IOSR Journal of Pharmacy and Biological Sciences最新文献_第9页

Studies on Metal Chelating Property and Pharmaceutical Applications of Curcumin Metal Complex. 姜黄素金属配合物的金属螯合性能及医药应用研究。

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203017277

M. Amutha, J. Sivasakthi, Dr.A. Gubendran, P. Dhanasekaran, R. Imayatharasi

引用次数: 3

Impact of Marjoram (Origanum marjorana L.) Essential Oil on Some Virulence Factors and DNA Integrity of Multidrug Resistant Klebsiella pneumoniae 马郁兰(Origanum marjorana L.)的影响精油对多重耐药肺炎克雷伯菌毒力因子及DNA完整性的影响

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203016371

Y. El-TablawyS., E. Araby

{"title":"Impact of Marjoram (Origanum marjorana L.) Essential Oil on Some Virulence Factors and DNA Integrity of Multidrug Resistant Klebsiella pneumoniae","authors":"Y. El-TablawyS., E. Araby","doi":"10.9790/3008-1203016371","DOIUrl":"https://doi.org/10.9790/3008-1203016371","url":null,"abstract":"Infectious diseases represent an important cause of morbidity and mortality among the populations, particularly in developing countries. Therefore, pharmaceutical companies have been motivated to develop new antimicrobial drugs in the recent years especially due to the constant emergence of microorganisms resistant to conventional antimicrobials. The current study aims to evaluate the antimicrobial efficacy of some essential oils (EOs) against multidrug resistant (MDR) K. pneumoniae. Antibiotic susceptibility profile of 15 K. pneumoniae isolates was performed against 14 antibiotics and 14 essential oils. The effect of the most potent EO against the chosen isolate regarding some virulence factors and DNA fragmentation was studied. Among all the tested antibacterial agents, MEO was the most effective one. Gas chromatography/mass spectrometry of MEO revealed that, terpinen-4-ol was the major constituent followed by γ-terpinene. Treatment using MEO led to a significant reduction in biofilm formation, complete killing within 4 hours, change in membrane permeability and reduction of capsular layer of the tested cells. Also, 2 MIC of MEO caused the highest damage of bacterial DNA. This study strongly suggests that MEO possesses antibacterial properties and induces DNA degradation. These results were correlated with chemical composition of the tested oil. Key Words; Antimicrobial resistance; Essential oils; Biofilm formation; DNA fragmentationn","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"52 1","pages":"63-71"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83965544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cauda Equina Syndrome: A Case Report 马尾综合征1例报告

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203031516

T. Keerthana, Vijay Jagadeesh Kakimani, N. Reddy, K. Chandrasekhar, D. Ranganayakulu

{"title":"Cauda Equina Syndrome: A Case Report","authors":"T. Keerthana, Vijay Jagadeesh Kakimani, N. Reddy, K. Chandrasekhar, D. Ranganayakulu","doi":"10.9790/3008-1203031516","DOIUrl":"https://doi.org/10.9790/3008-1203031516","url":null,"abstract":"Cauda equina syndrome (CES) is a rare syndrome which is characterized by low back pain, unilateral or bilateral sciatica, motor weakness of lower extremities, saddle anesthesia, bowel and bladder dysfunction and occasionally paraplegia—resulting from compression of the cauda equina. It can be caused by herniated disc, tumor, infection, fracture, or narrowing of spinal cord. It can be described in two forms based on the onset of signs and symptoms. if symptoms appear within 24hours then it is acute in onset and if patient develop symptoms after several weeks or months then it is gradual in onset. The sooner it can be diagnosed, the better chance the patient makes a better recovery from symptoms of nerve damage. It generally requires prompt surgical decompression in order to decrease or eliminate pressure on the affected nerves. surgical decompression is advocated as soon as possible, within about 8 hours of the onset of symptoms if symptoms develop suddenly. If patients with cauda equina syndrome do not receive treatment quickly, adverse results can include paralysis, impaired bladder, and/or bowel control, difficulty walking, and/or other neurological and physical problems.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"9 1","pages":"15-16"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82419209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect of Omeprazole Drug on the Blood Picture of Laboratory Rat Rattus Norvegicus 奥美拉唑类药物对褐家鼠血液图像的影响

