Ella S Smith, Alannah K A McKay, Kathryn E Ackerman, Kirsty J Elliott-Sale, Trent Stellingwerff, Rachel Harris, Louise M Burke
{"title":"Female Athletes Report Positive Experiences as Research Participants.","authors":"Ella S Smith, Alannah K A McKay, Kathryn E Ackerman, Kirsty J Elliott-Sale, Trent Stellingwerff, Rachel Harris, Louise M Burke","doi":"10.1123/ijsnem.2024-0182","DOIUrl":"https://doi.org/10.1123/ijsnem.2024-0182","url":null,"abstract":"<p><p>Given the underrepresentation of women in sports and exercise science research, we sought to understand the experiences of female athletes currently involved in applied sports and exercise science research to inform future studies and potentially increase participation rates. Accordingly, we investigated the experiences of 89 female athletes (n = 48 cyclists/triathletes, n = 19 race walkers, n = 22 National Rugby League Indigenous Women's Academy players) who participated in four separate studies of sports performance with different methodological characteristics. Participants completed a questionnaire upon study completion that queried prior research participation, reasons for participating and experiences during the current study. Across all 89 athletes, 81% were first-time research participants, with the primary barriers cited as a perceived lack of opportunities or being unaware of opportunities (93%). Participants rated an interest in the research outcome as the most important aspect influencing their decision to participate (90 ± 14 [out of 100]), followed by the opportunities to receive personalized results (84 ± 20) and education (78 ± 27). Most participants (87%) stated that they would apply the study findings to their sports involvement, while the remaining 13% reported that they required support to understand the application of results. The majority (94%) of participants indicated a willingness to participate in future studies, while the research experience was rated positively at a mean 77 out of 100. Ultimately, our findings uncovered a perceived lack of opportunity as the primary barrier to female athlete research participation. As such, opportunities for women to participate in high-quality studies should be prioritized.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Ferreira Vieira, Eduarda Blanco-Rambo, Marcelo Bandeira-Guimarães, Ramiro Teixeira Silva, Andressa Fergutz, Isabel de Almeida Paz, Samuel Vargas Munhoz, Renato Colombelli, Marco Aurélio Vaz, Rodrigo Cauduro Oliveira Macedo, Eduardo Lusa Cadore
{"title":"Impact of Overnight Fasted State Versus Fed State on Adaptations to Resistance Training: A Randomized Clinical Trial.","authors":"Alexandra Ferreira Vieira, Eduarda Blanco-Rambo, Marcelo Bandeira-Guimarães, Ramiro Teixeira Silva, Andressa Fergutz, Isabel de Almeida Paz, Samuel Vargas Munhoz, Renato Colombelli, Marco Aurélio Vaz, Rodrigo Cauduro Oliveira Macedo, Eduardo Lusa Cadore","doi":"10.1123/ijsnem.2024-0215","DOIUrl":"https://doi.org/10.1123/ijsnem.2024-0215","url":null,"abstract":"<p><p>The aim was to verify the effects of 12 weeks of resistance training (RT) performed in the fasted state compared with the fed state on body composition and physical performance in young adults. Participants were randomly assigned into fasting RT group (Fast-RT, n = 15) and fed RT group (Fed-RT, n = 13). Both groups trained two weekly resistance exercise sessions after an overnight fast or between 1 and 2 hr after consumption of a carbohydrate-rich meal, associated with isocaloric nutritional guidance. Assessments of body composition (dual-energy X-ray absorption), quadriceps muscle thickness (ultrasonography), maximum dynamic strength (one repetition maximum test), and muscle power in bench press and knee-extension exercises were performed before and after 12 weeks of intervention. Both Fast-RT and Fed-RT groups showed increases (p time ≤ .01) in quadriceps muscle thickness (1.21 and 1.18 cm, respectively; p group = .371; p Group × Time = .871), maximum dynamic strength (bench press: 10.53 and 4.89 kg, respectively; p group = .251; p Group × Time = .268; knee extension: 28.53 and 29.31 kg, respectively; p group = .919; p Group × Time = .846), and muscle power (knee extension mean power 70% one repetition maximum: 59.28 and 46.21 W, respectively; p group = .833; p Group × Time = .616; knee extension maximal power 70% one repetition maximum: 100.65 and 54.76 W, respectively; p group = .812; p Group × Time = .409). Regardless of food consumption prior to the sessions (fasted state and fed state), RT performed twice weekly across 12 weeks was associated with improvements in muscle hypertrophy and neuromuscular performance in young adults.