Iranian journal of kidney diseases最新文献

{"title":"Effects of Nafamostat Mesilate and Systemic Unfractionated Heparin Anticoagulation on Coagulation, Renal Function, and 28-day Survival Status in Critically Ill AKI CRRT Patients.","authors":"Xiaofeng Zhan, Xiaolei Qu, Di Wu, Guangpu Wang, Shoujun Bai, Tingting Ji","doi":"10.52547/5j9v7385","DOIUrl":"10.52547/5j9v7385","url":null,"abstract":"<p><strong>Introduction: </strong>To investigate the effect of continuous renal replacement therapy (CRRT) in patients with severe acute kidney injury (AKI) by using Nafamostat Mesilate (NM).</p><p><strong>Methods: </strong>Eighty patients with AKI who underwent CRRT from March 2022 to January 2022 were divided into control group (n = 40, treated with unfractionated heparin) and Observation group (n = 40, treated with NM). The duration of the first filter use, the number of filters used 72 hours after treatment, coagulation and renal functions, adverse reactions, bleeding events, length of stay in intensive care unit (ICU) and survival status at 28 days were compared between the two groups.</p><p><strong>Results: </strong>The observation group used the first filter for a longer period of time than the control group, and after 72 hours of treatment, the number of filters used was less than that of the control group (P < .05); Compared with before treatment, the levels of fibrinogen (FIB) and platelet count (PLT) in the observation group and control group decreased after 48 hours of treatment, while the levels of activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), and international normalized ratio (INR) increased. However, the levels of FIB and PLT in the former group were higher, while the levels of APTT, PT, TT, and INR were lower (P < .05); Compared with before treatment, the levels of creatinine (Scr), urea nitrogen (BUN), and serum cystatin C (CysC) in the observation group and control group decreased after 48 hours of treatment, and the former was even lower (P < .05); the incidence of bleeding events in the observation group was lower than that in the control group, the length of stay in ICU was shorter than that in the control group, and finally the 28-day survival rate was higher than that in the control group (P < .05). The adverse reactions of the two groups were similar (P > .05).</p><p><strong>Conclusion: </strong>NM can improve the coagulation function and renal function in patients with severe AKI undergoing CRRT, prolong the duration of the filter use, reduce the number of filters used, shorten the length of ICU stay, reduce the incidence of bleeding events, and improve the prognosis.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 1","pages":"41-49"},"PeriodicalIF":0.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Predictive Power of Intraoperative Surgical Apgar Scores in Foreseeing Renal Function after Radical Nephrectomy","authors":"Muharrem Baturu, Hasan Nimetigil, M. Sakıp Erturhan, Mehmet Ozturk, Ömer Bayrak, İlker Seçkiner, Haluk Şen","doi":"10.52547/nm5q0v13","DOIUrl":"10.52547/nm5q0v13","url":null,"abstract":"<p><strong>Introduction: </strong>This study was conducted to evaluate the predictive power of the Surgical Apgar Score (SAS) based on surgical blood loss, the lowest intraoperative heart rate and mean arterial pressure in foreseeing short- and long-term effects of radical nephrectomy (RN) on renal function.</p><p><strong>Methods: </strong>A prospective investigation was conducted on 111 patients who underwent RN for kidney tumors at a tertiary hospital between 2016 and 2019. The SAS and age-adjusted Charlson Comorbidity Index (CCI) scores were calculated in relation to glomerular filtration rates (GFR) changes on postoperative 1st day, 3rd and 12th months.</p><p><strong>Results: </strong>Patients in higher risk groups, stratified on the basis of SAS, had longer operation times, extended hospital stays, increased bleeding, and higher blood transfusion rates (P < .001).No significant difference existed between preoperative and early postoperative GFR values in SAS-stratified risk groups (P = .802, P = .342, respectively). However, a significant GFR decrease occurred in the high-risk group compared to the moderate and low risk groups at postoperative 3rd (60.79 ± 16.86, 76.22 ± 24.20, 69.80 ± 18.92,respectively) and 12th months (53.57 ± 12.74, 71.61 ± 17.52, 71.86 ± 19.33, respectively)(P = .034, P < .001). CCI scores predicted preoperative GFR in low, moderate, and high-risk groups (111.58 ± 30.91 ml/min, 94.81 ± 22.55 ml/min, and 85.43 ± 32.69 ml/min, respectively)(P = .001), but GFR changes between CCI-defined risk groups were not significant at postoperative 3rd and 12th months (P = .546, P = .481).