Italian Journal of Pediatrics最新文献

{"title":"Co-infection in unvaccinated infants with acute pertussis in Western China (2018-2019): pathogen distribution and impact on disease severity.","authors":"Chuan Gan, Yuanyuan Wu","doi":"10.1186/s13052-025-01949-1","DOIUrl":"https://doi.org/10.1186/s13052-025-01949-1","url":null,"abstract":"<p><strong>Background: </strong>Co-infections in pertussis patients are common, but there has been limited research on the distribution of co-infecting pathogens and their impact on disease severity in infant patients remaining unvaccinated against pertussis. This study aims to investigate the pathogen distribution in unvaccinated infants with acute pertussis and explore how the number and type of co-infecting pathogens influence disease severity.</p><p><strong>Method: </strong>This cross-sectional study analyzed clinical data from 302 unvaccinated infants diagnosed with acute pertussis in western China. We compared clinical variables across different co-infection groups (bacteria, viruses, bacterial-viral combinations) and by the number of co-infecting pathogens (0, 1, ≥ 2).</p><p><strong>Results: </strong>Of the 302 patients, 121 (40.1%) were infected solely with Bordetella pertussis, while 181 (59.9%) had co-infections with other pathogens. The most common co-infections were bacterial (93 of 139 cases), particularly Gram-negative bacteria, followed by viral co-infections, mainly parainfluenza virus type-3 (PIV-3), in 71.3% of viral cases. The number of co-infecting pathogens was positively associated with longer hospital stays, more severe pneumonia, and higher incidence of respiratory failure (P < 0.05). Notably, bacterial co-infections were associated with more severe clinical outcomes than viral co-infections, with significant differences in hospitalization duration, as well as in peak white blood cell and lymphocyte counts (P < 0.05). No significant differences were observed in co-infection types or pathogen numbers across different age groups.</p><p><strong>Conclusion: </strong>Co-infections are prevalent among unvaccinated infants with acute pertussis in western China. Bacterial and viral pathogens are the most common co-infecting agents, and disease severity increases with the number of co-infecting pathogens. Bacterial co-infections may lead to more severe outcomes compared to viral co-infections, underscoring the need for targeted diagnostic and therapeutic strategies.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"111"},"PeriodicalIF":3.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and mortality in children with severe pertussis: the role of exchange transfusion in a PICU.","authors":"Junming Huo, Song Chen, Yanran Qin, Feng Xu, Chenjun Liu","doi":"10.1186/s13052-025-01951-7","DOIUrl":"10.1186/s13052-025-01951-7","url":null,"abstract":"<p><strong>Objective: </strong>Although multiple risk factors have been reported for adverse outcomes in children with severe pertussis, their predictive values and the benefits of interventions such as exchange transfusion remain poorly understood. Therefore, we aimed to comprehensively evaluate the risk factors associated with mortality in children with severe pertussis and assess the potential benefits of exchange transfusion therapy.</p><p><strong>Methods: </strong>A retrospective analysis of 170 pertussis patients admitted to the Pediatric Intensive Care Unit (PICU) between January 2018 and June 2024 was performed.</p><p><strong>Results: </strong>Among the 170 patients, 38 (22.35%) died. The death group exhibited significantly higher white blood cell (WBC) counts (67.31 vs. 28.41 × 10^9/L, P < 0.001), neutrophils (29.95 vs. 11.61 × 10^9/L, P < 0.001), and C-reactive protein (CRP) (29 vs. 8 mg/L, P < 0.001). Additionally, sepsis (39.47% vs. 9.09%, P < 0.001), shock (63.16% vs. 6.06%, P < 0.001), ARDS (23.68% vs. 2.27%, P < 0.001), and acute kidney injury (21.05% vs. 0.76%, P < 0.001) were more prevalent in the death group. ROC analysis showed that WBC counts had a predictive value for mortality (AUC = 0.75, sensitivity = 0.78, specificity = 0.68), with an optimal cutoff of 48.58 × 10^9/L.</p><p><strong>Conclusion: </strong>High WBC counts are significantly correlated with increased mortality risk in severe pertussis children, with a threshold of 48.58 × 10^9/L marking high risk. Although exchange transfusion can reduce WBC counts and improve symptoms, its benefit is limited in patients with severe secondary infections, necessitating tailored treatment strategies.