Italian Journal of Pediatrics最新文献

{"title":"COVID-19 infection is associated with anti-M alloantibody development in pediatric patients: immunological characteristics and clinical implications for transfusion safety.","authors":"Ming-Wei Yin, Xue-Qi Peng, Ji-Hua Ma, Gui-Zhen Jiang, Ning Zhao, Xin-Yu Huang, Si Shi, Xue-Jun Chen","doi":"10.1186/s13052-026-02258-x","DOIUrl":"https://doi.org/10.1186/s13052-026-02258-x","url":null,"abstract":"","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of peripheral blood cell parameters and their derived ratios in predicting intravenous immunoglobulin resistance in Kawasaki disease.","authors":"Qiqin Tang, Xiujuan Xu, Chuan Gan","doi":"10.1186/s13052-026-02267-w","DOIUrl":"https://doi.org/10.1186/s13052-026-02267-w","url":null,"abstract":"","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping of pediatric allergy structures in Italy: a nationwide survey.","authors":"Giulio Dinardo, Mattia Giovannini, Francesca Galletta, Angela Klain, Maria de Filippo, Cristiana Indolfi, Gian Luigi Marseglia, Michele Miraglia Del Giudice, Sara Manti","doi":"10.1186/s13052-026-02261-2","DOIUrl":"https://doi.org/10.1186/s13052-026-02261-2","url":null,"abstract":"","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Münchausen syndrome by proxy: a literary review and a reminder for every health care professional.","authors":"Alessandra Giliberti, Stefania Giustiniano, Ylenia Carbonaro, Adele Maria Frisina, Michele Roccella, Rosaria Nardello","doi":"10.1186/s13052-026-02232-7","DOIUrl":"https://doi.org/10.1186/s13052-026-02232-7","url":null,"abstract":"","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effects of single-carbon metabolism and vitamin levels on autism spectrum disorder risk: a bidirectional Mendelian randomized study.","authors":"Jun Zhu, Yun Yi, Ling Ma, Sheng Tao, Jingjing Sun, Danwei Zhang, Xue Sun, Kaimo Ding","doi":"10.1186/s13052-026-02254-1","DOIUrl":"10.1186/s13052-026-02254-1","url":null,"abstract":"","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"52 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of systemic inflammatory indices and metabolically healthy vs. unhealthy obesity in children.","authors":"Meliha Esra Bіlіcі","doi":"10.1186/s13052-026-02262-1","DOIUrl":"https://doi.org/10.1186/s13052-026-02262-1","url":null,"abstract":"","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram for early prediction of pertussis-associated pneumonia in children: a retrospective clinical study.","authors":"Jiaying Ren, Dan Chen, Tipei Zhang, Yanhong Ren, Xiaomin Sun","doi":"10.1186/s13052-026-02263-0","DOIUrl":"https://doi.org/10.1186/s13052-026-02263-0","url":null,"abstract":"<p><strong>Background: </strong>Pertussis, an acute respiratory infection caused by Bordetella pertussis, has recently shown a global resurgence. Pneumonia represents one of its most frequent and severe complications. The present study aimed to identify risk factors for pertussis-associated pneumonia and to develop a predictive model for early identification of high-risk pediatric patients.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 123 children hospitalized with pertussis at the Children's Hospital Affiliated to Zhengzhou University between 1 June 2024 and 31 December 2024(training cohort). Using univariate analysis, least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression analysis, identified the predictors for pertussis-associated pneumonia. An independent cohort enrolled between 1 January 2025 and 31 July 2025, was used for external validation cohort. Receiving operating characteristic curve (ROC), calibration plots, decision curve analysis (DCA), and clinical impact curves (CIC) were used to evaluate the performance of the model.</p><p><strong>Results: </strong>We identified five independent predictors of pertussis-associated pneumonia: white blood cell count (WBC; OR = 1.112, 95% CI: 1.012-1.221), interleukin-6 (IL-6; OR = 1.153, 95% CI: 1.049-1.267), lymphocyte percentage (Lym%; OR = 1.045, 95% CI: 1.013-1.078), interleukin-17a (IL-17a; OR = 1.209, 95% CI: 1.024-1.427), and Co-infection (OR = 3.096, 95% CI: 1.260-7.610). The area under the receiver operating characteristic curve (AUC) was 0.824 (95% CI: 0.747-0.900) in the training cohort and 0.792 (95% CI: 0.718-0.865) in the external validation cohort. The Hosmer-Lemeshow test indicated good calibration (P = 0.590 in the training cohort; P = 0.735 in the external validation cohort). Decision curve analysis and clinical impact curves confirmed clinical utility.