JACC. Clinical electrophysiology最新文献

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2405-500X(25)00042-8","DOIUrl":"10.1016/S2405-500X(25)00042-8","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages I-CCXVI"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact Force Increases During Radiofrequency Ablation","authors":"Keita Watanabe MD ,&nbsp;Moritz Nies MD ,&nbsp;Steffy Rodrigues MEng ,&nbsp;Vivek Y. Reddy MD ,&nbsp;Jacob S. Koruth MD","doi":"10.1016/j.jacep.2024.10.010","DOIUrl":"10.1016/j.jacep.2024.10.010","url":null,"abstract":"<div><h3>Background</h3><div>Contact force (CF) changes after onset of radiofrequency (RF) delivery are not well understood and often ascribed to catheter instability.</div></div><div><h3>Objectives</h3><div>This study sought to characterize CF changes during RF-based pulmonary vein (PV) isolation.</div></div><div><h3>Methods</h3><div>Catheter-tip parameters including CF for all RF sessions were extracted from a novel catheter-mapping system from 6 patients undergoing PV isolation.</div></div><div><h3>Results</h3><div>Of a total 416 RF sessions, 241 demonstrated progressive increases in CF during RF delivery (group 1). Zero to 5 seconds of RF delivery demonstrated the greatest increase in CF, with no differences between right and left PV sites (2.2 ± 2.2 g vs 1.9 ± 2.3 g, <em>P</em> = 0.26). Subsequent 5-second intervals demonstrated greater increases for right vs left PV sites (eg, 1.2 ± 1.3 g vs 0.5 ± 0.3 g, <em>P</em> = 0.01 for 20 to 25 seconds). CF increment was greater for posterior vs anterior PV sites (3.4 ± 3.1 g vs 1.4 ± 1.4 g, <em>P</em> &lt; 0.001), but similar for roof and floor sites. Higher power and greater impedance drops were associated with greater CF increases. Perpendicular contact had greater CF increases, followed by diagonal and parallel contact. The remaining 175 of 416 sessions demonstrated at least 1 CF decrement, typically occurring after 15 seconds of RF (group 2). This was observed least frequently at inferior PV sites. Except for minor differences in power, there were no differences in CF, tip excursion, and impedance drop between groups.</div></div><div><h3>Conclusions</h3><div>Progressive CF increase during RF ablation is a distinct phenomenon that likely reflects the “push-back” effect of local myocardial swelling against the catheter tip. This may explain certain catheter-tip behaviors such as tip displacement and instability during ablation.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 337-349"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of Structural Abnormalities of Papillary Muscles to the Site of Origin of Ventricular Arrhythmias","authors":"Nithi Tokavanich MD ,&nbsp;Anurut Huntrakul MD ,&nbsp;Miki Yokokawa MD ,&nbsp;Boldizsar Kovacs MD ,&nbsp;Michael Ghannam MD ,&nbsp;Jackson L. Liang DO ,&nbsp;Anil Attili MD ,&nbsp;Hubert Cochet MD ,&nbsp;Rakesh Latchamsetty MD ,&nbsp;Krit Jongnarangsin MD ,&nbsp;Fred Morady MD ,&nbsp;Frank Bogun MD","doi":"10.1016/j.jacep.2024.10.004","DOIUrl":"10.1016/j.jacep.2024.10.004","url":null,"abstract":"<div><h3>Background</h3><div>Arrhythmias originating from papillary muscles (PAPs) can be challenging when targeted with catheter ablation. The prevalence and impact of structural abnormalities on PAPs in patients with focal PAP arrhythmias is unknown.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to analyze, in a consecutive patient series with focal PAP arrhythmias, the impact of structural abnormalities detected by multimodality imaging.</div></div><div><h3>Methods</h3><div>In a series of 43 consecutive patients with focal PAP arrhythmias referred for ablation, the prevalence and location of structural abnormalities on PAPs were assessed with cardiac magnetic resonance imaging, computed tomographic angiography and intracardiac echocardiography (ICE). Sites of origin of ventricular arrhythmias (VAs) were correlated with structural abnormalities.</div></div><div><h3>Results</h3><div>On PAPs, late gadolinium enhancement (LGE) was present on cardiac magnetic resonance imaging in 19 of 43 patients, calcifications on computed tomography in 2 of 43 and on ICE in 3 of 43 patients, and increased echogenicity on ICE in 39 of 43 patients. A total of 141 focal PAP arrhythmias were identified, and VA target sites were localized adjacent to areas with increased echogenicity on ICE for 59 of 141 (44%) VAs, adjacent to LGE for 35 of 141 (25%) VAs, and adjacent to calcifications for 14 of 141 (10%) VAs. At least one VA target site was localized to areas of structural abnormalities in 32 of 43 (74%) patients.