</p><p><strong>Conclusion: </strong>A significant correlation was found between SAS estimated during the RN procedure and GFR changes at three and twelve months after surgery. Based on SAS, early kidney-preserving therapies like diet, and avoidance of nephrotoxic agents may be recommended for high-risk patients to prevent prolonged GFR alterations.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 1","pages":"12-19"},"PeriodicalIF":0.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Continuous Veno-venous Hemodiafiltration Treatment Effects on Biomarkers and Outcomes in Sepsis-Induced Acute Kidney Injury","authors":"Yingying Gao, Jie Wen, Feng Zhao, Yanqin Zhang","doi":"10.52547/kmayqh63","DOIUrl":"10.52547/kmayqh63","url":null,"abstract":"<p><strong>Introduction: </strong>Acute kidney injury (AKI) is commonly precipitated by sepsis. Continuous veno-venous hemofiltration (CVVHD) is a critical intervention for managing AKI, but further exploration is needed to understand its effects on novel renal injury markers and patient outcomes. The aim of this study is to evaluate the impact of CVVHD on novel renal injury markers and its prognostic significance in individuals suffering from sepsis-related AKI.</p><p><strong>Methods: </strong>Retrospective analysis was carried out on the medical data of 84 patients with sepsis-induced AKI treated at Baoji High-Tech Hospital from February 2022 to August 2023. We assessed changes in serum biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and liver fatty acid-binding protein (L-FABP) pre- and post-CVVHDF treatment, and correlated these changes with the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. Cox regression was utilized to identify independent prognostic factors influencing 28-day survival, from which Kaplan-Meier curves and a prognostic nomogram were derived.</p><p><strong>Results: </strong>A significant reduction in the serum concentrations of s-NGAL, L-FABP, and KIM-1 was observed following treatment (all P < .001). A positive correlation between these serum biomarkers and APACHE II scores was observed both before and after CVVHDF treatment (all P < .001). According to multivariate Cox regression analysis, coronary heart disease (P = .016), the stage of renal injury (P = .014), APACHE II score (P < .001), and s-NGAL (P < .001) were independent predictors of prognosis for 28-day survival.</p><p><strong>Conclusion: </strong>CVVHD effectively decreases KIM-1, L-FABP, and NGAL levels, thereby enhancing kidney function in individuals suffering from sepsis-related AKI. Key prognostic indicators for 28-day survival include the presence of coronary artery disease, advanced kidney injury stage, APACHE II score ≥ 26, and NGAL levels ≥ 5.49.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"19 1","pages":"20-29"},"PeriodicalIF":0.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Descriptive Study on \"Renal Biopsy\" Samples of Patients Admitted to Shahid Labbafinezhad Hospital (2019-2022).","authors":"Manouchehr Nasrollahzadeh Saravi, Fariba Samadian, Mahzad Rahmani, Mahdi Mohseni","doi":"10.52547/ijkd.8074","DOIUrl":"10.52547/ijkd.8074","url":null,"abstract":"<p><p>This epidemiological study aimed to identify the primary categories of kidney pathology diagnosis and their prevalence among patients admitted to Shahid Labbafinezhad Teaching Hospital. We included 1006 kidney biopsy findings from 2019 to 2022. The majority of kidney patients (78%) were between the ages of 20 and 60 years. Nephrotic syndrome made up 62% of the patient population. The findings revealed that primary glomerulonephritis, secondary glomerulonephritis, tubular/interstitial nephritis, end-stage kidney disease, and unclassified cases accounted for 63%, 17%, 12%, 6%, and 2% of kidney disease cases, respectively. The inclusion of a large number of patients from various regions across the country, combined with the expertise of the laboratory staff, underscores the reliability and significance of the results obtained in this study.