JAMA ophthalmology最新文献

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Gender Differences in Case Volume Among Ophthalmology Resident Graduates, 2014-2023. 2014-2023年眼科住院医师毕业生病例量的性别差异
IF 8.1 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.0935
Susan M Culican,Misha F Syed,Yoon Soo Park,Sean O Hogan
{"title":"Gender Differences in Case Volume Among Ophthalmology Resident Graduates, 2014-2023.","authors":"Susan M Culican,Misha F Syed,Yoon Soo Park,Sean O Hogan","doi":"10.1001/jamaophthalmol.2025.0935","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.0935","url":null,"abstract":"ImportanceA previous multisite study found gender differences in cataract and total surgical volume among US residency programs. Whether that was representative of all ophthalmology residents in the US is unclear.ObjectiveTo determine whether reported surgical volume among US ophthalmology resident graduates varied by self-reported gender or by underrepresented in medicine (URiM) status.Design, Setting, and ParticipantsRetrospective observational longitudinal cohort study of deidentified Accreditation Council for Graduate Medical Education (ACGME) surgical log data for all graduates of US ophthalmology residency programs from the years 2014-2023 compared by self-reported gender or URiM status. Surgical experience was obtained from the ACGME Accreditation Data System resident case log. Data were analyzed from November 2023 to April 2024.Main Outcomes and MeasuresThe main outcome was a difference in mean reported surgical volume between comparison groups by gender or URiM status for cataract or total surgical procedures. The secondary outcomes were differences for other surgical categories by gender or URiM status.ResultsOf 4811 resident graduates, 41.6% (1999) were female and 58.4% were male (2812); 7.1% (343) self-identified as URiM. Cataract cases had a mean difference of -4.4% (-8.3 of 189.2) (95% CI, -6.4% to -2.4%; P < .001) fewer surgeries for female residents than male residents over the 10-year study, and total procedures had a mean difference of -7.4% (-43.4 of 587.3) (95% CI, -9.7% to -5.1%; P < .001) fewer surgeries for female than male residents over the 10-year study. URiM status over the same time period was not associated with a difference in cataract surgeries but was associated with a mean difference of -5.3% (-31.5 of 587.3) (95% CI, -9.8% to -0.9%; P = .02) fewer total procedures.Conclusions and RelevanceIn this study, female residents reported fewer cataract procedures than male residents from 2014-2023. Female and URiM residents reported fewer total procedures than their nonfemale or non-URiM colleagues. Future studies to assess the causes of these disparities are warranted.","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"21 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular Morbidity and Mortality After Amaurosis Fugax. 富盖黑朦后的心血管发病率和死亡率。
IF 7.8 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.0249
Karen M Wai, Deanne K Loube, Nathan H Pham, Chase A Ludwig, Euna Koo, Prithvi Mruthyunjaya, Ehsan Rahimy
{"title":"Cardiovascular Morbidity and Mortality After Amaurosis Fugax.","authors":"Karen M Wai, Deanne K Loube, Nathan H Pham, Chase A Ludwig, Euna Koo, Prithvi Mruthyunjaya, Ehsan Rahimy","doi":"10.1001/jamaophthalmol.2025.0249","DOIUrl":"10.1001/jamaophthalmol.2025.0249","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"446-448"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Severity of Astigmatism in Children After COVID-19. COVID-19后儿童散光的患病率和严重程度
IF 7.8 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.0205
Ka Wai Kam, Erica Shing, Yuzhou Zhang, Xiu Juan Zhang, Arnold S H Chee, Mandy P H Ng, Patrick Ip, Wei Zhang, Alvin L Young, Amanda French, Ian Morgan, Kathyrn Rose, Clement C Tham, Chi Pui Pang, Li Jia Chen, Jason C Yam