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"108"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of eating disorders in children: a comprehensive systematic review and meta-analysis.","authors":"Nader Salari, Pegah Heidarian, Mohammad Javad Tarrahi, Marjan Mansourian, Zara Canbary, Alireza Daneshkhah, Maryam Nasirian, Seyed Hassan Faghihi, Masoud Mohammadi","doi":"10.1186/s13052-025-01958-0","DOIUrl":"10.1186/s13052-025-01958-0","url":null,"abstract":"<p><strong>Background: </strong>Eating disorders (EDs) are known as chronic mental disorders that can cause adverse physical and mental effects and affect different age groups, including children, and disrupt their growth and development. Based on this, the aim of this research is to determine the global prevalence of EDs in children.</p><p><strong>Methods: </strong>To conduct this research, each of the databases PubMed, Scopus, Web of science, Embase, ScienceDirect and Google Scholar search engine were systematically searched using relevant keywords (\"prevalence,\"\"outbreak,\"\"eating disorder,\"\"feeding disorder,\"\"eating problem,\"\"appetite disorder,\"to find all the studies that refer to the prevalence of EDs in children until July 23, 2024 to obtain and perform further evaluations. After data extraction, their analysis was done by Comprehensive Meta-Analysis software (Version 2); Random effects model was used for analysis and I² index was also used to check the heterogeneity of studies.</p><p><strong>Results: </strong>Based on the global prevalence of EDs in children based on meta-analysis was 1% (95% CI: 0.6-1.6); Subgroup analysis based on the study of eating disorders in children showed that the prevalence of pica among children is 2.1% (95% CI: 1-4.6), the prevalence of binge eating disorder is 1% (95% CI: 0.6-1.8), and the prevalence of anorexia nervosa and Bulimia nervosa among children is 0.6% (95% CI: 0.01-34.4) and 0.1% (95% CI: 0-0.4), respectively.</p><p><strong>Conclusion: </strong>Considering the importance of nutrition in children and the report of EDs among them, healthcare workers and medical personnel must pay attention to this category of disorders by timely informing parents to reduce the complications caused by it.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"107"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cultural adaptation, and validation of the Concussion Recognition Tool 6 (CRT6™), Sport Concussion Assessment Tool 6 (SCAT6®) and Sport Concussion Office Assessment Tool 6 (SCOAT6™): the Italian process.","authors":"Veronica Baioccato, Marco Bazo, Irene Leo, Alessandra Simonelli, Andrea Ermolao, Jon S Patricios, Ruben J Echemendia, Gavin A Davis, Valentina Re, Silvia Bressan","doi":"10.1186/s13052-025-01950-8","DOIUrl":"10.1186/s13052-025-01950-8","url":null,"abstract":"<p><strong>Background: </strong>To ensure wide implementation of the Concussion in Sport Group (CISG) recommendations beyond English-speaking countries, the availability of recommended concussion assessment tools in other languages is a key step, especially in countries where few sport-related concussion guidelines exist. We describe the process and adaptations followed in the Italian translation of the latest CISG concussion assessment tools: the Concussion Recognition Tool 6 (CRT6™), the Sport Concussion Assessment Tool 6 (SCAT6®) and the Sport Concussion Office Assessment Tool 6 (SCOAT6™).</p><p><strong>Methods: </strong>Based on CISG procedures, we engaged in an 8-step process which sequentially included verbatim translation in Italian, reconciliation of translation and cultural adaptation, back-translation (from Italian into English), appraisal of the back-translation, validation of the refined Italian version, review and adjustment by an expert committee, pilot testing in 12 amateur athletes and document finalization.</p><p><strong>Results: </strong>The immediate memory test required replacement with Rey Words to be meaningful in Italian, as per the advice of the working group neuropsychologists. The remaining tests did not need any substantial changes except for translation and cultural adaptation. The refinement process continued until the Italian CRT6 ™, SCAT6® and SCOAT6 ™ were rated as 'extremely clear/coherent/grammatically correct' (score 7 on a 7-point Likert scale). The average time needed to carry out assessments using the final Italian version of CRT6 ™, SCAT6® and SCOAT6 ™, was 3.2 min (SD 0.69), 21.12 min (SD 3.16) and 24.50 min (SD 3.18), respectively. These were found to have acceptable clarity, understandability, grammatical correctness, and coherence.