</div></div><div><h3>Conclusions</h3><div>Multimodality imaging identifies arrhythmogenic PAPs preprocedurally and in real time during the ablation procedure in most patients. Increased echogenicity, LGE, and calcifications are often seen on PAPs in patients with focal PAP arrhythmias and can indicate the site of origin.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 259-269"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Success and Complications in Catheter Ablation for Idiopathic Premature Ventricular Contractions in Japan","authors":"Kentaro Goto MD, PhD ,&nbsp;Shinsuke Miyazaki MD, PhD ,&nbsp;Reina Tonegawa-Kuji MD, PhD ,&nbsp;Koshiro Kanaoka MD, PhD ,&nbsp;Seigo Yamashita MD, PhD ,&nbsp;Tetsuo Sasano MD, PhD ,&nbsp;Koichi Inoue MD, PhD ,&nbsp;Kengo Kusano MD, PhD ,&nbsp;Teiichi Yamane MD, PhD ,&nbsp;Wataru Shimizu MD, PhD","doi":"10.1016/j.jacep.2024.10.011","DOIUrl":"10.1016/j.jacep.2024.10.011","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 408-410"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial Differences in Device-Detected Incident Atrial Fibrillation","authors":"Jack A. Goergen MD ,&nbsp;Graham Peigh MD, MSc ,&nbsp;Nathan Varberg BS ,&nbsp;Paul D. Ziegler MS ,&nbsp;Anthony I. Roberts MSc ,&nbsp;Evan Stanelle MS ,&nbsp;Dana Soderlund MPH ,&nbsp;Sadiya S. Khan MD, MS ,&nbsp;Rod S. Passman MD, MSCE","doi":"10.1016/j.jacep.2024.10.006","DOIUrl":"10.1016/j.jacep.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Prior research suggests Black individuals have a lower risk of atrial fibrillation (AF) than White individuals, but this may be related to the underdetection of AF. Whether this trend persists using highly sensitive methods of AF diagnosis has not been well-studied.</div></div><div><h3>Objectives</h3><div>The objective of this study was to use cardiac implantable electronic devices (CIEDs) capable of AF diagnosis to compare AF incidence between Black and White individuals.</div></div><div><h3>Methods</h3><div>This was a retrospective observational study involving Black and White patients who had a CIED implanted between January 1, 2007, and June 1, 2019. Patients with insertable cardiac monitors, insufficient monitoring, or prior AF were excluded. The primary endpoint was the overall adjusted incidence of device-detected AF between Black and White individuals.</div></div><div><h3>Results</h3><div>Of 441,047 patients with a CIED implanted during the study period, 88,427 patients (mean age, 69 ± 13 years; 80,382 White [91%]; 55,840 male [63%]) were included in analysis. The mean follow-up duration was 2.2 ± 1.7 years, and 35,143 patients (40%) had device-detected AF. The crude incidence of AF was greater among White, compared with Black, individuals (27.95 vs 24.86 cases per 100 person-years, <em>P</em> &lt; 0.001). After adjusting for age, sex, and medical comorbidities, the hazard of AF was similar between Black and White individuals (HR: 1.02; 95% CI: 0.98-1.06). In subgroup analysis by type of CIED, White individuals had a greater hazard of AF in the pacemaker cohort, whereas Black individuals had a greater hazard of AF in the implantable cardioverter defibrillator cohort.</div></div><div><h3>Conclusions</h3><div>The adjusted hazard of AF was similar between Black and White individuals with CIEDs.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 298-308"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Chronic Kidney Disease and Third-Degree Atrioventricular Block","authors":"Hannah K. Wood-Kurland MD ,&nbsp;Anne Storgaard Nørskov MD ,&nbsp;Nicholas Carlson MD, PhD ,&nbsp;Anders Møller Greve MD, PhD ,&nbsp;Lars Køber MD, DMSc ,&nbsp;Gunnar Gislason MD, PhD ,&nbsp;Christian Torp-Pedersen MD, DMSc ,&nbsp;Casper N. Bang MD, PhD","doi":"10.1016/j.jacep.2024.10.007","DOIUrl":"10.1016/j.jacep.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Chronic kidney disease (CKD) is frequently complicated by arrhythmias, plausibly leading to the increased risk of sudden cardiac death in this population. However, little is known about the association between CKD and third-degree atrioventricular block (3AVB) and need for permanent pacing.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the association between CKD and 3AVB.</div></div><div><h3>Methods</h3><div>In a population-based nested case-control study, patients with 3AVB were identified between July 1995 and December 2018 using Danish administrative registries. Cases were risk set matched 1:5 with controls on sex and birth year. Multivariable Cox regression was used to analyze the association between CKD and 3AVB, with subsequent logistic regression analyses for computation of odds ratios for pacemaker implantation stratified by dialysis or nondialysis CKD.