JAMA ophthalmology最新文献

{"title":"Repeat Exposures to Spaceflight or Bed Rest and Spaceflight-Associated Neuro-Ocular Syndrome Findings.","authors":"Katrina J Carter, Jennyffer D Smith, Alex S Huang, Claudia Stern, Larry A Kramer, Khader M Hasan, Xi Chen, Bryn A Martin, Millennia Young, Tyson J Brunstetter, Brandon R Macias, Steven S Laurie","doi":"10.1001/jamaophthalmol.2026.2140","DOIUrl":"10.1001/jamaophthalmol.2026.2140","url":null,"abstract":"<p><strong>Importance: </strong>Crewmembers on long-duration spaceflight missions are at risk of developing mild to moderate optic disc edema and ventricular volume expansion. The effect of repeat exposures on ocular and brain tissues is unknown and needs to be better understood for astronauts flying multiple missions.</p><p><strong>Objective: </strong>To evaluate whether a second exposure to spaceflight or a spaceflight analog is associated with larger changes in optic disc edema or brain ventricular volume expansion.</p><p><strong>Design, setting, and participants: </strong>Peripapillary total retinal thickness (TRT) extending from the Bruch membrane opening to 250 µm was quantified using optical coherence tomography imaging before and during spaceflight or the spaceflight analog head-down tilt bed rest (HDTBR). Magnetic resonance imaging was performed before and after spaceflight or HDTBR to quantify changes in brain volumetrics. Included were astronauts and participants in HDTBR from the International Space Station or German Aerospace Center :envihab facility. Study data were analyzed from November to December 2025.</p><p><strong>Exposures: </strong>Two spaceflight missions of approximately 6 months or 2 HDTBR campaigns of 30 to 60 days in duration.</p><p><strong>Main outcomes and measures: </strong>The change in TRT (∆TRT) from preflight/pre-HDTBR to approximately 30 days before return to Earth or 30 days into HDTBR and the change in lateral ventricular volume (∆LVV) from preexposure to postexposure. Data were analyzed to determine if repeat exposure to spaceflight or HDTBR augmented the magnitude of change from the first exposure to the second.</p><p><strong>Results: </strong>This study included a total of 7 astronauts (mean [SD] age, 43 [5] years; 5 male [71%]) and 5 participants in HDTBR (mean [SD] age, 35 [9] years; 3 male [60%]). ΔTRT was not different between spaceflight missions (mean difference, -5.6 µm; 95% CI, -15 to 3.7 µm; P = .23) or between HDTBR campaigns (mean difference, 3.1 µm; 95% CI, -3.3 to 9.5 µm; P = .33). ΔLVV was not different between spaceflight missions (mean difference, 0.1 mL; 95% CI, -0.9 to 1.1 mL; P = .78). The 3 participants in HDTBR with magnetic resonance imaging data presented with a similar ΔLVV after each campaign (0.4 vs 0.1, 1.1 vs 0.4, and 0.9 vs -0.2 mL, respectively).</p><p><strong>Conclusions and relevance: </strong>Findings of this case series show that a single repeat exposure to HDTBR or spaceflight did not appear to be associated with an increase in the magnitude of change in ocular or brain structures. Whether these exposures are additive in causing increased long-term functional changes remains unknown. These findings may be used by the space medicine community to guide the prediction of changes that might occur in those who undertake multiple spaceflight missions.</p>","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"682-690"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in Conflict of Interest Disclosures.","authors":"","doi":"10.1001/jamaophthalmol.2026.3632","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.3632","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"144 8","pages":"800"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STROBE Guideline Adherence Among Ophthalmology Journals.","authors":"Calvin J Winkler, Meghan J Ludke, Timothy M Janetos","doi":"10.1001/jamaophthalmol.2026.1930","DOIUrl":"10.1001/jamaophthalmol.2026.1930","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"786-788"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13261508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partnering to Improve Pickleball Ocular Safety Awareness-Reply.","authors":"Daniel Henick, Brian Debroff, Maryam Tahvildari","doi":"10.1001/jamaophthalmol.2026.1899","DOIUrl":"10.1001/jamaophthalmol.2026.1899","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"798-799"},"PeriodicalIF":10.