</p><p><strong>Conclusion: </strong>The Italian CRT6 ™, SCAT6® and SCOAT6 ™ are the first concussion assessment tools available in the Italian language for both healthcare providers and athletes and enable improvement of concussion management based on the CISG recommendations.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"109"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Native kidney and graft survival in a cohort of Egyptian children with nephropathic cystinosis: national referral center experience.","authors":"Rasha Helmy, Fatma M Atia, Neveen A Soliman","doi":"10.1186/s13052-025-01943-7","DOIUrl":"10.1186/s13052-025-01943-7","url":null,"abstract":"<p><strong>Background: </strong>Nephropathic Cystinosis is a rare autosomal recessive lysosomal storage disorder. In addition to kidney dysfunction, this disorder can also affect other organs, such as the eyes, thyroid, muscles, and central nervous system.</p><p><strong>Methods: </strong>The current cross-sectional study included 56 patients with nephropathic cystinosis to evaluate the clinical outcome in nephropathic cystinosis patients cohort with regarding kidney function and the need for kidney replacement therapy. Clinical and laboratory data were collected.</p><p><strong>Results: </strong>Among the 56 patients in our study, 32 (57.1%) were male. Furthermore, 52 (92%) of these patients were offspring of consanguineous marriage. Patients' mean age was 116.96 ± 54.1 months, and the mean onset of nephropathic cystinosis suggestive symptoms was 7.63 ± 3.2 months. In addition, the mean age of confirmed diagnosis was 45.38 ± 35.3 months, and the mean age of end-stage kidney disease (ESKD) was 104 ± 25.7 months. Eighteen patients (32.1%)underwent hemodialysis, whereas 12 patients (21.4%) underwent kidney transplantation. When comparing siblings within the same family, we observed a significant difference in the age at diagnosis. The median age for the first sibling was 60 months, while it was 24 months for the second sibling (p-value = 0.031). Additionally, there were significant differences in weight, chronic kidney disease (CKD) stage, and outcome.</p><p><strong>Conclusion: </strong>Improvement in the awareness and the accessibility to diagnosis over years, early sibling screening, and kidney transplantation have a significant impact on the survival of both patients and kidney in children with nephropathic cystinosis.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"110"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for bronchiolitis obliterans development in children after Mycoplasma pneumoniae pneumonia: a retrospective study of 981 patients.","authors":"Weihan Xu, Heng Wang, Xiaohui Wen, Haiming Yang, Shunying Zhao, Jinrong Liu","doi":"10.1186/s13052-025-01932-w","DOIUrl":"10.1186/s13052-025-01932-w","url":null,"abstract":"<p><strong>Background: </strong>Bronchiolitis obliterans (BO) is a rare and severe chronic pulmonary condition in children following an injury to lower respiratory tract lesion. Mycoplasma pneumoniae (M. pneumoniae) is the second etiology of post-infectious bronchiolitis obliterans (PIBO). The aim of this study was to determine risk factors for PIBO development in children after M. pneumoniae pneumonia.</p><p><strong>Methods: </strong>This retrospective study enrolled 981 children admitted to Beijing children's hospital due to M. pneumoniae pneumonia between January 2016 and December 2022. The medical records of the PIBO and non-PIBO groups, including demographic, clinical, radiologic, and laboratory data were analyzed by multivariate logistic regression to reveal PIBO development-associated risk factors.</p><p><strong>Results: </strong>Seventy-two of the study patients developed PIBO after M. pneumoniae pneumonia. Multivariate analysis showed that large lobar consolidation (OR 4.06, 95% CI 1.18-14.03), diffuse bronchiolitis (OR 11.78, 95% CI 3.28-42.22), co-infection (OR 3.65, 95% CI 1.60-8.33), atopic conditions (OR 12.32, 95% CI 5.2-29.11), bronchial mucus plug (OR 2.48, 95% CI 1.10-5.58), CPR (OR 1.01, 95% CI 1.00-1.02), mechanical ventilation (OR 2.95, 95% CI 1.00-8.67), and duration of fever (OR 1.19, 95% CI 1.05-1.37) were significantly associated with development of PIBO after M. pneumoniae pneumonia.</p><p><strong>Conclusions: </strong>In children with M. pneumoniae pneumonia, large lobar consolidation, diffuse bronchiolitis, co-infections, atopic conditions, bronchial mucus plug, CRP, mechanical ventilation, and duration of fever appeared as prominent independent risk factors for PIBO. Timely application of HRCT could provide a basis for the early prediction of PIBO development in children.