</div></div><div><h3>Results</h3><div>A total of 31,301 patients with 3AVB were identified and matched with 155,506 controls. The mean age was 74.7 ± 12 years, and 40.2% were female. A significant association was found between CKD and 3AVB after adjustment for comorbidities and potential atrioventricular node blocking agents (HR: 1.83; 95% CI: 1.73-1.93). In stratified analyses, the association was stronger in patients using dialysis compared with nondialysis patients (HR: 7.71; 95% CI: 5.84-10.18; vs HR: 1.73; 95% CI: 1.64-1.83). The odds of pacemaker implantation were lower for patients using dialysis (OR: 0.77; 95% CI: 0.60-0.98) but comparable between patients with nondialysis CKD (OR: 1.04; 95% CI: 0.96-1.12) and patients without CKD.</div></div><div><h3>Conclusions</h3><div>CKD was independently associated with a higher rate of 3AVB, especially for patients using dialysis.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 376-385"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical and Ablation Therapies for Atrial Appendage Tachycardia in Children","authors":"Yi Zhang MD,&nbsp;Xiao-mei Li MD,&nbsp;Yongqiang Jin MD,&nbsp;Mei-ting Li MD,&nbsp;Huiming Zhou MD,&nbsp;Danlei Chen MD","doi":"10.1016/j.jacep.2024.10.012","DOIUrl":"10.1016/j.jacep.2024.10.012","url":null,"abstract":"<div><h3>Background</h3><div>Atrial tachycardia (AT) originate from the atrial appendage present unique clinical challenges in pediatrics. It is typically persistent, frequently leading to tachycardiomyopathy, and poses significant treatment difficulties.</div></div><div><h3>Objectives</h3><div>This study aimed to collate and analyze the clinical characteristics and therapeutic outcomes of radiofrequency ablation (RFCA) and with atrial appendage resection for the treatment of AT originating from the atrial appendages in pediatric patients.</div></div><div><h3>Methods</h3><div>This retrospective study encompassed a cohort of 70 pediatric patients diagnosed with AT originating from the atrial appendage, identified through RFCA diagnostics. The study period spanned from January 2010 to February 2022 and provided a comprehensive analysis of patient outcomes following the treatment approaches.</div></div><div><h3>Results</h3><div>The mean age was 6.94 ± 3.46 years with the mean weight of 26.69 ± 13.59 kg. Tachycardia cardiomyopathy developed in 44.3% (31 of 70 patients) of the patients. The immediate success rate of RFCA was 72.9% (51 of 70), whereas the recurrence rate after RFCA was 25.5% (13 of 51 patients). Thirty-two (45.7%) patients underwent atrial appendage resection because of unsuccessful ablation or recurrence. These included 20 right atrial appendage (RAA) and 12 left atrial appendages resections. Following resection, sinus rhythm was achieved in all patients without recurrence. Notably, RAA aneurysms were discovered in 45.0% (9 of 20 patients) of RAA resections, representing 22.5% (9 of 40) of RAA and 57.1% (8 of 14) of RFCA failures in AT originating from the RAA.</div></div><div><h3>Conclusions</h3><div>RFCA for AT originating from the atrial appendage in children has relatively low success and high recurrence rates. Electrophysiological mapping and surgical resection is a safe and effective alternative. In particular, in cases of AT originating from the RAA and unresponsive to RFCA, the possibility of an atrial appendage aneurysm should be considered.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 400-407"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Screening of Obstructive Sleep Apnea in Atrial Fibrillation","authors":"Reena Mehra MD, MS ,&nbsp;Younghoon Kwon MD","doi":"10.1016/j.jacep.2024.12.016","DOIUrl":"10.1016/j.jacep.2024.12.016","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 318-320"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Catheter Ablation of Atrial Fibrillation on Disease Progression","authors":"Karim Benali MD ,&nbsp;Laurent Macle MD ,&nbsp;Michel Haïssaguerre MD ,&nbsp;Stanley Nattel MD, PhD ,&nbsp;Marc Deyell MD ,&nbsp;Antoine Da Costa MD ,&nbsp;Jason G. Andrade MD","doi":"10.1016/j.jacep.2024.10.017","DOIUrl":"10.1016/j.jacep.2024.10.017","url":null,"abstract":"<div><div>Atrial fibrillation (AF) remains a major public health challenge worldwide with a globally increasing prevalence and exponential increase in health care costs. The progression