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Betterment the production of prodigiosin that was produced from Serratia marcescen by means mutations. 利用突变方法提高粘质沙雷氏菌产生的芥子皂苷的产量。
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203024145
H. Hasan
{"title":"Betterment the production of prodigiosin that was produced from Serratia marcescen by means mutations.","authors":"H. Hasan","doi":"10.9790/3008-1203024145","DOIUrl":"https://doi.org/10.9790/3008-1203024145","url":null,"abstract":"Serratia marcescens was exposed to mutation for becoming better the production of prodigiosin (quantitatively and qualitatively) and examined it as antibacterial activities. One isolate of S.marcescen (Wild) was exposed to different kinds of antibiotics (Gentamycin 10μg/ml) to produce mutant isolates from S.marcescen and examined to produce prodigiosin. The isolate that produce the largest amount of prodigiosin among four isolates was used for more studies. Staphyllococcus Baciilus, E.coli, and Pseudomonas were exposed to prodigiosin for testing inhibiting activity of it against these bacterial strains.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"19 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89370806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Problem-Solving Ability Through Culture-Based Learning Model Of Tudang Sipulung 通过《土当四普隆》的文化学习模式提高问题解决能力
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203031114
Evi Ristiana, M. Amin, S. Zubaidah, Mimien Heni Irawati Al Muhdar
{"title":"Improving Problem-Solving Ability Through Culture-Based Learning Model Of Tudang Sipulung","authors":"Evi Ristiana, M. Amin, S. Zubaidah, Mimien Heni Irawati Al Muhdar","doi":"10.9790/3008-1203031114","DOIUrl":"https://doi.org/10.9790/3008-1203031114","url":null,"abstract":"This study aims to describe the problem solving ability of students in the subjects of General Biology. Learning model used culture-based prawn shrimp. Subjects in this study are students semester 1 majoring in biology education academic year 2014-2015 Muhammadiyah University of Makassar and the object of research is the ability problem-solving and student responses with a culture-based model of shrimp ponds. Data analysis techniques used are average, percentage and likert scale. The results of this study indicate that based on the average student problem solving ability after using the BTS model is 84.4 with excellent qualification. Recapitulation of student response indicate that from six statement there are dominant statement that strongly agree that statement of BTS teaching model motivate student to work in group, and two dominant statement agree that learning with BTS model can explore ability and train student problem solving. Students agree that learning with BTS model makes students more active and more memorable because in the model of learning BTS students construct knowledge independently. Keyword: Problem Solving, Culture-Based Learning Model of Tudang Sipulung.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"5 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90638045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Lipases, Definition, and their Application 脂肪酶，定义及其应用
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203025560
Waznah Moayd, Yunjun Yan
{"title":"Lipases, Definition, and their Application","authors":"Waznah Moayd, Yunjun Yan","doi":"10.9790/3008-1203025560","DOIUrl":"https://doi.org/10.9790/3008-1203025560","url":null,"abstract":"Esterase and lipase have been consisted of α/β hydroxylase super family that characterized primarily by their α/β hydroxylase fold (common fold), which is in the center, pre-dominantly parallel β-sheet and flanked via the connections of α-helical. Nucleophilic elbow is an esterases and lipases that shared the characteristic sequence motifs (GXSXG). The residues of these amino acids compose a triad of catalyse in the specific-order (serine – aspartic acid histidine) in the chain of polypeptide. Consequently, the most of lipases and esterases resemble serine-proteases and lipases in hydrolytic mechanism. Esterases (EC 3.1.1.1), as well as lipases (EC 3.1.1.3) are the versatile classes of biocatalysts. Due to their region-, enatio-selectivity and high specificity. Esterases are those that can catalyze the hydrolysis of short-acyl-chain-lengthed triglycerides less than 10, whereas, lipases are catalysts that can hydrolyze long-acyl-chain-lengthed triglycerides more than 10. Lipases applications can widely produce from a bacterial and fungal production. Lipases applications and their biotechnology significant are presented in different field such as medical biotechnology, detergent industries, organic synthesis, biodiesel production, agrochemical industries, flavor industries, and food industries.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"57 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80825589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Characterization of Effervescent Gastro Retentive Floating Tablets by Using Venlafaxine Hcl as a Model Drug 以盐酸文拉法辛为模型药物的泡腾式胃保留漂浮片的设计与表征
