Iranian Journal of Pharmaceutical Sciences最新文献_第9页

Histopathological and Biomedical parameters Determination in the Protective Effect of Hydroalcoholic Extract of Allium Jesdianum on Hepatotoxicity Induced by Bromobenzene in Mice 大蒜水醇提取物对溴苯致小鼠肝毒性保护作用的组织病理学和生物医学参数测定

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-04-01 DOI: 10.22034/IJPS.2018.33690

H. Kalantari, Tahere Shamsi Ehsan, A. Samimi, P. Kheradmand, M. Shirani, L. Zeidooni

{"title":"Histopathological and Biomedical parameters Determination in the Protective Effect of Hydroalcoholic Extract of Allium Jesdianum on Hepatotoxicity Induced by Bromobenzene in Mice","authors":"H. Kalantari, Tahere Shamsi Ehsan, A. Samimi, P. Kheradmand, M. Shirani, L. Zeidooni","doi":"10.22034/IJPS.2018.33690","DOIUrl":"https://doi.org/10.22034/IJPS.2018.33690","url":null,"abstract":"Allium Jesdianum (AJ) is the native plant mostly grown in Middle East region that has the excellent pharmacological properties. In this study, we evaluated the hepatoprotective effect of hydroalcoholic extract of AJ on liver injury induced by Bromobenzene (BB) in male mice. Animals were randomly divided into five groups, control group received normal saline plus olive oil, groups 2-4 received(500, 1000 and 2000 mg/kg) AJ extract plus BB for 5 days and 5th group received BB (460 mg/kg). On the fifth day all groups received hexobarbital sodium (25 mg/kg, i.p). it should be noted that sleeping time of all mice were recorded. After 24 hours mice were sacrificed. By serum and tissue biomarkers such as alanine aminotransferase (ALT), aspartate aminotransferase(AST), reduced glutathione(GSH), malondialdehyde(MDA) and histopathological studies were measured. The results showed that BB significantly increased sleeping time, ALT, AST and MDA levels besides and decreased GSH level compared with control group. AJ extract at doses1000and 2000 mg/kg showed a significant alter in all studied endpoints and dose 2000 mg/kg showed a marked improvement in histopathological examination. The present finding showed that administration of the hydroalcoholic extract of AJ could prevent of hepatotoxicity induced by BB via improvement serum and tissue parameters and histopathological alterations in liver tissue.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"14 1","pages":"15-24"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48946069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Pharmaceutical Formulation of Garlic and Turmeric Dried Crude Extract and Their Synergistic Antifungal Activity and Safety 大蒜和姜黄干粗提取物的药物配方及其协同抗真菌活性和安全性

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-04-01 DOI: 10.22034/IJPS.2018.33740

H. Kazi, T. Channa, A. Unar, Khalida Unar, W. Sabzoi, S. Perveen, A. Mangi, Arslan Ahmer

{"title":"Pharmaceutical Formulation of Garlic and Turmeric Dried Crude Extract and Their Synergistic Antifungal Activity and Safety","authors":"H. Kazi, T. Channa, A. Unar, Khalida Unar, W. Sabzoi, S. Perveen, A. Mangi, Arslan Ahmer","doi":"10.22034/IJPS.2018.33740","DOIUrl":"https://doi.org/10.22034/IJPS.2018.33740","url":null,"abstract":"ABSTRACT: Candidiasis is a fungal infection caused by Candida albicans. Allium sativum (garlic) and Curcuma longa (turmeric) have been used as antifungal agents. The main aim of this study was to identify the effectiveness of these natural products towards C. albicans and on their pharmacological and toxicity aspects. Thus, agar disc diffusion method was used to study the antifungal activity of the ethanolic extracts. Fluconazole served as the positive control while solvent (ethanol) served as the negative control. Minimum inhibitory concentration (MIC) of the plant extracts were tested by using two fold agar dilution method at concentrations ranging from 0.390g/L to 100g/L. As delivery agents, cream and gel formulations demonstrated good stability test results. Furthermore, both plants showed synergistic effects. Active compound of garlic and turmeric which is allicin and curcumin were observed through Thin Layer Chromatography (TLC). Moreover, all the formulation resulted in optimum MIC at pH 5.5 and temperature 25.5oC. Toxicity test using Brine Shrimp Lethality Test (BSLT) showed that ethanolic extracts of both plants displayed LC50 values at 77.93µg/mL and 31.97µg/mL. Whereas, LC50 value of synergistic experiments of extract was 10.77µg/mL. Besides, synergistic cream formulation was most potent against brine shrimp larvae compared to others with LC50 value of 5.35µg/mL. Synergistic experiment using gel formulation also showed potency against brine shrimp larvae with LC50 value of 3.58µg/mL. As a conclusion, both plant extracts and preparations showed significant effectiveness against C. albicans and potency on shrimps.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"14 1","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45401258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Simultaneous estimation of amlodipine besylate and nebivolol hydrochloride in pharmaceutical tablets formulation by RP-HPLC using PDA detector PDA检测器反相高效液相色谱法同时测定苯磺酸氨氯地平和盐酸奈比洛尔片剂中的含量

