Infantile Prognosis of Neonates Conceived by Assisted Reproductive Technology: A Prospective Study

IF 0.4 4区医学 Q4 PEDIATRICS

Iranian Journal of Pediatrics Pub Date : 2023-02-27 DOI:10.5812/ijp-132408

Ellieh Khoei, Seyed Abolfazl Afjehi, S. Tajalli, Roqayeh Aliyari, M. Fallahi

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引用次数: 0

Abstract

Background: Neonates of infertile couples are golden babies, and taking care of them is of paramount importance. However, it is not yet clear if the prognosis is different between these neonates and those from fertile couples. Objectives: The present study aimed to assess neonates conceived by assisted reproductive technology (ART). Methods: In this cohort study, 165 newborns conceived by ART and 165 naturally conceived newborns were included. The prospective study was conducted from April 2020 to October 2021. A neonatologist examined all newborns after birth, and outcomes were followed up over one year and compared with neonates of fertile couples using appropriate statistical tests. Results: The preterm neonates (60% vs. 38%) were higher in ART cases (P < 0.001) than in the other cases. Also, the mean gravid and parity were lower, but the nulliparity was higher in the ART group (P < 0.001) than in the other cases. Moreover, multiple pregnancies (45% vs. 10%; P < 0. 001) and the C/S rate (91% vs. 67%) were higher in ART cases (P < 0.001) than in the other cases. Similarly, the preeclampsia rate (16 % vs. 6%; P = 0.004) and the number of females were higher in the ART group (P = 0.035) than in the other groups. However, birth weight (P = 0.002) and the Apgar were significantly lower (P = 0.002; P = 0.012) in the ART group than in the other groups. IUGR was significantly higher (17% vs. 7%) (P = 0.006), while NEC and RDS were more common in the ART group (P < 0.001) than in the other groups. In addition, more extended hospital stay (P < 0.001) and more common re-admission and weight < the 5th percentile after one year were observed in the ART group (P = 0.021) than in the other groups. Conclusions: According to the findings, pregnancy after ART has more side effects before and after birth and in infancy, not only because of multistation but also due to manipulations in ART.

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辅助生殖技术对新生儿预后的前瞻性研究

背景:不孕夫妇的新生儿是黄金婴儿，照顾好他们是至关重要的。然而，目前尚不清楚这些新生儿与那些有生育能力的夫妇的预后是否不同。目的:本研究旨在评估通过辅助生殖技术(ART)受孕的新生儿。方法:本队列研究纳入165例ART妊娠新生儿和165例自然妊娠新生儿。该前瞻性研究于2020年4月至2021年10月进行。一名新生儿科医生在所有新生儿出生后对其进行了检查，并对结果进行了一年多的随访，并使用适当的统计检验将其与有生育能力夫妇的新生儿进行了比较。结果:ART组早产率(60% vs 38%)高于其他组(P < 0.001)。ART组平均妊娠和胎次较低，但无胎次高于其他组(P < 0.001)。此外，多胎妊娠(45% vs. 10%;P < 0。ART组的C/S率(91%对67%)高于其他组(P < 0.001)。同样，子痫前期患病率(16% vs. 6%;P = 0.004)， ART组女性人数高于其他组(P = 0.035)。然而，出生体重(P = 0.002)和Apgar显著降低(P = 0.002;P = 0.012)。IUGR显著高于对照组(17% vs. 7%) (P = 0.006)，而NEC和RDS在ART组较其他组更常见(P < 0.001)。此外，ART组的住院时间延长(P < 0.001)、再入院发生率和1年后体重<第5百分位的发生率均高于其他组(P = 0.021)。结论:ART后妊娠在出生前、出生后和婴儿期的不良反应较多，这不仅与ART的多站性有关，也与ART的操作有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Pediatrics 医学-小儿科

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.