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Caffeine Augments Sustained Hyperemia in Previously Exercised Leg in Male Competitive Long-Distance Runners.","authors":"Naoto Fujii, Taiga Hirayama, Ryoko Matsutake, Shota Ohki, Yoshiharu Nabekura, Tsutomu Hiroyama, Takeshi Nishiyasu","doi":"10.1123/ijsnem.2024-0191","DOIUrl":"https://doi.org/10.1123/ijsnem.2024-0191","url":null,"abstract":"<p><p>Blood flow in exercised skeletal muscle remains elevated postexercise, potentially playing a critical role in recovery and adaptation process. However, effective and easily implementable interventions that augment this response have yet to be identified. In this study, we investigated whether caffeine intake enhances sustained postexercise hyperemia in previously active leg in competitive long-distance runners. Ten competitive male long-distance runners participated in baseline measurements, during which cardiorespiratory responses, including leg blood flow measured by ultrasound Doppler equipment, were assessed in a supine position. Subsequently, they ingested either (a) placebo capsules or (b) capsules containing 6 mg/kg caffeine in a randomized, counterbalanced, double-blind, and crossover manner. They then completed 8-min high-intensity treadmill running at 98% of the average running speed of their estimated 10,000-m best time, followed by postexercise measurements assessing the same cardiorespiratory responses. Postexercise leg blood flow was elevated from baseline, and this response was 17% higher in caffeine relative to placebo condition (between-trial difference in average with [95% CI] = 182 [2.33, 363] ml/min, p = .048, d = 1.03). Caffeine ingestion also increased minute ventilation (2.06 [0.603, 3.53] L/min, p = .011, d = 1.17), whereas it reduced end-tidal CO2 partial pressure (-2.09 [-3.68, -0.504] mmHg, p = .015, d = 1.15) postexercise relative to placebo condition. We show that preexercise 6 mg/kg caffeine intake increases postexercise leg blood flow following high-intensity running in male competitive long-distance runners. Our results stimulate future studies to assess if caffeine-induced elevations in leg blood flow accelerates recovery and/or adaptations.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ida A Heikura, Ming-Chang Tsai, Erik Sesbreno, Walter T P McCluskey, Liz Johnson, Holly Murray, Trent Stellingwerff
{"title":"Current Resting Metabolic Rate Prediction Equations Lack Sensitivity and Specificity to Indicate Relative Energy Deficiency in Sport: A Large Cohort Study in Elite Athletes.","authors":"Ida A Heikura, Ming-Chang Tsai, Erik Sesbreno, Walter T P McCluskey, Liz Johnson, Holly Murray, Trent Stellingwerff","doi":"10.1123/ijsnem.2024-0254","DOIUrl":"https://doi.org/10.1123/ijsnem.2024-0254","url":null,"abstract":"<p><strong>Objectives: </strong>Measured resting metabolic rate (RMR) was compared to predicted RMR equations (RMRratio) to see whether a low RMRratio relates to the Relative Energy Deficiency in Sport (REDs) Clinical Assessment Tool 2 (CAT2) severity/risk score.</p><p><strong>Methods: </strong>Female (n = 127) and male (n = 53) athletes (performance Tiers 3-5) were assigned green/yellow/orange/red light according to CAT2. RMR and submaximal exercise energy expenditure (via cycle ergometer) were assessed fasted on the same morning via indirect calorimetry. Low RMR was defined as RMRratio < 0.90, with 11 RMR prediction equations tested for sensitivity, specificity, and predictive validity against the CAT2.</p><p><strong>Results: </strong>RMRratio (Cunningham) was only lower in red versus green light (0.90 ± 0.07 vs. 0.99 ± 0.10; p = .023; but RMRratio was only low in 44% of red light athletes). The prevalence of low RMRratio ranged from 1% (Owen equation) to 68% (van Hooren equation) despite the overall prevalence of REDs being 46%. As a diagnostic (no REDs [green] vs. REDs [yellow + orange + red]), Cunningham equation reported sensitivity (true positives) of 0.77 at RMRratio of 1.00 and specificity (true negatives) of 1.00 at RMRratio of 0.70. Exercise energy expenditure was significantly lower in green versus orange (0.131 ± 0.013 vs. 0.142 ± 0.008 kcal·kg fat-free mass-1·min-1; p < .001) but was greater in red (0.127 ± 0.011) versus orange.</p><p><strong>Conclusion: </strong>Interpretation of RMRratio is radically impacted by choice of prediction equation. Although there may be some utility in cross-sectionally detecting extreme REDs cases (red light) via RMRratio, more research with a focus on sport/phenotype-specific prediction equations and varying risk thresholds is required to strengthen the validity and reliability of RMR as a part of REDs diagnostics.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"1-13"},"PeriodicalIF":3.