</p><p><strong>Conclusion: </strong>A clinically useful nomogram model was developed for early prediction of pertussis-associated pneumonia in children. Application of this model may assist clinicians in promptly identifying high-risk patients and implementing timely interventions to improve outcomes.Notably, this study had a small sample size (n = 123) relative to the five predictors, and the external validation cohort was from the same center, which may limit the model's generalizability to heterogeneous clinical settings.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent use of broad-spectrum antibiotics for suspected community acquired urinary tract infections in children in Italian primary care settings.","authors":"Emelyne Gres, Piero Veronese, Giulia Brigadoi, Maria Vego Scocco, Giangiacomo Nicolini, Daniele Dona', Elisa Barbieri","doi":"10.1186/s13052-026-02260-3","DOIUrl":"https://doi.org/10.1186/s13052-026-02260-3","url":null,"abstract":"","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of IL-6 gene polymorphisms in children with autism spectrum disorders.","authors":"Noha M Abdullah, Hend M Moness, Marwa Waly Eldin Ali, Ebtihal Mokhtar Abdelsamei, Ebtesam Esmail Hassan, Dalia Abdelrahman Meshref","doi":"10.1186/s13052-026-02245-2","DOIUrl":"10.1186/s13052-026-02245-2","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by impairment in social interaction, and communication skills, along with restricted or repetitive behaviors. The diagnosis of ASD depends on behavioral parameters. Numerous studies have reported immune system abnormalities and proposed a potential role of autoimmunity in the pathogenesis of ASD. This study aims to assess the correlation between specific cytokines, such as interleukin-6 (IL-6), and particular IL-6 polymorphisms, including IL-6-174G/C (rs1800795) gene polymorphism, IL-6-572 C/G (rs1800796) gene polymorphism and IL-6-597G/A (rs1800797) gene polymorphism among children with ASD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The current study included 100 children with ASD were recruited during their regular follow up to Pediatric Neuro-Psychiatry Clinic of Minia University Hospital of Children. They diagnosed according to DSM-5 ASD criteria. A another 100 children were recruited as control group by simple randomly selected school (pre & elementary school) in Mina Governate, Upper Egypt, their ages and sex matched with the ASD children, they were apparently neuropsychiatric and developmentally normal and free from any chronic systemic illness. The participants were assessed for serum IL-6 levels and single-nucleotide changes in IL-6-174G/C, IL-6-572 C/G and IL-6-597G/A gene polymorphisms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The prevalence of the GG genotype and G allele of the IL-6-174G/C gene polymorphism was significantly higher in ASD patients compared to healthy control (P value = 0.0002, 0.03 respectively). In contrast, the GC genotype and C allele of IL-6 -174G/C gene polymorphism were significantly elevated in the control group compared to children with ASD, indicating a protective role against ASD in the Egyptian population. The prevalence of the CG genotype, GG genotype, and G allele of the IL-6-572 C/G gene polymorphism was significantly higher in ASD patients compared to control individuals, indicating an increased risk of ASD within the Egyptian population. The IL-6-597G/A gene polymorphism analysis revealed no significant differences between the two groups in GG and GA genotypes or allelic frequencies. Nevertheless, the AA genotype was only found in the autistic group. Furthermore, ASD patients exhibited significantly higher serum levels of IL-6 than the healthy controls. The GG genotype distribution of IL-6-174G/C gene polymorphism was significantly associated with increased serum levels of IL-6.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The IL-6 (-174G/C) gene polymorphism (GG genotype) was associated with ASD. Moreover, the (CG + GG) genotypes of IL-6-572 C/G gene polymorphism were associated with ASD, and the (AA genotype) of IL-6-597G/A gene polymorphism was detected only in ASD. This indicates their role in the increased incidence of ASD among the Egyptian population. In addition, IL-6 serum level was significantly elevated ","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines on diagnosis and management of gastroesophageal reflux disease in infants, children and adolescents: a joint consensus from Italian pediatric societies (SIP and SIGENP) -part I. diagnosis.","authors":"Silvia Salvatore, Caterina Strisciuglio, Elena Bozzola, Stefania Cappa, Antonio Corsello, Giovanni Di Nardo, Maurizio Fuoti, Antonino Gulino, Chiara Mameli, Massimiliano Orso, Licia Pensabene, Barbara Polistena, Renato Tambucci, Francesca Vassallo, Claudio Romano, Annamaria Staiano","doi":"10.1186/s13052-026-02218-5","DOIUrl":"https://doi.org/10.1186/s13052-026-02218-5","url":null,"abstract":"","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}