International Journal of Veterinary Medicine最新文献

{"title":"The role of chronic systemic inflammation syndrome in pregnant cows in the development of antenatal liver pathology in newborn calves","authors":"P. Parshin, G. Vostroilova, Yu. N. Brigadirov, I. Shaposhnikov, M. S. Zhukov, K. O. Akulova","doi":"10.52419/issn2072-2419.2023.4.361","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.361","url":null,"abstract":"Studies have been conducted to study the effect of the cytokine profile of cows with chronic systemic inflammation syndrome in the third trimester of pregnancy on the hematobiochemical  status  of  newborn  calves. The  experiment  was  conducted  on  redmottled  cows,  which  were  divided  into  2 groups: group 1 (n = 15) – clinically healthy cows  with  uncomplicated  pregnancy,  average fatness 3.6 ± 0.16 points, group 2 (n = 7) – cows with lowintensity chronic systemic inflammation  syndrome,  average  fatness 4.4±  0.20  points.  At  the  beginning  of  the third  trimester  of  pregnancy,  blood  serum samples were taken from cows to determine the  level  of  interleukin-1β  (IL-1β),  tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2),  interleukin-4  (IL-4),  interleukin-10  (IL-10) and interferon-γ (INF-γ). On the 3rd day after birth, blood samples were taken from the received calves for analysis. The above cytokines  and  hematobiochemical  parameters  were  determined.  It  was  found  that  in calves from group 2, the level of IL-2, IL-4, IL-10 and INF-γ was lower than the comparison group by 10.0; 29.3; 24.5 and 17.4%, respectively,  and  IL-1ß  and  TNF-α  were 45.8  and  8.7%  higher.  Spearman's  correlation analysis showed that there is a significant direct correlation of noticeable and high strength  between  the  level  of  cytokines  of maternal cows and similar indicators in newborns, which indicates the influence of signaling proteins of the mother's body on fetal development.  As  a  result,  neonatal  hepatodystrophy  was  diagnosed  in  calves  born from cows with chronic systemic inflammation  syndrome,  accompanied  by  cytolysis and  cholestasis  syndrome,  accumulation  of endotoxins  and  a  decrease  in  energy  substrates. The data obtained show that a change in  the  cytokine  profile  during  pregnancy towards  the  predominance  of  proinflammatory  cytokines  creates  a  risk  of developing  antenatal  liver  pathology  in  future offspring, thereby forming prerequisites for the development of comorbid pathology in newborns.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"28 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid composition of plasma membranes of rooster sperm (Gallus gallus domesticus) and its dynamics during cryopreservation","authors":"O. Stanishevskaya, Y. Silyukova","doi":"10.52419/issn2072-2419.2023.4.379","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.379","url":null,"abstract":"The  structural  features  of  the  plasma membranes of avian sperm make them more sensitive, compared to those of mammals, to low-temperature  stress.  The  qualitative  and quantitative composition of membrane lipids can become a determining factor in the development of new effective compositions of cryoprotective  media.  The  purpose  of  the study was to determine the lipid composition of the plasma membranes of native rooster sperm, the content of carbohydrates and polyols  in  their  cytosol,  as  well  as  dynamic changes in the membrane lipidome and cytosol  composition  under  the  influence  of  the cryopreservation protocol, depending on the composition  of  the  cryoprotective  medium. The  studies  were  carried  out  on  Rhode  Island roosters (n=10), the total and progressive sperm motility and membrane damage were determined. Semen freezing and thawing was carried out using fast protocols. To determine the lipid composition of the plasma  membranes  of sperm and  the composition of their cytosol, a chromatographic analysis method was used. The following were identified in the membranes of native spermatozoa:  phospholipids,  glycolyllipids  and neutral lipids, represented by phosphatidylethalamine,  phosphatidylserine,  phosphatidylcholine,  sphingomyelin  and  sterol.  