Iranian Red Crescent Medical Journal最新文献

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Impact of Parents Cancer on Family Communication Models from Adolescents' Perspective 从青少年角度看父母癌症对家庭沟通模式的影响
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-08-18 DOI: 10.32592/ircmj.2023.25.10.2202
{"title":"Impact of Parents Cancer on Family Communication Models from Adolescents' Perspective","authors":"","doi":"10.32592/ircmj.2023.25.10.2202","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.10.2202","url":null,"abstract":"Background: Cancer is a common and fatal disease that affects family members, especially adolescents, and causes changes in family communication patterns Objectives: To investigate the impact of parental cancer on family communication patterns from the adolescents' perspective. Methods: The present study was a descriptive correlational study conducted on one hundred adolescents with parents with cancer who were selected by available sampling method. The research instruments were a demographic questionnaire and a revised standard questionnaire of the Ritchie and Fitzpatrick family communication model. The information was analysed using S.P.S.S. version 16 software and descriptive statistics, analysis of variance, and correlation coefficient. Results: The proportion of consensual communication in the family was lowest (3%) and the proportion of laissez-faire communication in the family was highest (58%). The correlation is inverse in the number of children and in the range of treatment level, and a significant direct correlation is observed in the range of family communication pattern and child rank, but in other cases, the correlation coefficient shows no significant communication (p< 0/05). Conclusion: From the adolescents' perspective, most families whose parents have cancer move toward a laissez-faire family. In these families, there is a low level of conversation and harmony, there is little interaction between family members, and usually only a limited number of topics are discussed. Therefore, the importance of family communication during this time, especially with adolescents, should be emphasized through appropriate education of families whose parents have cancer.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curative Effect of Lateral Transforaminal Endoscopy on the Treatment of Thoracic Disc Herniation 外侧经椎间孔内窥镜治疗胸椎椎间盘突出症的疗效
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-08-18 DOI: 10.32592/ircmj.2023.25.9.2673
{"title":"Curative Effect of Lateral Transforaminal Endoscopy on the Treatment of Thoracic Disc Herniation","authors":"","doi":"10.32592/ircmj.2023.25.9.2673","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.9.2673","url":null,"abstract":"Background: The importance of lateral transforaminal endoscopic treatment of thoracic disc herniation lies in the fact that the use of a needle can remove some of the disc contents and cause the disc herniation to disappear. The present study aimed to evaluate the effect of percutaneous endoscopy on the treatment of patients with thoracic disc herniation. Objectives: To investigate the clinical efficacy and feasibility of transforaminal endoscopic discectomy in the treatment of thoracic disc herniation Methods: This retrospective analysis was conducted on patients with thoracic hernias between January 2014 and December 2019. A total of 13 operative cases were selected via census sampling. Lateral endoscopic treatment of thoracic disc herniation was performed on patients, and they were followed up for 6-18 months. All patients were assessed by the visual analog scale Visual Analogue Score (VAS) and Oswestry Disability Index (ODI) before the surgery, as well as one week, three months, and six months after the operation, respectively. Results: The sample included 13 patients with a mean age of 60.3 years. The location of the thoracic disc herniation varied among the patients. The VAS scores before the surgery, as well as one week, three months, and six months after the surgery, were 7±0.8, 3.3±0.6, 2.3±0.8, 1.4±0.3, and 1.3±0.4, respectively, pointing to a significant decrease (P≤0.001). The ODI scores before the surgery, one day after surgery, one week after surgery, three months after surgery, and six months after surgery were 65.2±5.8%, 11.5±5.3%, 8.9±3.3%, 5.3±2.5, and 4.7±3.5, demonstrating a significant decrease (P≤0.001). The score of the Macnab standard, a rating system evaluating the effectiveness of spine surgeries, was also satisfactory. Conclusion: As evidenced by the results of this study, percutaneous endoscopy in the treatment of patients with thoracic disc herniation was able to improve the clinical condition of patients and replace the previous methods of thoracic hernia surgery as an effective, efficient, and safe method.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Profile and Quality of Life in Patients with Resistant to Treatment Vitiligo Lesions in Iran: Vitiligo Patients need Medico-psycho-social Assistance 伊朗难治性白癜风患者的临床概况和生活质量:白癜风患者需要医疗-心理-社会援助
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-08-14 DOI: 10.32592/ircmj.2023.25.9.2626