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is It Required to Abstain From Fluid Consumption in the 10 Min Before Collection of a Saliva Sample?","authors":"Diogo V Leal, John Hough","doi":"10.1123/ijsnem.2024-0192","DOIUrl":"https://doi.org/10.1123/ijsnem.2024-0192","url":null,"abstract":"<p><p>The noninvasive and reliable saliva collection method for stress-related endocrine biomarkers analysis has become common in field- and laboratory-based research in the last 15 years. Current guidelines recommend interrupting water consumption 10 min before saliva sampling to avoid inaccurate, diluted concentrations of the biomarkers being examined. However, the impact of saliva dilution on salivary cortisol and testosterone levels has not been examined yet. This was a randomized, crossover experiment. Fourteen active healthy males completed three separate cycle-bout trials, where a set volume of water (250 ml) was consumed 10, 5, or 1 min before saliva sampling. Saliva was collected pre-, post-, and 30 min postexercise. No differences were observed in resting samples in any of the trials (p < .05). However, salivary cortisol increased from pre- to postexercise in the 10 (+52%, p = 0.022) and 5-min trial (+36%, p = .005) only. Salivary testosterone also increased in 10 (+34%, p = .005), 5 (+37%, p < .001), and 1-min trials (+24%, p < .035). This study proposes that consuming water up to 1 min before providing a saliva sample will not dilute the sample, allowing for an accurate determination of salivary cortisol and testosterone concentration levels. Practically, the 10-min fluid abstinence required before saliva sampling in the previous guidelines could be reduced to 1 min; however, if examining the response of salivary cortisol to an exercise trail, a fluid abstinence of 5 min may be more appropriate. This conclusion will allow for less restriction on researchers and participants alike.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"1-8"},"PeriodicalIF":3.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher Lamb, Fletcher Collins-Shirley, Sion Rees-Millns, Alex Cowley, Thomas D Love, Mark Waldron, Yung-Chih Chen, Richard S Metcalfe
{"title":"No Effect of Delaying a Carbohydrate-Rich Breakfast on Afternoon High-Intensity Intermittent Exercise Performance in Trained Games Players: A Randomized, Single-Blind, Placebo-Controlled Trial.","authors":"Christopher Lamb, Fletcher Collins-Shirley, Sion Rees-Millns, Alex Cowley, Thomas D Love, Mark Waldron, Yung-Chih Chen, Richard S Metcalfe","doi":"10.1123/ijsnem.2024-0239","DOIUrl":"https://doi.org/10.1123/ijsnem.2024-0239","url":null,"abstract":"<p><p>This study tested the hypothesis that delaying consumption of a carbohydrate-rich breakfast by 2 hr would impair prolonged high-intensity intermittent exercise performance in the afternoon. Fifteen intermittent games players (mean ± SD: age: 24 ± 6 years; V˙O2peak: 46 ± 6 ml·kg-1·min-1) completed a randomized, single-blind, placebo-controlled crossover study with two trials (EARLY and DELAY) matched for dietary intake. In EARLY, participants consumed a high-carbohydrate (semisolid) breakfast shake (2 g/kg BM maltodextrin, 1 ml/kg BM orange squash, 0.15 g/kg BM xanthan gum, 0.067 g/kg BM artificial sweetener, and 6 ml/kg BM water) at 8 a.m., followed by a taste and texture matched, but energy depleted, placebo shake 2 hr later. In DELAY, the order of these shakes was reversed. Three hours following a high-carbohydrate lunch (888 ± 107 Kcal, 145 ± 28 g carbohydrate), participants completed a 90-min intermittent cycling test, consisting of two 40-min halves, with 10 min of rest in between. Each half involved 18 repeated 2-min blocks of steady-state cycling (100 s; 35% Wmax), followed by 15 s of unloaded pedaling and a 6-s all-out sprint. There were no differences in peak power (first half: mean difference [95% confidence interval]: 6.6 [-10.9, 24.1] W, d = 0.03 and second half: 8.5 [-6.5, 23.6] W, d = 0.04) or mean power (first half: mean difference: 6.4 [-10.7, 23.5] W, d = 0.03 and second half: mean difference: 7.3 [-6.5, 21.3] W, d = 0.04) during the sprints between the DELAY and EARLY conditions. In contrast with our hypothesis, these data provide no evidence that delaying consumption of a carbohydrate-rich breakfast by 2 hr impairs prolonged high-intensity intermittent exercise performance in the afternoon.