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203045659

S. Jassim, A. M. Hussin

引用次数: 0

Inhibition of Coxsackievirus A24 in permissive Hep2 cells by small interfering RNA (siRNA) 小干扰RNA (siRNA)对柯萨奇病毒A24在容许型Hep2细胞中的抑制作用

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203042126

A. Mishra, G. Satpathy

{"title":"Inhibition of Coxsackievirus A24 in permissive Hep2 cells by small interfering RNA (siRNA)","authors":"A. Mishra, G. Satpathy","doi":"10.9790/3008-1203042126","DOIUrl":"https://doi.org/10.9790/3008-1203042126","url":null,"abstract":"RNA interference is a sequence specific post transcriptional gene silencing mechanism which works through cleaving of nucleic acids by small RNA molecules of 19-21 mers. RNA interference tool found very effective to destroy the pathogenicity of several viruses. The molecular scissor activity of small interfering RNA (siRNA) was applied for inhibition of CoxsackievirusA24 (CA24), an Enterovirus of family Picornaviridae responsible for acute haemorrhagic conjunctivitis in humans. Four different siRNA molecules were used to target 5’ untranslated region (si5U), cis acting replication element of 2C (siCre), RNA dependent RNA polymerase enzyme coding region (si3D pol ) and 3’ untranslated region of CA24. Virus inhibition study by siRNA was done in Hep2 cells. Cytopathic effect, immunofluorescence assay, 50% tissue culture infectious dose (TCID50), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and virus copy number in Real-time PCR assays were used for the validation of virus inhibition potential of designed siRNA. Analysis of cumulative data reflected that si5U and si3D pol are highly efficient to stop CA24 propagation in Hep2 cells. Transfected Hep2 cells with any of these siRNA found refrained for CA24 infection in cell culture, immunofluorescence assay, TCID50 and Real Time PCR assay (p<0.05).","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"43 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90893986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Studies on Skin Sensitivity to Various Allergens in Jeddah, Saudi Arabia Using Skin Prick Test 用皮肤点刺试验研究沙特阿拉伯吉达地区皮肤对各种过敏原的敏感性

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203023540

Eman Beyari, Hussein A. Almehdar

{"title":"Studies on Skin Sensitivity to Various Allergens in Jeddah, Saudi Arabia Using Skin Prick Test","authors":"Eman Beyari, Hussein A. Almehdar","doi":"10.9790/3008-1203023540","DOIUrl":"https://doi.org/10.9790/3008-1203023540","url":null,"abstract":"Skin prick test is one of the more important diagnostic tests against allergic diseases, it uses a synthesized allergic extracts from different allergens. In this study skin prick test was done on 83 allergic persons and 20 controls (54 male and 49 female). The test was done in the Allergic Clinic in the King Abdulaziz University Hospital with 9 different allergens which were isolated from Jeddah city. The used allergens were extract of 2 species of house dust mite, extract of house dust and extracts of 6 species of identified fungi. The extracts were used in the skin prick test and compared with the same commercial allergen extracts, imported from Omega company, Canada. The results revealed a significant difference between the two results and the Canadian extracts were better than the Saudi extracts. Conclusion: From the over mentioned results could concluded that the Saudi allergens able to be applied and gave the valuable results if compared with the imported Canadian allergens which isvery expensive using skin prick test. Also the Saudi allergens need more studies to standardize to give promising economic impact results.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"2 1","pages":"35-40"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88925947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ethnobotanical Survey of Uses of Leguminosae in Raipur District 赖布尔地区豆科植物利用的民族植物学调查

