Iranian Red Crescent Medical Journal最新文献

{"title":"Tourniquet in surgery of the limbs: a review of history, types and complications.","authors":"Alireza Saied, Alia Ayatollahi Mousavi, Fateme Arabnejad, Afshin Ahmadzadeh Heshmati","doi":"10.5812/ircmj.9588","DOIUrl":"10.5812/ircmj.9588","url":null,"abstract":"<p><strong>Context: </strong>A tourniquet is a device that is used frequently in most orthopaedic surgeries but this routine device can lead to serious complications so we decided to review and declare it for safe instruction and use.</p><p><strong>Evidence acquisition: </strong>We searched the word \"tourniquet\" in PubMed and Google and reviewed all full text English articles and abstracts of non-English articles. In addition, we read all the reference pages of articles to find the new references.</p><p><strong>Results: </strong>The use of tourniquet in orthopedic surgery can lead to serious but rare complications that can be prevented by its correct knowledge and use.</p><p><strong>Conclusions: </strong>At present, there is not enough evidence to discontinue the routine uses of tourniquets.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5812/ircmj.9588","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of three speckle reducing methods for intima-media thickness ultrasound images.","authors":"Mehravar Rafati,&nbsp;Masoud Arabfard,&nbsp;Mehrdad Rafati Rahimzadeh,&nbsp;Hasan Voshtani,&nbsp;Hassan Moladoust","doi":"10.5812/ircmj.25013","DOIUrl":"https://doi.org/10.5812/ircmj.25013","url":null,"abstract":"<p><strong>Background: </strong>Ultrasonic evaluation of intima-media thickness (IMT) is an early marker of assessing the development of atherosclerosis and determining cardiovascular risk. To attain the best possible diagnosis, it is essential that medical images be clear, sharp and without noise and artifacts.</p><p><strong>Objectives: </strong>Comparison of speckle reducing anisotropic diffusion (SRAD), discrete (DTD) and continuum topological derivative (CTD) on B-mode ultrasound images of common carotid and brachial arteries throughout the cardiac cycle.</p><p><strong>Patients and methods: </strong>In a cross-sectional design, an examination was performed on forty-two human subjects with a mean age of 44 ± 6 years from April 2013 to June 2013. This study was approved by the ethics committees of Kashan University of Medical Sciences and Beheshti Hospital. An ultrasonic examination of common carotid and brachial arteries of forty-two human subjects was performed. The program was designed in MATLAB software to extract consecutive B-mode images and apply region of interest (ROI) on the IMT of the common carotid and brachial arteries. Then, three different noise reduction filters with the Canny edge detection were used in ROI separately. Finally, the program measured the image quality metrics.</p><p><strong>Results: </strong>According to values of eleven different image quality metrics (mentioned in the main text), there was a significant difference between CTD, DTD and SRAD filters with the Canny edge detection status in the common carotid and brachial arteries throughout the cardiac cycle (all P values < 0.001). For example, peak signal to noise ratios (PSNR) using CTD, DTD and SRAD filters were 95.43 ± 0.64, 88.86 ± 0.82 and 73.02 ± 0.20 in common carotid and 96.39 ± 1.25, 92.58 ± 0.11 and 88.27 ± 0.63 in brachial arteries, respectively (both P values < 0.001).</p><p><strong>Conclusions: </strong>By measuring image quality metrics, this study showed that DTD and CTD filters with the Canny edge detection respectively, are better than SRAD filter with the Canny detection for speckle suppression and details preservation in both arteries in the ultrasound images.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/26/10/ircmj-17-02-25013.PMC4376986.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33061962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Coping Self-Efficacy Scale Among HIV-Infected Iranian Patients.","authors":"Maryam Mahmoudi,&nbsp;Davoud Shojaezadeh,&nbsp;Tahereh Dehdari,&nbsp;Ebrahim Hajizadeh,&nbsp;Mohammad Hossein Taghdisi,&nbsp;Ladan Abbasian,&nbsp;Mahdiyeh Roohi","doi":"10.5812/ircmj.25074","DOIUrl":"https://doi.org/10.5812/ircmj.25074","url":null,"abstract":"<p><strong>Background: </strong>Self-efficacy is an important predicator of coping with stress.</p><p><strong>Objectives: </strong>This study aimed to determine the psychometric characteristics of the coping self-efficacy (CSE) scale among HIV-infected Iranian patients.