{"title":"Clinical Profile and Quality of Life in Patients with Resistant to Treatment Vitiligo Lesions in Iran: Vitiligo Patients need Medico-psycho-social Assistance","authors":"","doi":"10.32592/ircmj.2023.25.9.2626","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.9.2626","url":null,"abstract":"Background: Vitiligo is a common chronic disease associated with physical effects, psychological impacts, and impaired quality of life (QoL). Lesions in acral areas are resistant to treatments. Since these areas are exposed and visible, they have a profound effect on patients' self-confidence. Despite the high prevalence of these conditions, information in this field, especially for Iranian patients, is scarce. Objectives: To study the clinical profile of patients with vitiligo lesions in the acral areas, assess the burden of QoL impairment, and investigate the association between patient's characteristics and their QoL outcomes Methods: A total of 84 patients with non-segmental vitiligo who had involvement in resistant treatment areas were recruited in this study. Clinical characteristics and disease outcomes, with a special emphasis on the quality of life (QoL), were investigated using the Dermatology Life Quality Index (DLQI) questionnaire. Furthermore, the extent of the disease was calculated by utilizing the Vitiligo Area Scoring Index (VASI). Descriptive and comparative analyses were conducted using SPSS software (version 29). Results: The most common comorbidity observed among the patients was various types of immune diseases. The mean total score of DLQI was 8.1, indicating a moderate effect of the disease on the patient's life since the score falls within the range of 6-10. The Kruskal-Wallis non-parametric test illustrated a significant difference in QoL among different age groups (P=0.020). The results indicated a positive, direct, and significant relationship between the extent of the disease and DLQI (r=0.269,;P=0.013). Nonetheless, the relationship between the engagement of the genital area in married patients and difficulties in sexual relations was not found to be statistically significant at α=0.05. Conclusion: The involvement of end-extremities based on existing studies is a frequent occurrence in vitiligo. These affected areas hold considerable significance in terms of the patient's quality of life (QoL) due to their prominent visibility and resistance to available treatments. Considering the high prevalence of psychological consequences, diversity in skin phototypes, and social acceptance, regional studies are necessary for more efficient and responsive medical management integrated with psychosocial assistance.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Telehealth on Pregnant Women's Self-care, Self-efficacy, and Satisfaction during the COVID-19 Pandemic: A Quasi-experimental Study 在 COVID-19 大流行期间,远程保健对孕妇自我护理、自我效能和满意度的影响:准实验研究
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-08-12 DOI: 10.32592/ircmj.2023.25.10.2982
{"title":"Impact of Telehealth on Pregnant Women's Self-care, Self-efficacy, and Satisfaction during the COVID-19 Pandemic: A Quasi-experimental Study","authors":"","doi":"10.32592/ircmj.2023.25.10.2982","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.10.2982","url":null,"abstract":"Background: Pregnant women need correct information and skills for effective self-care and improved self-efficacy during pregnancy. Maternal training will raise women's awareness of pregnancy and childbirth, leading to higher self-efficacy. Objectives: The present study aimed to assess the impact of telehealth on pregnant women's self-care, self-efficacy, and satisfaction during the COVID-19 pandemic. Methods: This quasi-experimental study involved low-risk pregnant women selected from prenatal public clinics in Ahvaz, Iran. Eligible pregnant women (n=150) were assigned to three groups: WhatsApp training (n=50), phone call training (n=50), and control (n=50). Women in the three groups received four face-to-face prenatal care sessions based on the content recommended by the Iranian Ministry of Health. In addition to these four face-to-face sessions, four more virtual training sessions were held for the WhatsApp and phone call groups. Results: Raising the awareness of pregnant women through telephone counseling was found to not only increase their self-efficacy, self-care, and satisfaction but also reduce the need for in-person visits during the COVID-19 pandemic. Furthermore, a moderate positive correlation was observed between self-efficacy and self-care scores; moreover, they have a relatively negative weak correlation with face-to-face visits. Conclusion: The results of this study suggested that most pregnant women were satisfied with telehealth during the COVID-19 pandemic, and thanks to this type of care provision, their self-efficacy and self-care levels were high. Reduced face-to-face visits during the pandemic are the main advantage of telehealth.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on the Transitional Care Model-based Health Management Protocol for Patients after Sleeve Gastrectomy 基于过渡护理模式的袖状胃切除术后患者健康管理方案研究
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-08-05 DOI: 10.32592/ircmj.2023.25.10.2807