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Limbal Epithelial and Stromal Cell Transplant for Aniridia-Related Keratopathy: A Nonrandomized Clinical Trial.","authors":"Abigail Eve Kaye,Louise Morgan,Radhika Shah,Amanda J Vernon,Andrew Embleton-Thirsk,Hakim-Moulay Dehbi,Daniel Sibley,Ahmed Oreaba,Julie T Daniels,Sajjad Ahmad","doi":"10.1001/jamaophthalmol.2026.2701","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.2701","url":null,"abstract":"ImportanceAdvanced aniridia-related keratopathy (ARK) is a progressive ocular surface disorder associated with limbal stem cell deficiency and limited effective treatment options.ObjectiveTo evaluate the safety, feasibility, and clinical outcomes of Real Architecture for 3D Tissues-Ocular Surface (RAFT-OS), a tissue-engineered collagen scaffold incorporating allogeneic limbal epithelial stem cells and stromal keratocytes, in adults with advanced ARK.Design, Setting, and ParticipantsThis single-arm, open-label nonrandomized clinical trial was conducted at a tertiary referral center in London, United Kingdom. Adults with congenital aniridia and advanced ARK underwent RAFT-OS transplant. Untreated fellow eyes served as natural history comparators. Recruitment occurred between February 2022 and April 2024, with final study completion in April 2025. Follow-up was 12 months. Data analysis was performed from May 2025 through February 2026.InterventionSurgical transplant of a good manufacturing practice-manufactured RAFT-OS construct.Main Outcomes and MeasuresThe primary end points were safety and ocular surface normalization at 3 and 12 months, assessed using the Ocular Surface Score (OSS). Secondary outcomes included best-corrected visual acuity (BCVA, via Early Treatment Diabetic Retinopathy Study [ETDRS] acuity charts) and patient-reported outcomes (Visual Function Questionnaire [VFQ-25], 36-Item Short Form Survey [RAND-36]).ResultsNine participants were included (3 female [33%]; mean [SD] age, 50.6 [11.6] years). One early serious adverse event prompted amendment of the manufacturing protocol; no further major RAFT-OS-related safety events occurred. Two participants developed persistent epithelial defects. In treated eyes, mean (SD) OSS was 9.4 (1.9) at baseline, 5.9 (2.4) at 3 months (mean difference from baseline, -3.6; 95% CI, -5.6 to -1.6), and 6.7 (2.4) at 12 months (mean difference, -2.8; 95% CI, -4.5 to -1.0). In untreated fellow eyes, mean (SD) OSS was 8.4 (2.7) at baseline, 8.4 (2.4) at 3 months (mean difference, 0; 95% CI, -2.5 to 2.5), and 8.0 (2.5) at 12 months (mean difference, -0.4; 95% CI, -2.4 to 1.5). Mean (SD) treated eye BCVA was 2.23 (0.16) logMAR (Snellen equivalent, <20/1600) at baseline and 1.77 (0.67) logMAR (20/1280) at 12 months (mean difference, -0.47; 95% CI, -0.97 to 0.04). Mean (SD) fellow eye BCVA was 1.47 (0.71) logMAR (Snellen equivalent, 20/640) at baseline and 1.44 (0.75) logMAR (20/640) at 12 months (mean difference, -0.04; 95% CI, -0.44 to 0.37).Conclusions and RelevanceIn this 9-participant nonrandomized clinical trial, RAFT-OS transplant was feasible and associated with early ocular surface improvement, partly sustained through 12 months, without substantial safety concerns. Additional controlled studies with longer follow-up are needed to define safety and clinical effects.Trial RegistrationClinicalTrials.gov Identifier: NCT05044598.","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"14 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Sectoral Iris Heterochromia and Hirschsprung Disease in a 5-Year-Old Child.","authors":"Anji Jain,Arun Sharma,Sampoorna Raj Choudhary","doi":"10.1001/jamaophthalmol.2026.2682","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.2682","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"157 