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case Series: Management of Exercise-Associated Gastrointestinal Symptoms in Endurance Athletes Using a High-Carbohydrate Low-FODMAP Therapeutic Intervention.","authors":"Rachel Scrivin, Gary Slater, Ricardo J S Costa","doi":"10.1123/ijsnem.2024-0133","DOIUrl":"https://doi.org/10.1123/ijsnem.2024-0133","url":null,"abstract":"<p><p>This case-series describes a four-phase management approach implementing gastrointestinal assessment during exercise (GastroAxEx) to develop therapeutic interventions for athletes affected by exercise-associated gastrointestinal symptoms (Ex-GIS). Recreational to elite-level athletes who experienced recurrent severe Ex-GIS (n = 9) and controls (n = 2) (without Ex-GIS) volunteered to participate in the case series. The four-phased approach involved a clinical assessment (Phase 1), a standardized laboratory GastroAxEx where physiological strain and GIS data were collected (Phase 2), individualized therapeutic intervention and management strategies based on Phase 2 outcomes that specifically included implementation of a 48-hr high carbohydrate low FODMAP diet (Phase 3), and the monitoring and adjustment of therapeutic interventions (Phase 4). The majority of athletes (n = 6/9) consumed <400 ml/hr of fluid ad libitum, resulting in 2%-4% body mass loss, and <40 g/hr of exogenous carbohydrate (n = 8/9), during the GastroAxEx. Severe Ex-GIS (predominantly loose stools) was reported by n = 4/9 athletes, whereas n = 8/9 athletes reported severe Ex-GIS (predominantly loose stools) in the recovery period. All athletes reported low food and fluid intake tolerance during exercise and recovery. Orocecal transit time was slow or delayed for n = 2/9 athletes. Most athletes (n = 8/9) successfully implemented a 48-hr high carbohydrate low FODMAP prior to and improved intake tolerance during the targeted event. In addition, the incidence and severity of Ex-GIS were reduced, resulting in improved perceived work output during the targeted events. A 48-hr high carbohydrate low FODMAP before endurance exercise appears to be a valuable addition to suggested therapeutic interventions used to mitigate Ex-GIS.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"1-18"},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Bagot, Jennifer Miles-Chan, Anthony C Hackney, Martine Duclos, Laurie Isacco
{"title":"Female Exercise Metabolism: Quality Assessment of Existing Knowledge Base and Key Challenges in Study Design.","authors":"Sarah Bagot, Jennifer Miles-Chan, Anthony C Hackney, Martine Duclos, Laurie Isacco","doi":"10.1123/ijsnem.2024-0095","DOIUrl":"10.1123/ijsnem.2024-0095","url":null,"abstract":"<p><p>A better understanding of the practical and methodological challenges inherent in accurately tracking female hormonal status would enhance the clarity of research findings in exercise metabolism. The purpose of this study was to conduct an objective assessment of the quality of existing literature in this area and to provide a general overview of the practical conditions and issues encountered in studies investigating substrate metabolism during exercise in women, both in those using (HC+) or not using (HC-) hormonal contraceptives. Forty-four articles were identified through systematic reviews, meta-analyses, and searches on PubMed/MEDLINE. A quality assessment framework was developed and applied using a double-blind scoring approach. The loss/exclusion of data between baseline and final analyses per study was quantified, and the main challenges were highlighted. A higher mean global score was observed in studies conducted among HC+ women (81%) than those among HC- women (46%). Although the dropout rates were rarely mentioned in HC+ women articles, the mean rate of participant/data loss in HC- groups was 22.1%. The rate of HC- participant loss was positively correlated with the global score (r = .504, p = .02). High-quality research may be easier to achieve in studies involving HC+ women compared with those involving HC- women. Studies on HC- women seem to face more practical challenges, such as tracking the menstrual cycle and targeting specific (sub)phases of the menstrual cycle, along with technical and feasibility limitations. Thus, although the framework for designing such studies exists, the quality assessment of the available literature emphasizes its challenge in terms of research implementation.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"255-268"},"PeriodicalIF":3.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher E Rauch, Kayla Henningsen, Isabel Martinez, Pascale Young, Alice Mika, Zoya Huschtscha, Alan McCubbin, Rebecca Henry, Doville Anderson, Ricardo J S Costa