</p><p><strong>Patients and methods: </strong>Psychometric properties of the CSE scale were examined by using a cross-sectional study design. One hundred and twenty HIV-infected Iranian patients that had been referred to the Counseling of Behavioral Diseases Center at Imam Khomeini Hospital in Tehran, Iran in 2014 were selected through simple random sampling method. To determine the Content Validity Index (CVI) and the content validity ratio (CVR), a panel of experts (n = 20) reviewed items of CSE scale. Reliability was estimated through the internal consistency (n = 30) and the conformity factor analysis was performed.</p><p><strong>Results: </strong>Iranian version of the CSE scale contained 16 items, including 7 items on the \"use of problem-focused coping\" method, 5 items on \"stopping unpleasant emotions and thoughts\", and 4 items on \"getting support from friends and family\". CVI and CVR scores were 0.79, 0.42 and more, respectively. Internal consistencies (range, 0.64 to 0.84) of 3 subscales were acceptable. Confirmatory factor analysis showed that comparative indices of the model, including CFI, IFI, GFI, RMSEA, and Chi-square (χ2/df) were 0.96, 0.95, 0.84, 0.83, and 1.82, respectively, which indicated a good fit for the data.</p><p><strong>Conclusions: </strong>The Iranian version of the CSE scale is a valid instrument to measure the coping self-efficacy among people living with HIV in research and community settings in Iran.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/fe/ircmj-17-02-25074.PMC4353189.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How well establishment of research plans can improve scientific ranking of medical universities.","authors":"Seyed Hassan Saadat,&nbsp;Morteza Izadi,&nbsp;Jafar Aslani,&nbsp;Mostafa Ghanei","doi":"10.5812/ircmj.18269","DOIUrl":"https://doi.org/10.5812/ircmj.18269","url":null,"abstract":"<p><strong>Background: </strong>As a developing country, Iran has not had a substantial share in global science production activities; however, this country has recently been the forth country in the world regarding research output publications, and biomedical research has played a crucial role in achieving this honorable position.</p><p><strong>Objectives: </strong>In this paper, we aimed to introduce the strategies employed at Baqiyatallah University of Medical Sciences of Iran, to enhance scientific research output of this university.</p><p><strong>Patients and methods: </strong>The present study used the qualitative content analysis technique. The Research deputies and the head of research centers of Baqiyatallah University of Medical Sciences were the research subjects. The main researcher conducted all the interviews. The participants were all authorities of the university. Sampling continued until data saturation. After speaking with 16 participants, the interviews yielded no new information, and no new categories or subcategories were added to the previous ones. Deep and semi-structured interviews with open-ended questions were used to collect data.</p><p><strong>Results: </strong>Diplomacies employed to promote research, organizing educational classes, and foundation of infrastructural organizations for research and true surveillance of research programs were the main characteristics of Baqiyatallah University of Medical Sciences research strategies.</p><p><strong>Conclusions: </strong>Baqiyatallah University of Medical Sciences is a military university of limited resources that has won several awards in the recent years, and has been categorized as one of the leading first ranked medical universities in Iran; a position quite higher than several other larger universities of the country. We recommend more enhanced strategies for other universities.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/14/ircmj-17-02-18269.PMC4353188.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of auditory brain stems evoked response in newborns with pathologic hyperbilirubinemia in mashhad, iran.","authors":"Tooba Okhravi,&nbsp;Saeedeh Tarvij Eslami,&nbsp;Ali Hushyar Ahmadi,&nbsp;Hossain Nassirian,&nbsp;Reza Najibpour","doi":"10.5812/ircmj.18288","DOIUrl":"https://doi.org/10.5812/ircmj.18288","url":null,"abstract":"<p><strong>Background: </strong>Neonatal jaundice is a common cause of sensorneural hearing loss in children.</p><p><strong>Objectives: </strong>We aimed to detect the neurotoxic effects of pathologic hyperbilirubinemia on brain stem and auditory tract by auditory brain stem evoked response (ABR) which could predict early effects of hyperbilirubinemia.