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 6","pages":"313-317"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Alpha-Pinene Pre-Treatment in Renal Ischemia-Reperfusion Injury in Male Rats.","authors":"Sedighe Khodsooz, Ali Gol, Shahriar Dabiri","doi":"10.52547/ijkd.8070","DOIUrl":"10.52547/ijkd.8070","url":null,"abstract":"<p><strong>Introduction: </strong>Ischemia followed by reperfusion in organ transplantations can lead to ischemia-reperfusion (I-R) injury, which is associated with oxidative stress and inflammatory responses. Alpha-pinene is an organic terpene with well-known antioxidant, anti-inflammatory, and anti-apoptotic properties. This study examines the preventive effects of alpha-pinene against renal I-R-induced kidney dysfunction, oxidative and inflammatory status, apoptosis, and histopathology changes.</p><p><strong>Methods: </strong>Forty-two adult male Wistar rats weighting 200-250 gr were divided into six groups (n = 7): Control, Right Nephrectomy, Ischemia-Reperfusion (45 min ischemia and 24 h reperfusion), and I-R + three different doses of alpha-pinene (2.5, 5, and 10 mg/kg) 24 hours and just before induction of ischemia through gavage. After 24 hours, urine, serum, and the remaining kidney were collected for biochemical and tissue analysis.</p><p><strong>Results: </strong>Renal I-R caused kidney damage indicated by a significant decrease in creatinine clearance, induction of oxidative stress, increased inflammatory cytokines, and histopathological injuries. Alpha-pinene significantly improved the damage by restoring the changes toward the control group. Alpha-pinene, in the effective dose (2.5 mg/kg), reduced the levels of Bax, Bcl-2, TNF-α, and IL1β and contributed to regenerating tissue damage following renal I-R.</p><p><strong>Conclusions: </strong>Aalpha-pinene has been able to reduce the complications due to its antioxidant, anti-inflammatory, and anti-apoptotic properties. It is suggested that it can be used as a pretreatment in reducing renal complications in renal transplantation.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 6","pages":"376-379"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Incidence, Risk Factors, and Outcomes of Acute Kidney Injury in Pediatric Hematopoietic Stem Cell Transplant Recipients.","authors":"Atbin Latifi, Nader Momtazmanesh, Bibi Shahin Shamsian, Sharareh Kamfar, Masoumeh Mohkam, Mojtaba Ahmadlou, Armin Shirvani, Mahnaz Jamee","doi":"10.52547/3jdey681","DOIUrl":"10.52547/3jdey681","url":null,"abstract":"<p><strong>Introduction: </strong>Acute kidney injury (AKI) is a frequent complication after hematopoietic stem cell transplantation (HSCT), with reported incidences ranging from 20-70% within the first 100 days post-transplant. AKI can adversely impact outcomes and survival in this patient population.</p><p><strong>Methods: </strong>This retrospective study evaluated 110 pediatric patients who underwent HSCT at Mofid Children's Hospital, affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Iran, between 2016-2021. AKI was defined and staged according to the criteria for Kidney Disease Improving Global Outcomes (KDIGO).</p><p><strong>Results: </strong>The cohort comprised 68 (61.8%) males and 42 (38.2%) females, with a mean age of 6.4 ± 4.1 years. Underlying disorders were malignant in 64 (58.1%) and non-malignant in 46 (41.9%) patients. Among the cohort, 84 (76.3%) patients underwent allogeneic HSCT, while 26 (23.7%) received autologous HSCT. Myeloablative and reduced-intensity conditioning regimens were used in 77 (70%) and 33 (30%) patients, respectively. AKI developed in 53 (48%) patients within 100 days post-transplant, with incidences of 38%, 40%, and 22% for stages 1, 2, and 3 AKI, respectively. AKI incidence was higher in allogeneic HSCT (52%) compared to autologous HSCT (17%; P = 0.023). Younger age (P = 0.033) and non-malignant disorders (P = 0.033) were associated with increased AKI risk. At the end of the study, 77 (70%) patients were alive, and 33 (30%) had deceased, with a significant positive correlation between AKI stage and mortality (P = 0.004).</p><p><strong>Conclusion: </strong>This study highlights the high prevalence of AKI among pediatric HSCT recipients, particularly those undergoing allogeneic HSCT, at a younger age, and with non-malignant disorders. Regular post-transplant renal monitoring may improve survival in this population.