JAMA ophthalmology最新文献

{"title":"Expanding the Potential Treatment of Thyroid Eye Disease.","authors":"Caroline Vloka,Sophie D Liao","doi":"10.1001/jamaophthalmol.2025.3476","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.3476","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"111 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Spaceflight-Associated Neuro-Ocular Syndrome in International Space Station Astronauts","authors":"Tyson J. Brunstetter, Sara S. Mason, Suzi Osborne, Millennia Young, Thomas Oswald, C. Robert Gibson, Nimesh Patel, Thomas H. Mader, Andrew G. Lee, David M. Brown, Ann Tsung, William Tarver","doi":"10.1001/jamaophthalmol.2025.3406","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.3406","url":null,"abstract":"ImportanceSpaceflight-associated neuro-ocular syndrome (SANS) could severely impact astronaut performance during long-duration spaceflight (LDSF). The pathophysiology of SANS remains elusive, and no predictors of SANS have been discovered; reliable prediction may offer novel insight into individual susceptibility and interperson variability for SANS and permit prelaunch preparations for in-flight treatment.ObjectiveTo conduct a preliminary analysis of SANS flight data to determine mission-to-mission trends in SANS diagnosis and optic disc edema (ODE) severity.Design, Setting, and ParticipantsIn this cohort study, ocular testing, including optical coherence tomography (OCT), was completed preflight, during flight, and postflight, then retrospectively analyzed in a unique cohort of US National Aeronautics and Space Administration (NASA) astronauts who completed 2 LDSF missions onboard the International Space Station (ISS) from 2007 to 2024. Data were analyzed from April 2024 to April 2025.ExposureWeightlessness, with average durations of 6 months for each mission.Main Outcomes and MeasuresThe primary outcome was SANS or non-SANS diagnosis, determined by OCT-based ODE data (when available after 2013) for each mission.ResultsOf 71 NASA astronauts who have participated in ISS LDSF, 16 (22.5%) have completed 2 long-duration missions. Four astronauts (20%) were female, and mean ages of astronauts participating in missions 1 and 2 were 46.1 (4.0) and 53.5 (5.2) years, respectively. For these 16 individuals, a SANS diagnosis or nondiagnosis from prior LDSF predicted SANS diagnosis during subsequent LDSF (sensitivity, 85.7%; 95% CI, 42%-100%; specificity, 100%; 95% CI, 66%-100%; positive predictive value, 100%, 95% CI, 54%-100%; negative predictive value, 90%; 95% CI, 56%-100%; <jats:italic>P</jats:italic> &amp;amp;lt; .001). A subset of this group (5 participants, 10 eyes) possessed an objective metric of ODE across both missions (ie, change in peripapillary total retinal thickness within 250 µm of Bruch membrane opening [ΔTRT]). For individual eyes, ΔTRT of a prior LDSF mission was highly predictive of ΔTRT for a subsequent LDSF (<jats:italic>r</jats:italic> = 0.94; <jats:italic>P</jats:italic> &amp;amp;lt; .001).Conclusions and RelevanceIn this cohort study, SANS cases from previous LDSF were highly likely to be diagnosed with SANS in subsequent LDSF missions and vice versa, while SANS ODE severity appeared remarkably similar across LDSF missions for individual eyes. To our knowledge, these findings represent the first and only reliable forecast for SANS, permitting precise in-flight treatment and prevention strategies to be tailored for individual astronauts in subsequent LDSF missions, even before launch.","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"60 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitreous Floaters Functional Questionnaire for Vision-Degrading Myodesopsia From Vitreous Floaters.","authors":"Justin H Nguyen,Stefaniya K Boneva,Jeannie Nguyen-Cuu,Kenneth M Yee,Fei Yu,Alfredo A Sadun,J Sebag","doi":"10.1001/jamaophthalmol.2025.3369","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.3369","url":null,"abstract":"ImportanceVision-degrading myodesopsia (VDM) from vitreous floaters can be associated with degraded contrast sensitivity and poor visual quality of life, although it is unclear how to best evaluate subjective patient disturbances. Floater-specific, vision-related, patient-reported outcomes might improve assessment of disease severity and case selection for therapy as well as provide useful outcome measures of present and future treatments.ObjectivesTo develop a Vitreous Floaters Functional Questionnaire (VFFQ) and to determine if the VFFQ score correlates with vitreous density measured by quantitative ultrasonography and with visual function evaluated by measuring contrast sensitivity.Design, Setting, and ParticipantsIn a single-center cross-sectional study, Rasch analysis was performed in 169 participants with floaters. Test-retest reliability at 3 time points over 6 months was performed in 24 other participants. Correlations of the VFFQ score with contrast sensitivity and quantitative ultrasonography were performed in a separate group of 224 participants. Data analysis was performed from 2017 to 2024.ExposuresParticipants completed the self-administered questionnaire and underwent ultrasonography, measures of contrast sensitivity, and clinical evaluation.Main Outcomes and MeasuresContrast sensitivity (Freiburg Acuity Contrast Test), Cook distance, intraclass correlation, quantitative ultrasonography, Rasch analysis, and VFFQ composite score were measured.ResultsFrom 169 participants (mean [SD] age, 57.5 [14.4] years; 74 [43.8%] female), Rasch analysis eliminated 8 questions and identified 23 questions meeting acceptable criteria for the VFFQ. The intraclass correlation of Rasch-calibrated composite scores from 24 participants (mean [SD] age, 56.0 [13.5] years; 14 [58.3%] female) who completed the 23-item VFFQ (VFFQ-23) on 3 occasions found high test-retest reliability (0.850 [95% CI, 0.721 to 0.928]; P < .001). Clinical correlations