International Journal of Technology Assessment in Health Care最新文献

{"title":"Trust, validation, and accountability: implementing uses of generative artificial intelligence into Health Technology Assessment practice.","authors":"Rachael Fleurence, Jagpreet Chhatwal","doi":"10.1017/S0266462326103638","DOIUrl":"10.1017/S0266462326103638","url":null,"abstract":"<p><p>The 2025 HTAi Global Policy Forum (GPF) report offers a timely and thoughtful synthesis of the opportunities and challenges associated with the use of artificial intelligence (AI), and particularly generative AI (GenAI), in Health Technology Assessment (HTA) (1). Its emphasis on trust, human agency, and risk-based approaches reflects both the maturity of the discussion within the HTA community and a shared recognition that technical capability alone is insufficient for responsible adoption. The report succeeds in articulating a common set of principles and a broadly aligned vision across HTA bodies, life sciences, and other interest holders.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e41"},"PeriodicalIF":3.1,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two decades of impact: lessons from the HTAi Patient and Citizen Involvement in HTA Interest Group.","authors":"Aline Silveira Silva, Fiona Pearce, Karen M Facey, Neil Bertelsen, Janet Wale, Anke-Peggy Holtorf, Ann Single","doi":"10.1017/S0266462326103651","DOIUrl":"10.1017/S0266462326103651","url":null,"abstract":"<p><p>Since its establishment in 2005, the HTAi Patient and Citizen Involvement in HTA Interest Group (PCIG) has worked to strengthen health technology assessment (HTA) by systematically incorporating patient and citizen perspectives. Over two decades, PCIG has advanced this goal through multistakeholder projects and collaborations that have produced practical tools, guidance, and methods to support patient involvement in HTA worldwide. Through global knowledge exchange, PCIG has fostered shared learning and capacity building for inclusive, participatory HTA. Its work continues to drive a shift in the mindset of the HTA community - from passive consultation to active partnership with patients and citizens - and encourages investment in robust research to understand patient perspectives. As health systems increasingly aim to reflect lived experiences and community values to improve the implementation and impact of services, PCIG's journey offers a compelling example of the long-term value of collective action, sustained engagement, and meaningful involvement in HTA.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e32"},"PeriodicalIF":3.1,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What do HTA agencies need for generating health-related quality of life evidence? Findings from a global survey.","authors":"Annushiah Vasan Thakumar, Paula Lorgelly, Louise Longworth, Lucila Rey-Ares, Fredrick Purba, Dominik Golicki, Federico Augustovski, Kim Rand, Rosalie Viney, Nick Bansback, Nan Luo","doi":"10.1017/S0266462326103602","DOIUrl":"10.1017/S0266462326103602","url":null,"abstract":"<p><strong>Objectives: </strong>The overall aim is to understand the practices, views, and needs of health technology assessment (HTA) practitioners worldwide regarding the use of health-related quality of life (HRQoL) data for generating cost-effectiveness evidence.</p><p><strong>Methods: </strong>We invited HTA practitioners in sixty countries to complete an online survey on their perspectives on the measurement and valuation of health. We performed descriptive analyses of the overall sample, examined response differences across six regions, and pooled responses to open-ended questions for content analysis.</p><p><strong>Results: </strong>A total of 238 individuals from 45 countries completed the survey, with a mean response number per country of 5.28 (SD: 4.45). Most responses came from public sector employees (seventy-two percent), and ninety percent were involved in cost-effectiveness-related work. The top three most frequently used utility instruments were EQ-5D, SF-6D, and EQ-5D-Y, and the elicitation methods were time trade-off, visual analogue scale, and standard gamble. Health-state preferences of the general public from another country were more frequently used than the preferences of the local public. Common data quality issues were poor sample representativeness and a small sample size of utility data. In Asia and Western Europe, the top-voted research priority was developing utility instruments that capture both healthcare and social care impact. In four regions, developing utility instruments for children was the second-highest research priority.