Iranian Journal of Pediatrics最新文献

{"title":"Different Placental Transfusion Strategies and Their Effects on Short - Term Hematological Parameters in Term Infants","authors":"B. Yaşa, Ilker Gonen, E. Dincer, Aslan Babayiğit, Ozge Saglam, M. Çetinkaya","doi":"10.5812/ijp-133597","DOIUrl":"https://doi.org/10.5812/ijp-133597","url":null,"abstract":"Background: Deferring the umbilical cord clamping produces more satisfactory neurological and hematological outcomes. Another alternative for the deferred umbilical cord clamping is the umbilical cord milking. Objectives: This study aimed to evaluate different placental transfusion techniques in terms of hematological parameters for term neonates. Methods: This observational study included 120 term infants assigned to groups of deferred cord clamping for 60 seconds (DCC), cut cord milking for four times with a speed of 10 cm/second (CCM), intact cord milking for four times (ICM), and a historical control group of immediate cord clamping (ICC). The primary outcome of this study was hematological parameters at birth and 24th hours. Hyperbilirubinemia, polycythemia, or respiratory distress were secondary outcomes. Results: The median gestational ages and birth weights of neonates were 39 (37 - 40) weeks and 3270 (2365 - 4850) grams, respectively. Umbilical cord hemoglobin (Hb) and hematocrit (Hct) levels were significantly higher in the ICM group (P < 0.01). Hemoglobin and Hct levels at 24th hours of life were similar in DCC, CCM, and ICM groups and significantly higher than those in the ICC group (P < 0.01). No significant difference was found among the groups in terms of hyperbilirubinemia, polycythemia, and respiratory distress. Conclusions: To the best of our knowledge, this study was one of the most comprehensive studies evaluating the effects of different placental transfusion strategies on hematological parameters in term infants and the first study exploring intact cord milking in term infants. Intact cord milking was suggested to be associated with higher hemoglobin levels at birth. All DCC, ICM, and CCM techniques were found to be more effective than ICC in terms of early hematological parameters.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"44 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73758551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Hypernatremia Dehydration in Three Neonates with Ichthyosis","authors":"Razieh Sangsari, M. Saeedi, K. Mirnia","doi":"10.5812/ijp-129542","DOIUrl":"https://doi.org/10.5812/ijp-129542","url":null,"abstract":"Introduction: Ichthyosis is an epidermal disruption that increases insensible water loss. Hypernatremic dehydration is a consequence of skin disruption. This study reviewed the treatment of hypernatremic dehydration in patients with ichthyosis comparing to patients with intact skin. Case Presentation: We studied five neonates with hypernatremia, including three ichthyosis cases and two normal-skin neonates. This case-series study showed that the sodium correction rate is slower in infants with ichthyosis than in infants with normal skin. The first and second neonates needed less sodium than fluid intake than normal skin infants, although fluid requirement was lower in the third ichthyosis infant than in others due to less skin disruption in this infant. Conclusions: Fluid therapy in hypernatremic dehydration in ichthyosis patients is different from neonates with intact skin because of excessive insensible water loss in these patients. It may be needed to give more fluid and less sodium depending on the degree of skin disruption, which may not be determined by physical examination.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"63 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81116976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Long-term Social Distancing on Sleep and Mood in Adolescents During the COVID-19 Pandemic","authors":"S. Rhie","doi":"10.5812/ijp-130598","DOIUrl":"https://doi.org/10.5812/ijp-130598","url":null,"abstract":"Background: School timings could influence teens' sleeping patterns by interrupting their sleep or the timing of light can shift their biological clock. The COVID-19 pandemic has altered teens’ sleeping schedule making it important to analyze the effects of long-term social distancing on adolescents’ sleep and mood. Objectives: This study analyzes the effects of long-term social distancing, due to the COVID-19 pandemic, on their sleeping patterns and mood. Methods: In this cohort study, data from the 2018 – 2020 Korea Youth Risk Behavior Web-based Survey (KYRBS) were used to compare teens’ sleep patterns in 2020 with those in 