JAMA ophthalmology最新文献

{"title":"Capsular Tension Ring Implantation for Intraocular Lens Power Calculation in Highly Myopic Eyes: Secondary Analysis of a Randomized Clinical Trial.","authors":"Haowen Lin, Jiaqing Zhang, Aixia Jin, Yifan Zhang, Yu Zhang, Ling Jin, Yifan Xu, Xiaohang Xie, Xiaozhang Qiu, Boyufei Dai, Xuhua Tan, Lixia Luo, Yizhi Liu","doi":"10.1001/jamaophthalmol.2025.0110","DOIUrl":"10.1001/jamaophthalmol.2025.0110","url":null,"abstract":"<p><strong>Importance: </strong>Capsular tension ring (CTR) implantation has been shown to reduce intraocular lens (IOL) decentration and tilt in high myopia. However, the effect of CTR implantation in highly myopic eyes on IOL power calculation remains unclear, particularly in new-generation formulas.</p><p><strong>Objective: </strong>To evaluate the influence of CTR implantation on IOL power calculation in highly myopic eyes.</p><p><strong>Design, setting, and participants: </strong>This is a prespecified secondary analysis of outcomes of a randomized clinical trial conducted between November 2021 and September 2023 at the Zhongshan Ophthalmic Center in Guangzhou, China. Cataract patients with an axial length (AL) of 26 mm or longer were enrolled and stratified into 3 strata based on AL (stratum 1: AL 26-<28 mm; stratum 2: AL 28-<30 mm; stratum 3: AL ≥30 mm).</p><p><strong>Interventions: </strong>Participants were stratified based on AL and randomized to the CTR group (a C-loop IOL combined with a CTR) or the control group (only a C-loop IOL) within each stratum.</p><p><strong>Main outcomes and measures: </strong>Predictive outcomes of 6 new-generation formulas and 4 traditional formulas were evaluated. The arithmetic and absolute prediction error (PE) and the percentages of eyes within ±0.25 diopter (D), ±0.50 D, ±0.75 D, and ±1.00 D of PE were analyzed.</p><p><strong>Results: </strong>A total of 186 eyes of 186 participants were randomized into the CTR group (93 eyes [50%]) or control group (93 eyes [50%]). Excluding a withdrawal case and 24 eyes with best-corrected visual acuity less than 20/40, 80 eyes in the CTR group (86.0%) and 81 eyes in the control group (87.1%) were analyzed. Of 161 participants analyzed, overall mean (SD) participant age was 56.7 (10.5) years, and 100 participants (62.1%) were female. No differences were observed in arithmetic PE between the CTR and control groups in any strata. The CTR group showed smaller absolute PE in all new-generation formulas and higher percentage of PE within ±0.50 D in the Emmetropia Verifying Optical 2.0, Hoffer QST, LISA, and Pearl-DGS formulas only for eyes with an AL of 30 mm or longer compared with the control group. In traditional formulas, no differences were observed between the 2 groups in any strata.</p><p><strong>Conclusions and relevance: </strong>In this secondary analysis, CTR implantation in highly myopic eyes did not affect the target refraction and can improve the prediction accuracy of new-generation IOL calculation formulas in eyes with AL of 30 mm or longer. These findings support use of CTR implantation in eyes with an AL of 30 mm or longer.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05161520.</p>","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"373-381"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The OHDSI Network in Ophthalmology-The Promise of Observational Health Data.","authors":"Michelle R Hribar, Cindy X Cai, Kerry E Goetz, George Hripcsak","doi":"10.1001/jamaophthalmol.2025.0399","DOIUrl":"10.1001/jamaophthalmol.2025.0399","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"369-370"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy Risk Among Patients With Diabetes.","authors":"Alan Y Hsu, Hou-Ting Kuo, Yu-Hsun Wang, Chun-Ju Lin, Yi-Ching Shao, Chun-Chi Chiang, Ning-Yi Hsia, Chun-Ting Lai, Hsin Tseng, Bing-Qi Wu, Huan-Sheng Chen, Yi-Yu Tsai, Min-Yen Hsu, James Cheng-Chung Wei","doi":"10.1001/jamaophthalmol.2025.0349","DOIUrl":"10.1001/jamaophthalmol.2025.0349","url":null,"abstract":"<p><strong>Importance: </strong>Recent studies have suggested an association between nonarteritic anterior ischemic optic neuropathy (NAION) with semaglutide usage. However, the limitations of those analyses warrant further investigation, given the frequency of use of these medications in people with and without diabetes.</p><p><strong>Objective: </strong>To investigate the association between semaglutide use and the risk of NAION among patients with diabetes.</p><p><strong>Design, setting, and participants: </strong>This cohort study used data from the TriNetX database between October 1, 2019, and December 31, 2023, to identify patients with diabetes with no history of NAION who were prescribed semaglutide. The semaglutide cohort was compared with a control group of randomly selected patients with diabetes who were prescribed non-glucagonlike peptide 1 (non-GLP-1) receptor agonist (RA) antidiabetic medications. The data analysis for this study was performed on September 1, 2024.</p><p><strong>Exposures: </strong>Semaglutide history, identified using diagnostic codes.</p><p><strong>Main outcomes and measures: </strong>Cumulative incidence and (HR) hazard ratio of NAION.