IOSR Journal of Pharmacy and Biological Sciences最新文献_第8页

Betterment the production of prodigiosin that was produced from Serratia marcescen by means mutations. 利用突变方法提高粘质沙雷氏菌产生的芥子皂苷的产量。

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203024145

H. Hasan

引用次数: 0

Improving Problem-Solving Ability Through Culture-Based Learning Model Of Tudang Sipulung 通过《土当四普隆》的文化学习模式提高问题解决能力

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203031114

Evi Ristiana, M. Amin, S. Zubaidah, Mimien Heni Irawati Al Muhdar

{"title":"Improving Problem-Solving Ability Through Culture-Based Learning Model Of Tudang Sipulung","authors":"Evi Ristiana, M. Amin, S. Zubaidah, Mimien Heni Irawati Al Muhdar","doi":"10.9790/3008-1203031114","DOIUrl":"https://doi.org/10.9790/3008-1203031114","url":null,"abstract":"This study aims to describe the problem solving ability of students in the subjects of General Biology. Learning model used culture-based prawn shrimp. Subjects in this study are students semester 1 majoring in biology education academic year 2014-2015 Muhammadiyah University of Makassar and the object of research is the ability problem-solving and student responses with a culture-based model of shrimp ponds. Data analysis techniques used are average, percentage and likert scale. The results of this study indicate that based on the average student problem solving ability after using the BTS model is 84.4 with excellent qualification. Recapitulation of student response indicate that from six statement there are dominant statement that strongly agree that statement of BTS teaching model motivate student to work in group, and two dominant statement agree that learning with BTS model can explore ability and train student problem solving. Students agree that learning with BTS model makes students more active and more memorable because in the model of learning BTS students construct knowledge independently. Keyword: Problem Solving, Culture-Based Learning Model of Tudang Sipulung.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"5 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90638045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Lipases, Definition, and their Application 脂肪酶，定义及其应用

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203025560

Waznah Moayd, Yunjun Yan

{"title":"Lipases, Definition, and their Application","authors":"Waznah Moayd, Yunjun Yan","doi":"10.9790/3008-1203025560","DOIUrl":"https://doi.org/10.9790/3008-1203025560","url":null,"abstract":"Esterase and lipase have been consisted of α/β hydroxylase super family that characterized primarily by their α/β hydroxylase fold (common fold), which is in the center, pre-dominantly parallel β-sheet and flanked via the connections of α-helical. Nucleophilic elbow is an esterases and lipases that shared the characteristic sequence motifs (GXSXG). The residues of these amino acids compose a triad of catalyse in the specific-order (serine – aspartic acid histidine) in the chain of polypeptide. Consequently, the most of lipases and esterases resemble serine-proteases and lipases in hydrolytic mechanism. Esterases (EC 3.1.1.1), as well as lipases (EC 3.1.1.3) are the versatile classes of biocatalysts. Due to their region-, enatio-selectivity and high specificity. Esterases are those that can catalyze the hydrolysis of short-acyl-chain-lengthed triglycerides less than 10, whereas, lipases are catalysts that can hydrolyze long-acyl-chain-lengthed triglycerides more than 10. Lipases applications can widely produce from a bacterial and fungal production. Lipases applications and their biotechnology significant are presented in different field such as medical biotechnology, detergent industries, organic synthesis, biodiesel production, agrochemical industries, flavor industries, and food industries.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"57 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80825589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Characterization of Effervescent Gastro Retentive Floating Tablets by Using Venlafaxine Hcl as a Model Drug 以盐酸文拉法辛为模型药物的泡腾式胃保留漂浮片的设计与表征

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203020111

A. Kauser, A. Haseena, Faheem Unnisa Begum, Taiyaba Fatima

{"title":"Design and Characterization of Effervescent Gastro Retentive Floating Tablets by Using Venlafaxine Hcl as a Model Drug","authors":"A. Kauser, A. Haseena, Faheem Unnisa Begum, Taiyaba Fatima","doi":"10.9790/3008-1203020111","DOIUrl":"https://doi.org/10.9790/3008-1203020111","url":null,"abstract":"In the present research work the gastro retentive floating matrix formulation of Venlaflaxine hydrochloride by using various hydrophillic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various grades of HPMC and Guar gum. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared by using Guar gum were in the concentration of 120mg (F4) showed maximum drug release 99.76% in 12 hours with good floating lag time and duration of floating.The formulations prepared with HPMC K 15 M retarded the drug release up to 12 hours in the concentration of 120 mg (F8).The formulations prepared with HPMC K100M were also retarded the drug release for more than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed peppas mechanism of drug release.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"7 1","pages":"01-11"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89795543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Methods of Hydrolysis on the Composition of Prosopis Africana seed Hydrolysates 水解方法对非洲藜种子水解产物组成的影响