from paroxysmal (defined as self-terminating episodes of AF lasting &lt;7 days) to persistent AF (eg, AF episodes lasting longer than 7 days) is associated with premature mortality, increasing incidence of thromboembolism and heart failure, as well as increased rates of hospitalization and health care use. Given recognition that complications of AF increase as the disease advances, there is an urgent need to ensure therapeutic interventions are capable of delaying or halting disease progression. Whereas pharmacotherapy can be relatively effective at managing the symptoms associated with AF, antiarrhythmic drugs are less effective than catheter ablation in reducing arrhythmia burden, improving quality of life, and reducing health care use. Moreover, pharmacologic therapy does not modify the pathophysiological processes responsible for disease progression. Catheter ablation confers a more comprehensive disease-modifying intervention, targeting multiple mechanisms underlying AF progression through a combination of trigger elimination, electroanatomical substrate modification, and autonomic nervous system modulation. Until recently, the belief that catheter ablation was an effective method to prevent disease progression was mostly speculative. However, recent randomized controlled trials have established catheter ablation as disease-modifying intervention. Given this knowledge, it appears that early intervention is critical to optimally affect the disease progression. The purpose of this paper is to review the rationale and evidence supporting disease modification using catheter ablation as a key part of the AF treatment paradigm.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 421-435"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Multicenter Cohort Study on Beta-Blocker–Free Treatment Strategies for Catecholaminergic Polymorphic Ventricular Tachycardia Patients","authors":"Raquel Neves MD ,&nbsp;Sahej Bains BS ,&nbsp;J. Martijn Bos MD, PhD ,&nbsp;Christian van der Werf MD, PhD ,&nbsp;Auke T. Bergeman MD ,&nbsp;Puck Peltenburg MD ,&nbsp;Nico A. Blom MD, PhD ,&nbsp;Shubhayan Sanatani MD ,&nbsp;Heikki Swan MD ,&nbsp;Vincent Probst MD ,&nbsp;Prince J. Kannankeril MD, MSCI ,&nbsp;Jonathan R. Skinner MD ,&nbsp;Ramon Brugada MD ,&nbsp;Tomas Robyns MD ,&nbsp;Martin Borggrefe MD ,&nbsp;Wataru Shimizu MD, PhD ,&nbsp;Janneke A.E. Kammeraad MD, PhD ,&nbsp;Andrew D. Krahn MD ,&nbsp;Arthur A.M. Wilde MD, PhD ,&nbsp;Michael J. Ackerman MD, PhD","doi":"10.1016/j.jacep.2024.10.005","DOIUrl":"10.1016/j.jacep.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare, potentially life-threatening genetic heart disease. Nonselective beta-blockers (BBs) are highly effective in reducing CPVT-triggered arrhythmic events. However, some patients suffer from unacceptable BB side effects and might require strategies without a BB.</div></div><div><h3>Objectives</h3><div>This study sought to review the spectrum of and outcomes associated with BB-free treatment configurations in patients with CPVT enrolled in the International CPVT Registry.</div></div><div><h3>Methods</h3><div>From the Registry, patients with <em>RYR2</em> variant-positive CPVT treated with a BB-free strategy for ≥6 months were included. Two treatment groups were defined: patients classified as very low risk and treated with intentional nontherapy (INT) and patients who needed to be treated but did not tolerate BBs and were treated with 3 different strategies.</div></div><div><h3>Results</h3><div>Overall, 100 of 1,017 patients (10%) were on a BB-free treatment strategy. There were 73 patients (33 females [42%]) in the INT group. In patients 66 (90%), INT was pursued after low-risk assessment in asymptomatic patients and absent or negligible stress test phenotype. Twenty-seven patients (22 females, 81%) were treated using 3 different BB-free treatment strategies (flecainide monotherapy, n = 21; left cardiac sympathetic denervation monotherapy, n = 2; flecainide + left cardiac sympathetic denervation, n = 4). In total, 25 patients (93%) were previously treated with BBs. During a median follow-up of 6 years (IQR: 3-9 years), 2 patients (2%) had a CPVT-associated event.</div></div><div><h3>Conclusions</h3><div>Although nonselective BBs remain the cornerstone treatment for CPVT, 10% of patients with CPVT required a BB-free treatment strategy. After careful risk assessment, safe and effective BB-free treatment strategies can be configured.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 270-278"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}