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 6","pages":"318-325"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Analysis of Autophagy-Related Genes in Kidney Transplantation.","authors":"Cankun Xie, Wingkeung Yiu, Jiahui Jie, Yonglu Wu, Guanjun Li","doi":"10.52547/c9btn873","DOIUrl":"10.52547/c9btn873","url":null,"abstract":"<p><strong>Introduction: </strong>Autophagy related genes (ARGs) may play important roles in various biological processes involving kidney transplantation (KT); however, their expression characteristics are rarely used to study the relationship between autophagy and prognosis in KT patients. This study aims to construct a new autophagy related gene feature based on high-throughput sequencing datasets.</p><p><strong>Methods: </strong>Differentially expressed ARGs (DEARGs) were identified in KT patients based on the Gene Expression Omnibus (GEO) database. Gene Ontology (GO)and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to explore potential biological and pathological functions of DEARGs. Univariate and Lasso Cox regression analyses identified survival-related DEARGs and established a prognostic gene signature whose performance was evaluated by Kaplan-Meier curve and receiver operating characteristic (ROC). Moreover, the prognostic value of the gene signature was further validated in 48 KT patients from the GSE21374 dataset.</p><p><strong>Results: </strong>A total of 28 common DEARGs were identified between rejection and non-rejection samples in 3 datasets, including GSE21374, GSE36059, and GSE48581. GO and KEGG enrichment analyses showed that DEARGs were mainly involved in regulating apoptotic processes. In addition, we identified and validated 7 DEARGs (CASP1, CASP3, FKBP1A, RAB11A, NFKB1, RGS19, and CCL2) as the prognostic signatures. The Kaplan-Meier (K-M) analysis showed that the survival rate of the high-risk patients was significantly lower than that of the low-risk patients.</p><p><strong>Conclusion: </strong>The effectiveness of autophagy related features was validated by using 48 KT patients in the GSE21374 dataset, and establishing and confirming a new ARG signal with independent survival prognostic value for KT patients.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 6","pages":"337-359"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Protein Energy Wasting and Oxidative Stress Markers in Peritoneal Dialysis.","authors":"Francisco Gerardo Yanowsky-Escatell, Leonardo Pazarin-Villaseñor, Jorge Andrade-Sierra, Yessica García-Salas, Andrés García Sánchez, Alejandra Guillermina Miranda-Díaz, Tonatiuh Delgado-Figueroa, Pedro Alberto Mendoza-Rosales, Eduardo de Jesús Torres-Vázquez, Carlos Alberto Andrade-Castellanos, María Teresa Tapia de la Paz, Diana Mercedes Hernández-Corona, Tonatiuh González-Heredia, Kevin Javier Arellano-Arteaga, Luis Miguel Róman-Pintos","doi":"10.52547/ijkd.7805","DOIUrl":"10.52547/ijkd.7805","url":null,"abstract":"<p><strong>Introduction: </strong>Protein-energy wasting (PEW) is highly prevalent among patients undergoing peritoneal dialysis (PD), and it has been proposed that oxidative stress (OS) may contribute to its pathogenesis. This study was an attempt to determine the association between the presence of PEW and OS levels in PD patients.</p><p><strong>Methods: </strong>This analytical cross-sectional study involved 62 clinically stable PD patients aged ≥ 18 years, between September 2017 and July 2018. PEW was assessed using PEW definition criteria, 7-point Subjective Global Assessment (SGA), and Malnutrition-Inflammation Score (MIS). Redox state was evaluated through oxidants (lipoperoxides, 8-Isoprostane, nitric oxide), antioxidants (superoxide dismutase, catalase, glutathione peroxidase-GPx, total antioxidant capacity), and oxidative DNA damage [8-hydroxy2'-deoxyguanosine-8-OHdG, 8-Oxoguanine-DNA-N-Glycosylase-1(8-OHdG)].</p><p><strong>Results: </strong>Among study participants, 38 (61.2%) were males and 24 (38.8%) were females; 22 (35.4%) had diabetes mellitus [males 15 (68.1%) and females 7 (31.8%)]. The average PD duration was 11 (4-27) months, body mass index: 23.5 ± 4.1 kg/m2, energy intake: 1138.4 ± 394.2 kcal/day, and protein intake: 50.2 ± 18.5 g/day. Prevalence of PEW varied based on the assessment method used (50-88.7%). Plasma 8-OHdG levels were higher in patients with PEW evaluated by MIS (0.1 [0.1-56.4] vs. 1.8 [0.1-74.7] ng/mL, P = .028), while GPx activity was lower in the presence of PEW as measured by MIS (3.6 [3.1-7.6] vs. 2.8 [1.2-10] nmol/min/mL, P = .021). No significant differences were observed between PEW markers and remaining OS levels.