</p><p><strong>Conclusions: </strong>The survey addressed important knowledge gaps regarding current practices in measuring and valuing HRQoL in HTA and provided insights into HTA practitioners' views on instruments, methods, and data-related challenges and needs for generating HRQoL evidence.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e33"},"PeriodicalIF":3.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of health technology assessment process-related skills among doctors in Croatia: a cross-sectional survey study.","authors":"Miro Vuković, Mirjana Huić, Ljubo Znaor, Željko Krznarić, Ana Marušić","doi":"10.1017/S0266462326103572","DOIUrl":"10.1017/S0266462326103572","url":null,"abstract":"<p><strong>Introduction: </strong>The European Union's Health Technology Assessment Regulation (HTAR) and its implementing acts foresee various forms of clinician involvement, such as joint clinical assessment or Joint Scientific Consultation. However, considering the varying preparedness levels for HTAR, as well as the understanding of the health technology assessment (HTA) principles and processes, this study aimed to evaluate the levels of HTA-related skills among medical and dental doctors in Croatia.</p><p><strong>Methods: </strong>A cross-sectional survey study was conducted among medical and dental medicine doctors in Croatia. The survey recorded respondents' relevant experience with HTA processes along with skill levels across the entire HTA process, mainly for acting as individual clinical experts or on behalf of their professional organizations, as well as potential HTA doers. Skill levels were evaluated using a 5-point scale (1 - <i>no knowledge</i> to 5 - <i>full expertise</i>).</p><p><strong>Results: </strong>Among the 376 respondents included, only 6.1 percent had previous involvement in HTA, and 2.2 percent were familiar with HTAR. Related to the HTA process, the highest scores were observed in the understanding of key concepts and results of searching for studies, critical appraisal, study synthesis preparation, and ethics. The lowest scores were recorded in health economics, evidence grading, qualitative synthesis, and public/patient involvement. Respondents with prior research experience and those who reported frequent research use had significantly higher HTA skill scores.</p><p><strong>Conclusions: </strong>A significant gap in HTA-related skills highlights the need for targeted professional development programs and long-term educational reforms to build the capacity for various modes of involvement in HTA processes and their implementation.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e34"},"PeriodicalIF":3.1,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative artificial intelligence in health technology assessment: a patient and citizen dialogue on trust, human oversight, and shared governance.","authors":"Fiona Pearce, Aline Silveira Silva","doi":"10.1017/S0266462326103560","DOIUrl":"10.1017/S0266462326103560","url":null,"abstract":"","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e21"},"PeriodicalIF":3.1,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early health technology assessment of a primary care tool for the diagnosis and management of headaches in Alberta, Canada.","authors":"Sarah Koles, Diepreye Ayabina, Sasha van Katwyk, Brian Chan, Charles Yan","doi":"10.1017/S0266462326103547","DOIUrl":"10.1017/S0266462326103547","url":null,"abstract":"<p><strong>Background: </strong>Lasoo Health is an e-software in the early stages of development, designed to generate a consult report with the most probable headache diagnosis and treatment plan from direct patient input. A patient accesses the program with their consent and a referral from primary care. Digital consult is then reviewed by a medical specialist and then sent to the primary care provider to initiate care. This early health technology assessment (eHTA) assesses the potential impact of Lasoo Health on timely access to effective headache management, cost savings, and health outcomes compared to the current standard of care (SOC) in Alberta, Canada.</p><p><strong>Methods: </strong>We developed a discrete event simulation (DES) of headache diagnostic pathways for Albertan patients suffering from headaches. The model was parameterized using secondary data sources identified via relevant published literature and subject matter expert opinion. Cost-effectiveness was expressed from a societal perspective using the incremental net monetary benefit (iNMB) of Lasoo Health incorporated with the SOC compared to SOC alone over an analytical time frame of five years.</p><p><strong>Results: </strong>Our analysis suggests that incorporating Lasoo Health into the SOC may reduce specialist assessment wait times by 70 percent and total per-patient costs by 7 percent. Using a willingness-to-pay (WTP) threshold of Canadian dollars (CAD) 50,000 (U.S. dollars (USD) $35,240), the iNMB per patient was estimated to be CAD 1,069 (USD $753).