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"105"},"PeriodicalIF":3.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and validation of a predictive model for coronary artery lesions in children with KDSS.","authors":"Zhihui Zhao, Yue Yuan, Lu Gao, Hongxia Li, Qirui Li, Zhen Zhen, Shunying Zhao, Yanyan Xiao","doi":"10.1186/s13052-025-01908-w","DOIUrl":"10.1186/s13052-025-01908-w","url":null,"abstract":"<p><strong>Background: </strong>Kawasaki Disease Shock Syndrome (KDSS) represents a severe manifestation of Kawasaki Disease (KD). In recent years, logistic regression prediction models have gained widespread application in forecasting the occurrence probabilities of various diseases. The objective of this study is to explore the clinical characteristics of pediatric patients with KDSS complicated by coronary artery lesions (CALs) and to develop and validate a logistic regression model for predicting the likelihood of CALs in children with KDSS.</p><p><strong>Methods: </strong>Our study enrolled 102 pediatric patients diagnosed with KDSS at the Cardiology Department of our hospital between January 2020 and March 2024, all of whom had comprehensive medical histories and physical examination results. Logistic regression analysis was employed to identify the most predictive variables. Utilizing a training set (n = 72), we constructed a logistic regression model to predict CALs in children with KDSS. The model's predictive capabilities were further assessed using logistic regression. The Receiver Operating Characteristic (ROC) curve served as a tool to evaluate the performance of the logistic regression model. Additionally, a nomogram model was developed through the visualization of the calibration curve using a 1000-bootstrap resampling method. The efficacy of these results was validated in an independent validation set (n = 30).</p><p><strong>Results: </strong>Univariate analysis revealed nine variables that exhibited significant differences between the CAL and normal coronary artery groups. Further logistic regression analysis identified fever duration, low hemoglobin levels, and low serum phosphorus as independent predictors of CALs in KDSS. The training set demonstrated an area under the ROC curve of 0.837, with a sensitivity of 83.3% and a specificity of 81.2%. The calibration curve indicated a strong agreement between the predicted values of the logistic regression model and the actual observed values in both the training and validation sets.</p><p><strong>Conclusion: </strong>We have successfully established a feasible and highly accurate logistic regression model for predicting CALs in patients with KDSS. This model holds potential for early prediction of CALs and possesses significant clinical implications.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"106"},"PeriodicalIF":3.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel compound heterozygous OBSCN variants in Chinese children with congenital pulmonary airway malformation.","authors":"Jiali Xu, Siyu Ma, Zhaocong Yang, Yang Xu, Jirong Qi, Min Da, Xuming Mo","doi":"10.1186/s13052-025-01942-8","DOIUrl":"https://doi.org/10.1186/s13052-025-01942-8","url":null,"abstract":"<p><strong>Background: </strong>Congenital pulmonary airway malformation (CPAM) belongs to rare lung abnormalities which may result in poor lung development outcomes. However, the etiology of CPAM has not been well described.</p><p><strong>Methods: </strong>In this study, whole-exome sequencing (WES) technology was used to sequence 9 CPAM families to screen the pathogenic genes and their mutations for CPAM. Sanger sequencing was performed for verify the functions of these mutations.</p><p><strong>Results: </strong>We found compound heterozygous mutations in OBSCN gene in two patients with CPAM: one with p.G8837A mutation inherited from her father and p.G1126S mutation inherited from her mother; the other with p.R5167W mutation inherited from his father and p.A7475T mutation inherited from his mother. Immunofluorescence results showed that the expression of OBSCN protein in the central lung tissue of CPAM patients was lower than that in the distal lung tissue of the lesion, and the expression of OBSCN protein was decreased in OBSCN mutated. We further explored the expression of OBSCN during mouse lung development, confirming that the gene mainly acts on the pseudoglandular stage.</p><p><strong>Conclusions: </strong>The OBSCN gene may play a key role in pseudoglandular stage during mouse lung development. The mutation of OBSCN gene may play a role in promoting the occurrence of CPAM, providing a possible therapeutic target for clinical intervention of CPAM.