A change in the ratio between membrane lipids of the inner and outer layers of the plasma membrane of rooster spermatozoa under the influence  of  the  cryopreservation  protocol was shown. In native spermftozoa this ratio was  41.2%  and  39.4%,  respectively,  in thawed sperm when using the LCM-control medium –  38.3% and  47.2%, respectively, when using the LCM-T20 medium - 40.7% and 44.5%, respectively. There was a significant decrease, more than 3 times, in the total amount of carbohydrates (fructose, glucose, trehalose)  and  polyols  (glycerol,  mannitol, inositol)  in  the  cytosol  of  frozen/thawed spermatozoa when using the cryoprotective medium  LCM-control  compared  with  the values of the native spermatozoa - 0 .1145 mg/ml  and  0.0360  mg/ml,  respectively. When  using  the  LCM-T20  medium,  the change was insignificant and the delta was 5.2%. The effectiveness of using cryoprotective medium LCM-T20 containing trehalose has been proven to maintain the lipid membrane  architecture  of  rooster  spermatozoa, the carbohydratepolyol composition of their cytosol and, as a consequence, the morphofunctional usefulness of gametes during the freezing/thawing process.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial vascularization of the pelvic limb of the reindeer fetus","authors":"D. Bylinskaya, V. Khvatov","doi":"10.52419/issn2072-2419.2023.4.340","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.340","url":null,"abstract":"The  reindeer  is  a  representative  of  the order  artiodactyls,  most  of  the  individuals inhabit  the  territory  of  the  Northern  hemisphere. It is a significant hunting and commercial  species,  and  reindeer  husbandry  is the main branch of animal husbandry in the conditions of the Far North. The morphology of the reindeer has always been of interest to researchers. In different years, the architectonics  of  the  vascular  bed  of  the  reindeer have been  studied  by  many  researchers  [3, 4].  However,  in  the  available  literature sources, we have not found data concerning arterial blood supply to organs and tissues in reindeer  fetuses.  In  the  prenatal  period  of development, there is a restructuring of organs and tissues, and with them the vascular bed. The aim of the study was to study the arterial vascularization of the pelvic limb in a reindeer fetus, to give morphometric characteristics  to  the  arteries.  The  studies were conducted on 5 reindeer fetuses at the age of 4.0-4.5 months. The fruits were delivered to the Department of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine from reindeer herding farms of the Republic of Sakha (Yakutia). The fruits were extracted after the slaughter of vazhenok for household  needs.  Classical  methods  were chosen as research methods: fine anatomical dissection, morphometry, photographing and vasorentgenography.  During  the  study,  it was found that the main arterial trunk of the pelvic limb in a reindeer fetus is the external iliac  artery.  Skeletotopy  and  angioarchitectonics of the main arteries of the pelvic limb of  the  reindeer  fetus  have  typical  patterns characteristic of adult animals. Morphometric parameters of the arteries are consistent with the topographic position of the muscle groups – a greater number of large arterial branches are noted in the hip area. The presence of collateral blood flow in the foot area is noted – the vessels of the dorsal and plantar surfaces are connected to each other due to the perforating metatarsal and perforating metatarsal arteries, as well as at the confluence of the axial and non-axial finger arteries.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"24 s2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative indicators of sperm from producing goats before and after cryopreservation","authors":"E. Korochkina, A. V. Trifonova, E. Finageev, D. Glavatskaya, V. Pushkina","doi":"10.52419/issn2072-2419.2023.4.353","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.353","url":null,"abstract":"Currently, artificial insemination, as one of the types of assisted reproductive technologies, is widely used in dairy and beef cattle breeding.  The  same  cannot  be  said  about such a promising direction in the agricultural industry as goat breeding. One of the limiting  factors  is  the  negative  impact  of  low temperature on the morphofunctional charateristics  of  sperm  of  breeding  goats.  The purpose of this research was to test a protocol of sperm cryopreservation of stud goats with  modification  of  prepreparation  and subsequent assessment of the quality indicators of sperm before and after its deep freezing. A comprehensive assessment of sperm quality (volume, concentration, morphology, motility)  of  goats  (n=10)  was  carried  out using generally accepted methods and protocols. The assessment of sperm quality indicators included five stages: after sperm collection, two hours after cooling, after thawing: 0 hours, 1 and 2 hours. According on the obtained results, the sperm of breeding goats ha low cryoresistance. After cryopreservation  (0,  1  and  2  hours  after  thawing), there is an increase in the number of sperm with tail damage by 7.5% (p≤0.05), 15.5% and 21.8% (p≤0.01), and also a decrease in the number of progressively moving sperm by 1.4; 1.6 and 2.5 times (p≤0.01) compared with  the  results  of  the  assessment  0  hours after collection. The use of a deep two-phase sperm freezing protocol allows maintaining the viability of sperm with a progression of movements equal to 54.2±5.1% and a number of morphologically normal sperm equal to  64.1±1.9%.  