</p><p><strong>Patients and methods: </strong>This case-control study was performed on newborns with pathologic hyperbilirubinemia. The inclusion criteria were healthy term and near term (35 - 37 weeks) newborns with pathologic hyperbilirubinemia with serum bilirubin values of ≥ 7 mg/dL, ≥ 10 mg/dL and ≥14 mg/dL at the first, second and third-day of life, respectively, and with bilirubin concentration ≥ 18 mg/dL at over 72 hours of life. The exclusion criteria included family history and diseases causing sensorineural hearing loss, use of auto-toxic medications within the preceding five days, convulsion, congenital craniofacial anomalies, birth trauma, preterm newborns < 35 weeks old, birth weight < 1500 g, asphyxia, and mechanical ventilations for five days or more. A total of 48 newborns with hyperbilirubinemia met the enrolment criteria as the case group and 49 healthy newborns as the control group, who were hospitalized in a university educational hospital (22 Bahaman), in a north-eastern city of Iran, Mashhad. ABR was performed on both groups. The evaluated variable factors were latency time, inter peak intervals time, and loss of waves.</p><p><strong>Results: </strong>The mean latencies of waves I, III and V of ABR were significantly higher in the pathologic hyperbilirubinemia group compared with the controls (P < 0.001). In addition, the mean interpeak intervals (IPI) of waves I-III, I-V and III-V of ABR were significantly higher in the pathologic hyperbilirubinemia group compared with the controls (P < 0.001). For example, the mean latencies time of wave I was significantly higher in right ear of the case group than in controls (2.16 ± 0.26 vs. 1.77 ± 0.15 milliseconds, respectively) (P < 0.001).</p><p><strong>Conclusions: </strong>Pathologic hyperbilirubinemia causes acute disorder on brain stem function; therefore, early diagnosis of neonatal jaundice for prevention of bilirubin neurotoxic effects is essential. As national neonatal hearing screening in not yet established in Iran, we recommend performing ABR for screening of bilirubin neurotoxicity in all cases with hyperbilirubinemia.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/a8/ircmj-17-02-18288.PMC4353218.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased interleukin-17 transcripts in peripheral blood mononuclear cells, a link between T-helper 17 and proinflammatory responses in bladder cancer.","authors":"Rasoul Baharlou,&nbsp;Abdolaziz Khezri,&nbsp;Mahboobeh Razmkhah,&nbsp;Mojtaba Habibagahi,&nbsp;Ahmad Hosseini,&nbsp;Abbas Ghaderi,&nbsp;Mansooreh Jaberipour","doi":"10.5812/ircmj.9244","DOIUrl":"https://doi.org/10.5812/ircmj.9244","url":null,"abstract":"<p><strong>Background: </strong>Interleukin (IL)-17-producing CD4+ T helper (Th17) cells thatare known by producing IL-17 have recently been defined as a unique subset of proinflammatory helper cells. IL-17 is an inflammatory cytokine with robust effect on many cells and it can play important roles in pathogenesis of diverse groups of immune-mediated diseases.</p><p><strong>Objectives: </strong>The aim of this case-control study was to determine the gene expression of IL-6, IL-17, and transforming growth factor beta (TGF-β) in Iranian patients with bladder cancer.</p><p><strong>Patients and methods: </strong>Blood samples were collected from 37 patients with bladder cancer and 37 healthy individuals with no history of malignancies or autoimmune disorders, based of simple sampling. The expression of IL-6, IL-17, and TGF-β were measured by quantitative real-time polymerase chain reaction (qRT-PCR).</p><p><strong>Results: </strong>The mean of IL-17 transcripts was significantly higher in patients with bladder cancer compared with healthy individuals (0.33 ± 0.06 vs. 0.42 ± 0.14, ) (P = 0.04), but their TGF-β was lower (12.53 ± 8.41 vs. 54.94 ± 17.95, ) (P = 0.04). However, the IL-6 transcripts level was similar in both groups (5.34 ± 2.40 vs. 8.07 ± 3.28, ) (P > 0.05) and there was not any significant difference between the noted cytokines expressions among patients with different stages and grades.</p><p><strong>Conclusions: </strong>As most of the cases studied in this investigation were in stages I and II, IL-17 as a prominent proinflammatory cytokine may play an important role in recruiting and infiltrating of antitumor immune responses in early stages of bladder cancer. Furthermore, it can be used as predictor for the clinical stage and prognosis of cancers such as bladder carcinoma.