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI: 10.22034/IJPS.2018.32048

Sinha Ashutosh Kumar, M. Debnath, Mendeli Sreenu, Maheshwer Singh

{"title":"Simultaneous estimation of amlodipine besylate and nebivolol hydrochloride in pharmaceutical tablets formulation by RP-HPLC using PDA detector","authors":"Sinha Ashutosh Kumar, M. Debnath, Mendeli Sreenu, Maheshwer Singh","doi":"10.22034/IJPS.2018.32048","DOIUrl":"https://doi.org/10.22034/IJPS.2018.32048","url":null,"abstract":"Background: The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines. Materials and Methods: The separation was achieved on a a stainless steel analytical column, Eclipse XDB plus C18 column (4.6 X 150 mm; 5 μm) in an isocratic mode. The mobile phase was composed acetonitrile and 0.01 M ammonium acetate (pH adjusted to 4.5 using glacial acetic acid), which were mixed in the ratio of 50 : 50. The flow rate was monitored at 1.0 mL/min. The wavelength selected for detection was 265 nm. Results: The retention time found for amlodipine besylate and nebivolol hydrochloride was 2.967 and 3.510 min respectively. The % recovery was 100.20- 100.86 for amlodipine and 100.20 - 100.78 for nebivolol. The linearity was established in the range of 5-25 µg/mL for amlodipine and 10-50 µg/mL for nebivolol. The slope, intercept, and correlation coefficient were found to be 314.2x, +162.4, and 0.999 for amlodipine besylate and 248x, -305.7, and 0.9998 for nebivolol hydrochloride, respectively. The limits of detection for amlodipine besylate and nebivolol hydrochloride obtained by the proposed method was 0.07 and 0.20 µg/ml and limits of quantification for amlodipine besylate and nebivolol hydrochloride obtained by the proposed method was 0.23 and 0.61 μg/mL respectively. Conclusion: The method was found to be suitable for the quality control test of amlodipine besylate and nebivolol hydrochloride simultaneously in a bulk drugs as well as in a formulations.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"14 1","pages":"45-56"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68024632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prioritizing the Factors Affecting the Abuse of Pharmaceutical Opioids by Applying Topsis Topsis对阿片类药物滥用影响因素排序的研究

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI: 10.22034/IJPS.2018.32050

F. Zeinali, M. Mohammadzadeh, Jamshid Salamzade

引用次数: 0

Evaluation of Ibuprofen Release from Gelatin /Hydroxyapatite /Polylactic Acid Nanocomposites 明胶/羟基磷灰石/聚乳酸纳米复合材料释放布洛芬的研究

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI: 10.22034/IJPS.2018.32051

Z. Nabipour, M. Nourbakhsh, M. Baniasadi

引用次数: 8

Effect of powder sizes, pH of water, ultrasound and method of distillation on extraction of fennel essential oil 粉末粒度、水pH、超声及蒸馏方法对茴香精油提取的影响

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI: 10.22034/IJPS.2018.32047

M. Tavakolizadeh, Gh. Hadian, M. Khoshayand, F. Mojab

{"title":"Effect of powder sizes, pH of water, ultrasound and method of distillation on extraction of fennel essential oil","authors":"M. Tavakolizadeh, Gh. Hadian, M. Khoshayand, F. Mojab","doi":"10.22034/IJPS.2018.32047","DOIUrl":"https://doi.org/10.22034/IJPS.2018.32047","url":null,"abstract":"The essential oils are frequently used in food processing industry, perfumery, cosmetics and pharmaceuticals. Most of the oils obtained by steam distillation and water distillation. It is necessary to specify the best conditions of essential oils production to get much more major compound(s) and higher yield oil. So, fennel oil was selected in this study. The objective of this work was to identify the effect of powder’s particle size, pH of water, method of distillation and using ultrasound on extraction of fennel essential oil (and its major constituent, anethole). We used a statistical method called D-optimal Design that appointed pH, particle size and method for each assay. First, the seeds powder distillated directly. In the second series seeds were placed in an ultrasonic apparatus for 30 minutes. The essential oils were subsequently isolated by two methods, hydro-distillation and steam-distillation in different sizes and pH in Clevenger apparatus. Gas chromatography was used to determine the essential oil composition. Finally, optimum conditions according to the statistical results are as follows: Method: steam distillation, and mesh size: 50. So it shows that steam distillation is more efficiently than water distillation.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"18 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68024615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water Absorption of Chitosan, Collagen and Chitosan/Collagen Blend Membranes Exposed to Gamma-ray Irradiation γ射线辐照下壳聚糖、胶原蛋白及壳聚糖/胶原蛋白共混膜的吸水性能

