JAMA ophthalmology最新文献

{"title":"Progressive Asymmetric Bilateral Violaceous Periorbital Edema","authors":"Lynchel M. Brumaire, Jodi Sassoon, Lalita Gupta","doi":"10.1001/jamaophthalmol.2026.3037","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.3037","url":null,"abstract":"A 66-year-old man had worsening bilateral periorbital erythema and edema for 1 month, greater on the right side. Examination showed 20/40 visual acuity with glasses in each eye, otherwise normal ocular findings, and right-sided induration and violaceous discoloration extending from the forehead to the cheek and involving both eyelids. What is your diagnosis?","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"34 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148675399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-Down Tilt Bed Rest-A Problematic Weightless Analog for SANS.","authors":"Jay C Buckey","doi":"10.1001/jamaophthalmol.2026.2297","DOIUrl":"10.1001/jamaophthalmol.2026.2297","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"690-691"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Safety of a Red Light Myopia Therapy Device-Reply.","authors":"Lisa A Ostrin, Alexander W Schill","doi":"10.1001/jamaophthalmol.2026.2010","DOIUrl":"10.1001/jamaophthalmol.2026.2010","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"799-800"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Racemose Hemangioma With Vascular Occlusion.","authors":"Yanping Zhou, Liyang Wang","doi":"10.1001/jamaophthalmol.2026.2089","DOIUrl":"10.1001/jamaophthalmol.2026.2089","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"783"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes in Neovascular Age-Related Macular Degeneration After Copayment Assistance Defunding.","authors":"William M Carrera, Anne Zeng, Kai Xiong Cheong, Quan V Hoang, Jesse J Jung, Soraya Rofagha","doi":"10.1001/jamaophthalmol.2026.2093","DOIUrl":"10.1001/jamaophthalmol.2026.2093","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"788-790"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Swept-Source Optical Coherence Tomography Angiography Indicators of Neurovascular Dysfunction in Alzheimer Disease.","authors":"Yi Zhang, Yu Jiang, Kiumars Edalati, Christina Duong, Sharon Henry, Zhaoyu Gong, Suman Jayadev, Yue Wu, Aaron Y Lee, Cecilia S Lee, Ruikang K Wang","doi":"10.1001/jamaophthalmol.2026.1986","DOIUrl":"10.1001/jamaophthalmol.2026.1986","url":null,"abstract":"<p><strong>Importance: </strong>Alzheimer disease (AD) affects millions globally, but current diagnostic approaches typically can be costly and invasive. Accessible, noninvasive screening tools for early detection of cognitive impairment are needed.</p><p><strong>Objective: </strong>To determine whether optical coherence tomography angiography (OCTA)-based biomarkers of the retina, choroid, and choriocapillaris differ across cognitive states and whether these biomarkers might discriminate among normal cognition, mild cognitive impairment (MCI), and AD dementia.</p><p><strong>Design, setting, and participants: </strong>This cross-sectional study enrolled 103 individuals referred from the University of Washington Alzheimer's Disease Research Center (ADRC) between April 2022 and September 2024. Participants included 49 cognitively normal controls, 29 with MCI, and 25 with AD dementia per ADRC research-criteria evaluations. All participants underwent swept-source OCTA (SS-OCTA). These data were analyzed from February 2025 to March 2026.</p><p><strong>Main outcomes and measures: </strong>Cognitive status, retinal vessel skeleton density (VSD), choriocapillaris flow deficit (CCFD), and ganglion cell complex (GCC) thickness.</p><p><strong>Results: </strong>Among 103 participants (mean [SD] age, 74.8 [6.72] years; 50 [48.5%] female and 53 male [51.5%]), the adjusted mean GCC was thinner in AD dementia (63.31 μm) vs controls (67.93 μm) (difference, -4.62 μm; 95% CI, -8.92 to -0.31 μm; P = .03). Adjusted mean CCFD was lower in MCI (8.12%) than AD dementia (9.07%) (difference, -0.95%; 95% CI, -1.71 to -0.19; P = .01) but higher in AD dementia than controls (8.33%) (difference, 0.74%; 95% CI, 0.02-1.46; P = .04). In multivariable models, VSD (MCI: odds ratio [OR], 0.79; 95% CI, 0.77-0.81; AD dementia: OR, 0.66; 95% CI, 0.65-0.68; P < .001) and CCFD (MCI: OR, 0.66; 95% CI, 0.65-0.67; AD dementia: OR, 1.50; 95% CI, 1.49-1.52; P < .001) were significantly associated with cognitive status, with an area under the curve of 0.72 to 0.87 in a 21-participant test set (10 controls, 6 MCI, 5 AD dementia).