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/b5/ircmj-17-02-9244.PMC4353256.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health knowledge, attitude and practice among Iranian pilgrims.","authors":"Aminreza Tabatabaei,&nbsp;Seyyed Mostafa Mortazavi,&nbsp;Navvab Shamspour,&nbsp;Naser Shushtarizadeh","doi":"10.5812/ircmj.12863","DOIUrl":"https://doi.org/10.5812/ircmj.12863","url":null,"abstract":"<p><strong>Background: </strong>Iran has the highest number of Umrah pilgrims among Islamic countries. Health care plays a major role in fulfilling the Umrah rites. Pilgrims' health situation depends on their health knowledge, attitude, and practice (KAP).</p><p><strong>Objectives: </strong>In this study, we aimed to determine the health KAP among Iranian Umrah pilgrims.</p><p><strong>Patients and methods: </strong>In this cross-sectional study, 157 Iranian Umrah pilgrims were randomly selected in Mecca, Saudi Arabia in June 2011. Data were collected using a questionnaire. The questionnaire consisted of demographic information (sex, age, degree of education, and resource of health knowledge), health knowledge (5 questions), health attitude (5 questions) and health practice (10 questions).</p><p><strong>Results: </strong>Level of knowledge were very low in 12.1%, low in 25.2%, average in 38.1%, good in 20.4% and very good in 4.2% of respondents. Mean and standard deviation of attitude score was 18.58 ± 2.20 out of 25 (ranged between 13.00 and 25.00). The pilgrims were given 74.2 % out of total score. The Mean and standard deviation of practice score was 8.19 ± 1.32 out of 10 (ranged between 3 and 10). Although the old and low educated pilgrims had little knowledge of health tips, they had a good health attitude and practice.</p><p><strong>Conclusions: </strong>Educational strategy to improve knowledge regarding health-related problems and to develop health practices among pilgrims is needed.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/f1/ircmj-17-02-12863.PMC4376984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33188264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' creativity: advantage or disadvantage.","authors":"Sara Shahsavari Isfahani,&nbsp;Mohammad Ali Hosseini,&nbsp;Masood Fallahi Khoshknab,&nbsp;Hamid Peyrovi,&nbsp;Hamid Reza Khanke","doi":"10.5812/ircmj.20895","DOIUrl":"https://doi.org/10.5812/ircmj.20895","url":null,"abstract":"<p><strong>Background: </strong>Recently, global nursing experts have been aggressively encouraging nurses to pursue creativity and innovation in nursing to improve nursing outcomes. Nurses' creativity plays a significant role in health and well-being. In most health systems across the world, nurses provide up to 80% of the primary health care; therefore, they are critically positioned to provide creative solutions for current and future global health challenges.</p><p><strong>Objectives: </strong>The purpose of this study was to explore Iranian nurses' perceptions and experiences toward the expression of creativity in clinical settings and the outcomes of their creativity for health care organizations.</p><p><strong>Patients and methods: </strong>A qualitative approach using content analysis was adopted. Data were collected through in-depth semistructured interviews with 14 nurses who were involved in the creative process in educational hospitals affiliated to Jahrom and Tehran Universities of Medical Sciences in Iran.</p><p><strong>Results: </strong>Four themes emerged from the data analysis, including a) Improvement in quality of patient care, b) Improvement in nurses' quality of work, personal and social life, c) Promotion of organization, and d) Unpleasant outcomes.</p><p><strong>Conclusions: </strong>The findings indicated that nurses' creativity in health care organizations can lead to major changes of nursing practice, improvement of care and organizational performance. Therefore, policymakers, nurse educators, nursing and hospital managers should provide a nurturing environment that is conducive to creative thinking, giving the nurses opportunity for flexibility, creativity, support for change, and risk taking.