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203031720

A. Onah, V. Okore

{"title":"Effect of Methods of Hydrolysis on the Composition of Prosopis Africana seed Hydrolysates","authors":"A. Onah, V. Okore","doi":"10.9790/3008-1203031720","DOIUrl":"https://doi.org/10.9790/3008-1203031720","url":null,"abstract":"Variations in plant or animal species, climatic conditions as well as processing methods affects the reproducibility, quality and quantity of natural or industrial raw materials. In the present study, Prosopis africana seed was hydrolysed using two distinct methods. In a separate study, the hydrolysates were found to be good sources of peptone for microbial cultures. The proximate analyses of contents of hydrolysates obtained from enzyme-hydrolysed or acid-hydrolysed seeds were determined. The seeds obtained from a local market were thoroughly cleaned and boiled until the seed coats were softened. The softened seed coats were manually removed to reveal the cotyledons, which were washed, dried and powdered. The powdered cotyledon was subjected to hydrolysis using the enzyme, papain, or hydrochloric acid. Proximate analysis of the hydrolysates was determined using standard methods. The results revealed that papain-hydrolysed seeds (PHP) and acidhydrolysed seeds (AHP) had moisture contents of 32.7 % and 83.3 %, respectively whereas the ash values were 3.05% and 0.15 %. Protein contents of PHP and AHP were 39.69 % and 12.78 % respectively. Crude fibre compositions were 2.01 % in PHP while AHP showed no presence of fibre. It was observed that methods of hydrolysis significantly affected the quality of Prosopis africana seed hydrolysates.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"50 1","pages":"17-20"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79042473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Oral Zinc Sulfate on Local Inflammatory Cytokines Level in Iraqi Women Infected With Human Papillomavirus (HPV) 口服硫酸锌对感染人乳头瘤病毒(HPV)的伊拉克妇女局部炎症因子水平的影响

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203011417

H. Fadhil, I. Aufi, R. Aboud, F. Tuma

引用次数: 4

The Effect of Omeprazole Drug on the Blood Picture of Laboratory Rat Rattus Norvegicus 奥美拉唑类药物对褐家鼠血液图像的影响

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203045659

S. Jassim, A. M. Hussin

引用次数: 0

Impact of Marjoram (Origanum marjorana L.) Essential Oil on Some Virulence Factors and DNA Integrity of Multidrug Resistant Klebsiella pneumoniae 马郁兰(Origanum marjorana L.)的影响精油对多重耐药肺炎克雷伯菌毒力因子及DNA完整性的影响

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203016371

Y. El-TablawyS., E. Araby

{"title":"Impact of Marjoram (Origanum marjorana L.) Essential Oil on Some Virulence Factors and DNA Integrity of Multidrug Resistant Klebsiella pneumoniae","authors":"Y. El-TablawyS., E. Araby","doi":"10.9790/3008-1203016371","DOIUrl":"https://doi.org/10.9790/3008-1203016371","url":null,"abstract":"Infectious diseases represent an important cause of morbidity and mortality among the populations, particularly in developing countries. Therefore, pharmaceutical companies have been motivated to develop new antimicrobial drugs in the recent years especially due to the constant emergence of microorganisms resistant to conventional antimicrobials. The current study aims to evaluate the antimicrobial efficacy of some essential oils (EOs) against multidrug resistant (MDR) K. pneumoniae. Antibiotic susceptibility profile of 15 K. pneumoniae isolates was performed against 14 antibiotics and 14 essential oils. The effect of the most potent EO against the chosen isolate regarding some virulence factors and DNA fragmentation was studied. Among all the tested antibacterial agents, MEO was the most effective one. Gas chromatography/mass spectrometry of MEO revealed that, terpinen-4-ol was the major constituent followed by γ-terpinene. Treatment using MEO led to a significant reduction in biofilm formation, complete killing within 4 hours, change in membrane permeability and reduction of capsular layer of the tested cells. Also, 2 MIC of MEO caused the highest damage of bacterial DNA. This study strongly suggests that MEO possesses antibacterial properties and induces DNA degradation. These results were correlated with chemical composition of the tested oil. Key Words; Antimicrobial resistance; Essential oils; Biofilm formation; DNA fragmentationn","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"52 1","pages":"63-71"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83965544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Heteroside-321 Hepatoregeneration Activity In Cases Of Hepatitis Inducted By Local Hyperthermia 局部热疗致肝炎的肝再生活性

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203045155

Kabachnyy V.I, A. V. Kabachnaya

引用次数: 0

Cauda Equina Syndrome: A Case Report 马尾综合征1例报告

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203031516

T. Keerthana, Vijay Jagadeesh Kakimani, N. Reddy, K. Chandrasekhar, D. Ranganayakulu

{"title":"Cauda Equina Syndrome: A Case Report","authors":"T. Keerthana, Vijay Jagadeesh Kakimani, N. Reddy, K. Chandrasekhar, D. Ranganayakulu","doi":"10.9790/3008-1203031516","DOIUrl":"https://doi.org/10.9790/3008-1203031516","url":null,"abstract":"Cauda equina syndrome (CES) is a rare syndrome which is characterized by low back pain, unilateral or bilateral sciatica, motor weakness of lower extremities, saddle anesthesia, bowel and bladder dysfunction and occasionally paraplegia—resulting from compression of the cauda equina. It can be caused by herniated disc, tumor, infection, fracture, or narrowing of spinal cord. It can be described in two forms based on the onset of signs and symptoms. if symptoms appear within 24hours then it is acute in onset and if patient develop symptoms after several weeks or months then it is gradual in onset. The sooner it can be diagnosed, the better chance the patient makes a better recovery from symptoms of nerve damage. It generally requires prompt surgical decompression in order to decrease or eliminate pressure on the affected nerves. surgical decompression is advocated as soon as possible, within about 8 hours of the onset of symptoms if symptoms develop suddenly. If patients with cauda equina syndrome do not receive treatment quickly, adverse results can include paralysis, impaired bladder, and/or bowel control, difficulty walking, and/or other neurological and physical problems.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"9 1","pages":"15-16"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82419209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1