</p><p><strong>Conclusions and relevance: </strong>In a relatively small cohort study, OCTA revealed distinct microvascular signatures across cognitive stages. VSD decreased, and CCFD showed a biphasic pattern across cognitive stages in multivariable models, which may suggest early compensatory choriocapillaris hyperperfusion followed by perfusion failure in AD dementia. These findings suggest OCTA biomarkers may serve as accessible, noninvasive indicators of cognitive neurodegeneration, warranting larger longitudinal validation.</p>","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"673-681"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13261511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Safety of a Red Light Myopia Therapy Device.","authors":"Karl Schulmeister, John Marshall","doi":"10.1001/jamaophthalmol.2026.2007","DOIUrl":"10.1001/jamaophthalmol.2026.2007","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"799"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Axial Length Centile Charts.","authors":"Sander C M Kneepkens, Gareth Lingham, Dirk J van Hemert, James Loughman, Niall C Strang, Yih Chung Tham, Siofra C Harrington, Laura Guisasola, Amanda French, Xiangui He, David A Mackey, Lene A Hagen, Rigmor C Baraas, Olavi Pärssinen, Jason C Yam, Kathryn J Saunders, Jeremy A Guggenheim, Seang Mei Saw, Weizhong Z Lan, Caroline C W Klaver, D Ian Flitcroft","doi":"10.1001/jamaophthalmol.2026.2539","DOIUrl":"10.1001/jamaophthalmol.2026.2539","url":null,"abstract":"<p><strong>Importance: </strong>Myopia is increasingly common worldwide and poses major public health challenges because axial elongation drives sight-threatening complications. Because axial length (AL) is the primary target for myopia management, population-specific AL reference charts are needed.</p><p><strong>Objective: </strong>To generate region- and sex-specific reference centile charts for AL in children and adolescents.</p><p><strong>Design, setting, and participants: </strong>This was a pooled cohort analysis using individual-participant data from population- and school-based studies conducted in East Asia, Europe, and Australia contributing to the CREAM-Kids Consortium. A total of 147 404 children and adolescents contributing 559 799 AL measurements were included. Most participants were from East Asia (84%; ages 6-18 years), followed by Europe (12%; ages 6-21 years) and Australia (4%; ages 6-21 years). After assessment of comparability, European and Australian datasets were combined. Data were included from 1999 to 2024, with the analysis taking place from December 2024 to May 2026.</p><p><strong>Exposures: </strong>AL, age, sex, and geographic region.</p><p><strong>Main outcomes and measures: </strong>Region- and sex-specific AL centiles across age and agreement between modeled centiles and empirical values.</p><p><strong>Results: </strong>AL distributions among the 147 404 included individuals varied by sex and region. In female individuals, the 50th centile AL at age 7 years was 22.35 mm in Europe and Australia and 22.67 mm in East Asia; by age 18 years, the 50th centile ALs were 23.31 mm and 24.36 mm, respectively. Regional differences were larger at higher centiles: for female individuals at age 7 years, East Asia vs Europe and Australia differences were 0.33 mm at the 3rd centile and 0.50 mm at the 97th centile; at age 18 years, differences were 0.73 mm and 1.27 mm, respectively. Modeled centile curves closely matched empirical values (intraclass correlations >0.99) with minimal bias across sex and region subgroups (-0.08 mm to 0.04 mm).</p><p><strong>Conclusions and relevance: </strong>While not based solely on population-based cohorts, the region- and sex-specific AL centile charts developed in this pooled cohort study provide reference values for childhood and adolescence that may be used to support clinical and research applications, including identifying atypical axial elongation and informing targeted strategies for myopia prevention and management.</p>","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"744-753"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13377471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in Conflict of Interest Disclosures.","authors":"","doi":"10.1001/jamaophthalmol.2026.3632","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.3632","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"144 8","pages":"800"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gradual Reperfusion After Central Retinal Artery Occlusion.","authors":"Weilin Song, Wenjuan Chu, Xiuli Chen","doi":"10.1001/jamaophthalmol.2026.1916","DOIUrl":"10.1001/jamaophthalmol.2026.1916","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"782"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}