{"title":"Prevalence and Severity of Astigmatism in Children After COVID-19.","authors":"Ka Wai Kam, Erica Shing, Yuzhou Zhang, Xiu Juan Zhang, Arnold S H Chee, Mandy P H Ng, Patrick Ip, Wei Zhang, Alvin L Young, Amanda French, Ian Morgan, Kathyrn Rose, Clement C Tham, Chi Pui Pang, Li Jia Chen, Jason C Yam","doi":"10.1001/jamaophthalmol.2025.0205","DOIUrl":"10.1001/jamaophthalmol.2025.0205","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Astigmatism can cause blurred vision at near and distance. It is common among schoolchildren and associated with ametropia. Although the COVID-19 pandemic generated a surge in myopia prevalence in children, the association with child astigmatism remains unknown.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To report the prevalence of refractive astigmatism and corneal astigmatism in schoolchildren from 2015 to 2023 and explore the associations between the pandemic and astigmatism.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This population-based cross-sectional study stratified all the primary schools registered with Education Bureau in Hong Kong into 7 clustered regions used by Hospital Authority Services in Hong Kong. Participants were schoolchildren aged 6 to 8 years who underwent comprehensive ocular examinations at 2 academic medical centers in Hong Kong from 2015 to 2023. Astigmatism was measured with optical biometry and auto-refractor after cycloplegia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposure: &lt;/strong&gt;COVID-19 pandemic.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The annual prevalence rates of refractive astigmatism and corneal astigmatism were the primary outcome measures. Logistic regression was used to evaluate the association of the pandemic with the risks of refractive astigmatism and corneal astigmatism. Linear regression was used to explore the association of the pandemic with the magnitudes of refractive astigmatism and corneal astigmatism.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The cohort consisted of 21 655 children: 11 464 boys (52.9%) and 10 191 girls (47.1%); their mean (SD) age was 7.31 (0.90) years. The prevalence rate of refractive astigmatism of at least 1.0 diopter (D) was 21.4% and corneal astigmatism of at least 1.0 D 59.8% in 2015 and increased to 34.7% (difference, 13.3%; 95% CI, 9.3%-17.3%) and 64.7% (difference, 4.9%; 95% CI, 0.5%-9.2%), respectively, in 2022-2023. The pandemic was associated with a 20% increase in the risk of refractive astigmatism (odd ratio [OR], 1.20; 95% CI, 1.09-1.33; P &lt; .001), 26% increase in the risk of corneal astigmatism (OR, 1.26; 95% CI, 1.15-1.38; P &lt; .001), 0.04 D in the magnitude of refractive astigmatism (95% CI, 0.02-0.07; P &lt; .001), and 0.05 D in the magnitude of corneal astigmatism (95% CI, 0.02-0.08; P &lt; .001), compared with the prepandemic period of 2015-2019 and after adjusting for sociodemographic factors, parental astigmatism, and child myopia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;This study found an increase in both the prevalence and severity of refractive astigmatism and corneal astigmatism after the COVID-19 pandemic. Corneal changes especially along the steepest meridian may explain some of the progression of corneal astigmatism. The potential impact of higher degrees of astigmatism may warrant dedicated efforts to elucidate the relationship between environmental and/or lifestyle factors, as well as the pathophysiology of astigmatism.&lt;/p","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"383-391"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Errors in Figure 2. 图2中的错误。
IF 7.8 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.1372
{"title":"Errors in Figure 2.","authors":"","doi":"10.1001/jamaophthalmol.2025.1372","DOIUrl":"10.1001/jamaophthalmol.2025.1372","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"143 5","pages":"450"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noninfectious Intraocular Inflammation After Intravitreal Aflibercept. 非感染性眼内炎症。
IF 8.1 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.0969
Karoline E Binder,Nathalie Bleidißel,Peter Charbel Issa,Mathias Maier,Leonard M Coulibaly