{"title":"The Effects of Prebiotic Supplementation on Markers of Exercise-Induced Gastrointestinal Syndrome in Response to Exertional Heat Stress.","authors":"Christopher E Rauch, Kayla Henningsen, Isabel Martinez, Pascale Young, Alice Mika, Zoya Huschtscha, Alan McCubbin, Rebecca Henry, Doville Anderson, Ricardo J S Costa","doi":"10.1123/ijsnem.2024-0127","DOIUrl":"https://doi.org/10.1123/ijsnem.2024-0127","url":null,"abstract":"<p><p>Exercise perturbs various aspects of gastrointestinal integrity and function, which may lead to performance impeding gastrointestinal symptoms (GIS) and/or precipitate clinical issues warranting medical management. This study aimed to determine the impact of prebiotic supplementation on gastrointestinal integrity and functional status in response to exertional heat stress (EHS). Sixteen endurance athletes completed two trials of 3-hr running at 60% V˙O2max in 30 °C at baseline (T1) and following an 8-week supplementation period (T2), with 16 g/day prebiotic (PREBIOTIC) or matched placebo (PLACEBO). Blood samples were collected pre-EHS and post-EHS and in recovery for determination of stress response (cortisol), intestinal epithelial injury (intestinal fatty acid binding protein), bacterial endotoxemia (sCD14), and systemic inflammation (C-reactive protein). GIS and feeding tolerance variables were assessed throughout the EHS. Orocecal transit time was determined via a lactulose challenge given at 2.5 hr into EHS. Plasma cortisol (combined mean: +252 ng/ml), intestinal fatty acid binding protein (+800 pg/ml), and sCD14 (+487 ng/ml) concentrations increased in response to EHS in T1 (p ≤ .05), but not for C-reactive protein (+0.8 μg/ml; p > .05), in both PREBIOTIC and PLACEBO. PREBIOTIC supplementation resulted in a blunted intestinal fatty acid binding protein response on T2 (+316 pg/ml) compared with an increase (+1,001 ng/ml) in PLACEBO (p = .005). Lower sCD14 was observed at T2 (2,799 ng/ml) versus T1 (3,246 ng/ml) in PREBIOTIC only (p = .039). No intervention effects were observed for C-reactive protein. No difference within or between PREBIOTIC and PLACEBO at T1 and T2 was observed for orocecal transit time, GIS, and feeding tolerance. In conclusion, 8 weeks of prebiotic supplementation modestly attenuates EHS associated perturbations to intestinal integrity, but does not further impair gastrointestinal transit and/or exacerbate EHS associated GIS or feeding tolerance.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"1-18"},"PeriodicalIF":3.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew Morrison, Jonathon Weakley, Gregory D Roach, Charli Sargent, Dean J Miller, Lara Nyman, Carissa Gardiner, Gabriella Munteanu, Matthew D Pahnke, Shona L Halson
{"title":"Minimal Influence of Formulated Nutritional Interventions on Sleep and Next-Morning Physical Performance, Cognitive Function, and Postural Sway in Adult Males: A Randomized, Placebo-Controlled, Crossover Study.","authors":"Matthew Morrison, Jonathon Weakley, Gregory D Roach, Charli Sargent, Dean J Miller, Lara Nyman, Carissa Gardiner, Gabriella Munteanu, Matthew D Pahnke, Shona L Halson","doi":"10.1123/ijsnem.2024-0148","DOIUrl":"10.1123/ijsnem.2024-0148","url":null,"abstract":"<p><p>Athletes often experience poor sleep quality and quantity which may hinder physical performance and cognitive function. Presleep nutritional strategies may be an alternative to pharmacological interventions to improve sleep. The aim of this study was to examine the effect of two different doses of a nutritional intervention (both containing high Glycemic Index carbohydrate, whey, tryptophan, theanine, and 5'AMP) versus placebo on objective and subjective sleep, next-morning physical performance, cognitive function, and postural sway. Seventeen healthy, trained adult males completed three double-blind trials in a randomized, counterbalanced, crossover design. Participants were allocated to conditions using a Latin Square design. A (a) low-dose, (b) high-dose, or (c) placebo drink was provided 90 min before sleep each night. Polysomnography was used to measure objective sleep parameters. Cognitive function, postural sway, and subjective sleep quality were assessed 30 min after waking. Physical performance was assessed using a 10-min maximal effort cycling time trial each morning. All data were analyzed using linear mixed effects models and effect sizes were calculated using Cohen's d. This study was registered prospectively as a clinical trial with Australian New Zealand Clinical Trials Registry (registration number: NCT05032729). No significant main effects or improvements were observed in objective or subjective sleep parameters, physical performance, cognitive function, or postural sway. The low-dose intervention appeared to reduce N3 sleep duration compared with placebo (-13.6 min). The high-dose intervention appeared to increase N1 sleep duration compared with placebo (+7.4 min). However, the magnitude of changes observed were not likely to cause meaningful reductions in sleep quality and quantity.</p>","PeriodicalId":14334,"journal":{"name":"International journal of sport nutrition and exercise metabolism","volume":" ","pages":"192-205"},"PeriodicalIF":3.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}