</p><p><strong>Conclusions: </strong>In PD patients with PEW, assessed by MIS, 8-OHdG was significantly increased, while GPx activity was significantly low.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 6","pages":"360-368"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TACI Ig Fusion Protein Inhibits TLR4/MyD88/NF-κB Pathway Alleviates Renal Injury in IgA Nephropathy Rats.","authors":"Jianhua Sun, Yue Cheng, Wei Zhang, Peng Chen, Xinnan Chen, Caili Wang, Zengyan Li","doi":"10.52547/a63wam88","DOIUrl":"10.52547/a63wam88","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the impact of TACI fusion protein (TACI-Ig) on IgA nephropathy (IgAN) in rats, and to explore its mechanism and relationship with TLR4/MyD88/NF-κB pathway.</p><p><strong>Method: </strong>Sprague Dawley(SD)rats were divided into six groups: control, model, TACI-Ig low dose (TACI-Ig-L), medium dose (TACI-Ig-M), high dose (TACI-Ig-H), and prednisone acetate (PAT) group. The control group and model group received physiological saline injections, while the TACI-Ig groups were administered doses of 7.18, 14.36, and 28.72 mg/kg of TACI-Ig, respectively. PAT group was pretreated with prednisone acetate. After 8 weeks, kidney weight/body weight ratios, 24-hour urine protein (24 h UP), serum creatinine (SCr), and blood urea nitrogen (BUN) levels were measured. Additionally, concentrations of B cell activating factor (BAFF), APRIL, and Gd-IgA1 were evaluated by using ELISA. Pathological changes in kidney tissues were scored, and TLR4, MyD88, NF-κB expression levels were detected through western blot (WB) and RT-qPCR.</p><p><strong>Results: </strong>Renal function assessments showed that the IgAN model group exhibited increased in 24 h UP, SCr, BUN, and elevated serum levels of BAFF, APRIL, Gd-IgA1, alongside higher TLR4/MyD88/NF-κB protein expression. TACI-Ig treatment significantly reduced proteinuria, SCr, BUN, levels of BAFF, APRIL, and Gd-IgA1 in IgAN rats. Pathologically, TACI-Ig ameliorated glomerular mesangial deposition and fibrosis. It also inhibited TLR4/MyD88/NF-κB protein expression, demonstrating anti-inflammatory and immune regulatory effects.</p><p><strong>Conclusions: </strong>TACI-Ig mitigates renal injury in IgAN rats by reducing inflammatory infiltration and IgA deposition and suppressing the pathway of TLR4/MyD88/NF-κB, offering data for developing effective treatments for IgAN.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 6","pages":"326-336"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis of Blood Pressure Variability, Crystalloid Osmotic Pressure, and Cardiovascular Events in Maintenance Hemodialysis Patients.","authors":"Tanqi Chen, Shengsheng Cao, Lingzhi Shen, Zhong Liu","doi":"10.52547/ijkd.8172","DOIUrl":"10.52547/ijkd.8172","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to analyze the correlation between blood pressure variability (BPV), crystalloid osmotic pressure, and cardiovascular events (CEs) in patients undergoing maintenance hemodialysis (MHD).</p><p><strong>Methods: </strong>This retrospective analysis was conducted on 71 patients with end-stage kidney disease who underwent hemodialysis at Beilun District People's Hospital from September 2021 to September 2022. The patients were divided into two groups based on the occurrence of CEs: a cardiovascular event group and a non-cardiovascular event group.</p><p><strong>Results: </strong>The 71 patients were divided into two groups based on the occurrence of CEs: the CEs group (25 patients who experienced CEs) and the non-CEs group (46 patients who did not experience CEs). The CEs group had significantly higher levels of crystalloid osmotic pressure, standard deviation of systolic BP (SBP-SD), coefficient of variation of SBP (SBP-CV), SD of diastolic BP (DBP-SD), and DBP-CV (P < .05). Multivariate logistic regression analysis identified crystalloid osmotic pressure, SBP-CV, and DBP-CV as independent risk factors for CEs. The ROC curve analysis indicated that the combined predictive value of crystalloid osmotic pressure, SBP-CV, and DBP-CV was significant, with an area under the curve (AUC) of 0.963.</p><p><strong>Conclusion: </strong></p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"18 6","pages":"369-375"},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}