</p><p><strong>Conclusions: </strong>The benefits of implementing Lasoo Health over a 5-year period could translate to improved patient outcomes, reduced wait times for specialists, and lower productivity losses among headache patients.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e35"},"PeriodicalIF":3.1,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing an assessment tool to measure health equity considerations of guideline development handbooks.","authors":"Ramaa Chitale, Adam Richards, Precious Williams, Tari Turner, Stephanie Goodrick, Ana González Ramos, Christina McMillan Boyles, Deana Manassaram-Baptiste, Caleb Kimutai Sagam, Eleanor Ochodo, Rachel Kowalsky, Emily Smith","doi":"10.1017/S0266462326103559","DOIUrl":"10.1017/S0266462326103559","url":null,"abstract":"<p><strong>Objectives: </strong>Guideline development handbooks outline the methodology that authoring organizations use to create public health and clinical practice guidelines (CPGs). We created an Equity Assessment Tool (EquAT) for guideline development handbooks to identify areas of improvement and foster conversations.</p><p><strong>Methods: </strong>Sequential phases lead to tool development and face/content validation in this mixed-methods study. In phase 1, we reviewed the literature to generate a list of \"essential elements\" or tasks that are part of guideline development methodology, mapped \"essential elements\" with relevant equity concepts, and drafted our tool for use in reviewing guideline development handbooks. In phase 2, we surveyed experts for feedback on \"essential elements\" and explicit language for assessing equity within the tool and refined items. We piloted and finalized the tool based on feedback.</p><p><strong>Results: </strong>We identified 18 essential elements within five domains of guideline development and created a draft EquAT. Twenty of 25 invited experts responded to the online survey for feedback on the tool. Most experts provided limited feedback, and the most common suggestion was adding clarifying language to the existing tool criteria for assessing equity. Ten experts participated in pilot testing the revised tool. We found a diversity of scores, and potential reasons might be due to the complexity of the tool, differences in equity frameworks, and a variety of expertise. We incorporated their feedback and finalized the tool.</p><p><strong>Conclusions: </strong>We developed and validated the EquAT, a tool to foster discussion among assessors about the extent of health equity considerations in guideline development handbooks.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e28"},"PeriodicalIF":3.1,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic literature review (SLR) on the adoption of artificial intelligence-assisted SLRS: implications for health technology assessments.","authors":"Seye Abogunrin, Yifei Liu, Clarissa Higuchi Zerbini","doi":"10.1017/S0266462326103535","DOIUrl":"10.1017/S0266462326103535","url":null,"abstract":"<p><strong>Objectives: </strong>Systematic literature reviews (SLRs) are essential for evidence synthesis in healthcare decision making, including health technology assessment (HTA), but their time and resource demands are substantial. Artificial intelligence (AI) may enhance efficiency of conducting SLRs, but its acceptance by HTA bodies remains underexplored. This SLR quantifies published health-related SLRs reporting AI use, identifies AI tools used at each SLR stage, and evaluates HTA guidance on AI in evidence synthesis.</p><p><strong>Methods: </strong>We searched Embase, Medline, and the Cochrane Library (up to 9 September 2025), supplemented by hand searches and reviews of HTA agency websites. Titles and abstracts were screened in Rayyan by a single reviewer, with full-text review confirming eligibility. Data were extracted and synthesized narratively along key themes.</p><p><strong>Results: </strong>In total, 112 studies covering 111 unique SLRs were identified, reporting 134 implementations of 45 unique AI tools (29 publicly available; 16 custom-built). AI use has risen since 2013 and was most frequently applied during title and abstract screening (88 of the 134 implementations). Human oversight remained essential, with no fully autonomous AI reported. Three HTA agencies (CDA-AMC, IQWiG, NICE), EUnetHTA, JBI and Cochrane have provided guidance, indicating the formal integration of AI into HTA processes.