In  this  case,  the  prepreparation  of  sperm  for  the  cryopreservation  process  (current  protocol)  includes sperm  centrifugation  (mode:  7000  rpm  for 15  minutes),  removal  of  seminal  plasma, dilution  1:4  (OptiXcell  diluent),  cooling  (4 hours at 4℃); sperm cryopreservation protocol: 1. immersion of goblets with paillettes 4 cm above liquid nitrogen for 7 minutes; 2. complete immersion in liquid nitrogen.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"56 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dependence of coagulation activity of chicken blood IN VITRO on temperature","authors":"L. L. Fomina, D. I. Berezina, T. Kulakova, K. E. Modanova","doi":"10.52419/issn2072-2419.2023.4.327","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.327","url":null,"abstract":"The paper presents the results of examine  the  relationship  between  blood  plasma incubation  temperature  and  the  hemostasis parameters in chickens. The purpose of this research was to study of the blood coagulation  parameters  in  chickens  during  hypo-, normo- and hyperthermia in vitro. In addition, to assess the possibility of using a coagulometer to identify hemostasis activity and the use of hemostatic reactions in chickens as models for human medicine. The Vologda region was where the study was conducted. The coagulogram was examined for the following parameters: thrombin time (TT), prothrombin time (PT), activated partial thromboplastin  time  (APTT),  fibrinogen  activity, and antithrombin III activity (AT-III). It was found that at 46° C activation of blood clotting occurs, manifested as an acceleration of the  TT  by  29%  (13  seconds),  PT  by  72% (111  seconds),  and  decrease  in  the  antithrombin III activity by 6% (1.5 seconds) compared to normothermia. The parameters of  secondary  hemostasis  also  responded  to hypothermia (18 °C) with hypercoagulation. It  was  an  acceleration  of  PT  of  81%  (125 sec),  an  increase  in  fibrinogen  activity  by 77% (84 sec) and a decrease in AT-III activity  by  55%  (14  sec),  with  the  exception  of thrombin time, which was extended by 70% (104  seconds).  There  were  no  significant changes  in  the  APTT  at  different  temperatures.  The  correlation-regression  and  one-factor analysis of variance revealed a significant correlation between the temperature and the TT and the fibrinogen activity, where the coefficients of determination for which were 71%  and  39%,  respectively.  Plasma  hemostasis  activity  measured  on  a  coagulometer (at 37 °C) showed no significant differences from  those  measured  at  43  °C,  except  for prothrombin time, which was 71.51 seconds (47%) less than that measured at 43 °C.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"19 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the mitochondrial-directed antioxidant Mito-TEMPO on the quality of rooster sperm in the cryopreservation and lyophilization cycle","authors":"A. A. Kurochkin, O. Stanishevskaya, Y. Silyukova, N. V. Pleshanov","doi":"10.52419/issn2072-2419.2023.4.370","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.370","url":null,"abstract":"In  reproductive  technologies  applied  in animal husbandry, using  lyophilized semen is only possible with ICSI technology, due to complete loss sperm motility. However, the anatomical  structure’s  peculiarities  and  development  of  avian  oocyte  not  allows  use this technology. Strategies aimed at preserving  kinetic  apparatus  of  lyophilized  sperm are  the  most  relevant  for  birds.  Increasing mitochondrial activity of cells due to its connection with energy metabolism and sperm motility may be one of the ways to solve this problem. However, similar studies on freeze-dried bird semen haven’t been conducted on this  moment.  The  present  study  assessed effect  of  mitochondria-targeted  antioxidant Mito-TEMPO  on  viability,  mitochondria’s membrane potential and generation of intracellular hydrogen peroxide by rooster spermatozoa  in  a  cryopreservation  and  lyophilization cycle. Proportion of cells with intact plasma membrane in lyophilized semen was higher using extenders containing an antioxidant. Addition  of  Mito-TEMPO  at  concentration of 40 µM to diluents T-20 and T-30 for the purpose of cryopreservation of semen with  subsequent  freezedrying  allowed  to increase proportion of cells with intact plasma membrane in lyophilized semen in comparison  to  control  diluents  (6.12  ±  0.11  % versus  10.19±0.46%  and 13.19±1.30% versus  15.23±1.13%,  respectively,  p˂0.05). Effective concentration of Mito-TEMPO in diluents intended only for semen cryopreservation was significantly lower - 5 µM. Proportion of cells with intact plasma membrane was  47,97±0,64%  versus  55,85±1,69%  and 47,25±2,97%  versus  63,21±1,78%,  respectively,  p˂0,  05.  