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203021217

P. Dewangan, Acharya

{"title":"Ethnobotanical Survey of Uses of Leguminosae in Raipur District","authors":"P. Dewangan, Acharya","doi":"10.9790/3008-1203021217","DOIUrl":"https://doi.org/10.9790/3008-1203021217","url":null,"abstract":"Plants have been the part of life forms even with the progenitors of man. Term “Ethnobotany” was coined to denote use of plants by human being.Ethnobotany deals with the direct relationship of plants with man. The term today has come to denote the entire realm of direct relationship between plant and man. Plants show enormous diversity in the form of Algae, Fungi, Bryophytes, Pteridophytes, Gymnosperms, and Angiosperms of which later are the most diversified plants. Present study focuses on ethnobotanical study of one of the largest family of Angiosperms, the family Leguminosae, of Raipur city area. Leguminosae include three subfamilies viz: Papilionoideae, Caesalpinoideae and Mimosoideae. The family has approximately 18,000 species grouped into around 650 genera with cosmopolitan distribution. During the study seasonal field survey has been made. Information about the plants were obtained by interviewing the common people and folk healers. During the study 8 plant species were found to be used as pulses, 2 plant species (Glycine max andArachis hypogea) as edible oil yielding plants, 9 plant species used in different socio religious ceremonies (eg. Butea monosperma, Acacia catechu,Prosopis cineraria, Acacia pycnthus, Vigna sps ), 7 plant species as vegetable (eg. Trigonellafoenum-graecum), 3 species as dye yielding plants (e.g. Butea monosperma), 26 plants used in traditional medicine (e.g Cassia occidentalis, Acacia concinna, Psoralea corylifolia, Dolichos biflorus, Mucuna pruriens), 7 plants species are Non-wood Forest Produces (NWFPs), (e.g. Acacia nilotica), 13 plants are used as timber yielding plants e.g. Dalbergia sissoo). Some are fodder plants (e.g. Leucaena leucophloea) and 2 plant species are used as tooth brush (e.gAcacia nilotica) and some plants yields fibre. Some Weeds of this family are used to increase the fertility of soil due to the capacity of nitrogen fixation eg. Aeshchynomene indica,and Lathyrus odoratus. Conservation practices of plants of this family have been observed during the present studies.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"137 1","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89148985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Plate Tectonics and Reality 板块构造与现实

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203013539

D. Mitra

引用次数: 0

Accounting and Finance Educationin Nigeria: Challengesand Changesfor Efficiency. 尼日利亚的会计和金融教育:效率的挑战和变化。

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203049295

M. Bashar

引用次数: 0

Enhancement of Dissolution Rate of Ramipril Tablets by Solid Dispersion Technique 固体分散技术提高雷米普利片的溶出度

IOSR Journal of Pharmacy and Biological Sciences Pub Date : 2017-03-01 DOI: 10.9790/3008-1203015562

A. M. Hay, S. Adawy

{"title":"Enhancement of Dissolution Rate of Ramipril Tablets by Solid Dispersion Technique","authors":"A. M. Hay, S. Adawy","doi":"10.9790/3008-1203015562","DOIUrl":"https://doi.org/10.9790/3008-1203015562","url":null,"abstract":"Ramipril is an ACE inhibitor mainly used for management of mild to severe hypertension and myocardial infarction. The poor solubility and wettability of Ramipril leads to poor dissolution and hence showing variations in bioavailability.The present study is aimed to improve the physicochemical properties of the drug using solid dispersion [SD] techniques. Solid dispersions [SDs] of ramipril were prepared with different polymers or carriers such as polyvinylpyrrolidone (PVP K25, PVP K30 and PVP K90), polyethylene glycol (PEG 4000 and PEG 6000) at three drug : carrier ratios (1:1), (1:2) and (1:3). Different methods such as melting and kneading methods were used. The formulations were characterized by X-Ray Diffractometry studies, Fourier transform infrared spectroscopy and in vitro dissolution rate studies. In contrast to the slow dissolution rate of pure Ramipril, the dispersion of the drug in the PEG4000 or 6000 considerably enhanced the dissolution rate. Furthermore; Ramipril 10 mg immediate release tablets prepared in a ratio of 1:1 (drug: carrier) by the fusion method has been resulted in an acceptable dissolution results; 91% and 97% for ramiprilPEG4000 and ramipril-PEG6000 respectively.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"115 1","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79436706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0