{"title":"Noninfectious Intraocular Inflammation After Intravitreal Aflibercept.","authors":"Karoline E Binder,Nathalie Bleidißel,Peter Charbel Issa,Mathias Maier,Leonard M Coulibaly","doi":"10.1001/jamaophthalmol.2025.0969","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.0969","url":null,"abstract":"ImportanceAflibercept, 8 mg, is an anti-vascular endothelial growth factor (VEGF) formulation for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). While clinical trials report a comparable safety profile as aflibercept, 2 mg, clinical practice setting (so-called real-world) data on the incidence of intraocular inflammation (IOI) should be of value.ObjectiveTo determine the clinical practice setting incidence of IOI after intravitreal injection of aflibercept, 8 mg, for nAMD and DME.Design, Setting, and ParticipantsThis retrospective case series involved a review of medical records at a single tertiary care center. Participants were all patients who received an intravitreal injection of aflibercept, 8 mg, for nAMD or DME from March 2024 to October 2024. Patients had received injections with other VEGF inhibitors before. Standard care included slitlamp examination before each injection and follow-up examination within 4 days after every injection.ExposureIOI adverse events (AEs) after injections.Main Outcomes and MeasuresIncidence of IOI after intravitreal injection of aflibercept, 8 mg. Secondary outcomes included the time point of IOI and best-corrected visual acuity (BCVA) during and after recovery of IOI.ResultsForty-one patients were treated with intravitreal aflibercept, 8 mg, injections: 23 with nAMD (56%) and 18 with DME (44%). Twenty-seven patients (66%) were male and 14 patients female (34%). A total of 136 intravitreal injections of aflibercept, 8 mg, were administered during the observation period. Five patients of 41 developed mild sterile IOI within 1 to 3 days after the intervention (incidence per injection, 3.7%; 95% CI, 1.6%-8.3%; incidence per patient, 12%; 95% CI, 5.3%-25.5%). Four patients had prior exposure to aflibercept, 8 mg, before the inflammation occurred; only 1 patient developed inflammation after the first dose. All patients were treated with local anti-inflammatory therapy (topical or subconjunctival corticosteroids), and 2 patients received additional systemic oral corticosteroids. No reduction of BCVA was observed after IOI-associated AEs receded.Conclusions and RelevanceThis analysis in a clinical practice setting revealed a more frequent occurrence of IOI-associated AEs compared with previous clinical trials. All observed cases showed a mild IOI, which resolved under anti-inflammatory therapy without loss of BCVA.","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"13 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Training Inequities in Ophthalmology-Insights From Educators. 眼科培训的不公平——来自教育者的见解。
IF 8.1 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.1112
Fasika Woreta,Laura K Green,Grace Sun
{"title":"Training Inequities in Ophthalmology-Insights From Educators.","authors":"Fasika Woreta,Laura K Green,Grace Sun","doi":"10.1001/jamaophthalmol.2025.1112","DOIUrl":"https://doi.org/10.1001/jamaophthalmol.2025.1112","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":"10 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of AI Summaries on Interdisciplinary Understanding of Ophthalmology Notes. 人工智能对眼科笔记跨学科理解的评价
IF 7.8 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.0351
Prashant D Tailor, Haley S D'Souza, Clara M Castillejo Becerra, Heidi M Dahl, Neil R Patel, Tyler M Kaplan, Darrell Kohli, Erick D Bothun, Brian G Mohney, Andrea A Tooley, Keith H Baratz, Raymond Iezzi, Andrew J Barkmeier, Sophie J Bakri, Gavin W Roddy, David Hodge, Arthur J Sit, Matthew R Starr, John J Chen