were evaluated among 224 participants (mean [SD] age, 58.5 [15.0] years; 99 [44.2%] female). There were significant correlations between VFFQ-23 scores and both vitreous echodensity (r = -0.752 [95% CI, -0.805 to -0.688]; P < .001) and contrast sensitivity (r = -0.744 [95% CI, -0.799 to -0.677]; P < .001).Conclusions and RelevanceThe VFFQ-23 had high test-retest reliability and correlated with vitreous structure and visual function. This vision-related patient-reported outcome of disease severity in patients with vitreous floaters might be useful for individual patient evaluations, population screening and triage, and assessing the response to current therapies, like vitrectomy and YAG laser vitreolysis, and future therapies, such as nanoparticle treatments and pharmacologic vitreolysis.","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Centered Care in Symptomatic Floaters.","authors":"Louay Almidani, Pradeep Ramulu","doi":"10.1001/jamaophthalmol.2025.3477","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.3477","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glaucoma Surgery in Hispanic Individuals.","authors":"Thasarat Sutabutr Vajaranant, Deepak P Edward, Charlotte E Joslin","doi":"10.1001/jamaophthalmol.2025.2826","DOIUrl":"10.1001/jamaophthalmol.2025.2826","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"821-822"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iridolenticular Burns After Panretinal Photocoagulation.","authors":"Shivesh Varma, Richard Smallwood","doi":"10.1001/jamaophthalmol.2025.3073","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.3073","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"143 10","pages":"e253073"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveitis Risk and GLP-1RA Use-Signal, Confounding, or Both?","authors":"Brian C Toy, Alexander T Hong","doi":"10.1001/jamaophthalmol.2025.2824","DOIUrl":"10.1001/jamaophthalmol.2025.2824","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"832-833"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAMA Ophthalmology.","authors":"","doi":"10.1001/jamaophthalmol.2024.4190","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2024.4190","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"143 10","pages":"802"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atropine vs Cyclopentolate for Cycloplegic Refraction in Children.","authors":"Katherine K Weise,Safal Khanal","doi":"10.1001/jamaophthalmol.2025.3342","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.3342","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"15 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Importance of Functional Benefit in Geographic Atrophy.","authors":"Christiana Dinah,Jamie Enoch,Arevik Ghulakhszian,Mandeep Sekhon,Serena Salvatore,Gabriella DeSalvo,Praveen Kumar,Sanjiv Banerjee,Devaki Nayak,Winfried Amoaku,Marianne Shiew,Olayinka Osoba,David P Crabb,Deanna J Taylor","doi":"10.1001/jamaophthalmol.2025.3264","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.3264","url":null,"abstract":"ImportanceIntravitreal complement inhibitors injections (IVCIs) slowed progression of geographic atrophy (GA) lesions in several registration phase 3 trials although without benefit for prespecified secondary functional vision outcomes. Patient acceptability of these therapies needs further exploration.ObjectiveTo quantify the acceptability of IVCI therapy to United Kingdom patients with GA, assuming vision outcome benefits are expected.Design, Setting, and ParticipantsThis cross-sectional study took place at 9 geographically dispersed UK National Health Service centers from April 2023 to April 2024 among 153 participants with treatment-naive GA in at least 1 eye.ExposuresGA in at least 1 eye.Main Outcomes and MeasuresMain outcomes were (1) acceptability of IVCI therapy based on completion of validated acceptability questionnaire. Participants were provided with a treatment information leaflet coproduced by a patients with lived experience of GA to inform them about the risks and benefits of IVCI for GA, assuming there were vision outcome benefits to this treatment and (2) response to the EuroQol 5-dimension with a vision bolt-on questionnaire to assess general health and vision-related quality of life. Spearman rank correlations and χ2 tests were used to explore associations between acceptability levels and specific ocular and sociodemographic characteristics.ResultsA total of 153 participants were recruited (93 [60%] women; mean [SD] age, 82 [7]), 57 (38%) of whom had bilateral foveal involvement. Median (IQR) visual acuity with habitual correction in the better-seeing eye and in eyes where neither eye was better or worse was logMAR, 0.30 (0.14-0.54; approximate Snellen equivalent, 20/40) and 0.47 (0.14-0.84; approximate Snellen equivalent, 20/63), respectively. Among the 153 participants, 81 (53%; 95% CI, 45-61) reported IVCIs were very much or extremely acceptable under the theoretical scenarios provided. The proportion finding IVCIs acceptable rose to 82% (95% CI, 76-88) when including those who rated prospective treatment as moderately acceptable. Belief in the perceived effectiveness of the treatment (ρ, 0.52; 95% CI, 0.40-0.63; P < .001) and confidence in their ability to attend the eye clinic regularly (ρ, 0.51; 95% CI, 0.38-0.62; P < .001) correlated with overall acceptability.Conclusions and RelevanceIVCI therapy for GA may be acceptable to most UK patients with GA under the assumption that there are vision outcome benefits to this treatment. While current treatments do not result in vision outcome benefits, perceived effectiveness by patients was associated with acceptability, emphasizing the desire to quantify vision functional benefit concomitant with anatomical slowing of progression.","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"15 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}