2018 – 2019. The primary outcomes of this study were the sleep duration and sleep time of adolescents throughout the week, between 2018 and 2019, and in 2020. The secondary outcomes were the teens’ mood, health perception, and sleep satisfaction, including differences in total sleep time and sleep discrepancies between weekends and weekdays. Results: Around 58 – 63 thousand students were surveyed each year, and the participation rate was 94.9 – 95.6%. After exclusion, 132,839 teens participated in the survey. From 2018–2020, the height and body weight of the participants did not change. After adjusting for participants’ sex and school year, it was found that more teens felt happy, fewer teens experienced sadness and desperation, and fewer teens had suicidal thoughts in 2020, compared with the previous two years. They also slept 10 minutes later (9.743 (95% confidence interval 7.954 - 11.530)), with wake-up times of 3 – 5 minutes later on weekdays (4.684 (3.449 - 5.919)). On weekends during social distancing, they slept 16 minutes later (15.721 (14.077 - 17.366)), with wake-up times of 12 minutes later (12.309 (10.393 - 14.225)). Although they slept five minutes less on weekdays (-5.059 (-6.817 to -3.301)) and three minutes less on weekends (-3.413 (-5.419 to -1.407)), their overall sleep satisfaction increased, and differences in sleep duration between weekdays and weekends decreased in 2020. Conclusions: During social distancing, the mood and sleep efficiency of teens improved. In the future, once the COVID-19 pandemic subsides, online classes can be included in the curriculum of school systems to ensure healthy sleep patterns in teenagers.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"13 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74756354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive Electrical Source Imaging for Localizing Epileptiform Discharges in Children with Focal Epilepsy Based on Developing Country’s Limitations","authors":"Soheil Ahmadzadeh Irandoost, R. S. Badv, M. Oghabian, B. Yarali, Reza Azizi Malamiri, H. Hashemi, S. Raminfard, Tayyebeh Ebrahimi, Mahmoud Mohammadi, M. Ashrafi","doi":"10.5812/ijp-121981","DOIUrl":"https://doi.org/10.5812/ijp-121981","url":null,"abstract":"Background: Preliminary studies have shown that electrical source imaging (ESI) has numerous advantages for the pre-surgical evaluation of epileptic patients. However, the role of ESI for children with non-lesional drug resistance in focal epilepsy has been poorly characterized. Objectives: This study aimed to investigate this issue according to interictal epileptiform discharges (IEDs) and constraints in developing countries. Methods: The present study used long-term video electroencephalography (EEG) monitoring (LTM) data that were recorded using the standard 19 scalp electrodes (10 - 20 system) and 3 tesla T1 image data. Accordingly, first, IEDs were clustered and then assessed by an epileptologist. Afterward, some operations were conducted that included EEG inverse problem solving with three known methods, namely brain electrical source analysis (BESA) with the individual head model, cortical classical LORETA analysis recursively analysis (CLARA) with the individual head model, and BESA with the age template head model. Seven children were processed in this project. Results: In most cases (n = 5, 71%), the seizure onset zone (SOZ) was the same in the LTM report and the present proposed methodology. Moreover, this study succeeded in localizing the region of the predicted SOZ. Conclusions: According to limitations in a developing country, for the configuration of multi-modal studies (e.g., 3T magnetic resonance imaging, LTM, and ESI) with a specific and valuable protocol, this investigation defined a pilot study with a 7 data sample for the first step. These findings, based on the small sample size, suggest that ESI based on combining ensemble methods improves information for children with focal drug-resistant epilepsy. It is hoped that future studies with large sample sizes show the role of ESI in developing countries more than before.