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203020111
A. Kauser, A. Haseena, Faheem Unnisa Begum, Taiyaba Fatima
{"title":"Design and Characterization of Effervescent Gastro Retentive Floating Tablets by Using Venlafaxine Hcl as a Model Drug","authors":"A. Kauser, A. Haseena, Faheem Unnisa Begum, Taiyaba Fatima","doi":"10.9790/3008-1203020111","DOIUrl":"https://doi.org/10.9790/3008-1203020111","url":null,"abstract":"In the present research work the gastro retentive floating matrix formulation of Venlaflaxine hydrochloride by using various hydrophillic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various grades of HPMC and Guar gum. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared by using Guar gum were in the concentration of 120mg (F4) showed maximum drug release 99.76% in 12 hours with good floating lag time and duration of floating.The formulations prepared with HPMC K 15 M retarded the drug release up to 12 hours in the concentration of 120 mg (F8).The formulations prepared with HPMC K100M were also retarded the drug release for more than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed peppas mechanism of drug release.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"7 1","pages":"01-11"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89795543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Methods of Hydrolysis on the Composition of Prosopis Africana seed Hydrolysates 水解方法对非洲藜种子水解产物组成的影响
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203031720
A. Onah, V. Okore
{"title":"Effect of Methods of Hydrolysis on the Composition of Prosopis Africana seed Hydrolysates","authors":"A. Onah, V. Okore","doi":"10.9790/3008-1203031720","DOIUrl":"https://doi.org/10.9790/3008-1203031720","url":null,"abstract":"Variations in plant or animal species, climatic conditions as well as processing methods affects the reproducibility, quality and quantity of natural or industrial raw materials. In the present study, Prosopis africana seed was hydrolysed using two distinct methods. In a separate study, the hydrolysates were found to be good sources of peptone for microbial cultures. The proximate analyses of contents of hydrolysates obtained from enzyme-hydrolysed or acid-hydrolysed seeds were determined. The seeds obtained from a local market were thoroughly cleaned and boiled until the seed coats were softened. The softened seed coats were manually removed to reveal the cotyledons, which were washed, dried and powdered. The powdered cotyledon was subjected to hydrolysis using the enzyme, papain, or hydrochloric acid. Proximate analysis of the hydrolysates was determined using standard methods. The results revealed that papain-hydrolysed seeds (PHP) and acidhydrolysed seeds (AHP) had moisture contents of 32.7 % and 83.3 %, respectively whereas the ash values were 3.05% and 0.15 %. Protein contents of PHP and AHP were 39.69 % and 12.78 % respectively. Crude fibre compositions were 2.01 % in PHP while AHP showed no presence of fibre. It was observed that methods of hydrolysis significantly affected the quality of Prosopis africana seed hydrolysates.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"50 1","pages":"17-20"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79042473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Oral Zinc Sulfate on Local Inflammatory Cytokines Level in Iraqi Women Infected With Human Papillomavirus (HPV) 口服硫酸锌对感染人乳头瘤病毒(HPV)的伊拉克妇女局部炎症因子水平的影响
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203011417
H. Fadhil, I. Aufi, R. Aboud, F. Tuma
{"title":"Effect of Oral Zinc Sulfate on Local Inflammatory Cytokines Level in Iraqi Women Infected With Human Papillomavirus (HPV)","authors":"H. Fadhil, I. Aufi, R. Aboud, F. Tuma","doi":"10.9790/3008-1203011417","DOIUrl":"https://doi.org/10.9790/3008-1203011417","url":null,"abstract":"This study was aimed to monitor oral zinc sulfate role on local cervical proinflammatory cytokines in HPV-infected women comparing with these cytokines before treatment application. A cervical secretion got from 28 infected women before and after treatment with zinc sulfate, these samples assessed various markers of inflammation including interleukin-1β, IL-8, and IL-12. Results manifested that improve and clear the cervical HPV infections after three months of zinc treatment 46.43% and 21.43%, respectively. Viral infections with single and multiple HPV high-risk types are raising of studied cytokines after 3-month compared with single HPV low-risk type. Moreover, this increasing was statistically significant only in IL-12 and IL-1. Women more than 30 years and with multiple HPV genotypes are the most benefit of zinc treatment had a high level of cytokines. This study concludes that IL-1 and IL-12 secretion are the most effects with zinc treatment at over three months to improve mild HPV infection with good hygiene.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"07 1","pages":"14-17"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86081864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Antimicrobial Effect of Rheum ribes and Tio2 Nps on Bacterial Biofilm in Escherichia Coli 大黄渣和Tio2 Nps对大肠杆菌生物膜的抑菌作用