Dose-dependent  effect  of trehalose in cryoprotective diluents has been proven.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lymphatic bed of the oral cavity in sheep of the Edilbaev breed","authors":"S. Melnikov, D. Vasiliev","doi":"10.52419/issn2072-2419.2023.4.347","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.347","url":null,"abstract":"The study of the lymphatic system is of interest not only for morphology, but also for physiology and pathology, since it is in the organs and tissues where the lymphatic capillaries are located that metabolism occurs. The  lymphatic  bed  is  represented  by  intramural vessels, regional lymph nodes of the first and second order. The aim of the study was to determine the lymph nodes and vessels involved in the lymph outflow from the lip area in sheep of the Edilbaev breed. The study  was  conducted  at  the  Department  of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine. The material was sheep of the Edilbaevsky breed in the amount of five pieces at the age of one year. As methods, an interstitial (interstitial) injection with cotrust masses in the form of a blue  mass  of  Gerot  was  used,  which  was prepared by rubbing 2.0 g of blue oil paint in 30.0 g of gum turpentine. The resulting mass was mixed with 15.0 g of ether and passed through  a  filter.  Before  the  injection,  the sheep's head was placed in warm water for several  hours.  The  injection  is  carried  out with  a  syringe  with  thin  needles.  Contrast masses  were  injected  very  slowly,  gently massaging the injected area. As a result of our research, we came to the conclusion that the direction of the main lymphatic vessels of the upper lip and the edges of the nasal opening corresponds to the line drawn from the corner of the lips to the mandibular joint; the direction of the diverting lymphatic vessels of the lower lip corresponds to the direction of the free edge of the lower jaw; the main regional lymph nodes for the diverting lymphatic vessels of the lips of the sheep of the Edilbaev breed are the parotid and mandibular  and,  in  isolated  cases,  the  lateral pharyngeal.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138968043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the possibility of using indicators of the blood coagulation system of cows to predict late toxicosis of pregnant women","authors":"V. Mikhalev, G. Chusova","doi":"10.52419/issn2072-2419.2023.4.396","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.396","url":null,"abstract":"Indicators of  the blood  coagulation  system (thrombin time, prothrombin time, activated  partial  thromboplastin  time -  aPTT) were studied on 42 pregnant cows at 60-75, 135-150  and  210-230  days  of  pregnancy, divided  according  to  the  principle  of  analogues  into  three  groups:  physiological course,  fetal  growth  restriction  syndrome without  late  toxicosis  of  pregnancy,  fetal growth restriction syndrome complicated by gestosis.  Pregnancy  was  diagnosed  using transrectal  and  ultrasound  examinations. Fetal growth restriction syndrome was diagnosed at 60-75 days of pregnancy using an ultrasound scanner with a linear sensor with a  frequency  of  7.5  MHz.  Late  toxicosis  of pregnant animals was diagnosed at 210-230 days of pregnancy by the presence of hypertension, proteinuria and edema. Blood samples were taken from the animals included in the experiment to determine the platelet content,  thrombin  and  prothrombin  time  and aPTT.  It  has  been  established  that  platelet content is an informative indicator for predicting  gestosis  in  the  first  five  months  of pregnancy  with  a  sensitivity  of  80.0%  and specificity  of  87.5%.  The  sensitivity  of thrombin time at 60-150 days of pregnancy is  77.8%,  specificity -  90.0%,  prothrombin time  -  70.0  and  88.9%,  aPTT  at  135-150 days of pregnancy - 77.8 and 85.7%, respectively. Prognostic markers for early diagnosis of late toxicosis in pregnant animals, determined  at  2  months  of  pregnancy  are: platelet  level -  451.2  x  109/L  and  higher; thrombin  time –  87.3 seconds  and  below; prothrombin time – 35.1 seconds and below. Indicators  for  early  diagnosis  of  gestosis, determined  at  5  months  of  pregnancy,  are: platelet  level -  437.5  x  109/L  and  higher; thrombin  time –  78.6 seconds  and  below; prothrombin time – 30.3 seconds and below; aPTT – 41.8 sec and below.