{"title":"Research on the Transitional Care Model-based Health Management Protocol for Patients after Sleeve Gastrectomy","authors":"","doi":"10.32592/ircmj.2023.25.10.2807","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.10.2807","url":null,"abstract":"Background: Postoperative care after sleeve gastrectomy is critical to a successful outcome because of the increasing popularity of the procedure in the treatment of obesity and related conditions. Objectives: The purpose of this study was to evaluate the effectiveness of a health intervention plan for sleeve gastrectomy patients based on the Transitional Care Model (TCM). Methods: This study was conducted from January 2021 to January 2022 at Mudanjiang Hospital. The study included a total of 72 patients who underwent sleeve gastric volume reduction. Patients were randomly divided into an intervention group (36 cases) and a control group (36 cases). The intervention group received care based on a health intervention plan, while the control group received routine care. Various assessments were performed on the first day of hospitalization and three months after surgery, such as questionnaires on general information, physical activity, eating behavior, quality of life, and adherence to implementation. Results: After the intervention, the intervention group showed significant improvements in total duration of physical activity, moderate-intensity activity, restrained eating, emotional eating, physical pain, mental health, and social functioning (p<0.05). However, there were no significant differences between groups in activity intensity, walking, external diet, physical functioning, physical role, general health, or vitality (p>0.05). Adherence to the health management protocol was significantly higher in the intervention group (p<0.05). Conclusion: The health intervention plan based on the transitional care model improves physical activity, eating behaviors, quality of life, and compliance in sleeve gastrectomy patients.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139351647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lessons from Flood Disaster Management of Khuzestan Province, Iran, Based on the Experiences of Policymakers: A Qualitative Study 基于决策者经验的伊朗胡齐斯坦省洪水灾害管理教训:定性研究
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-08-05 DOI: 10.32592/ircmj.2023.25.10.2199
{"title":"Lessons from Flood Disaster Management of Khuzestan Province, Iran, Based on the Experiences of Policymakers: A Qualitative Study","authors":"","doi":"10.32592/ircmj.2023.25.10.2199","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.10.2199","url":null,"abstract":"Background: Floods are among the most destructive crises in various countries, including Iran, and are considered a national issue. To reduce flood damages, the flood management process must be regularly reviewed and its problems be identified. Objectives: Therefore, the present study aimed to focus on flood management in April 2019 in Khuzestan province, Iran, to investigate the flood disaster management in Iran based on the experiences of policymakers, identify problems, improve the process of flood disaster management, and reduce damage in the future. Methods: This study was designed based on qualitative content analysis. Data was collected using one-on-one, semi-structured interviews with open-ended questions. According to the targeted sampling method, six policymakers related to the Khuzestan flood disaster management in April 2019 were selected as interviewees. Interviews continued until data saturation. Results: After data analysis, three main themes were identified, namely 1) actions before the flood disaster, such as provision of infrastructure and public awareness, 2) actions during the flood disaster, such as flood disaster level assessment and coordination of actions, and 3) actions after the flood disaster, such as damage assessment. It should be mentioned that each theme included sub-themes and categories. Conclusion: Increased effectiveness of disaster management requires integration and centralization of disaster management and coordination between organizations involved in the disaster at all stages of disaster management, including before, during, and after the disaster. It is also necessary to pay attention to research and successful models and implement preparedness programs along with disaster drills to prevent disaster damage. Engagement of the participation of people should be considered as well.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139351623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of ALCOCK Tube Ultrasound-guided Internal Pudendal Nerve Block in Postoperative Anal Analgesia ALCOCK 管超声引导下的耻骨内神经阻滞在术后肛门镇痛中的应用
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-08-05 DOI: 10.32592/ircmj.2023.25.8.2675