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203041420
Hind. H. Obaid, Z. Khalaf, Heba K. Tawfeeq, RoaaThaer Sabri, Zeina Abdul-Qader Abdul-Jabba
{"title":"Antimicrobial Effect of Rheum ribes and Tio2 Nps on Bacterial Biofilm in Escherichia Coli","authors":"Hind. H. Obaid, Z. Khalaf, Heba K. Tawfeeq, RoaaThaer Sabri, Zeina Abdul-Qader Abdul-Jabba","doi":"10.9790/3008-1203041420","DOIUrl":"https://doi.org/10.9790/3008-1203041420","url":null,"abstract":"Rheum ribs reported to have used in traditional medicine system, and also used as antimicrobial agent against different species of bacteria. Tio2 NPs one of the most widely material that investigated for killing or inhibition of bacteria. In order that, this research was came to study the effects of antibiofilm R. ribs extract and Tio2 on uropathogenic E. coli. Furthermore, study the effect of R. ribs and Tio2 combination by using tissue culture plate method. The results showed that R. ribs extract and Tio2 gave inhibition effect against bacterial biofilm in high percentage (60-80%) and (65-76%) respectively, the first effect on (E7-E16) and the second (E9E16), but the highly effect observed when mix each one of them with others one in percentage (60-78%) against 11 bacterial isolates from (E6-E16). From these results we can concluded that the R. ribs extract and Tio2 may act as an antibacterial agents in thefuture.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"33 4 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77228163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Heteroside-321 Hepatoregeneration Activity In Cases Of Hepatitis Inducted By Local Hyperthermia 局部热疗致肝炎的肝再生活性
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203045155
Kabachnyy V.I, A. V. Kabachnaya
{"title":"Heteroside-321 Hepatoregeneration Activity In Cases Of Hepatitis Inducted By Local Hyperthermia","authors":"Kabachnyy V.I, A. V. Kabachnaya","doi":"10.9790/3008-1203045155","DOIUrl":"https://doi.org/10.9790/3008-1203045155","url":null,"abstract":"","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"6 1","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77197147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biology of A Dragaonfly Crocothemis Servilia Servilia Drury (Odonata: Libellulidae), A Predator of Paddy Pests in Kolhapur. 科尔哈布尔稻田害虫捕食者——龙鳄Servilia Servilia Drury的生物学
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203011820
A. R. Bhusnar, T. Sathe
{"title":"Biology of A Dragaonfly Crocothemis Servilia Servilia Drury (Odonata: Libellulidae), A Predator of Paddy Pests in Kolhapur.","authors":"A. R. Bhusnar, T. Sathe","doi":"10.9790/3008-1203011820","DOIUrl":"https://doi.org/10.9790/3008-1203011820","url":null,"abstract":"Crocothemis servilia servilia (Drury) (Odonata: Libellulidae) is biocontrol agent of paddy pests in Kolhapur region of Maharashtra. It predates on paddy jassid Nilaparvata sp., Paddy borer Chilo suppersalis (Walker) and Jowar stem a borer Chilo partellus (Swin). Therefore, biology of C. servilia servilia has been studied under laboratory conditions (24 C, 70 75% RH and 12 hr Photo period). It completes its life cycle within 3 months, egg stage lasts for 18 days and nymphal period is 72 days. There are 12 instars, each has about 7 – 10 days duration. During nymphal period they feed on paramoecium, daphnia, redworms and mosquito larvae. Adult survives for 4 days without food. Mated female can lay about 140 – 150 eggs in water body/water trough. A single mated female, an average can produce 142 adults under laboratory conditions.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"20 1","pages":"18-20"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77767018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Ibopamine Eye Drops In Ophthalmology 伊多巴胺滴眼液在眼科中的应用
IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203042731
I. Giuffré
{"title":"Ibopamine Eye Drops In Ophthalmology","authors":"I. Giuffré","doi":"10.9790/3008-1203042731","DOIUrl":"https://doi.org/10.9790/3008-1203042731","url":null,"abstract":"Ibopamine eyedrops are used in ophthalmology. This molecule is characterized by a dual mechanism of action, since it acts on both adrenergic and dopaminergic receptors. The adrenergic action is responsible for a marked mydriasis without accommodative paralysis, while the dopaminergic action promotes the production of aqueous humor. Given this dual action, ibopamine may be useful for diagnostic purposes in ophthalmology. This review article aims at presenting the most intriguing evidence on ibopamine and discusses the profile of patients who may be best suitable to this molecule. Key-words: Glaucoma, ibopamine, provocative test, safety mydriasis.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"446 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75081739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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