</p><p><strong>Results: </strong>A total of 3 344 205 patients with diabetes were included in this study. Regarding the diabetes cohort, a total of 174 584 patients with diabetes who received semaglutide (mean [SD] age, 58.3 [12.5] years; 90 427 female [51.8%]; 71 739 male [41.1%]) and 174 584 patients with diabetes who received non-GLP-1 RA medications (mean [SD] age, 58.2 [14.3] years; 90 475 female [51.82%]; 71 989 male [41.24%]) were recruited. Patients with diabetes taking semaglutide exhibited an absence of NAION risk at the 1-month (HR, 2.99; 95% CI, 0.31-28.75), 3-month (HR, 1.33; 95% CI, 0.30-5.93), 6-month (HR, 1.79; 95% CI, 0.60-5.35), and 1-year (HR, 1.94; 95% CI: 0.93-4.02) time points after the index date. However, those taking semaglutide were found to have an increased risk for NAION at the 2-year (HR, 2.39; 95% CI, 1.37-4.18), 3-year (HR, 2.44; 95% CI, 1.44-4.12), and 4-year (HR, 2.05; 95% CI, 1.26-3.34) time points from the index date. Increased risk for NAION was also noted in patients with diabetes and concomitant hypertension who were taking semaglutide (HR, 2.42; 95% CI, 1.19-4.92). An increased NAION risk was also observed among patients with diabetes who had a history of Ozempic (Novo Nordisk) use or stand-alone Ozempic (Novo Nordisk) prescription history.</p><p><strong>Conclusions and relevance: </strong>Results of this cohort study suggest that semaglutide use was associated with an increased risk of NAION in patients with diabetes. However, the study's retrospective design presents limitations, as it can only infer associations rather than establish causality; further studies are needed.</p>","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"400-407"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjunctival Melanoma With Invasion of a LASIK Flap Interface.","authors":"Tyler Bahr, Jenna Krivit, Diva R Salomao, Keith H Baratz, Lauren A Dalvin","doi":"10.1001/jamaophthalmol.2025.0400","DOIUrl":"10.1001/jamaophthalmol.2025.0400","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"448-450"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAMA Ophthalmology Peer Reviewers in 2024.","authors":"","doi":"10.1001/jamaophthalmol.2025.0394","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.0394","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"143 5","pages":"e250394"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plain Language Summaries to Bolster Team-Based Care.","authors":"Patrice M Hicks, Rithambara Ramachandran, Paula Anne Newman-Casey","doi":"10.1001/jamaophthalmol.2025.0352","DOIUrl":"10.1001/jamaophthalmol.2025.0352","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"419-420"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAMA Ophthalmology.","authors":"","doi":"10.1001/jamaophthalmol.2024.4170","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2024.4170","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"143 5","pages":"368"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in Figures.","authors":"","doi":"10.1001/jamaophthalmol.2025.0555","DOIUrl":"10.1001/jamaophthalmol.2025.0555","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"450"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Case Volume Among Ophthalmology Resident Graduates, 2014-2023.","authors":"Susan M Culican,Misha F Syed,Yoon Soo Park,Sean O Hogan","doi":"10.1001/jamaophthalmol.2025.0935","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.0935","url":null,"abstract":"ImportanceA previous multisite study found gender differences in cataract and total surgical volume among US residency programs. Whether that was representative of all ophthalmology residents in the US is unclear.ObjectiveTo determine whether reported surgical volume among US ophthalmology resident graduates varied by self-reported gender or by underrepresented in medicine (URiM) status.Design, Setting, and ParticipantsRetrospective observational longitudinal cohort study of deidentified Accreditation Council for Graduate Medical Education (ACGME) surgical log data for all graduates of US ophthalmology residency programs from the years 2014-2023 compared by self-reported gender or URiM status. Surgical experience was obtained from the ACGME Accreditation Data System resident case log. Data were analyzed from November 2023 to April 2024.Main Outcomes and MeasuresThe main outcome was a difference in mean reported surgical volume between comparison groups by gender or URiM status for cataract or total surgical procedures. The secondary outcomes were differences for other surgical categories by gender or URiM status.ResultsOf 4811 resident graduates, 41.6% (1999) were female and 58.4% were male (2812); 7.1% (343) self-identified as URiM. Cataract cases had a mean difference of -4.4% (-8.3 of 189.2) (95% CI, -6.4% to -2.4%; P < .001) fewer surgeries for female residents than male residents over the 10-year study, and total procedures had a mean difference of -7.4% (-43.4 of 587.3) (95% CI, -9.7% to -5.1%; P < .001) fewer surgeries for female than male residents over the 10-year study. URiM status over the same time period was not associated with a difference in cataract surgeries but was associated with a mean difference of -5.3% (-31.5 of 587.3) (95% CI, -9.8% to -0.9%; P = .02) fewer total procedures.Conclusions and RelevanceIn this study, female residents reported fewer cataract procedures than male residents from 2014-2023. Female and URiM residents reported fewer total procedures than their nonfemale or non-URiM colleagues. Future studies to assess the causes of these disparities are warranted.","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"21 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Morbidity and Mortality After Amaurosis Fugax.","authors":"Karen M Wai, Deanne K Loube, Nathan H Pham, Chase A Ludwig, Euna Koo, Prithvi Mruthyunjaya, Ehsan Rahimy","doi":"10.1001/jamaophthalmol.2025.0249","DOIUrl":"10.1001/jamaophthalmol.2025.0249","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"446-448"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}