantly reduced the elevated plasma H2O2 and increased FRAP values. Chronic administration of LF strongly reduced the blood pressure and production of ROS and improved antioxidant capacity in Dex-induced hypertension, suggesting the role of inhibition of oxidative stress as another mechanism of antihypertensive action of LF. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"943523"},"PeriodicalIF":0.0,"publicationDate":"2014-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/943523","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32168834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Intravesical liposome and antisense treatment for detrusor overactivity and interstitial cystitis/painful bladder syndrome. 针对逼尿肌过度活动和间质性膀胱炎/膀胱疼痛综合征的膀胱内脂质体和反义治疗。

ISRN Pharmacology Pub Date : 2014-01-15 eCollection Date: 2014-01-01 DOI: 10.1155/2014/601653

Pradeep Tyagi, Mahendra P Kashyap, Naoki Kawamorita, Tsuyoshi Yoshizawa, Michael Chancellor, Naoki Yoshimura

{"title":"Intravesical liposome and antisense treatment for detrusor overactivity and interstitial cystitis/painful bladder syndrome.","authors":"Pradeep Tyagi, Mahendra P Kashyap, Naoki Kawamorita, Tsuyoshi Yoshizawa, Michael Chancellor, Naoki Yoshimura","doi":"10.1155/2014/601653","DOIUrl":"10.1155/2014/601653","url":null,"abstract":"Purpose. The following review focuses on the recent advancements in intravesical drug delivery, which brings added benefit to the therapy of detrusor overactivity and interstitial cystitis/painful bladder syndrome (IC/PBS). Results. Intravesical route is a preferred route of administration for restricting the action of extremely potent drugs like DMSO for patients of interstitial cystitis/painful bladder syndrome (IC/PBS) and botulinum toxin for detrusor overactivity. Patients who are either refractory to oral treatment or need to mitigate the adverse effects encountered with conventional routes of administration also chose this route. Its usefulness in some cases can be limited by vehicle (carrier) toxicity or short duration of action. Efforts have been underway to overcome these limitations by developing liposome platform for intravesical delivery of biotechnological products including antisense oligonucleotides. Conclusions. Adoption of forward-thinking approaches can achieve advancements in drug delivery systems targeted to future improvement in pharmacotherapy of bladder diseases. Latest developments in the field of nanotechnology can bring this mode of therapy from second line of treatment for refractory cases to the forefront of disease management. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2014 ","pages":"601653"},"PeriodicalIF":0.0,"publicationDate":"2014-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32115779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug utilization study in ophthalmology outpatients at a tertiary care teaching hospital. 一家三级教学医院眼科门诊患者的药物使用情况研究。

ISRN Pharmacology Pub Date : 2013-12-22 DOI: 10.1155/2013/768792

Pradeep R Jadhav, Vijay V Moghe, Yeshwant A Deshmukh

{"title":"Drug utilization study in ophthalmology outpatients at a tertiary care teaching hospital.","authors":"Pradeep R Jadhav, Vijay V Moghe, Yeshwant A Deshmukh","doi":"10.1155/2013/768792","DOIUrl":"10.1155/2013/768792","url":null,"abstract":"In view of the advancement in drug development and availability of new ocular therapeutics in the discipline of ophthalmology, we attempted to study the drug utilization and describe the prescribing practices of ophthalmologists in a tertiary care teaching hospital. Method. A prospective, cross-sectional, observational study was conducted on patients attending Outpatient Department of Ophthalmology for curative complaints. Prescriptions of 600 patients treated were analyzed by the WHO prescribing indicators and additional indices. Results. Analysis showed that the average number of drugs per prescription was 1.49. Percentage of drugs prescribed by generic name was 2.35%. Percentage of encounters with antibiotics was 44.83%. Percentage of drugs prescribed from National Essential drug list (NEDL)/National Formulary of India (NFI) was 19.48%. Patient's knowledge of correct dosage was 93.83%. Antimicrobial agents were the most commonly prescribed drugs followed by antiallergy drugs and ocular lubricants. Fluoroquinolones accounted for 60% of the total antimicrobial drugs, of which gatifloxacin was the most frequently prescribed fluoroquinolone. Conclusion. The study indicated an awareness of polypharmacy, but showed ample scope for improvement in encouraging the ophthalmologists to prescribe by generic name and selection of essential drugs from NEDL/NFI. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2013 ","pages":"768792"},"PeriodicalIF":0.0,"publicationDate":"2013-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32054041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0