</p><p><strong>Conclusions: </strong>This SLR provides a quantitative overview of AI use in health-related SLRs and current HTA guidance. These findings may inform development of clearer methodological recommendations and support integration of AI-assisted evidence synthesis in HTA submissions. Further research and policy development are needed to optimize its role in evidence synthesis and healthcare decision making.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e29"},"PeriodicalIF":3.1,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building capacity for medical device assessment: online training for Ukrainian experts.","authors":"Olena Filiniuk, Antonio Migliore, Rossella Di Bidino, Nicola Vicari, Rebecca Kohler, Rabia Sucu","doi":"10.1017/S026646232610350X","DOIUrl":"10.1017/S026646232610350X","url":null,"abstract":"<p><p>As Ukraine works to modernize its healthcare system and align with international standards, integrating health technology assessment (HTA) into the national decision-making process has become a strategic priority. While HTA practices for pharmaceuticals have advanced, substantial gaps persist in the evaluation of medical devices (MDs), which require distinct methodological approaches given their characteristics. This article presents the rationale, development, implementation, and results of a comprehensive online training program aimed at building national capacity in the MD assessment. The program targeted 71 Ukrainian professionals with prior experience in pharmaceutical evaluation but limited exposure to MD. Through 40 hours of live online sessions delivered from September to December 2024, the course emphasized interactive learning, contextual adaptation, and international best practices. Assessments showed significant knowledge gains, with 87 percent of participants completing the program successfully. The initiative demonstrates that targeted, competency-based training can enhance national HTA capacity and may serve as a model for other transitioning healthcare systems.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e22"},"PeriodicalIF":3.1,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12979014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening health technology assessment (HTA) in the European Union: insights from Slovenia's implementation journey.","authors":"Katarina Beravs-Bervar, Wim Goettsch, Iñaki Gutierrez-Ibarluzea, Adam Skali, Alric Rűther, Iga Lipska, Eva Turk","doi":"10.1017/S0266462325103383","DOIUrl":"10.1017/S0266462325103383","url":null,"abstract":"<p><strong>Introduction: </strong>Slovenia has engaged with Health Technology Assessment (HTA) for over two decades, but its system remains fragmented and underdeveloped. Until recently, responsibilities for evaluating health technologies were dispersed across multiple institutions without a central coordinating body or standardized methodology. Medicinal products have been subject to structured evaluation through the Health Insurance Institute of Slovenia, while other health technologies, including medical devices, diagnostics, and preventive interventions, have followed less consistent pathways under the Ministry of Health. The adoption of the European Union Health Technology Assessment Regulation), entering into force in January 2025, has provided new impetus for reform, requiring Slovenia to designate a national HTA body to participate in joint clinical assessments and align national processes with EU standards.</p><p><strong>Methods: </strong>A mixed-methods analysis combining a narrative overview of HTA in Slovenia with findings from two multi-stakeholder workshops held in 2025. These workshops, which convened Slovenian and international experts, policymakers, clinicians, and patient representatives, explored opportunities and challenges for developing a robust HTA framework.</p><p><strong>Results: </strong>Key findings highlight the need to strengthen methodological capacity, introduce systematic stakeholder engagement, ensure transparency, and integrate real-world evidence into decision-making. Particular emphasis was placed on expanding HTA to medical devices, diagnostics, and digital health technologies, and on anticipating future innovations such as artificial intelligence.</p><p><strong>Conclusions: </strong>Slovenia now stands at a pivotal juncture. Establishing a central HTA body with a clear legal mandate, building national expertise, and leveraging regional and European collaboration is essential to creating a transparent, evidence-based, and patient-centred HTA system.</p>","PeriodicalId":14467,"journal":{"name":"International Journal of Technology Assessment in Health Care","volume":" ","pages":"e23"},"PeriodicalIF":3.1,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12979015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}