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI: 10.22034/IJPS.2018.32049

F. Lukitowati, D. J. Indrani

{"title":"Water Absorption of Chitosan, Collagen and Chitosan/Collagen Blend Membranes Exposed to Gamma-ray Irradiation","authors":"F. Lukitowati, D. J. Indrani","doi":"10.22034/IJPS.2018.32049","DOIUrl":"https://doi.org/10.22034/IJPS.2018.32049","url":null,"abstract":"TThis study investigated the water absorption of chitosan, collagen, and chitosan/collagen blend membranes exposed to gamma-ray irradiation. These membranes were produced via the solvent evaporation method. All membranes then underwent irradiation at 15 or 25 kGy gamma-ray doses, while membranes without irradiation were used as controls. After immersing the membranes in distilled water for up to 180 min, water absorption was determined by calculating the percentage weight increase. The results showed changes in the water absorption curves with differing membranes and irradiation doses. However, after 60 min, all of the water absorption curves plateaued. With respect to membrane type, chitosan membranes exhibited the highest water absorption, the blend displayed the lowest, and collagen was in the mid range. With the use of higher radiation doses, chitosan membranes displayed lower water absorption, which was also true of the blend but not collagen membranes. To conclude, the water absorption of chitosan, collagen, and chitosan/collagen blend membranes with and without gamma-ray irradiation initially increased steadily and then plateaued. The water absorption values of the irradiated blend membranes were the lowest; however, the values were relatively steady.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"14 1","pages":"57-66"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68024279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

A Participative Process of Strategy-Making and Firm Performance in Iranian Pharmaceutical Companies 伊朗制药公司战略制定与企业绩效的参与式过程

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI: 10.22034/IJPS.2018.32044

seyed Abolfazli Abolfazli, M. Mohammadzadeh, F. Peiravian, Sayyed hesam Sharifnia

{"title":"A Participative Process of Strategy-Making and Firm Performance in Iranian Pharmaceutical Companies","authors":"seyed Abolfazli Abolfazli, M. Mohammadzadeh, F. Peiravian, Sayyed hesam Sharifnia","doi":"10.22034/IJPS.2018.32044","DOIUrl":"https://doi.org/10.22034/IJPS.2018.32044","url":null,"abstract":"Pharmaceutical companies are regarded as principal contributors to national economies all over the world owing to their substantial assistance to public health system; GDP, employment, and market growth. Consequently, pharmaceutical managers must take the necessary steps to improve strategy-making and firm performance. This study investigates the relationship between four conventional modes of strategy-making process and performance in pharmaceutical companies in Iran. This paper argues that small or knowledge-based pharmaceutical companies, similar to large pharmaceutical companies, place differing emphasis on strategy-making and could apply different approaches to strategy-making. Furthermore, the present research offers an explanation of the nature of these processes in pharmaceutical companies and hypothesizes how they are related to firm performance. It then describes the results of an empirical study on the strategy-making processes of pharmaceutical companies in Iran. Analysis of the data obtained from 125 pharmaceutical companies indicates that participative approaches to strategy-making exist in these pharmaceutical companies and could have a significant and strong relationship with firm performance.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"8 3 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68024657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Chemical Permeation Enhancers on the in vitro Skin Permeation of Minoxidil through Excised Rat Skin: A Mechanistic Study 化学渗透促进剂对米诺地尔体外经大鼠皮肤渗透的影响:机制研究