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"11 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80242369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An 11-Year-Old Boy with Dry Cough and Respiratory Distress (from Children’s Medical Center Grand Rand)","authors":"Narges Khazaei, M. Shariat, M. Effatpanah, Mohammad Ali Pourmirzaiee, M. Olfat, S. H. Mirlohi","doi":"10.5812/ijp-127928","DOIUrl":"https://doi.org/10.5812/ijp-127928","url":null,"abstract":": The patient was an 11-year-old boy who was referred to our emergency department with a chief complaint of dry cough and shortness of breath. He was diagnosed with asthma when he was three years old and was treated with inhalers as needed. On physical examination, he had respiratory distress and biphasic wheezing. The patient was initially managed as an asthma attack; however, he did not respond to the treatment completely. After a pulmonology consult, he underwent a spirometry test, which was compatible with an obstructive pattern. He was a candidate for fiberoptic bronchoscopy, which revealed findings in favor of vocal cord dysfunction (VCD) and adult-onset laryngomalacia. As part of the management of VCD, we referred him to a psychiatric clinic, evaluating for psychological problems as aggravating factors. We found that he suffered from psychological disorders, including somatic symptoms disorders and mild to moderate depression. The patient was treated for his psychiatric problems. He responded to the treatment well, and the cough and dyspnea attacks resolved gradually after a few months.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"2003 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82930427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Relationship Between Perfusion Index and the Improvement of Patent Ductus Arteriosus","authors":"Razieh Sangsari, Hosein Dalili, M. Kadivar, M. Saeedi, K. Mirnia, Azam Fathi, Javad Hakimelahi","doi":"10.5812/ijp-134709","DOIUrl":"https://doi.org/10.5812/ijp-134709","url":null,"abstract":"Background: Patent ductus arteriosus (PDA) is a disease presenting on the first days of birth, associated with unpleasant complications such as exaggerated respiratory distress and increased mortality, requiring prompt treatment. Objectives: This study evaluated the relationship between perfusion index and the recovery of patients diagnosed with PDA. Methods: In this cross-sectional study, 22 neonates with PDA (as the case group) and 22 healthy neonates (as the control group) were selected. The difference in perfusion index (PI) before and after arterial duct closing was determined, and also the relationship between pre-ductal and post-ductal PI in the case and control groups was evaluated. Data were analyzed by SPSS version 21. Results: The results showed a significant difference in the mean scores of pre-ductal and post-ductal PI before and after arterial duct closure (P = 0.004). Also, pre-ductal and post-ductal PI scores were significantly lower in the case group than in the control group (P < 0.001) Conclusions: According to our findings, PI in infants with PDA is low at presentation and increases after treatment. Therefore, PI can be used as an indicator to evaluate response to treatment during follow-up, particularly when repeated echocardiography is not accessible.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"47 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84349032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infantile Prognosis of Neonates Conceived by Assisted Reproductive Technology: A Prospective Study","authors":"Ellieh Khoei, Seyed Abolfazl Afjehi, S. Tajalli, Roqayeh Aliyari, M. Fallahi","doi":"10.5812/ijp-132408","DOIUrl":"https://doi.org/10.5812/ijp-132408","url":null,"abstract":"Background: Neonates of infertile couples are golden babies, and taking care of them is of paramount importance. However, it is not yet clear if the prognosis is different between these neonates and those from fertile couples. Objectives: The present study aimed to assess neonates conceived by assisted reproductive technology (ART). Methods: In this cohort study, 165 newborns conceived by ART and 165 naturally conceived newborns were included. The prospective study was conducted from April 2020 to October 2021. A neonatologist examined all newborns after birth, and outcomes were followed up over one year and compared with neonates of fertile couples using appropriate statistical tests. Results: The preterm neonates (60% vs. 38%) were higher in ART cases (P < 0.001) than in the other cases. Also, the mean gravid and parity were lower, but the nulliparity was higher in the ART group (P < 0.001) than in the other cases. Moreover, multiple pregnancies (45% vs. 10%; P < 0. 