Effects of Carotenoid Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

IF 3 3区 医学 Q2 NUTRITION & DIETETICS
Xing Ye, Yanchun Li
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引用次数: 0

Abstract

Objective: This study aims to investigate the potential effects of carotenoid supplementation on mitigating exercise-induced oxidative stress and to provide guidance for future research.

Methods: We conducted a systematic review and meta-analysis using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched multiple databases from inception to August 2024 for randomized clinical trials investigating the effects of carotenoid supplementation on biomarkers of oxidative stress, inflammatory markers, antioxidant levels, and metabolic parameters in the context of exercise-induced oxidative stress. The search terms included "carotenoids," "supplementation," "exercise," "oxidative stress," "inflammation," "antioxidants," "metabolic parameters," and their synonyms. Two reviewers independently extracted study data, with disagreements resolved by a third reviewer. Quality was assessed by the Cochrane risk-of-bias method. Random and fixed effects models were used for the analysis of standard mean differences (SMD) or weighted mean differences (MDs) with 95% confidence intervals (CI).

Results: A total of 12 studies were included in the final analysis. Carotenoid supplementation led to significant effects in assessing oxidative stress induced by exercise (overall oxidative stress: SMD = -0.55, 95% CI [-1.04, -0.06]; malondialdehyde: MD = -0.05, 95% CI [-0.09,-0.02]; total antioxidant capacity: MD = 0.03, 95% CI [0.02, 0.03]; 8-isoprostane: MD = -35.70, 95% CI [-59.32, -12.09]; lipid peroxide: SMD = -1.07, 95% CI [-1.94, -0.20]; and nitric oxide: MD = -8.07, 95% CI [-12.54,-3.59]), inflammatory markers (inflammatory levels: SMD = 1.63, 95% CI [0.81, 2.46]; interleukin levels: SMD = 1.54, 95% CI [0.69, 2.40]; and C-reactive protein: MD = 4.56, 95% CI [0.97, 8.14]), antioxidant levels (SMD = 0.84, 95% CI [0.14, 1.53]), and metabolic parameters (energy expenditure: SMD = -0.52, 95% CI [-0.78, -0.26]; p < .05).

Conclusion: Carotenoid supplementation appears to attenuate exercise-induced oxidative stress and the inflammatory response and improve antioxidant levels and metabolic capabilities. However, these results may be influenced by participant variability or methodological differences. Further research with larger sample sizes, longer supplementation periods, higher doses, and carotenoid bioavailability is needed to confirm these findings.

补充类胡萝卜素对运动诱导氧化应激的影响:随机临床试验的系统回顾和荟萃分析。
目的:探讨补充类胡萝卜素对减轻运动性氧化应激的潜在作用,为今后的研究提供指导。方法:我们使用系统评价和meta分析指南的首选报告项目进行了系统评价和meta分析。我们检索了从开始到2024年8月的多个数据库,进行随机临床试验,研究类胡萝卜素补充对运动诱导氧化应激背景下氧化应激生物标志物、炎症标志物、抗氧化水平和代谢参数的影响。搜索词包括“类胡萝卜素”、“补充剂”、“运动”、“氧化应激”、“炎症”、“抗氧化剂”、“代谢参数”及其同义词。两位审稿人独立提取研究数据,分歧由第三位审稿人解决。采用Cochrane风险偏倚法评估质量。采用随机效应和固定效应模型对标准平均差异(SMD)或加权平均差异(MDs)进行95%置信区间(CI)分析。结果:最终分析共纳入12项研究。类胡萝卜素补充剂对评估运动引起的氧化应激有显著影响(总体氧化应激:SMD = -0.55, 95% CI [-1.04, -0.06];丙二醛:MD = -0.05, 95% CI [-0.09,-0.02];总抗氧化能力:MD = 0.03, 95% CI [0.02, 0.03];8-异前列腺素:MD = -35.70, 95% CI [-59.32, -12.09];过氧化脂质:SMD = -1.07, 95% CI [-1.94, -0.20];一氧化氮:MD = -8.07, 95% CI[-12.54,-3.59]),炎症标志物(炎症水平:SMD = 1.63, 95% CI [0.81, 2.46];白细胞介素水平:SMD = 1.54, 95% CI [0.69, 2.40];和c反应蛋白:MD = 4.56, 95% CI[0.97, 8.14]),抗氧化水平(SMD = 0.84, 95% CI[0.14, 1.53])和代谢参数(能量消耗:SMD = -0.52, 95% CI [-0.78, -0.26];P < 0.05)。结论:补充类胡萝卜素可以减轻运动引起的氧化应激和炎症反应,提高抗氧化水平和代谢能力。然而,这些结果可能受到参与者差异或方法差异的影响。进一步的研究需要更大的样本量、更长的补充周期、更高的剂量和类胡萝卜素的生物利用度来证实这些发现。
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来源期刊
CiteScore
5.00
自引率
8.00%
发文量
50
审稿时长
6-12 weeks
期刊介绍: The International Journal of Sport Nutrition and Exercise Metabolism (IJSNEM) publishes original scientific investigations and scholarly reviews offering new insights into sport nutrition and exercise metabolism, as well as articles focusing on the application of the principles of biochemistry, physiology, and nutrition to sport and exercise. The journal also offers editorials, digests of related articles from other fields, research notes, and reviews of books, videos, and other media releases. To subscribe to either the print or e-version of IJSNEM, press the Subscribe or Renew button at the top of your screen.
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