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI: 10.22034/IJPS.2018.32053

Eskandar Mmoghimipour, A. Salimi, Ali Talebpour Jahromi

{"title":"Influence of Chemical Permeation Enhancers on the in vitro Skin Permeation of Minoxidil through Excised Rat Skin: A Mechanistic Study","authors":"Eskandar Mmoghimipour, A. Salimi, Ali Talebpour Jahromi","doi":"10.22034/IJPS.2018.32053","DOIUrl":"https://doi.org/10.22034/IJPS.2018.32053","url":null,"abstract":"Abstract: Minoxidil, a pyrimidine derivative (2, 4-diamino-6-piperidinopyrimidine-3-oxide) is the only topical medical treatment with proven efficacy for the treatment of Androgenetic alopecia that shown low skin penetration and bioavailability. The main aim of this research was to investigate the effect of some permeation enhancers on the in vitro skin permeability of minoxidil . Minoxidil permeability experiments through rat skin pretreated with some of permeation enhancers namely, Urea, Eucalyptus oil and Menthol were performed in fabricated Franz diffusion cells and compared with hydrated rat skin as control. The permeability parameters evaluated include steady-state flux (Jss), permeability coefficient (Kp) and diffusion coefficient (D). The penetration enhancer’s permeability enhancement mechanisms were investigated by comparing of changes in peak position and their intensities of asymmetric (Asy) and symmetric (Sym) C-H stretching, C=O stretching, C=O stretching (Amide I) and C-N stretching of keratin (Amide II ) absorbance using Fourier transform infrared spectroscopy (FTIR), as well as by comparing mean transition temperature (Tm) and their enthalpies (∆H) using differential scanning calorimetery (DSC). Minoxidil permeability parameters through rat skin, were evaluated with and without chemical enhancers such as Eucalyptus oil, menthol and urea. The skin showed barrier for minoxidil permeability through whole skin and that diffusion into the skin was the rate-limiting step for drug flux. Urea , Eucalyptus oil and Menthol were the most effective enhancers as they increased flux 1.86 ,2.16 and 1.75 times and diffusion coefficient 3.25,1.34 and 2.16 folds in comparison with hydrated skin, respectively. FTIR and DSC results showed lipid fluidization , extraction ,disruption of lipid structure and irreversible denaturation of proteins in the SC layer of skin by permeation enhancers.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"15 1","pages":"97-110"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68025625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Phytochemical Screening, Phenolic Content and Antioxidant Activity of Citrus aurantifolia L. Leaves Grown in Two Regions of Oman 阿曼两个地区金叶柑橘叶片的植物化学筛选、酚类含量及抗氧化活性

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI: 10.22034/IJPS.2018.32046

Jokha Al Namani, Esra Baqir, Ajwaa Al Abri, Tamadher Al Hubaishi, A. Husain, Shahalam Khan

{"title":"Phytochemical Screening, Phenolic Content and Antioxidant Activity of Citrus aurantifolia L. Leaves Grown in Two Regions of Oman","authors":"Jokha Al Namani, Esra Baqir, Ajwaa Al Abri, Tamadher Al Hubaishi, A. Husain, Shahalam Khan","doi":"10.22034/IJPS.2018.32046","DOIUrl":"https://doi.org/10.22034/IJPS.2018.32046","url":null,"abstract":"Lime or Citrus aurantifolia L., is a small citrus fruit that belongs to the family Rutaceae. The fruit and leaves of C. aurantifolia have been used traditionally for weight loss, skin care, relief from constipation and treatment of scurvy, etc. The purpose of this study was to determine the flavonoid, total phenolic content and investigation of anti-oxidant potential of Citrus aurantifolia leaves grown in Oman. Lime leaves were collected from Batinah (Nakhal) and Ad-dakhiliya (Nizwa) region of Oman. The leaves were dried, powdered and extracted with ethanol using a hot extraction method. Standard chemical tests were used to check the presence of secondary plant metabolites in the lime leaves extract. Quantitative analysis of the phenolics and flavonoids were done by colorimeteric methods. The antioxidant activity was assessed by DPPH and phosphomolybdenum in vitro assay methods respectively. Chemical analysis of the lime leaves extract showed the presence of major secondary plant metabolites. The obtained results revealed variation in the content of flavonoid (41.38-64.2 μg of QE/mg of dry extract) and phenolic compounds (96.55-322.57 μg of GAE/mg of dry extract). Both the lime leaves extracts from Nakhal and Nizwa showed concentration dependent moderate anti-oxidant activity (11.79-56.89 and 10.11-51.91%). Lime leaves from Batinah region also exhibited better total antioxidant capacity calculated with reference to the standard gallic acid. The aerial part of C. aurantifolia seems to be a rich source of flavonoids. Further studies are recommended to isolate and quantify the pure phytoconstituents from lime leaves grown in the Batinah (Nakhal) region which might serve as natural antioxidants in food and drug industry.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"14 1","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68024424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11