001) and the C/S rate (91% vs. 67%) were higher in ART cases (P < 0.001) than in the other cases. Similarly, the preeclampsia rate (16 % vs. 6%; P = 0.004) and the number of females were higher in the ART group (P = 0.035) than in the other groups. However, birth weight (P = 0.002) and the Apgar were significantly lower (P = 0.002; P = 0.012) in the ART group than in the other groups. IUGR was significantly higher (17% vs. 7%) (P = 0.006), while NEC and RDS were more common in the ART group (P < 0.001) than in the other groups. In addition, more extended hospital stay (P < 0.001) and more common re-admission and weight < the 5th percentile after one year were observed in the ART group (P = 0.021) than in the other groups. Conclusions: According to the findings, pregnancy after ART has more side effects before and after birth and in infancy, not only because of multistation but also due to manipulations in ART.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84662733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is a New Post-infectious Inflammatory Phenomenon Emerging? Increasing Evidence of a New Multiple Organ Involvement Syndrome in Children","authors":"M. Olfat, S. H. Mirlohi, Meisam Sharifzadeh, M. Mohammadpour","doi":"10.5812/ijp-135265","DOIUrl":"https://doi.org/10.5812/ijp-135265","url":null,"abstract":"<jats:p />","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"18 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81725127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Newborn Fatality Due to Persistent Pulmonary Hypertension","authors":"K. Zeng, A. Huang, Yun-xia Sun, J. Zhong, M. Zheng, Youqun Zou, Xin Sun, Yumei Liu","doi":"10.5812/ijp-132747","DOIUrl":"https://doi.org/10.5812/ijp-132747","url":null,"abstract":"Objectives: This study is designed to explore factors associated with death in newborns with persistent pulmonary hypertension (PPHN). Methods: The clinical data of PPHN cases in the past ten years from a neonatal center in China were retrospectively collected and analyzed, and the death-related factors attributable to PPHN were analyzed by binary stepwise logistic regression analysis. Results: A total of 161 neonates with PPHN were included in this study, with a mortality rate of 18.0% (29/161). Multivariate binary logistic regression analysis indicated that cesarean delivery was negatively associated with death in infants with PPHN (adjusted odds ratio [OR] = 0.289, 95% confidence interval [CI] 0.104 – 0.803), while premature rupture of membranes (PROM) (adjusted OR = 4.032, 95% CI 1.32 - 12.32), congenital lung developmental abnormalities/congenital diaphragmatic hernia (CDH) (adjusted OR = 12.65, 95% CI 1.088 – 147.068), respiratory distress syndrome (RDS) (adjusted OR = 4.802, 95% CI 1.512 – 15.251), inhaled nitric oxide (iNO) (adjusted OR = 12.377, 95% CI 3.22 – 47.576) and norepinephrine (adjusted OR = 2.891, 95% CI 1.03 – 8.118) were the independent factors associated with a higher risk of death from PPHN. Conclusions: Caesarean delivery with medical indication is an independent protective factor against death in neonates with PPHN. PROM, congenital lung developmental abnormalities/CDH, RDS, iNO, and norepinephrine were independent death-related factors in neonates with PPHN.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"105 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78384328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Spherocytosis Caused by a Novel Compound Heterozygous Mutation of SPTA1 and Autoimmune Hepatitis in a Pediatric Patient","authors":"Yu Qin, Yan-yun Chen, L. Liao, Yang-yang Wu, Min Chen, Fa-quan Lin","doi":"10.5812/ijp-123389","DOIUrl":"https://doi.org/10.5812/ijp-123389","url":null,"abstract":"Objectives: It is uncommon for autoimmune hepatitis (AIH) to occur in combination with hereditary spherocytosis (HS). The present study examined the genetic and clinical features of a seven-year-old girl with yellow sclerae and abnormalities in liver function test results. Methods: Blood samples were taken from this girl, her parents, and a parental grandmother to be analyzed using laboratory tests and Sanger and next-generation sequencing (NGS). Results: Spectrin alpha, erythrocytic 1 (SPTA1) gene compound heterozygous mutations, were detected from this proband. Moreover, the proband inherited mutations c.6544G>C (p.D2182H) and Thec.134G>A (p.R45K) from her father and mother respectively. Moreover, both her father and grandmother shared an identical mutation. The mutations were not depicted in the Human Gene Mutation Database. Conclusions: HS shares some clinical features close to AIH hence, in the co-existence of AIH, its diagnosis can be challenging. The concurrent disorder may exist if a single autoimmune hepatopathy cannot explain laboratory findings. Pedigree investigations and genetic analyses might be required for the final diagnosis.","PeriodicalId":14593,"journal":{"name":"Iranian Journal of Pediatrics","volume":"22 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78277145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}