{"title":"Evaluation of AI Summaries on Interdisciplinary Understanding of Ophthalmology Notes.","authors":"Prashant D Tailor, Haley S D'Souza, Clara M Castillejo Becerra, Heidi M Dahl, Neil R Patel, Tyler M Kaplan, Darrell Kohli, Erick D Bothun, Brian G Mohney, Andrea A Tooley, Keith H Baratz, Raymond Iezzi, Andrew J Barkmeier, Sophie J Bakri, Gavin W Roddy, David Hodge, Arthur J Sit, Matthew R Starr, John J Chen","doi":"10.1001/jamaophthalmol.2025.0351","DOIUrl":"10.1001/jamaophthalmol.2025.0351","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Specialized ophthalmology terminology limits comprehension for nonophthalmology clinicians and professionals, hindering interdisciplinary communication and patient care. The clinical implementation of large language models (LLMs) into practice has to date been relatively unexplored.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate LLM-generated plain language summaries (PLSs) integrated into standard ophthalmology notes (SONs) in improving diagnostic understanding, satisfaction, and clarity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;Randomized quality improvement study conducted from February 1, 2024, to May 31, 2024, including data from inpatient and outpatient encounters in a single tertiary academic center. Participants were nonophthalmology clinicians and professionals and ophthalmologists. The single inclusion criterion was any encounter note generated by an ophthalmologist during the study dates. Exclusion criteria were (1) lack of established nonophthalmology clinicians and professionals for outpatient encounters and (2) procedure-only patient encounters.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Intervention: &lt;/strong&gt;Addition of LLM-generated plain language summaries to ophthalmology notes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The primary outcome was survey responses from nonophthalmology clinicians and professionals assessing understanding, satisfaction, and clarity of ophthalmology notes. Secondary outcomes were survey responses from ophthalmologists evaluating PLS in terms of clinical workflow and accuracy, objective measures of semantic quality, and safety analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 362 (85%) nonophthalmology clinicians and professionals (33.0% response rate) preferred the PLS to SON. Demographic data on age, race and ethnicity, and sex were not collected. Nonophthalmology clinicians and professionals reported enhanced diagnostic understanding (percentage point increase, 9.0; 95% CI, 0.3-18.2; P = .01), increased note detail satisfaction (percentage point increase, 21.5; 95% CI, 11.4-31.5; P &lt; .001), and improved explanation clarity (percentage point increase, 23.0; 95% CI, 12.0-33.1; P &lt; .001) for notes containing a PLS. The addition of a PLS was associated with reduced comprehension gaps between clinicians who were comfortable and uncomfortable with ophthalmology terminology (from 26.1% [95% CI, 13.7%-38.6%; P &lt; .001] to 14.4% [95% CI, 4.3%-24.6%; P &gt; .06]). PLS semantic analysis found high meaning preservation (bidirectional encoder representations from transformers score mean F1 score: 0.85) with greater readability than SONs (Flesch Reading Ease: 51.8 vs 43.6; Flesch-Kincaid Grade Level: 10.7 vs 11.9). Ophthalmologists (n = 489; 84% response rate) reported high PLS accuracy (90% [320 of 355] a great deal) with minimal review time burden (94.9% [464 of 489] ≤1 minute). PLS error rate on ophthalmologist review was 26% (126 of 489). A total of 83.9% (104 of 126) of errors wer","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"410-419"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aflibercept With vs Without Reduced-Fluence Photodynamic Therapy for Polypoidal Choroidal Vasculopathy: A Randomized Clinical Trial. 阿非利西普联合与不联合降低通量光动力治疗息肉样脉络膜血管病变:一项随机临床试验。
IF 7.8 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.0250
Yu Jeat Chong, Kelvin Yi Chong Teo, Wendy Wong, Anna C S Tan, Xinyi Su, Noa Gilead, Hiok Hong Chan, Farah Ibrahim, Beau Fenner, Charles Ong, Christopher Sun, Shaun Sim, Caroline Chee, Usha Chakravarthy, Chui Ming Gemmy Cheung