{"title":"Application of ALCOCK Tube Ultrasound-guided Internal Pudendal Nerve Block in Postoperative Anal Analgesia","authors":"","doi":"10.32592/ircmj.2023.25.8.2675","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.8.2675","url":null,"abstract":"Background: While surgery is the most effective treatment for anorectal diseases, traditional anesthesia methods are increasingly regarded not suitable for the clinical needs of anorectal patients. Although pudendal nerve block can play a good analgesic role in the anal region, the traditional pudendal nerve block is performed under blind probing, which is inaccurate in positioning, has poor anesthesia effect, and causes many complications. Objectives: At present, ultrasound-guided pudendal nerve block for analgesia has emerged in clinical practice. Therefore, the present study aimed to investigate the analgesic effect of ALCOCK tube ultrasound-guided internal pudendal nerve block in anal surgery. Methods: A prospective study was conducted. A total of 134 patients who underwent anal surgery in Hangzhou Lin'an District First People's Hospital from May, 2021 to July, 2022 were divided into three categories according to mixed hemorrhoids, anal fistula, and anal fissure and randomly divided into control and experimental groups. The two groups were treated with corresponding surgical treatment, and the experimental group was treated with bilateral pudendal nerve block under the guidance of ALCOCK tube ultrasound at the end of the operation. The operation time, blood loss, initial postoperative pain time, and visual analogue scale, postoperative pain score at each time point, incidence of complications, and patient satisfaction were recorded and analyzed. Results: The operation time of the experimental group was significantly longer than that of the control group, the bleeding volume of anal fistula in the experimental group was more than the control group, the first pain time of anal fistula in the experimental group was higher than that of the control group. The first pain score of anal fistula in the experimental group was lower than that of the control group. Follow-up showed that the pain scores of anal fistula and anal fissure groups were inconsistent 48 h after surgery. The total incidence of adverse reactions was lower, and the patient satisfaction was higher in the experimental group than in the control group. Conclusion: The application of internal pudendal nerve block under the guidance of ALCOCK tube ultrasound in anal surgery has a good analgesic effect and high patient satisfaction, which is worthy of promotion.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139351631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Immediate Latissimus Dorsi Breast Reconstruction after Breast Cancer Surgery 乳腺癌术后即刻背阔肌乳房再造的有效性和安全性
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-08-02 DOI: 10.32592/ircmj.2023.25.8.2817
{"title":"Efficacy and Safety of Immediate Latissimus Dorsi Breast Reconstruction after Breast Cancer Surgery","authors":"","doi":"10.32592/ircmj.2023.25.8.2817","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.8.2817","url":null,"abstract":"Background: Most traditional breast reconstruction surgeries require the removal of the patient's own tissue or the use of artificial implants for reconstruction. The improvement of the efficiency and safety of breast reconstruction surgery assumes critical importance for the rehabilitation of breast cancer patients. Immediate latissimus dorsi breast reconstruction surgery, which utilizes the patient's own tissue to perform immediate reconstruction, can address this issue in a targeted manner, avoiding the cumbersome and complex nature of multiple surgeries. Objectives: To analyze the efficacy and safety of immediate latissimus dorsi breast reconstruction (BR) after breast cancer surgery. Methods: A total of 91 female patients with breast cancer diagnosed and treated by breast surgery in our hospital from August 2017 to July 2021 were retrospectively analyzed. The patients were assigned to the prosthetic implant group (n=39) and latissimus dorsi group (n=52) according to the method of immediate postoperative BR. The difference in curative effect can be analyzed by comparing the operation time, intraoperative bleeding, postoperative drainage time, and aesthetic evaluation of BR. The safety of postoperative BR was analyzed by comparing the postoperative complications, local recurrence rate, distant metastasis rate of breast cancer, and rehabilitation rate. Results: There was no dramatic difference in intraoperative bleeding, postoperative drainage time, and rehabilitation rate between the latissimus dorsi and prosthetic implantation groups (P>0.05). Nonetheless, there was a significant difference in operation time, aesthetic evaluation of BR, postoperative complications, local recurrence rate, and distant metastasis rate of breast cancer in the latissimus dorsi group than the prosthetic implant group(P<0.05). In general, the latissimus dorsi group exhibited better therapeutic effects. Conclusion: Immediate latissimus dorsi BR dramatically affects postoperative breast repair of breast cancer patients and is safer than prosthesis implantation. As an evaluation of their safety and effectiveness, it is necessary to provide patients with more stable and reliable medical outcomes to ensure their surgical safety.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139351981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Silico and Experimental Outcomes of the Expression of miR508-5p and miR-635 in Tumor Tissues of Patients with Breast Cancer 乳腺癌患者肿瘤组织中 miR508-5p 和 miR-635 表达的硅学和实验结果
