Evaluation of Ibuprofen Release from Gelatin /Hydroxyapatite /Polylactic Acid Nanocomposites

Q4 Pharmacology, Toxicology and Pharmaceutics

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI:10.22034/IJPS.2018.32051

Z. Nabipour, M. Nourbakhsh, M. Baniasadi

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引用次数: 8

Abstract

Gelatin-hydroxyapatite-polylactic acid (PLA) nanocomposites were synthesized using five different formulations. The nanocomposites were loaded with ibuprofen and the amount of drug in the carriers was determined. X-ray diffraction (XRD) analysis was conducted before and after drug loading to ensure the presence of ibuprofen on the nanocomposites. Drug delivery was evaluated in phosphate buffered saline (PBS) solution at pH 7.4 and 37°C. The results of XRD analysis showed acceptable synthesis of hydroxyapatite and the composites, confirming the loading of ibuprofen onto the synthesized nanocarriers. The results showed that maximum drug loading (58.2%) was recorded for sample D (30% gelatin, 40% nHA and 30% PLA), and minimum loading was recorded for sample E (30% gelatin, 30% nHA and 40% PLA). The maximum percentage of drug release over the course of 72 h (95.8%) was for nanocomposite D (30% gelatin, 40% nHA and 30% PLA). The minimum percentage of drug delivery (77%) was for nanocomposite E (30% gelatin, 30% nHA, 40% PLA), which contained the maximum PLA content.

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明胶/羟基磷灰石/聚乳酸纳米复合材料释放布洛芬的研究

采用五种不同配方合成了明胶-羟基磷灰石-聚乳酸(PLA)纳米复合材料。将布洛芬装入纳米复合材料中，并测定其载药量。在载药前后进行x射线衍射(XRD)分析，以确定布洛芬在纳米复合材料上的存在。在pH 7.4和37°C的磷酸盐缓冲盐水(PBS)溶液中评估药物递送。XRD分析结果表明羟基磷灰石和复合材料的合成可以接受，证实了布洛芬在合成的纳米载体上的负载。结果表明，样品D(30%明胶、40% nHA和30% PLA)的载药量最大，为58.2%;样品E(30%明胶、30% nHA和40% PLA)的载药量最小。纳米复合材料D(30%明胶、40% nHA和30% PLA)在72 h内的最大释药率为95.8%。纳米复合材料E(30%明胶、30% nHA、40% PLA)的给药率最低(77%)，其PLA含量最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： Iranian Journal of Pharmaceutical Sciences (IJPS) is an open access, internationally peer-reviewed journal that seeks to publish research articles in different pharmaceutical sciences subdivisions: pharmacology and toxicology, nanotechnology, pharmaceutics, natural products, biotechnology, pharmaceutical chemistry, clinical pharmacy and other pharmacy related topics. Each issue of the journal contents 16 outstanding research articles in area of pharmaceutical sciences plus an editorial written by the IJPS editors on one of the most up to date advances topics in pharmacy. All articles published by IJPS would be permanently accessible online freely without any subscription charges. Authors of the published articles have granted the right to use and disseminate their article to third parties.