{"title":"Aflibercept With vs Without Reduced-Fluence Photodynamic Therapy for Polypoidal Choroidal Vasculopathy: A Randomized Clinical Trial.","authors":"Yu Jeat Chong, Kelvin Yi Chong Teo, Wendy Wong, Anna C S Tan, Xinyi Su, Noa Gilead, Hiok Hong Chan, Farah Ibrahim, Beau Fenner, Charles Ong, Christopher Sun, Shaun Sim, Caroline Chee, Usha Chakravarthy, Chui Ming Gemmy Cheung","doi":"10.1001/jamaophthalmol.2025.0250","DOIUrl":"10.1001/jamaophthalmol.2025.0250","url":null,"abstract":"<p><strong>Importance: </strong>The potential benefit of adding photodynamic therapy (PDT) to intravitreal aflibercept injection (IAI) in eyes with polypoidal choroidal vasculopathy (PCV) remains unclear.</p><p><strong>Objective: </strong>To compare the functional and anatomical benefit of combination therapy using reduced-fluence PDT (RF-PDT) plus IAI vs IAI monotherapy in participants with PCV.</p><p><strong>Design, setting, and participants: </strong>This double-masked, sham-controlled, randomized clinical trial was conducted at 2 centers in Singapore from January 2021 to June 2024 for participants aged 50 years or older with symptomatic macular PCV confirmed on indocyanine green angiography. Data were analyzed from January 2021 to June 2024.</p><p><strong>Interventions: </strong>Randomization 1:1 to RF-PDT plus 2 mg of IAI or sham-PDT plus 2 mg of IAI at week 0. Follow-up was at 4 weeks and retreatment with IAI, per protocol pro re nata regimen.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was the mean change in best-corrected visual acuity (BCVA) from baseline to week 52. Secondary outcomes, not adjusted for multiple analyses, included proportion of eyes with polypoidal lesion (PL) closure at week 12 per indocyanine green angiography .</p><p><strong>Results: </strong>Only 60 (43 male [71.6%] and 17 female [28.4%]; mean [SD] age, 71.3 [5.7] years) of the planned 160 participants were enrolled between January 2021 and June 2023. Among these, 30 of 30 (100%) and 30 of 30 participants (100%) in combination and monotherapy groups, respectively, returned for the 52-week follow-up. Baseline BCVA letter score (approximate Snellen equivalent [SD]) was 62.0 (20/63 [10.6]) and 62.0 (20/63 [10.7]) in the combination and monotherapy arms, respectively. At week 52, mean gain in BCVA was 12.7 (combination) vs 11.9 (monotherapy) (difference = 0.8 letters; 95% CI, -3.0 to 6.0 letters; P = .82). At week 12, the PL closure rate occurred in 20 of 30 eyes (66.7%) vs 10 of 30 eyes (33.3%) in the combination and monotherapy arms, respectively (difference = 33.4%; 95% CI, 9.5%-57.2%; P = .02).</p><p><strong>Conclusions and relevance: </strong>With less than half of the planned sample size enrolled, no superiority in BCVA outcomes for either arm was detected and the combination arm could not be shown to be not worse (not noninferior) to the monotherapy arm. While PL closure at week 12 was greater in the combination arm, secondary outcome results, which were not adjusted for multiple analyses, should be considered hypothesis generating and not associated with a clinically relevant functional outcome in this trial.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT03941587.</p>","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"393-399"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of Population-Based Studies in Childhood Eye Disease-Seeing the Bigger Picture. 以人群为基础的儿童眼病研究的重要性——看到更大的图景。
IF 7.8 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.0251
Jonathan R Morse, Jeremy D Keenan, Julius T Oatts
{"title":"Importance of Population-Based Studies in Childhood Eye Disease-Seeing the Bigger Picture.","authors":"Jonathan R Morse, Jeremy D Keenan, Julius T Oatts","doi":"10.1001/jamaophthalmol.2025.0251","DOIUrl":"10.1001/jamaophthalmol.2025.0251","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"391-392"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Myopia and Capsular Tension Rings-To Be or Not To Be? 高度近视和荚膜张力环——是还是不是?
IF 7.8 1区 医学
JAMA ophthalmology Pub Date : 2025-05-01 DOI: 10.1001/jamaophthalmol.2025.0442
Eubee B Koo
{"title":"High Myopia and Capsular Tension Rings-To Be or Not To Be?","authors":"Eubee B Koo","doi":"10.1001/jamaophthalmol.2025.0442","DOIUrl":"10.1001/jamaophthalmol.2025.0442","url":null,"abstract":"","PeriodicalId":14518,"journal":{"name":"JAMA ophthalmology","volume":" ","pages":"381-382"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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