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"103"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vigorous-intensity exercise on the working memory and inhibitory control among children with attention deficit hyperactivity disorder: a systematic review and meta-analysis.","authors":"Ruiyun Zhang, Haixia Li","doi":"10.1186/s13052-025-01924-w","DOIUrl":"https://doi.org/10.1186/s13052-025-01924-w","url":null,"abstract":"<p><p>This study primarily evaluated the effects of vigorous-intensity exercises on working memory and inhibitory control in children with attention deficit hyperactivity disorder (ADHD). Search for eligible studies through four databases, and then proceed with screening. The inclusion criteria are as follows: (1) Children with ADHD; (2) Randomised controlled trial; (3) The intervention group received exercise, while the control group did not perform any exercises as the treatment; (4) Conducted pre- and post-exercise assessments, which include working memory and inhibitory control parameters. Use the Cochrane bias risk assessment tool to evaluate the quality of the selected study. Select standardized mean difference as the appropriate effect scale index, and use Revman 5.4 software to analyze the mean difference. This study was registered in the PROSPERO (CRD42024597510). A total of ten studies fulfilled the inclusion criteria and were selected for the meta-analysis. The included studies involved 367 males and 159 females, where 273 belonged to the exercise group and 253 from the control group. Participants in the exercise group enhanced working memory [0.37 (0.12, 0.63) p < 0.05, I² = 0%] than the control group. In addition, the results indicated that submaximal intensity exercise improved inhibition regulation levels significantly [- 0.34 (- 0.65, - 0.03), p < 0.05, I² = 0%]. Based on the systematic meta-analysis results, vigorous-intensity exercises have effective working memory, cognitive function, and motor ability-increasing effects on children with ADHD. Furthermore, Submaximal intensity exercise can effectively improve control inhibition in children with ADHD.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"104"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and influencing factors of social support for main caregivers of children with traumatic brain injury: a cross-sectional survey.","authors":"Deli Liu, Minghui Hu, Li Ma, Qing Yan, Yiming Liu, Ping Li","doi":"10.1186/s13052-025-01906-y","DOIUrl":"10.1186/s13052-025-01906-y","url":null,"abstract":"<p><strong>Background: </strong>Children with Traumatic Brain Injury (TBI) frequently undergo rapid fluctuations in their health status, imposing significant strain on their caregivers. This study aimed to evaluate the social support available to primary caregivers of pediatric TBI patients, to provide actionable insights to improve clinical support systems.</p><p><strong>Methods: </strong>Primary caregivers of pediatric TBI patients treated at our hospital from February 1, 2024, to August 31, 2024, were included in this study. The Social Support Rating Scale was utilized to assess the social support of these caregivers. Pearson correlation analysis and logistic regression were conducted to identify determinants significantly associated with the level of social support.</p><p><strong>Results: </strong>Two hundred forty-two primary caregivers of children with TBI were enrolled in this study. The mean social support score for these caregivers was 38.52 (± 9.29), suggesting a moderate level of social support. Correlations were identified between social support scores and several caregiver characteristics: age (r=-0.564), educational level (r = 0.602), place of residence (r = 0.542), and monthly per capita family income (r = 0.633). Logistic regression analysis revealed that age (OR = 2.184, 95%CI: 1.904-3.022), educational level (OR = 2.462, 95%CI: 1.755-4.086), residence (OR = 2.189, 95%CI: 1.805-2.753), and monthly per capita family income (OR = 3.428, 95%CI: 2.402-4.216) significantly influenced the level of social support.</p><p><strong>Conclusion: </strong>Enhancing the social support for primary caregivers of children with TBI is imperative. Clinical healthcare providers are advised to develop and implement targeted interventions aimed at the modifiable factors identified, in order to bolster the social support levels of these caregivers.</p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":"51 1","pages":"101"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}