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Bias in Glaucoma IOP Management.","authors":"Mohammed Rajib Haque,Lily Hoque","doi":"10.1001/jamaophthalmol.2026.2710","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.2710","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"34 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Hockey-Related Ocular Trauma","authors":"Leo L. T. Meller, Darren Chau, Marissa K. Shoji, Nahia Dib El Jalbout, Rolika Bansal, Sarah Cheng, Robert N. Weinreb, Catherine Y. Liu, Bobby S. Korn, Don O. Kikkawa","doi":"10.1001/jamaophthalmol.2026.2676","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.2676","url":null,"abstract":"Importance While hockey has been listed as a leading sport associated with eye injuries by the American Academy of Ophthalmology, characterization of hockey-related ocular trauma and injury severity and type remain limited. Objective To characterize epidemiologic trends and hockey-related ocular trauma in the US. Design, Setting, and Participants This was a cross-sectional study conducted from January 2004 to December 2023 using the National Electronic Injury Surveillance System (NEISS). NEISS was queried for hockey-related eye injuries based on product codes for hockey and body part code for eyeball. NEISS’s built-in algorithm for estimating national incidence was used, and patient demographic characteristics, hockey type, and injury mechanism, diagnosis, and severity were analyzed. Data were analyzed from January to March 2025. Exposure Hockey participation. Main Outcomes and Measures National incidence of injuries, injury type, and severity. Results A total of 215 cases were identified, extrapolating to 6466 US cases (95% CI, 3736-9195) over the last 20 years. Of 215 patients, 169 were male (79%), 148 were pediatric (&amp;amp;lt;18 years; 69%), and 178 had equipment-related trauma (83%). Protective goggle use was reported in only 4 cases (2%). Injury incidence was similar among ice (23 [11%]), field (21 [10%]), and street hockey (23 [11%]). Minor anterior segment injuries were common (136 [63.3%]). Thirty-two (15%) patients had multiple ocular injuries. Of 259 total diagnoses, 32 (12%) were vision-threatening injuries. Pediatric patients had more minor anterior segment injuries (95 of 148) compared with adults (31 of 67; 64% vs 46%; difference, 18%; 95% CI, 3.8-31.9; <jats:italic toggle=\"yes\">P</jats:italic> = .02), while adult patients had more major posterior segment injuries (4 of 67; 6% vs 0%; difference, 6%; 95% CI, 1.6-14.4; <jats:italic toggle=\"yes\">P</jats:italic> = .009). Male individuals had more major anterior segment injuries (35 of 169) than female individuals (1 of 46; 21% vs 2%; difference, 19%; 95% CI, 7.9-25.5; <jats:italic toggle=\"yes\">P</jats:italic> = .002). Conclusion and Relevance Hockey-related eye injuries can be severe and vision threatening. Optimal care may require prompt and thorough assessment and appropriate management of ocular and periorbital trauma. The low prevalence of reported goggle use in this investigation supports the need for greater awareness and advocacy for protective eyewear to reduce the risk of vision-threatening hockey-related injuries.","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"10 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Bias in Glaucoma IOP Management-Reply.","authors":"Ashley Polski,Ben J Brintz,Brian C Stagg","doi":"10.1001/jamaophthalmol.2026.2757","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.2757","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"25 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subretinal Fluid After Repeated Low-Level Red Light Therapy.","authors":"Haixia Bai,Jinyu Li,Shijing Wu,Zhiqing Chen","doi":"10.1001/jamaophthalmol.2026.2709","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2026.2709","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"43 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}