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-07-30 DOI: 10.32592/ircmj.2023.25.8.2505
Fatemeh Zeinali Sehrig, Mohammad Zaefizadeh, C. Ahmadizadeh, M. Alivand, S. Ghorbian
{"title":"In Silico and Experimental Outcomes of the Expression of miR508-5p and miR-635 in Tumor Tissues of Patients with Breast Cancer","authors":"Fatemeh Zeinali Sehrig, Mohammad Zaefizadeh, C. Ahmadizadeh, M. Alivand, S. Ghorbian","doi":"10.32592/ircmj.2023.25.8.2505","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.8.2505","url":null,"abstract":"Background: Breast cancer (BC) is a malignant tumor that occurs in the epithelial tissue of the breast gland and has become the most common malignancy in women. Various studies have reported the effect of epigenetic changes, including DNA methylation and microRNAs, on breast carcinogenesis. microRNAs play an important role in the post-transcriptional regulation of genes and are important regulators of oncogenic pathways. Studying microRNAs in BC facilitates the development of targeted therapies and early detection of this cancer. Objectives: This study aimed to evaluate the expression level of miR-508-5p and miR-635 in BC tumor tissues compared to healthy marginal tissues. Methods: In silico analysis confirmed microarray datasets (GSE40525, GSE44124 and GSE45666) downloaded from the GEO database. The analysis was defined using the Affy packages in R software to screen remarkably dysregulated miRNAs attended by utilized to predict the potential biological processes and molecular pathways of miR-508-5p and miR-635. Experimental statistical significance of differences in miRNA relative expression results was analyzed by pair-wise fixed reallocation randomization test as a statistical model included in the REST (relative expression software tool). Results: GEO microarray data set, similar to qPCR results, showed that miR-508-5p was downregulated in the sample group by a mean factor of 0.327 (S.E.M range is 0.031-2.000). Moreover, miR-635 was upregulated in the sample group by a mean factor of 2.361 (S.E.M range is 0.250-16.000). Conclusion: miR-508-5p was downregulated, while miR-635 was upregulated in BC tissues. They may be proposed as diagnostic and therapeutic biomarkers for patients with BC.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing a Model to Predict the Mortality in Multiple Trauma Patients due to Traffic Accidents 设计一个模型来预测交通事故导致的多发性创伤患者的死亡率
IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2023-07-30 DOI: 10.32592/ircmj.2023.25.10.2299
{"title":"Designing a Model to Predict the Mortality in Multiple Trauma Patients due to Traffic Accidents","authors":"","doi":"10.32592/ircmj.2023.25.10.2299","DOIUrl":"https://doi.org/10.32592/ircmj.2023.25.10.2299","url":null,"abstract":"Background: It is of prime importance to manage trauma patients in the early hours and use easy trauma severity scoring systems to make decisions and evaluate patient prognosis. Objectives: The present study aimed to design a predictive model of the mortality of multi-trauma patients due to traffic accidents. Methods: This cross-sectional analytical study was performed on 600 patients who suffered from multi-trauma caused by traffic accidents from December 2019 to September 2021. Collected data included age, sex, vital signs, trauma mechanism, involved vehicle in the accident, accident location, and hospital outcome. Results: In this study, 600 multi-trauma cases caused by traffic accidents were evaluated. Among the significant variables included in the regression model, age, Mean Arterial Pressure (MAP), Glasgow Coma Scale (GCS), AVPU (Alert, Verbal response, Pain response, Unresponsive), and vehicle versus fixed objects (in Vehicle 2) in the presence of other variables in the model, significantly predicted patient outcomes. Therefore, with the other variables being constant, one unit increase in the age variable increases the probability of death by 1.04 times, one unit increase in the score of the two variables of MAP and GCS, and also the transfer of trauma mechanism from the fixed object to the vehicle reduces death by 0.92, 0.62, and 0.10 times, respectively. In the AVPU variable, the transition from Alert to Verbal, the transition from Verbal to Pain, and the transition from Pain to Unresponsive increases the probability of death by 32, 104, and 567, respectively. Conclusion: In this study, AVPU, age, MAP, primary GCS, and trauma mechanism due to hitting a vehicle with a fixed object had significantly the highest predictive power of hospital mortality in patients with multiple trauma due to traffic accidents, respectively. It is suggested that further studies be performed to replace the AVPU variable with GCS in the newly designed formulas for calculating the severity of trauma to simplify these scores.","PeriodicalId":14628,"journal":{"name":"Iranian Red Crescent Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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