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"53 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the concentration of β-hydroxybutyrate and glucose in the blood on the reproductive function and milk productivity of cows","authors":"S. V. Nikolaev","doi":"10.52419/issn2072-2419.2023.4.388","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.388","url":null,"abstract":"The  intensity  of  metabolic  processes  in highly  productive  cows  is  associated  with metabolic disorders and the development of dystrophic  changes  in  the body.  The  paper evaluates the effect of the concentration of β-hydroxybutyrate and glucose in the blood of new-bodied cows on the indicators of reproductive ability and milk productivity. To do this, venous blood was obtained from cows of different ages after childbirth, where the concentration  of  glucose  and  β-hydroxybutyrate was determined. Depending on  the  level of glucose  and  ketone  bodies, animals  were  retrospectively  differentiated into groups and the severity of economically useful  signs  was  determined.  It  was  found that  cows  with  a  glucose  level  above  3.3 mmol/l  required  0.6  more  inseminations (P≤0.01), compared  with  animals  whose indicators  were  in  the  range  of  2.2...3.3 mmol/l. At the same time, the greatest difference in the multiplicity of insemination was present in animals 3...7 lactation (1.2 inseminations per fertilization; P≤0.001). The period from calving to fertilization in cows with a high glucose content was longer by 39.4 days (P < 0.05), while the maximum deviation was found among animals older than the 2nd  lactation  (by  43.4%;  P<  0.05).  An  increase in the level of β-hydroxybutyrate over 0.7 mmol/l was also accompanied by a deterioration in reproductive function. Thus, the lengthening  of  the  infertility  period  for  all lactation was 21.2 days (P≤0.05). The most pronounced negative effect on reproductive function in ketonemia was observed in first-heifers and cows of the second lactation. So, after  the  first  birth,  the  lengthening  of  the period from calving to fertilization was 42.0 days (P < 0.05), and after the second lactation - 29.2 days (P < 0.05). Thus, an increase in  the  level  of  glucose  and  β-hydroxybutyrate in the blood negatively affects, first of all, the reproductive function of cows, and to a lesser extent, the indicators of milk productivity.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"10 s1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the use of ready-made Expert hepatic diets for adult cats liver care company Miratorg","authors":"L. Karpenko, A. Bakhta","doi":"10.52419/issn2072-2419.2023.4.293","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.4.293","url":null,"abstract":"This  work  is  devoted  to  studying  the effect  of  Expert  Hepatic  ready-made  diets for  adult  cats  liver  care  company  MIRATORG  on  cats  in  the  complex  therapy  of hepatopathy. An important component in the complex treatment of cats with liver diseases is the use of complete diets. The purpose of these diets is to replenish energy and nutrients to maintain the body's needs and ensure the regeneration of hepatocytes to maintain liver  function.  This  can  be  achieved  if  the diet is easily digestible and has high palatability, high energy density and modified protein  content.  In  the  course  of  the  studies, biochemical blood parameters were studied, reflecting the condition of the liver in cats, which used ready-made Expert Hepatic diets for  adult  cats’ liver  care  from  the  MIRATORG company in the complex treatment of hepatopathy.  The  study  was  conducted  on the  basis  of  the  Multifunctional  Veterinary Center \"SPbGUVM\" in the period from February 2022 to October 2023. The study was carried out on cats of different breeds aged 6-9 years. The study revealed that at the beginning of the experiment, all experimental animals had increased indicators characterizing the condition of the liver. At the same time,  the  activity  of  the  cytolysis  marker enzymes AlAT and AST was higher than the upper limit of the reference values for this animal species by an average of 1.5 times. A less pronounced increase in activity was observed  in  alkaline  phosphatase,  the  main marker of cholestasis. These changes corresponded to a moderate increase in the content of total bilirubin. By the end of the experiment, a significant decrease in all studied parameters was observed. The level of bilirubin and alkaline phosphatase was at the upper limit of the reference values for this animal species. The activity of aminotransferases significantly decreased, but still remained above normal.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"29 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}