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5812/ircmj.20895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33147566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expectations of multiple sclerosis patients and their families: a qualitative study in iran.","authors":"Shahla Abolhassani,&nbsp;Ahmadreza Yazdannik,&nbsp;Fariba Taleghani,&nbsp;Ahmadreza Zamani","doi":"10.5812/ircmj.18293","DOIUrl":"https://doi.org/10.5812/ircmj.18293","url":null,"abstract":"<p><strong>Background: </strong>Multiple Sclerosis (MS) is a neurological disease that is most commonly observed among young people. Drug and non-drug treatments are used to prevent the progression of the disease and to control illness-related disorders. Patients with MS often have multiple and complicated needs that require a broad spectrum of health services.</p><p><strong>Objectives: </strong>This study was conducted to identify the expectations of individuals with MS and their families for healthcare services.</p><p><strong>Patients and methods: </strong>This article is part of a qualitative case study. The participants were selected by a purposive sampling method. In this study, semi-structured interviews of 20 individuals with MS and 8 family members were conducted to identify the expectations of MS patients and their families. In addition to the interviews, the documents related to the aim of the study, including weblogs, MS magazines, special websites of individuals with MS, and news agencies were gathered. Analysis of data was performed by a conventional content analysis method.</p><p><strong>Results: </strong>The age of the participants ranged from 22-63 years. The data obtained from this study was classified into 5 main categories as follows: being cured, need for comfort, promoting knowledge, economic welfare, and social security.</p><p><strong>Conclusions: </strong>Individuals with MS and their families had different expectations pertaining to all dimensions of life, such that not meeting the needs related to any dimension could have affect the other dimensions. Therefore, it is necessary for healthcare providers to have a holistic assessment as well as try to meet all needs and expectations.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/dc/ircmj-17-02-18293.PMC4376979.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33182959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of radiographic and laboratory findings between Beta thalassemia major and Beta thalassemia intermedia patients with and without treatment by hydroxyurea.","authors":"Amin Abolhasani Foroughi,&nbsp;Hosein Ghaffari,&nbsp;Sezaneh Haghpanah,&nbsp;Masoume Nazeri,&nbsp;Roghieh Ghaffari,&nbsp;Marzieh Bardestani,&nbsp;Mehran Karimi","doi":"10.5812/ircmj.23607","DOIUrl":"https://doi.org/10.5812/ircmj.23607","url":null,"abstract":"<p><strong>Background: </strong>In patients with thalassemia, chronic anemia causes bone marrow expansion and consequently skeletal manifestation in spine, skull, face and rib bones.</p><p><strong>Objectives: </strong>We aimed to compare chest radiographic findings and facial bone deformity in patients with thalassemia major (TM) and intermedia.</p><p><strong>Patients and methods: </strong>In this cross sectional study, 86 consecutive thalassemia patients referring to the Thalassemia clinic in Shiraz, Southern Iran were evaluated during 2012. Patients were divided into three groups including TM and thalassemia intermedia (TI) with and without taking hydroxyurea (HU). Findings ofchest radiography (trabeculation, rib widening and paraspinal masses) as well as facial bone deformity were evaluated by an expert radiologist. Besides, laboratory findings were measured regarding hemoglobin, ferritin, NRBC and platelet count.</p><p><strong>Results: </strong>All radiologic findings were significantly higher in patients with TI compared to TM (P< 0.05). In patients with TI, only trabeculation was observed with a higher frequency in patients with HU compared to those without HU (68% vs. 27.3%, P= 0.008). In the regression model, from all variables evaluated, only NRBC showed a significant correlation with trabeculation (Exp B = 1.014, CI: 1.004-1.025, P = 0.008) and age showed a significant correlation with paravertebral mass (Exp B = 1.147, CI: 1.03-1.27, P = 0.013).</p><p><strong>Conclusions: </strong>In patients with TM, bone widening, trabeculation, paraspinal masses and facial bone deformity were lower than patients with TI, whichcan be related to effectiveness of therapy with blood transfusion irrespective of its adverse effects in TM patients.</p>","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/e4/ircmj-17-02-23607.PMC4376990.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33067870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}